PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27088648-0	2016	Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.	Cyproheptadine	18-32	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	52-102	
29882380-0	2018	Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine.	Cyproheptadine	78-92	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	62-68	
29882380-2	2018	Previously, our group identified cyproheptadine, used clinically as a serotonin receptor antagonist and histamine receptor (H1) antagonist, as a novel scaffold of the SET7/9 inhibitor.	Cyproheptadine	33-47	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	167-173	
29882380-7	2018	In addition, a SET7/9 loop, which was only partially visible in the complex with cyproheptadine, became more clearly visible in the complex with 2-hydroxycyproheptadine.	Cyproheptadine	81-95	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	15-21	
27448773-0	2016	Steric structure-activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9.	Cyproheptadine	42-56	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	112-118	
27448773-2	2016	We previously identified cyproheptadine, which has a characteristic butterfly-like molecular conformation with bent tricyclic dibenzosuberene and chair-form N-methylpiperidine moieties, as a Set7/9 inhibitor.	Cyproheptadine	25-39	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	191-197	
27088648-0	2016	Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.	Cyproheptadine	18-32	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	104-110	
27088648-3	2016	We identified cyproheptadine, a clinically approved antiallergy drug, as a Set7/9 inhibitor in a high-throughput screen using a fluorogenic substrate-based HMT assay.	Cyproheptadine	14-28	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	75-81	
27088648-4	2016	Kinetic and X-ray crystallographic analyses revealed that cyproheptadine binds in the substrate-binding pocket of Set7/9 and inhibits its enzymatic activity by competing with the methyl group acceptor.	Cyproheptadine	58-72	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	114-120