PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32949301-5 2021 Cells were basally stimulated with agonists Pam2CSK4 (Pam; TLR2), polyinosinic/polycytidylic acid (Poly I:C; TLR3), and lipopolysaccharide (LPS; TLR4) for 24 h. Supernatants were evaluated with ELISA for cytokines TNFalpha, IL-6, and IL-1beta. Carbon 0-1 tumor necrosis factor Homo sapiens 214-222 33544162-0 2021 Novel voltammetric tumor necrosis factor-alpha (TNF-alpha) immunosensor based on gold nanoparticles involved in thiol-functionalized multi-walled carbon nanotubes and bimetallic Ni/Cu-MOFs. Carbon 146-152 tumor necrosis factor Homo sapiens 19-46 33544162-0 2021 Novel voltammetric tumor necrosis factor-alpha (TNF-alpha) immunosensor based on gold nanoparticles involved in thiol-functionalized multi-walled carbon nanotubes and bimetallic Ni/Cu-MOFs. Carbon 146-152 tumor necrosis factor Homo sapiens 48-57 33544162-4 2021 Herein, a novel, sensitive, and selective voltammetric TNF-alpha immunosensor was prepared by using gold nanoparticles involved in thiol-functionalized multi-walled carbon nanotubes (AuNPs/S-MWCNTs) as sensor platform and bimetallic Ni/Cu-MOFs as sensor amplification. Carbon 165-171 tumor necrosis factor Homo sapiens 55-64 32949301-11 2021 Poly I:C induced IL-6 and TNFalpha primarily at the basal side at lower but on both sides at higher concentrations. Carbon 7-8 tumor necrosis factor Homo sapiens 26-34 32443416-3 2020 In vitro, increased TNF-alpha and IL-1ss cytokine mRNA expression was observed in Nano-11-KAg-poly(I:C)-treated porcine monocyte-derived dendritic cells. Carbon 101-103 tumor necrosis factor Homo sapiens 20-29 33413430-4 2021 Interestingly, NK-4 augmented TNF-alpha production by THP-1 macrophages in combination with LPS, Pam3CSK4, or poly(I:C). Carbon 101-102 tumor necrosis factor Homo sapiens 30-39 32305864-4 2020 Herein, we developed an in vivo electrochemical immunosensing device based on glassy carbon rod to simultaneously detect three proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha). Carbon 85-91 tumor necrosis factor Homo sapiens 173-182 32898511-8 2020 RESULTS: LPS and TNFalpha significantly reduce cell viability after 1 day and 7 days, Poly I:C after 7 days and 4 weeks. Carbon 93-94 tumor necrosis factor Homo sapiens 17-25 32898511-11 2020 TNFalpha secretion is increased by Poly I:C and LPS after 1 day but not at later time points. Carbon 42-43 tumor necrosis factor Homo sapiens 0-8 32738418-4 2020 MATERIALS AND METHODS: The role of CYLD in PD-L1 expression was assessed by knockdown of CYLD in TET cells upon stimulation with interferon gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) or polyinosinic-polycytidylic acid (poly I:C). Carbon 35-36 tumor necrosis factor Homo sapiens 159-186 32841189-13 2020 There was a significant decrease in uric acid concentration, pro- (IL-1beta, TNF-alpha) and anti-inflammatory cytokine (IL-10) content after treatment in both groups, but more in patients who received carbon enterosorbent with basic therapy. Carbon 201-207 tumor necrosis factor Homo sapiens 77-86 30708020-0 2019 Carbon dot festooned and surface passivated graphene-reinforced chitosan construct for tumor-targeted delivery of TNF-alpha gene. Carbon 0-6 tumor necrosis factor Homo sapiens 114-123 31817918-6 2019 Moreover, we observed that rubioncolin C inhibited the TNF-alpha- and LPS-induced NF-kappaB activation upstream of the p65 protein, which contributed to rubioncolin C-induced cell death. Carbon 27-40 tumor necrosis factor Homo sapiens 55-64 31817918-6 2019 Moreover, we observed that rubioncolin C inhibited the TNF-alpha- and LPS-induced NF-kappaB activation upstream of the p65 protein, which contributed to rubioncolin C-induced cell death. Carbon 153-166 tumor necrosis factor Homo sapiens 55-64 30708020-5 2019 The surface passivated carrier (PEG-pDNA-TNF-alpha-CS-CGO) then festooned with the folic acid derived carbon dots (C-dots) for targeting folate receptors that are overexpressed in most of the cancer cells. Carbon 102-108 tumor necrosis factor Homo sapiens 41-50 25896631-4 2015 Both TNF-alpha and IL-1alpha were involved in the gamma-irradiation induced secondary bystander effect but only TNF-alpha contributed to the carbon ion induced response. Carbon 141-147 tumor necrosis factor Homo sapiens 112-121 31037071-6 2019 beta-Glucan, oS100A and tenascin C induced training of monocytes to release more TNFalpha. Carbon 33-34 tumor necrosis factor Homo sapiens 81-89 32263018-3 2016 This study demonstrated that conjugation of a corticosteroid (triamcinolone) on polyethylene-glycol (PEG)-fabricated multi-walled carbon nanotubes enhances intracellular drug delivery via increased lysosome transport and ultimately suppresses the expression of major pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, and IL-6) and matrix metalloproteinase-1 and -3 from fibroblast-like synoviocytes at a very low drug dose. Carbon 130-136 tumor necrosis factor Homo sapiens 301-310 23955578-0 2014 Single-walled carbon nanotubes induce cell death and transcription of TNF-alpha in macrophages without affecting nitric oxide production. Carbon 14-20 tumor necrosis factor Homo sapiens 70-79 25064241-1 2014 An amperometric immunoassay for the determination of tumor necrosis factor alpha (TNFalpha) protein biomarker in human serum based on the use of magnetic microbeads (MBs) and disposable screen-printed carbon electrodes (SPCEs) has been developed. Carbon 201-207 tumor necrosis factor Homo sapiens 82-90 23607494-8 2013 Furthermore, poly(I:C) and proinflammatory cytokines [(IL-1beta, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha] induced IL-32 expression strongly in cultured BECs, accompanying the constant expression of TLR-3 and caspase 1. Carbon 20-21 tumor necrosis factor Homo sapiens 92-126 23231781-7 2012 RESULTS: We found consistent positive associations between the following biomarkers and PM(2.5) chemical constituents across different models: TNF-alpha with secondary organic carbon, chloride, zinc, molybdenum and stannum; fibrinogen with magnesium, iron, titanium, cobalt and cadmium; PAI-1 with titanium, cobalt and manganese; t-PA with cadmium and selenium; vWF with aluminum. Carbon 176-182 tumor necrosis factor Homo sapiens 143-152 23084344-3 2012 Toda buffalo peripheral blood mononuclear cells (PBMC) produced significantly higher levels of IFN gamma and/or TNF alpha mRNAs in response to peptidoglycan, poly I:C, lipopolysaccharide, imiquimod and CpG. Carbon 52-53 tumor necrosis factor Homo sapiens 112-121 22231731-15 2012 Iloprost downregulated poly I:C-induced histone H3K4 trimethylation in the TNFA gene promoter region via suppressing translocation of histone 3 lysine 4 (H3K4)-specific methyltransferases MLL (mixed lineage leukemia) and WDR5 (WD repeat domain 5). Carbon 30-31 tumor necrosis factor Homo sapiens 75-79 20378330-4 2011 Biocompatible polyaniline doped with poly (acrylic acid) was electro-polymerized at the glass carbon electrode to construct the matrix for the immobilization of antibody TNF-alpha. Carbon 94-100 tumor necrosis factor Homo sapiens 170-179 20843633-7 2011 Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12). Carbon 11-17 tumor necrosis factor Homo sapiens 123-150 20843633-7 2011 Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12). Carbon 11-17 tumor necrosis factor Homo sapiens 152-161 22040060-10 2012 TNF-alpha production of macrophages with the nitric oxide (NO) inhibitor-treatment increased after carbon-ion broad-beam. Carbon 99-105 tumor necrosis factor Homo sapiens 0-9 21964048-5 2011 The treatment of EPCs with TLR3 agonist Poly I:C up-regulated the expression of cytokines IL-1beta, IL-6, IL-8, TNF-alpha, IFN-alpha, and IFN-beta, indicating that EPCs expressed functional TLR3. Carbon 19-20 tumor necrosis factor Homo sapiens 112-121 20932985-0 2011 Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-alpha via distinct NF-kappaB pathways in human nasal epithelial cells. Carbon 7-8 tumor necrosis factor Homo sapiens 72-81 20932985-6 2011 Both the reduction of JAM-A expression and the induction of secretion of IL-8 and TNF-alpha after treatment with poly(I:C) were modulated by distinct signal transduction pathways via EGFR, PI3K, and p38 MAPK and finally regulated by a TLR3-mediated NF-kappaB pathway. Carbon 120-121 tumor necrosis factor Homo sapiens 82-91 20185925-8 2010 RESULTS: Costimulation with TNF-alpha and Th2 cytokines (IL-4, IL-13) or with poly(I:C) and Th2 cytokines (IL-4, IL-13) induced TARC production by nasal (polyp and normal) fibroblasts. Carbon 9-10 tumor necrosis factor Homo sapiens 28-37 16806458-3 2006 Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Carbon 46-52 tumor necrosis factor Homo sapiens 133-136 12894502-6 2003 For LPC-10 cells treated with C-36 IL-6 and TNF-alpha levels also increase. Carbon 6-7 tumor necrosis factor Homo sapiens 44-53 34512346-9 2021 Adiponectin (3-30 microg ml-1) and AdipoRon (25-50 muM) markedly inhibited the LPS- and poly (I:C)-induced release of Tumor Necrosis Factor-alpha, IL-6 and chemokines (CCL3, CCL4, CCL5, CXCL1, CXCL8, CXCL10) and the IL-4-induced release of chemokines (CCL13, CCL17, CCL22) in a concentration-dependent manner. Carbon 96-98 tumor necrosis factor Homo sapiens 118-145 20338767-3 2010 In this study, we synthesized and examined a series of 5-carbon linker-containing mono-carbonyl analogues of curcumin with potent inhibitory activities against TNF-alpha and IL-6 release in LPS-stimulated RAW 264.7 macrophages. Carbon 57-63 tumor necrosis factor Homo sapiens 160-169 16914195-5 2006 The synthesized carbons, having tunable pore size with a large volume of slit-shaped mesopores, outperformed all other materials or methods in terms of efficiency of TNF-alpha removal and the results are comparable only with highly specific antibody-antigen interactions. Carbon 16-23 tumor necrosis factor Homo sapiens 166-175 11603298-2 2000 FI0-c, and its sulfated derivative, FI0-c-S, on production of human proinflammatory cytokines, interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha). Carbon 4-5 tumor necrosis factor Homo sapiens 132-159 10777484-5 2000 In addition, NO was found to exert an inhibitory effect downstream of the TNFalpha-triggered ceramide accumulation, because NO donors reversed the inhibition of endocytosis induced by the cell-permeant C(2)-ceramide. Carbon 202-203 tumor necrosis factor Homo sapiens 74-82 8283061-4 1994 When KS cells were incubated with poly (I:C) in combination with either IL-1 beta or TNF-alpha, there was a synergistic increase in the level of IL-6 production, whereas LPS and TNF-alpha in combination led to only an additive increase in the level of IL-6 production. Carbon 42-43 tumor necrosis factor Homo sapiens 85-94 8283061-4 1994 When KS cells were incubated with poly (I:C) in combination with either IL-1 beta or TNF-alpha, there was a synergistic increase in the level of IL-6 production, whereas LPS and TNF-alpha in combination led to only an additive increase in the level of IL-6 production. Carbon 42-43 tumor necrosis factor Homo sapiens 178-187 8509668-6 1993 Amniotic fluid concentrations of TNF-alpha, IL-1 beta and IL-6 in cases of term elective C/S were 22.8 +/- 19.2 pg/ml, 8.1 +/- 5.2 pg/ml and 166.8 +/- 126.1 pg/ml, respectively. Carbon 89-90 tumor necrosis factor Homo sapiens 33-42 2170531-5 1990 Pretreatment of neutrophils with either GM-CSF or TNF-alpha dose-dependently enhanced the production of superoxide induced by NaF, as determined by the superoxide dismutase-inhibitable reduction of ferricytochrome c. Carbon 82-83 tumor necrosis factor Homo sapiens 50-59 34602194-0 2021 Simple and facile carbon dots based electrochemical biosensor for TNF-alpha targeting in cancer patient"s sample. Carbon 18-24 tumor necrosis factor Homo sapiens 66-75 34435060-0 2021 Evaluation of TNF Family Gene Expression under the Influence of Single-Walled and Multi-Walled Carboxylated Carbon Nanotubes in Jurkat Cell Line and Rat. Carbon 108-114 tumor necrosis factor Homo sapiens 14-17 35510663-10 2022 Furthermore, poly I:C upregulates TLR3 (SMD = 0.64; CIs (0.56, 0.72); p = 0.00), downregulates nuclear factor-kappaB (NF-kappaB) (SMD = -1.78; CIs (-2.67, -0.88); p = 0.0)), and tumor necrosis factor alpha (TNF-alpha) (SMD = -16.83; CIs (-22.63, -11.02); p = 0.00). Carbon 20-21 tumor necrosis factor Homo sapiens 178-205 35510663-10 2022 Furthermore, poly I:C upregulates TLR3 (SMD = 0.64; CIs (0.56, 0.72); p = 0.00), downregulates nuclear factor-kappaB (NF-kappaB) (SMD = -1.78; CIs (-2.67, -0.88); p = 0.0)), and tumor necrosis factor alpha (TNF-alpha) (SMD = -16.83; CIs (-22.63, -11.02); p = 0.00). Carbon 20-21 tumor necrosis factor Homo sapiens 207-216