PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2191652-0	1990	Cyproheptadine-induced alterations in clonal insulin-producing cell lines.	Cyproheptadine	0-14	insulin	Mesocricetus auratus	45-52	
2191652-2	1990	To examine whether the inhibitory actions of CPH on insulin cell function are linked to the ability of glucose to stimulate insulin synthesis and secretion, studies were performed in two different insulin-producing cell lines.	Cyproheptadine	45-48	insulin	Mesocricetus auratus	52-59	
2191652-7	1990	Cellular insulin returned to control levels 48 hr after removal of CPH.	Cyproheptadine	67-70	insulin	Mesocricetus auratus	9-16	
2191652-8	1990	In experiments designed to test a direct inhibitory effect on stimulated insulin secretion, 1 and 10.0 microM concentrations of CPH were found to inhibit glucose-stimulated insulin release from HIT cells, and K+, alanine and glyceraldehyde-stimulated release from RIN cells.	Cyproheptadine	128-131	insulin	Mesocricetus auratus	73-80	
2191652-8	1990	In experiments designed to test a direct inhibitory effect on stimulated insulin secretion, 1 and 10.0 microM concentrations of CPH were found to inhibit glucose-stimulated insulin release from HIT cells, and K+, alanine and glyceraldehyde-stimulated release from RIN cells.	Cyproheptadine	128-131	insulin	Mesocricetus auratus	173-180	
2191652-9	1990	CPH was also shown to inhibit insulin biosynthesis in both cell lines at concentrations that did not alter the synthesis of total cellular proteins.	Cyproheptadine	0-3	insulin	Mesocricetus auratus	30-37