PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23675771-0	2013	Interactions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncoupling.	Toluene	91-98	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	60-66	
23675771-1	2013	The goal of this study was to characterize the effects of CYP1A2 CYP2B4 complex formation on the rates and efficiency of toluene metabolism by comparing the results from simple reconstituted systems containing P450 reductase (CPR) and a single P450 to those using a mixed system containing CPR and both P450s.	Toluene	121-128	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	58-64	
8558417-10	1996	Although CYP1A2 appears to be responsible for the formation of the minor (phenolic) metabolites of toluene and the xylene isomers, CYP2E1 catalyzed methylhydroxylation will be the major determinant of the clearance of these compounds in humans.	Toluene	99-106	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	9-15	
9253143-11	1997	Correlation analysis showed that CYP2E1 (benzyl alcohol formation) and CYP1A2/1 (o-cresol formation) contributed to the metabolism of toluene at the low substrate concentration, whereas CYP2C8 was the form more actively involved at the higher toluene concentrations.	Toluene	134-141	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-79	
9253143-11	1997	Correlation analysis showed that CYP2E1 (benzyl alcohol formation) and CYP1A2/1 (o-cresol formation) contributed to the metabolism of toluene at the low substrate concentration, whereas CYP2C8 was the form more actively involved at the higher toluene concentrations.	Toluene	243-250	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	71-79	
9253143-14	1997	These results suggest that CYP2E1 and CYP1A2/1 are the main isoforms responsible for the metabolism of toluene at low substrate concentrations in human liver microsomes, CYP2E1 at low styrene concentration, and CYP2C8 and CYP2B6 at high concentrations of toluene and styrene respectively.	Toluene	103-110	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-44	
9253143-14	1997	These results suggest that CYP2E1 and CYP1A2/1 are the main isoforms responsible for the metabolism of toluene at low substrate concentrations in human liver microsomes, CYP2E1 at low styrene concentration, and CYP2C8 and CYP2B6 at high concentrations of toluene and styrene respectively.	Toluene	255-262	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	38-44