PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10428953-0 1999 Stilbenes and fenamates rescue the loss of I(KS) channel function induced by an LQT5 mutation and other IsK mutants. Fenamates 14-23 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 80-84 10428953-0 1999 Stilbenes and fenamates rescue the loss of I(KS) channel function induced by an LQT5 mutation and other IsK mutants. Fenamates 14-23 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 104-107 10428953-5 1999 Here we show that binding of I(KS) channel activators, such as stilbenes and fenamates, to an extracellular domain flanking the human IsK transmembrane segment, restores normal I(KS) channel gating in otherwise inactive IsK C-terminal mutants, including the naturally occurring LQT5 mutant, D76N. Fenamates 77-86 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 134-137 10428953-5 1999 Here we show that binding of I(KS) channel activators, such as stilbenes and fenamates, to an extracellular domain flanking the human IsK transmembrane segment, restores normal I(KS) channel gating in otherwise inactive IsK C-terminal mutants, including the naturally occurring LQT5 mutant, D76N. Fenamates 77-86 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 220-223 10428953-5 1999 Here we show that binding of I(KS) channel activators, such as stilbenes and fenamates, to an extracellular domain flanking the human IsK transmembrane segment, restores normal I(KS) channel gating in otherwise inactive IsK C-terminal mutants, including the naturally occurring LQT5 mutant, D76N. Fenamates 77-86 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 278-282 10428953-8 1999 Owing to allosteric interactions, stilbene and fenamate compounds can rescue the dominant-negative suppression of I(KS) produced by IsK mutations and thus, may have important therapeutic relevance for LQT syndrome. Fenamates 47-55 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 132-135