PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2853663-0 1987 Effects of parachlorophenylalanine, quipazine and cyproheptadine on growth hormone and adrenocorticotropin secretion in steers. Cyproheptadine 50-64 growth hormone 1 Homo sapiens 68-82 1971804-1 1990 Cyproheptadine (CPH)--a putative serotonin antagonist--is known to inhibit growth hormone (GH) response to various pharmacological stimuli, as well as during sleep. Cyproheptadine 0-14 growth hormone 1 Homo sapiens 75-89 1971804-1 1990 Cyproheptadine (CPH)--a putative serotonin antagonist--is known to inhibit growth hormone (GH) response to various pharmacological stimuli, as well as during sleep. Cyproheptadine 0-14 growth hormone 1 Homo sapiens 91-93 1971804-1 1990 Cyproheptadine (CPH)--a putative serotonin antagonist--is known to inhibit growth hormone (GH) response to various pharmacological stimuli, as well as during sleep. Cyproheptadine 16-19 growth hormone 1 Homo sapiens 75-89 1971804-1 1990 Cyproheptadine (CPH)--a putative serotonin antagonist--is known to inhibit growth hormone (GH) response to various pharmacological stimuli, as well as during sleep. Cyproheptadine 16-19 growth hormone 1 Homo sapiens 91-93 1971804-5 1990 The oral administration of CPH (8-12 mg daily for 5 days; total dose 56 mg) significantly curbed GH response to GHRH as expressed in peak plasma GH values (32.0 +/- 6.1 micrograms/l vs. 12.6 +/- 3.2 micrograms/l; P less than 0.01) and in integrated GH response area (2368 +/- 517 micrograms x l-1 x 2 h vs. 744 +/- 172 micrograms x l-1 x 2 h; P less than 0.01). Cyproheptadine 27-30 growth hormone 1 Homo sapiens 97-99 1971804-5 1990 The oral administration of CPH (8-12 mg daily for 5 days; total dose 56 mg) significantly curbed GH response to GHRH as expressed in peak plasma GH values (32.0 +/- 6.1 micrograms/l vs. 12.6 +/- 3.2 micrograms/l; P less than 0.01) and in integrated GH response area (2368 +/- 517 micrograms x l-1 x 2 h vs. 744 +/- 172 micrograms x l-1 x 2 h; P less than 0.01). Cyproheptadine 27-30 growth hormone 1 Homo sapiens 112-114 1971804-5 1990 The oral administration of CPH (8-12 mg daily for 5 days; total dose 56 mg) significantly curbed GH response to GHRH as expressed in peak plasma GH values (32.0 +/- 6.1 micrograms/l vs. 12.6 +/- 3.2 micrograms/l; P less than 0.01) and in integrated GH response area (2368 +/- 517 micrograms x l-1 x 2 h vs. 744 +/- 172 micrograms x l-1 x 2 h; P less than 0.01). Cyproheptadine 27-30 growth hormone 1 Homo sapiens 112-114 2107017-4 1990 Administration of cyproheptadine (24 mg/day for one month) to those cases not responding to bromocriptine or with increased GH after the administration of diazepam, decreased GH in 75%, while increased GH in 25% of the cases. Cyproheptadine 18-32 growth hormone 1 Homo sapiens 124-126 2107017-4 1990 Administration of cyproheptadine (24 mg/day for one month) to those cases not responding to bromocriptine or with increased GH after the administration of diazepam, decreased GH in 75%, while increased GH in 25% of the cases. Cyproheptadine 18-32 growth hormone 1 Homo sapiens 175-177 2107017-4 1990 Administration of cyproheptadine (24 mg/day for one month) to those cases not responding to bromocriptine or with increased GH after the administration of diazepam, decreased GH in 75%, while increased GH in 25% of the cases. Cyproheptadine 18-32 growth hormone 1 Homo sapiens 175-177 3794875-0 1987 Enhancement of linear growth and weight gain by cyproheptadine in children with hypopituitarism receiving growth hormone therapy. Cyproheptadine 48-62 growth hormone 1 Homo sapiens 106-120 8035909-3 1994 After pre-treatment with cyproheptadine, an anti-serotoninergic drug known to inhibit GH secretion, the mean integrated sumatriptan-induced GH response decreased from 14.8 +/- 3.9 muI/l*hr to 3.7 +/- 1.7 mIU/l*hr. Cyproheptadine 25-39 growth hormone 1 Homo sapiens 86-88 8035909-3 1994 After pre-treatment with cyproheptadine, an anti-serotoninergic drug known to inhibit GH secretion, the mean integrated sumatriptan-induced GH response decreased from 14.8 +/- 3.9 muI/l*hr to 3.7 +/- 1.7 mIU/l*hr. Cyproheptadine 25-39 growth hormone 1 Homo sapiens 140-142 2853663-9 1987 Pretreatment of steers with cyproheptadine (.06 and .6 mg/kg BW) reduced the stimulation of GH by quipazine (P less than .0001) and decreased basal GH concentrations (P less than .0004). Cyproheptadine 28-42 growth hormone 1 Homo sapiens 92-94 2853663-9 1987 Pretreatment of steers with cyproheptadine (.06 and .6 mg/kg BW) reduced the stimulation of GH by quipazine (P less than .0001) and decreased basal GH concentrations (P less than .0004). Cyproheptadine 28-42 growth hormone 1 Homo sapiens 148-150 2853663-11 1987 Studies with quipazine and cyproheptadine indicated that serotonergic mechanisms are likely involved in the regulation of GH and ACTH secretion in steers. Cyproheptadine 27-41 growth hormone 1 Homo sapiens 122-124 2994332-0 1985 Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. Cyproheptadine 0-14 growth hormone 1 Homo sapiens 38-52 3774237-1 1986 The effect of cyproheptadine on growth hormone (GH) secretion and dental pain threshold elevation during physical exercise was studied in healthy human subjects. Cyproheptadine 14-28 growth hormone 1 Homo sapiens 32-46 2994332-1 1985 The effect of cyproheptadine on growth hormone (GH) and prolactin (Prl) secretion from cultured pituitary adenoma cells of acromegaly and pituitary gigantism was studied. Cyproheptadine 14-28 growth hormone 1 Homo sapiens 32-46 6799379-4 1981 Cyproheptadine pretreatment resulted in a substantial suppression of the GH response to glucagon. Cyproheptadine 0-14 growth hormone 1 Homo sapiens 73-75 6799379-5 1981 A significant difference between basal and post-cyproheptadine GH levels was observed at 150 minutes after glucagon. Cyproheptadine 48-62 growth hormone 1 Homo sapiens 63-65 504217-0 1979 Studies on the effect of cyproheptadine on growth hormone secretion. Cyproheptadine 25-39 growth hormone 1 Homo sapiens 43-57 7244331-0 1981 [Effect of phentolamine, diphenhydramine and cyproheptadine on arginine-induced growth hormone secretion (author"s transl)]. Cyproheptadine 45-59 growth hormone 1 Homo sapiens 80-94 6799708-0 1980 Effects of thyroliberin (TRH), bromocriptine and cyproheptadine on somatotropin secretion in acromegaly. Cyproheptadine 49-63 growth hormone 1 Homo sapiens 67-79 875737-0 1977 Suppression of human growth hormone secretion by cyproheptadine. Cyproheptadine 49-63 growth hormone 1 Homo sapiens 21-35 642945-5 1978 Symptoms appeared rapidly after ingestion and generally did not last longer than 6-12 h. When given in therapeutic doses, cyproheptadine reduces the secretion of ACTH, cortisol, prolactin, and growth hormone, lowers blood glucose concentrations, and raises the levels of unesterified free fatty acids. Cyproheptadine 122-136 growth hormone 1 Homo sapiens 193-207 875737-2 1977 The oral administration of cyproheptadine (12 mg daily) reduced GH responses to both L-dopa and glucagon; similarly, the mean GH response to oral glucose administration was significantly reduced after cyproheptadine administration. Cyproheptadine 27-41 growth hormone 1 Homo sapiens 64-66 875737-2 1977 The oral administration of cyproheptadine (12 mg daily) reduced GH responses to both L-dopa and glucagon; similarly, the mean GH response to oral glucose administration was significantly reduced after cyproheptadine administration. Cyproheptadine 201-215 growth hormone 1 Homo sapiens 126-128 180050-0 1976 Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep. Cyproheptadine 15-29 growth hormone 1 Homo sapiens 39-53 1020921-0 1976 Effects of fenfluramine and cyproheptadine on growth hormone secretion. Cyproheptadine 28-42 growth hormone 1 Homo sapiens 46-60 180050-1 1976 The effect of cyproheptadine on plasma growth hormone and cortisol levels was studied in seven male volunteers with polygraphic sleep monitoring. Cyproheptadine 14-28 growth hormone 1 Homo sapiens 39-53 180050-2 1976 Sleep-related growth hormone release was completely inhibited in three of the seven normal subjects by the intravenous infusion of cyproheptadine (5 mg) which was started at the onset of sleep. Cyproheptadine 131-145 growth hormone 1 Homo sapiens 14-28 180050-3 1976 In the other four, growth hormone release during sleep was significantly decreased or delayed by cyproheptadine when the drug infusion was started at 7:00 p.m., 1-2 h before the onset of sleep. Cyproheptadine 97-111 growth hormone 1 Homo sapiens 19-33 180050-7 1976 These results suggest that cyproheptadine inhibits growth hormone and ACTH secretion during sleep in man, possibly by antagonizing serotoninergic mechanisms although other actions of the drug are not ruled out. Cyproheptadine 27-41 growth hormone 1 Homo sapiens 51-65 4544468-0 1974 Effect of cyproheptadine on human growth hormone secretion. Cyproheptadine 10-24 growth hormone 1 Homo sapiens 34-48 1201741-0 1975 Suppressive effect of cyproheptadine on L-DOPA-induced growth hormone release in man. Cyproheptadine 22-36 growth hormone 1 Homo sapiens 55-69 765007-1 1976 We evaluated the effect of the serotonin antagonists cyproheptadine (Cypro) and methysergide (Methy) on growth hormone secretion in six patients with acromegaly. Cyproheptadine 53-67 growth hormone 1 Homo sapiens 104-118 4600047-0 1974 Suppression of human growth hormone secretion by melatonin and cyproheptadine. Cyproheptadine 63-77 growth hormone 1 Homo sapiens 21-35 4600047-1 1974 Pituitary growth hormone (GH) release in the rat is stimulated via serotoninergic pathways and can be inhibited by treatment with compounds that act as serotonin antagonists, such as cyproheptadine or the pineal gland hormone, melatonin. Cyproheptadine 183-197 growth hormone 1 Homo sapiens 10-24 4600047-3 1974 The oral administration of cyproheptadine (8-12 mg daily for 5 days) to normal subjects reduced their GH responses to both insulin-induced hypoglycemia and physical exercise to a highly significant extent. Cyproheptadine 27-41 growth hormone 1 Homo sapiens 102-104