PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33080936-10	2020	Esculetin was anti-fibrotic in HUA and UUO mice through inhibiting TGF-beta1-activated profibrotic signals.	esculetin	0-9	transforming growth factor, beta 1	Mus musculus	67-76	
25445053-4	2015	Esculetin inhibited the expressions of cyclin D1, cyclin-dependent kinase (CDK) 4 and matrix metalloproteinase (MMP)-2, and production of both transforming growth factor (TGF)-beta1 and vascular endothelial growth factor (VEGF) in LM8 cells.	esculetin	0-9	transforming growth factor, beta 1	Mus musculus	143-181	
25445053-6	2015	These results suggested that the antitumor and antimetastatic actions of esculetin may be partly attributed to G1 arrest by the inhibition of cyclin D1 and CDK4 expression, while its antiangiogenic action may have been due to the inhibition of MMP-2 expression and TGF-beta1 and VEGF productions at tumor sites.	esculetin	73-82	transforming growth factor, beta 1	Mus musculus	265-274	
25445053-7	2015	Esculetin (10-100muM) and fraxetin (50-100muM) inhibited the production of interleukin (IL)-10, monocyte chemoattractant protein (MCP)-1, and TGF-beta1 during the differentiation of M2 macrophages by reducing the phosphorylation of Stat 3 without affecting its expression.	esculetin	0-9	transforming growth factor, beta 1	Mus musculus	142-151	
19570833-9	2009	In addition, esculetin reduced subepithelial fibrosis and TGF-beta1 levels in the lung.	esculetin	13-22	transforming growth factor, beta 1	Mus musculus	58-67