PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11795493-8	2001	Taken together, these results suggest that in the DZA-induced apoptosis, caspase-8 may serve as an executioner caspase and be activated downstream of both caspase-3 and caspase-9, independently of Fas receptor-ligand interaction.	3-deazaadenosine	50-53	caspase 3	Homo sapiens	155-164	
11795493-0	2001	Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction.	3-deazaadenosine	27-43	caspase 3	Homo sapiens	98-107	
11795493-1	2001	3-Deazaadenosine (DZA), a cellular methylation blocker was reported to induce the caspase-3-like activities-dependent apoptosis in U-937 cells.	3-deazaadenosine	0-16	caspase 3	Homo sapiens	82-91	
11795493-1	2001	3-Deazaadenosine (DZA), a cellular methylation blocker was reported to induce the caspase-3-like activities-dependent apoptosis in U-937 cells.	3-deazaadenosine	18-21	caspase 3	Homo sapiens	82-91	
11190270-0	2000	Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity.	3-deazaadenosine	50-66	caspase 3	Homo sapiens	82-91	
11190270-3	2000	DZA induced a specific cleavage of poly ADP-ribose polymerase (PARP) and an activation of the cysteine protease caspase-3/CPP32 which is known to cleave PARP.	3-deazaadenosine	0-3	caspase 3	Homo sapiens	112-121	
11190270-3	2000	DZA induced a specific cleavage of poly ADP-ribose polymerase (PARP) and an activation of the cysteine protease caspase-3/CPP32 which is known to cleave PARP.	3-deazaadenosine	0-3	caspase 3	Homo sapiens	122-127	
11190270-4	2000	DZA-mediated nuclear DNA-fragmentation was completely blocked in the presence of a universal inhibitor of caspases (z-VAD-fmk) or the specific inhibitor of caspase-3 (z-DEVD-fmk) unlike of cycloheximide (CHX).	3-deazaadenosine	0-3	caspase 3	Homo sapiens	156-165	
11190270-7	2000	Taken together, these results demonstrate that DZA-induced apoptosis initiated through an active transport of DZA into human leukemia cells, is dependent on the caspase-3-like activity without de novo synthesis of proteins and possibly involves c-myc down-regulation.	3-deazaadenosine	47-50	caspase 3	Homo sapiens	161-170	
11190270-7	2000	Taken together, these results demonstrate that DZA-induced apoptosis initiated through an active transport of DZA into human leukemia cells, is dependent on the caspase-3-like activity without de novo synthesis of proteins and possibly involves c-myc down-regulation.	3-deazaadenosine	110-113	caspase 3	Homo sapiens	161-170