PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27497234-5 2016 In comparison with human CYP2E1, camel CYP2E1 more efficiently binds to small toxins as aniline, benzene, catechol, amides, butadiene, toluene and acrylamide. Toluene 135-142 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 25-31 23311134-7 2012 The expression of cyp2e1 in transgenic tobacco with cyp2e1 decreased obviously treated by ethyl alcohol and reduced slightly by benzene and toluene, while it enhanced by acetone, formaldehyde and oxygen deficit in different levels. Toluene 140-147 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 18-24 25963742-0 2015 CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit. Toluene 51-58 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 25963742-1 2015 BACKGROUND: CYP2E1 is a versatile phase I drug-metabolizing enzyme responsible for the biotransformation of most volatile organic compounds, including toluene. Toluene 151-158 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 12-18 25963742-2 2015 Human toluene exposure increases CYP2E1 mRNA and modifies its activity in leucocytes; however, epigenetic implications of this interaction have not been investigated. Toluene 6-13 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 33-39 25963742-3 2015 GOAL: To determine promoter methylation of CYP2E1 and other genes known to be affected by toluene exposure. Toluene 90-97 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 43-49 25963742-6 2015 RESULTS: In exposed group we found significant correlations between toluene airborne levels and CYP2E1 promoter methylation (r=-.36, p<0.05), as well as for IL6 promoter methylation levels (r=.44, p<0.05). Toluene 68-75 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 96-102 25963742-7 2015 Moreover, CYP2E1 promoter methylation levels where higher in toluene-exposed smokers compared to nonsmokers (p=0.009). Toluene 61-68 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 10-16 25963742-9 2015 CONCLUSION: These results highlight the importance of considering CYP2E1 epigenetic modifications, as well as its interactions with other genes, as key factors for unraveling the sub cellular mechanisms of toxicity exerted by oxidative stress, which can initiate disease process in chronic, low-level toluene exposure. Toluene 301-308 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 66-72 25963742-10 2015 People co-exposed to toluene and tobacco smoke are in higher risk due to a possible CYP2E1 repression. Toluene 21-28 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 84-90 23311134-7 2012 The expression of cyp2e1 in transgenic tobacco with cyp2e1 decreased obviously treated by ethyl alcohol and reduced slightly by benzene and toluene, while it enhanced by acetone, formaldehyde and oxygen deficit in different levels. Toluene 140-147 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 52-58 16581535-2 2006 Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens. Toluene 0-7 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 30-49 16464483-1 2006 The objective of the present study was to evaluate the magnitude of interindividual variability in the internal dose of toluene in children of various age groups, on the basis of subject-specific hepatic CYP2E1 content and physiology. Toluene 120-127 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 204-210 16464483-3 2006 The adult toluene PBPK model, with enzyme content-normalized CL(int), facilitated the calculation of child-specific CL(int) based on knowledge of hepatic CYP2E1 protein levels. Toluene 10-17 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 154-160 16464483-6 2006 The resulting model was used to simulate the blood concentration profiles in children exposed by inhalation, to 1 ppm toluene for 24 h. For this exposure scenario, the area under the venous blood concentration vs. time curve (AUC) ranged from 0.30 to 1.01 microg/ml x h in neonates with low CYP2E1 concentration (<3.69 pmol/mg protein). Toluene 118-125 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 291-297 16581535-0 2006 Occupational toluene exposure induces cytochrome P450 2E1 mRNA expression in peripheral lymphocytes. Toluene 13-20 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 38-57 22342293-0 2012 CYP2E1 phenotype in Mexican workers occupationally exposed to low levels of toluene. Toluene 76-83 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 20033806-1 2010 Benzene and toluene are common organic solvents currently in worldwide industrial usage, which are metabolized mainly by hepatic cytochrome P450 2E1 (CYP2E1) in humans. Toluene 12-19 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 129-148 20033806-1 2010 Benzene and toluene are common organic solvents currently in worldwide industrial usage, which are metabolized mainly by hepatic cytochrome P450 2E1 (CYP2E1) in humans. Toluene 12-19 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 150-156 20033806-4 2010 The K (m), V (max) and CL (int) values of CYP2E1.1 were 10.1 mM, 9.38 pmol/min/pmol CYP and 0.99 nL/min/pmol CYP for benzene hydroxylation, and 3.97 mM, 19.9 pmol/min/pmol CYP and 5.26 nL/min/pmol CYP for toluene methylhydroxylation, respectively. Toluene 205-212 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 42-48 20033806-5 2010 The K (m), V (max) and CL (int) values for benzene and toluene metabolism of CYP2E1.2, CYP2E1.3 and CYP2E1.4 were comparable to those of wild-type CYP2E1. Toluene 55-62 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 77-83 20033806-5 2010 The K (m), V (max) and CL (int) values for benzene and toluene metabolism of CYP2E1.2, CYP2E1.3 and CYP2E1.4 were comparable to those of wild-type CYP2E1. Toluene 55-62 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 87-93 20033806-5 2010 The K (m), V (max) and CL (int) values for benzene and toluene metabolism of CYP2E1.2, CYP2E1.3 and CYP2E1.4 were comparable to those of wild-type CYP2E1. Toluene 55-62 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 87-93 20033806-5 2010 The K (m), V (max) and CL (int) values for benzene and toluene metabolism of CYP2E1.2, CYP2E1.3 and CYP2E1.4 were comparable to those of wild-type CYP2E1. Toluene 55-62 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 87-93 20033806-6 2010 These findings may mean that the polymorphic alleles of CYP2E1 causing amino acid substitutions are not directly associated with the metabolic activation of benzene and toluene. Toluene 169-176 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 56-62 16581535-2 2006 Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens. Toluene 0-7 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 51-57 16581535-3 2006 Therefore, we investigated the association between toluene exposure and the CYP2E1 response, as assessed by mRNA content in peripheral lymphocytes or the 6-hydroxychlorzoxazone (6OH-CHZ)/chlorzoxazone (CHZ) quotient (known as CHZ metabolic ratio) in plasma, and the role of genotype (5 -flanking region RsaI/PstI polymorphic sites) in 97 male print workers. Toluene 51-58 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 76-82 16581535-7 2006 However, the average CYP2E1 mRNA level in peripheral lymphocytes was 1.07 (0.30-3.08), and CYP2E1 mRNA levels within subjects correlated with the toluene exposure ratio (environmental toluene concentration:urinary hippuric acid concentration) (p = 0.014). Toluene 146-153 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 91-97 16581535-7 2006 However, the average CYP2E1 mRNA level in peripheral lymphocytes was 1.07 (0.30-3.08), and CYP2E1 mRNA levels within subjects correlated with the toluene exposure ratio (environmental toluene concentration:urinary hippuric acid concentration) (p = 0.014). Toluene 184-191 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 91-97 16581535-9 2006 In summary, with further validation, CYP2E1 mRNA content in peripheral lymphocytes could be a sensitive and noninvasive biomarker for the continuous monitoring of toluene effects in exposed persons. Toluene 163-170 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 37-43 7645026-0 1995 Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toluene 94-101 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 30-36 9253143-11 1997 Correlation analysis showed that CYP2E1 (benzyl alcohol formation) and CYP1A2/1 (o-cresol formation) contributed to the metabolism of toluene at the low substrate concentration, whereas CYP2C8 was the form more actively involved at the higher toluene concentrations. Toluene 134-141 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 33-39 9253143-11 1997 Correlation analysis showed that CYP2E1 (benzyl alcohol formation) and CYP1A2/1 (o-cresol formation) contributed to the metabolism of toluene at the low substrate concentration, whereas CYP2C8 was the form more actively involved at the higher toluene concentrations. Toluene 243-250 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 33-39 9253143-14 1997 These results suggest that CYP2E1 and CYP1A2/1 are the main isoforms responsible for the metabolism of toluene at low substrate concentrations in human liver microsomes, CYP2E1 at low styrene concentration, and CYP2C8 and CYP2B6 at high concentrations of toluene and styrene respectively. Toluene 103-110 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 27-33 9253143-14 1997 These results suggest that CYP2E1 and CYP1A2/1 are the main isoforms responsible for the metabolism of toluene at low substrate concentrations in human liver microsomes, CYP2E1 at low styrene concentration, and CYP2C8 and CYP2B6 at high concentrations of toluene and styrene respectively. Toluene 103-110 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 170-176 9253143-14 1997 These results suggest that CYP2E1 and CYP1A2/1 are the main isoforms responsible for the metabolism of toluene at low substrate concentrations in human liver microsomes, CYP2E1 at low styrene concentration, and CYP2C8 and CYP2B6 at high concentrations of toluene and styrene respectively. Toluene 255-262 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 27-33 15129551-8 2004 Toluene metabolism to benzyl alcohol (BA), another CYP2E1-dependent reaction, was also highly dependent on CYP2E1 content in humans, and was more efficient than was CHCl3 metabolism. Toluene 0-7 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 51-57 15129551-8 2004 Toluene metabolism to benzyl alcohol (BA), another CYP2E1-dependent reaction, was also highly dependent on CYP2E1 content in humans, and was more efficient than was CHCl3 metabolism. Toluene 0-7 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 107-113 15129551-9 2004 The specific activity of human CYP2E1 toward toluene metabolism in human MSP was 23 pmol/min/pmol CYP2E1. Toluene 45-52 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 31-37 15129551-9 2004 The specific activity of human CYP2E1 toward toluene metabolism in human MSP was 23 pmol/min/pmol CYP2E1. Toluene 45-52 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 98-104 15129551-10 2004 These results demonstrate that differences in CYP2E1 content of MSP among individuals and between species are largely responsible for observed differences in toluene and CHCl3 metabolism in vitro. Toluene 158-165 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 46-52 10771285-5 2000 CYP2E1 contributes to chlorzoxazone 6-hydroxylation, p-nitroanisole O-demethylation, and toluene hydroxylation by 45.8%, 27.7% and 44.2% respectively, and CYP2C8/9/19 contribute to diazepam N-demethylation by 30.6%. Toluene 89-96 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 7645026-1 1995 In this study, we evaluated the effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on the toluene metabolism. Toluene 130-137 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 62-68 34612013-13 2021 In addition, effective compounds that target CYP2E1, including 18beta-glycyrrhetinic acid, styrene, toluene, nicotine, m-xylene, p-xylene, and colchicine, were identified. Toluene 100-107 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 45-51 32437847-2 2020 In previous studies, CYP2E1 activity in toluene-exposed workers was decreased compared to controls, however, CYP2E1 promoter methylation levels did not show significant differences. Toluene 40-47 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 21-27 33269480-7 2021 BEAS-2B cell exposure to toluene and its homologues revealed the involvement of major (CYP2E1) and minor metabolic pathways (CYP1A1). Toluene 25-32 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 87-93 32437847-7 2020 In toluene-exposed workers, we found significant, lower methylation levels for CYP2E1 compared to controls. Toluene 3-10 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 79-85 31316659-0 2019 Requirement Prediction for Toluene Detox with Foods Intake Rich in CYP2E1 Enzyme and Glycine to Prevent Nerve and Kidney Damage at Shoe Home Industry Workers in Romokalisari Surabaya. Toluene 27-34 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 67-73 31316659-3 2019 AIM: This research aimed to calculate the intake of foods rich in CYP2E1 enzyme and glycine to improve toluene detoxification. Toluene 103-110 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 66-72 31316659-13 2019 The greater the toluene concentration, the greater the needs for foods rich in CYP2E1 enzymes and glycine. Toluene 16-23 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 79-85