PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29671217-1	2018	Cyproheptadine (CPH), a first-generation antihistamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway.	Cyproheptadine	0-14	sigma non-opioid intracellular receptor 1	Mus musculus	147-163	
29671217-1	2018	Cyproheptadine (CPH), a first-generation antihistamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway.	Cyproheptadine	16-19	sigma non-opioid intracellular receptor 1	Mus musculus	147-163	
29671217-5	2018	This effect of CPH was mimicked by a sigma-1 receptor agonist and eliminated by an antagonist.	Cyproheptadine	15-18	sigma non-opioid intracellular receptor 1	Mus musculus	37-53	
22844454-0	2012	Cyproheptadine enhances the I(K) of mouse cortical neurons through sigma-1 receptor-mediated intracellular signal pathway.	Cyproheptadine	0-14	sigma non-opioid intracellular receptor 1	Mus musculus	67-83	
22844454-6	2012	Antagonists of the sigma-1 receptor, however, blocked the effect of CPH.	Cyproheptadine	68-71	sigma non-opioid intracellular receptor 1	Mus musculus	19-35	
22844454-8	2012	On the contrary, sigma-1 receptor agonist mimicked the effects of CPH on the induction of I(K).	Cyproheptadine	66-69	sigma non-opioid intracellular receptor 1	Mus musculus	17-33	
22844454-11	2012	In overall, we reveal for the first time that CPH enhances the I(K) by modulating activity of PKA, and that the associated activation of the sigma-1 receptor/G(i)-protein pathway might be involved.	Cyproheptadine	46-49	sigma non-opioid intracellular receptor 1	Mus musculus	141-157