PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23675771-0 2013 Interactions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncoupling. Toluene 91-98 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 60-66 23675771-1 2013 The goal of this study was to characterize the effects of CYP1A2 CYP2B4 complex formation on the rates and efficiency of toluene metabolism by comparing the results from simple reconstituted systems containing P450 reductase (CPR) and a single P450 to those using a mixed system containing CPR and both P450s. Toluene 121-128 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 58-64 8558417-10 1996 Although CYP1A2 appears to be responsible for the formation of the minor (phenolic) metabolites of toluene and the xylene isomers, CYP2E1 catalyzed methylhydroxylation will be the major determinant of the clearance of these compounds in humans. Toluene 99-106 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 9-15 9253143-11 1997 Correlation analysis showed that CYP2E1 (benzyl alcohol formation) and CYP1A2/1 (o-cresol formation) contributed to the metabolism of toluene at the low substrate concentration, whereas CYP2C8 was the form more actively involved at the higher toluene concentrations. Toluene 134-141 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 71-79 9253143-11 1997 Correlation analysis showed that CYP2E1 (benzyl alcohol formation) and CYP1A2/1 (o-cresol formation) contributed to the metabolism of toluene at the low substrate concentration, whereas CYP2C8 was the form more actively involved at the higher toluene concentrations. Toluene 243-250 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 71-79 9253143-14 1997 These results suggest that CYP2E1 and CYP1A2/1 are the main isoforms responsible for the metabolism of toluene at low substrate concentrations in human liver microsomes, CYP2E1 at low styrene concentration, and CYP2C8 and CYP2B6 at high concentrations of toluene and styrene respectively. Toluene 103-110 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 38-44 9253143-14 1997 These results suggest that CYP2E1 and CYP1A2/1 are the main isoforms responsible for the metabolism of toluene at low substrate concentrations in human liver microsomes, CYP2E1 at low styrene concentration, and CYP2C8 and CYP2B6 at high concentrations of toluene and styrene respectively. Toluene 255-262 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 38-44