PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24584631-1 2014 Carbon-carbon bond cleavage reactions are catalyzed by, among others, lanosterol 14-demethylase (CYP51), cholesterol side-chain cleavage enzyme (CYP11), sterol 17beta-lyase (CYP17), and aromatase (CYP19). Carbon 0-6 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 174-179 25482340-1 2015 The steroid hydroxylation and carbon-carbon bond cleavage activities of cytochrome P450 17A1 (CYP17A1) are responsible for the production of glucocorticoids and androgens, respectively. Carbon 30-36 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 72-92 25482340-1 2015 The steroid hydroxylation and carbon-carbon bond cleavage activities of cytochrome P450 17A1 (CYP17A1) are responsible for the production of glucocorticoids and androgens, respectively. Carbon 30-36 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 94-101 25482340-1 2015 The steroid hydroxylation and carbon-carbon bond cleavage activities of cytochrome P450 17A1 (CYP17A1) are responsible for the production of glucocorticoids and androgens, respectively. Carbon 37-43 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 72-92 25482340-1 2015 The steroid hydroxylation and carbon-carbon bond cleavage activities of cytochrome P450 17A1 (CYP17A1) are responsible for the production of glucocorticoids and androgens, respectively. Carbon 37-43 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 94-101 25224484-1 2015 A single enzyme, microsomal P450c17, catalyzes the 17alpha-hydroxylase activity needed to make cortisol and the subsequent 17,20 lyase activity needed to produce the 19-carbon precursors of sex steroids. Carbon 169-175 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 28-35 24593890-1 2015 P450c17 enzyme catalyses two different reactions: the 17alpha-hydroxylation of progesterone and pregnenolone, and segmenting the carbon 17-20 binding from the 17,20lyase producing adrenal androgens. Carbon 129-135 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 24584631-1 2014 Carbon-carbon bond cleavage reactions are catalyzed by, among others, lanosterol 14-demethylase (CYP51), cholesterol side-chain cleavage enzyme (CYP11), sterol 17beta-lyase (CYP17), and aromatase (CYP19). Carbon 7-13 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 174-179 21094255-3 2011 Certain members of the P-450 family, including CYP17 and CYP19, catalyze, at the same active site, not only the hydroxylation process but also an acyl-carbon bond cleavage reaction which has been interpreted to involve the nucleophilic attack of the ferric-peroxyanion, Fe(III)-O-O(-), on the acyl carbon to furnish a tetrahedral intermediate which fragments, leading to acyl-carbon cleavage. Carbon 151-157 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 47-52 24160919-2 2013 In the formation of the male hormone dehydroepiandrosterone, pregnenolone is first hydroxylated by P450 CYP17A1 at the 17-carbon, followed a second round of catalysis by the same enzyme that cleaves the C17-C20 bond, releasing acetic acid and the 17-keto product. Carbon 122-128 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 104-111 22064602-5 2012 The generation of DHT occurs in large part from adrenal 19-carbon precursor steroids, which are dependent on expression of CYP17A1. Carbon 59-65 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 123-130 21094255-4 2011 Evidence is presented to show that in the case of CYP17 the attack of Fe(III)-O-O(-) on the target carbon is promoted by cytochrome b(5), which acts as a conformational regulator of CYP17. Carbon 99-105 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 50-55 21094255-4 2011 Evidence is presented to show that in the case of CYP17 the attack of Fe(III)-O-O(-) on the target carbon is promoted by cytochrome b(5), which acts as a conformational regulator of CYP17. Carbon 99-105 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 182-187 21094255-3 2011 Certain members of the P-450 family, including CYP17 and CYP19, catalyze, at the same active site, not only the hydroxylation process but also an acyl-carbon bond cleavage reaction which has been interpreted to involve the nucleophilic attack of the ferric-peroxyanion, Fe(III)-O-O(-), on the acyl carbon to furnish a tetrahedral intermediate which fragments, leading to acyl-carbon cleavage. Carbon 298-304 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 47-52 21094255-3 2011 Certain members of the P-450 family, including CYP17 and CYP19, catalyze, at the same active site, not only the hydroxylation process but also an acyl-carbon bond cleavage reaction which has been interpreted to involve the nucleophilic attack of the ferric-peroxyanion, Fe(III)-O-O(-), on the acyl carbon to furnish a tetrahedral intermediate which fragments, leading to acyl-carbon cleavage. Carbon 298-304 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 47-52 12464252-2 2003 Both enzymes hydroxylate progesterone at carbon atoms that lie only 2.6A apart, but CYP17 also metabolizes other steroids and demonstrates additional catalytic activities. Carbon 41-47 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 84-89 15555906-0 2004 The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme"s cytochrome b5-dependent acyl-carbon cleavage activities. Carbon 146-152 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 59-77 15555906-0 2004 The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme"s cytochrome b5-dependent acyl-carbon cleavage activities. Carbon 146-152 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 79-84 15555906-1 2004 CYP17 (17alpha-hydroxylase-17,20-lyase; also P450c17 or P450(17alpha)) catalyses the17alpha-hydroxylation of progestogens and the subsequent acyl-carbon cleavage of the 17alpha-hydroxylated products (lyase activity) in the biosynthesis of androgens. Carbon 146-152 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 15555906-1 2004 CYP17 (17alpha-hydroxylase-17,20-lyase; also P450c17 or P450(17alpha)) catalyses the17alpha-hydroxylation of progestogens and the subsequent acyl-carbon cleavage of the 17alpha-hydroxylated products (lyase activity) in the biosynthesis of androgens. Carbon 146-152 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-52 15555906-4 2004 In the present study it was found that substitution of human CYP17 amino acids, Arg(347), Arg(358) and Arg(449), with non-cationic residues, yielded variants that were impaired in the two acyl-carbon bond cleavage activities, quantitatively to the same extent and these were reduced to between 3 and 4% of the wild-type protein. Carbon 193-199 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 61-66 12915666-1 2003 Cytochrome P450c17 catalyzes both 17alpha-hydroxylation and 17,20-lyase conversion of 21-carbon steroids to 19-carbon precursors of sex steroids. Carbon 89-95 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 34662099-12 2021 The observed switch in substrate specificity of the enzyme is consistent with this result if the hydrogen bonding to the proximal peroxo oxygen is necessary for a proposed nucleophilic peroxoanion-mediated mechanism for CYP17A1 in carbon-carbon bond scission. Carbon 231-237 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 220-227 9365181-5 1997 The acyl-carbon cleavage reaction of equation 1 is catalysed by sterol 14alpha-demethylases, accounts for several side-chain fission products formed by CYP17 (17alpha-hydroxylase-17,20-lyase), and constitutes a weak property of certain drug metabolizing P450s, when given aliphatic aldehydes as substrates. Carbon 9-15 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 152-157 7578007-0 1995 Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-450(17)alpha; 17 alpha-hydroxylase-17,20-lyase). Carbon 75-81 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 122-127 34662099-12 2021 The observed switch in substrate specificity of the enzyme is consistent with this result if the hydrogen bonding to the proximal peroxo oxygen is necessary for a proposed nucleophilic peroxoanion-mediated mechanism for CYP17A1 in carbon-carbon bond scission. Carbon 238-244 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 220-227 33781841-2 2021 This review discusses the complex activity of CYP17A1, looking at its role in both the classical and backdoor steroidogenic pathways and the complex chemistry it carries out to perform both a hydroxylation reaction and a carbon-carbon cleavage, or lyase reaction. Carbon 221-227 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 46-53 33781841-2 2021 This review discusses the complex activity of CYP17A1, looking at its role in both the classical and backdoor steroidogenic pathways and the complex chemistry it carries out to perform both a hydroxylation reaction and a carbon-carbon cleavage, or lyase reaction. Carbon 228-234 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 46-53 32007561-11 2020 Although CYP17A1 exhibited no catalytic activity towards the 5alpha-reduced intermediates, once the C4-C5 double bond and the keto group at C3 were reduced, both the hydroxylation and lyase reactions proceeded efficiently. Carbon 100-105 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 9-16 29888793-1 2018 Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two-step reaction process: allylic hydroxylation and carbo-carbon bond scission. Carbon 190-196 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 29888793-1 2018 Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two-step reaction process: allylic hydroxylation and carbo-carbon bond scission. Carbon 190-196 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 29283561-3 2018 However, the subsequent 17,20 carbon-carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17alpha-hydroxypregnenlone (OHPREG) versus 17alpha-hydroxyprogesterone (OHPROG). Carbon 30-36 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 118-125 29283561-3 2018 However, the subsequent 17,20 carbon-carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17alpha-hydroxypregnenlone (OHPREG) versus 17alpha-hydroxyprogesterone (OHPROG). Carbon 37-43 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 118-125