PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27009862-1 2016 CD44 is a receptor for hyaluronan (HA) that promotes epithelial-to-mesenchymal transition (EMT), induces cancer stem cell (CSC) expansion, and favors metastasis. Hyaluronic Acid 23-33 CD44 molecule (Indian blood group) Homo sapiens 0-4 26865006-0 2016 Mannosylation Allows for Synergic (CD44/C-Type Lectin) Uptake of Hyaluronic Acid Nanoparticles in Dendritic Cells, but Only upon Correct Ligand Presentation. Hyaluronic Acid 65-80 CD44 molecule (Indian blood group) Homo sapiens 35-39 26865006-2 2016 Here, materials have been designed for a synergic DC targeting: interacting with CD44 through the use of hyaluronic acid (HA), and with mannose-binding lectins (typical DC pattern recognition receptors) through HA mannosylation. Hyaluronic Acid 105-120 CD44 molecule (Indian blood group) Homo sapiens 81-85 26865006-2 2016 Here, materials have been designed for a synergic DC targeting: interacting with CD44 through the use of hyaluronic acid (HA), and with mannose-binding lectins (typical DC pattern recognition receptors) through HA mannosylation. Hyaluronic Acid 122-124 CD44 molecule (Indian blood group) Homo sapiens 81-85 26898631-5 2016 The hyaluronic acid-porphyrin conjugate (15) was radiolabeled with (64)Cu and its (15[(64)Cu]) receptor binding affinity to CD44-expressing tumor cells was evaluated. Hyaluronic Acid 4-19 CD44 molecule (Indian blood group) Homo sapiens 124-128 26853764-1 2016 UNLABELLED: CD44-specific and redox-responsive nanoparticles were prepared by coating a bioreducible chitosan-based nanoparticles with hyaluronic acid for intracellular glutathione-triggered reactive oxygen species (ROS) production and doxorubicin (DOX) release. Hyaluronic Acid 135-150 CD44 molecule (Indian blood group) Homo sapiens 12-16 27103799-3 2016 Studies on targeted liposomal delivery systems have indicated the conjugation of hyaluronan (HA), a primary ligand for CD44 surface markers, as an appropriate method for targeting BCSCs. Hyaluronic Acid 81-91 CD44 molecule (Indian blood group) Homo sapiens 119-123 27103799-3 2016 Studies on targeted liposomal delivery systems have indicated the conjugation of hyaluronan (HA), a primary ligand for CD44 surface markers, as an appropriate method for targeting BCSCs. Hyaluronic Acid 93-95 CD44 molecule (Indian blood group) Homo sapiens 119-123 26781684-1 2016 Hyaluronan (HA) is a promising drug carrier for cancer therapy because of its CD44 targeting ability, good biocompatibility, and biodegradability. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 78-82 26851390-0 2016 Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 98-102 26851390-8 2016 These results indicate that hyaluronic acid-shelled acid-activatable PTX prodrug micelles have a great potential for targeted chemotherapy of CD44-positive cancers. Hyaluronic Acid 28-43 CD44 molecule (Indian blood group) Homo sapiens 142-146 26855049-8 2016 The present study suggests that the ternary complexes stabilized with hyaluronic acid-green tea catechin conjugates can be widely utilized for CD44-targeted delivery of nucleic acid-based therapeutics. Hyaluronic Acid 70-85 CD44 molecule (Indian blood group) Homo sapiens 143-147 26781684-1 2016 Hyaluronan (HA) is a promising drug carrier for cancer therapy because of its CD44 targeting ability, good biocompatibility, and biodegradability. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 78-82 26900622-0 2016 Mechanistic Insight into Receptor-Mediated Delivery of Cationic-beta-Cyclodextrin:Hyaluronic Acid-Adamantamethamidyl Host:Guest pDNA Nanoparticles to CD44(+) Cells. Hyaluronic Acid 82-97 CD44 molecule (Indian blood group) Homo sapiens 150-154 33429536-0 2016 CD44 Mediated Nonviral Gene Delivery into Human Embryonic Stem Cells via Hyaluronic-Acid-Coated Nanoparticles. Hyaluronic Acid 73-88 CD44 molecule (Indian blood group) Homo sapiens 0-4 26753785-3 2016 Catch-bond interactions are used by the CD44 receptor to interact with this inert material and to roll on the surfaces coated with hyaluronans. Hyaluronic Acid 131-142 CD44 molecule (Indian blood group) Homo sapiens 40-44 26900622-2 2016 We have recently developed a CD44 receptor targeted, hyaluronic acid-adamantamethamidyl based pendant polymer system (HA-Ad), capable of forming complexes with cationic beta-cyclodextrins (CD-PEI(+)) and pDNA. Hyaluronic Acid 53-68 CD44 molecule (Indian blood group) Homo sapiens 29-33 26796235-0 2016 The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability. Hyaluronic Acid 16-31 CD44 molecule (Indian blood group) Homo sapiens 4-8 26785145-5 2016 When CD44-overexpressing HCT-116 colon cancer cells were treated with GzmB-encapsulated HA-EGCG nanogels in vitro, a significant cytotoxic effect was observed. Hyaluronic Acid 88-90 CD44 molecule (Indian blood group) Homo sapiens 5-9 26887530-1 2016 The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. Hyaluronic Acid 33-48 CD44 molecule (Indian blood group) Homo sapiens 54-58 26887530-1 2016 The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. Hyaluronic Acid 27-29 CD44 molecule (Indian blood group) Homo sapiens 54-58 26701141-7 2016 High narrow nanogap-containing Au@Au core-shell SERS tags (GCTs) were prepared via the functionalization of hyaluronic acid (HA) on GCNPs, which recognized the CD44 receptor, a tumor-associated surface biomarker. Hyaluronic Acid 108-123 CD44 molecule (Indian blood group) Homo sapiens 160-164 26708101-2 2016 The nanococktail can actively target tumors via specific interaction of hyaluronic acid (HA) with CD44 receptors and respond to HAase-rich tumor microenvironment to induce intracellular cascade reaction for controlled therapy. Hyaluronic Acid 72-87 CD44 molecule (Indian blood group) Homo sapiens 98-102 26708101-2 2016 The nanococktail can actively target tumors via specific interaction of hyaluronic acid (HA) with CD44 receptors and respond to HAase-rich tumor microenvironment to induce intracellular cascade reaction for controlled therapy. Hyaluronic Acid 89-91 CD44 molecule (Indian blood group) Homo sapiens 98-102 26904028-0 2016 Editorial: Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer. Hyaluronic Acid 31-46 CD44 molecule (Indian blood group) Homo sapiens 66-70 27186420-0 2016 Over expression of hyaluronan promotes progression of HCC via CD44-mediated pyruvate kinase M2 nuclear translocation. Hyaluronic Acid 19-29 CD44 molecule (Indian blood group) Homo sapiens 62-66 26701141-7 2016 High narrow nanogap-containing Au@Au core-shell SERS tags (GCTs) were prepared via the functionalization of hyaluronic acid (HA) on GCNPs, which recognized the CD44 receptor, a tumor-associated surface biomarker. Hyaluronic Acid 125-127 CD44 molecule (Indian blood group) Homo sapiens 160-164 26163139-0 2015 Smart Nanoparticles Based on Hyaluronic Acid for Redox-Responsive and CD44 Receptor-Mediated Targeting of Tumor. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 70-74 26699481-0 2015 Correction for Suzuki et al., Mechanical force effect on the two-state equilibrium of the hyaluronan-binding domain of CD44 in cell rolling. Hyaluronic Acid 90-100 CD44 molecule (Indian blood group) Homo sapiens 119-123 26440757-0 2015 Hyaluronic acid-conjugated polyamidoamine dendrimers for targeted delivery of 3,4-difluorobenzylidene curcumin to CD44 overexpressing pancreatic cancer cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 114-118 26440757-2 2015 Using amine terminated fourth generation poly(amidoamine) (PAMAM) dendrimer nanocarrier and hyaluronic acid (HA) as a targeting ligand, we engineered a CD44-targeted PAMAM dendrimer (HA-PAMAM) formulation of CDF. Hyaluronic Acid 92-107 CD44 molecule (Indian blood group) Homo sapiens 152-156 26440757-2 2015 Using amine terminated fourth generation poly(amidoamine) (PAMAM) dendrimer nanocarrier and hyaluronic acid (HA) as a targeting ligand, we engineered a CD44-targeted PAMAM dendrimer (HA-PAMAM) formulation of CDF. Hyaluronic Acid 109-111 CD44 molecule (Indian blood group) Homo sapiens 152-156 26722372-2 2016 It was found that the surface modification of hollow Prussian blue nanoparticles with hyaluronic acid grafting polyethylene endowed a great colloidal stability, long blood circulation time and the capability for targeting Hela cells over-expressing the CD44 receptor. Hyaluronic Acid 86-101 CD44 molecule (Indian blood group) Homo sapiens 253-257 26163139-1 2015 BACKGROUND: Since aggressive cancer cells highly express the CD44 receptor compared to normal cells, hyaluronic acid (HA) can be used for CD44 targeting molecule. Hyaluronic Acid 101-116 CD44 molecule (Indian blood group) Homo sapiens 61-65 26163139-1 2015 BACKGROUND: Since aggressive cancer cells highly express the CD44 receptor compared to normal cells, hyaluronic acid (HA) can be used for CD44 targeting molecule. Hyaluronic Acid 101-116 CD44 molecule (Indian blood group) Homo sapiens 138-142 26163139-1 2015 BACKGROUND: Since aggressive cancer cells highly express the CD44 receptor compared to normal cells, hyaluronic acid (HA) can be used for CD44 targeting molecule. Hyaluronic Acid 118-120 CD44 molecule (Indian blood group) Homo sapiens 61-65 26163139-1 2015 BACKGROUND: Since aggressive cancer cells highly express the CD44 receptor compared to normal cells, hyaluronic acid (HA) can be used for CD44 targeting molecule. Hyaluronic Acid 118-120 CD44 molecule (Indian blood group) Homo sapiens 138-142 26593948-2 2015 A new radiosensitizing agent containing 0.5% hydrogen peroxide and 0.83% sodium hyaluronate (a CD44 ligand) has been developed for intra-tumoral injection into various tumors. Hyaluronic Acid 73-91 CD44 molecule (Indian blood group) Homo sapiens 95-99 26136372-0 2015 A New Hyaluronic Acid Derivative Obtained from Atom Transfer Radical Polymerization as a siRNA Vector for CD44 Receptor Tumor Targeting. Hyaluronic Acid 6-21 CD44 molecule (Indian blood group) Homo sapiens 106-110 26263218-3 2015 In this study, tetramethyl-6-carboxy-rhodamine (TAMRA)-labeled aptamers that specifically interact with the hyaluronic acid binding domain of CD44 were used as targets to investigate the applicability of the method. Hyaluronic Acid 108-123 CD44 molecule (Indian blood group) Homo sapiens 142-146 26447611-3 2015 Stimulation with hyaluronan (HA), the native ligand for CD44, increased expression and activation of beta1-integrin receptors, and increased alpha5-integrin subunit expression. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Homo sapiens 56-60 26447611-3 2015 Stimulation with hyaluronan (HA), the native ligand for CD44, increased expression and activation of beta1-integrin receptors, and increased alpha5-integrin subunit expression. Hyaluronic Acid 29-31 CD44 molecule (Indian blood group) Homo sapiens 56-60 26140900-7 2015 Further, the hyaluronan-binding domain of CD44 was docked with RP-1 using computer modeling/docking approaches, revealing a RP-1/CD44 interaction with geometrical and energy match (-8.6 kcal/mol). Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 42-46 26140900-7 2015 Further, the hyaluronan-binding domain of CD44 was docked with RP-1 using computer modeling/docking approaches, revealing a RP-1/CD44 interaction with geometrical and energy match (-8.6 kcal/mol). Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 129-133 26375384-0 2015 Supramolecular Organization and siRNA Binding of Hyaluronic Acid-Coated Lipoplexes for Targeted Delivery to the CD44 Receptor. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 112-116 26301700-7 2015 To specifically target the tumor cells, the surface of apoferritin was modified with hyaluronic acid (HA) which can easily bind to the HA-receptor CD44. Hyaluronic Acid 85-100 CD44 molecule (Indian blood group) Homo sapiens 147-151 26301700-7 2015 To specifically target the tumor cells, the surface of apoferritin was modified with hyaluronic acid (HA) which can easily bind to the HA-receptor CD44. Hyaluronic Acid 102-104 CD44 molecule (Indian blood group) Homo sapiens 147-151 27182458-5 2015 To accomplish both, stabilization and targeting simultaneously, the apoptosis-inducing protein cytochrome c (Cyt c) was modified with the polysaccharide hyaluronic acid (HA) because its corresponding receptor CD44 is overexpressed in many cancers. Hyaluronic Acid 153-168 CD44 molecule (Indian blood group) Homo sapiens 209-213 25997408-0 2015 Design and syntheses of hyaluronan oligosaccharide conjugates as inhibitors of CD44-Hyaluronan binding. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 79-83 26722395-2 2015 Hyaluronan (HA) is one of the main components of ECM, and actively regulates cell adhesion, migration and proliferation by interacting with specific cell surface receptors such as CD44 and RHAMM. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 180-184 26722395-2 2015 Hyaluronan (HA) is one of the main components of ECM, and actively regulates cell adhesion, migration and proliferation by interacting with specific cell surface receptors such as CD44 and RHAMM. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 180-184 27182458-5 2015 To accomplish both, stabilization and targeting simultaneously, the apoptosis-inducing protein cytochrome c (Cyt c) was modified with the polysaccharide hyaluronic acid (HA) because its corresponding receptor CD44 is overexpressed in many cancers. Hyaluronic Acid 170-172 CD44 molecule (Indian blood group) Homo sapiens 209-213 26151392-1 2015 CD44 is a transmembrane receptor for hyaluronic acid. Hyaluronic Acid 37-52 CD44 molecule (Indian blood group) Homo sapiens 0-4 26379032-0 2015 CD44 Binding to Hyaluronic Acid Is Redox Regulated by a Labile Disulfide Bond in the Hyaluronic Acid Binding Site. Hyaluronic Acid 16-31 CD44 molecule (Indian blood group) Homo sapiens 0-4 26379032-0 2015 CD44 Binding to Hyaluronic Acid Is Redox Regulated by a Labile Disulfide Bond in the Hyaluronic Acid Binding Site. Hyaluronic Acid 85-100 CD44 molecule (Indian blood group) Homo sapiens 0-4 26379032-1 2015 CD44 is the primary leukocyte cell surface receptor for hyaluronic acid (HA), a component of the extracellular matrix. Hyaluronic Acid 56-71 CD44 molecule (Indian blood group) Homo sapiens 0-4 26379032-1 2015 CD44 is the primary leukocyte cell surface receptor for hyaluronic acid (HA), a component of the extracellular matrix. Hyaluronic Acid 73-75 CD44 molecule (Indian blood group) Homo sapiens 0-4 26302089-0 2015 Hyaluronic Acid Engineered Nanomicelles Loaded with 3,4-Difluorobenzylidene Curcumin for Targeted Killing of CD44+ Stem-Like Pancreatic Cancer Cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 109-113 26302089-2 2015 It has been established that pancreatic cancers overexpressing CD44 receptors (a target of hyaluronic acid; HA) is one of the major contributors for causing MDR. Hyaluronic Acid 91-106 CD44 molecule (Indian blood group) Homo sapiens 63-67 25985912-0 2015 Dual-stimuli responsive hyaluronic acid-conjugated mesoporous silica for targeted delivery to CD44-overexpressing cancer cells. Hyaluronic Acid 24-39 CD44 molecule (Indian blood group) Homo sapiens 94-98 25840344-11 2015 Moreover, the expression of hyaluronan and its surface receptor CD44 drastically decreased as observed during chronological skin aging. Hyaluronic Acid 28-38 CD44 molecule (Indian blood group) Homo sapiens 64-68 26189059-8 2015 Overexpression of CD44 allowed enhanced adhesion to its extracellular matrix ligand hyaluronic acid. Hyaluronic Acid 84-99 CD44 molecule (Indian blood group) Homo sapiens 18-22 26347743-0 2015 Lipid Raft-Mediated Regulation of Hyaluronan-CD44 Interactions in Inflammation and Cancer. Hyaluronic Acid 34-44 CD44 molecule (Indian blood group) Homo sapiens 45-49 26347743-2 2015 Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the transmembrane receptor CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 158-162 26347743-4 2015 This article focuses on the recent discovery that lipid rafts regulate the interaction between CD44 and hyaluronan, which depends largely on hyaluronan"s size. Hyaluronic Acid 104-114 CD44 molecule (Indian blood group) Homo sapiens 95-99 26347743-5 2015 Lipid rafts regulate CD44"s ability to bind hyaluronan in T cells, control the rolling adhesion of lymphocytes on vascular endothelial cells, and regulate hyaluronan- and CD44-mediated cancer cell migration. Hyaluronic Acid 44-54 CD44 molecule (Indian blood group) Homo sapiens 21-25 26082778-6 2015 In parallel studies, exogenous hyaluronan fragments of low-molecular mass (generally, <200 kDa) have been shown to affect cell behavior through binding to receptor proteins such as CD44 and RHAMM (gene name HMMR), and to signal either directly or indirectly through toll-like receptors. Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 184-188 25909172-5 2015 Furthermore, based on the binding property of CD44 with its ligand hyaluronan (HA), we self-assembled HA-coated nanoparticles and studied their selective targeting efficacy. Hyaluronic Acid 67-77 CD44 molecule (Indian blood group) Homo sapiens 46-50 25909172-5 2015 Furthermore, based on the binding property of CD44 with its ligand hyaluronan (HA), we self-assembled HA-coated nanoparticles and studied their selective targeting efficacy. Hyaluronic Acid 79-81 CD44 molecule (Indian blood group) Homo sapiens 46-50 26136744-0 2015 Revealing the Mechanisms of Protein Disorder and N-Glycosylation in CD44-Hyaluronan Binding Using Molecular Simulation. Hyaluronic Acid 73-83 CD44 molecule (Indian blood group) Homo sapiens 68-72 26136744-1 2015 The extracellular N-terminal hyaluronan binding domain (HABD) of CD44 is a small globular domain that confers hyaluronan (HA) binding functionality to this large transmembrane glycoprotein. Hyaluronic Acid 29-39 CD44 molecule (Indian blood group) Homo sapiens 65-69 26136744-1 2015 The extracellular N-terminal hyaluronan binding domain (HABD) of CD44 is a small globular domain that confers hyaluronan (HA) binding functionality to this large transmembrane glycoprotein. Hyaluronic Acid 110-120 CD44 molecule (Indian blood group) Homo sapiens 65-69 25762343-2 2015 The aim of this study was to investigate how the expression of CD44 isoforms influences the interaction with hyaluronic acid (HA) and how differential isoform expression impacts antitumoral responses in vivo to treatment with RG7356, a humanized anti-CD44 antibody inhibiting CD44-HA interaction. Hyaluronic Acid 109-124 CD44 molecule (Indian blood group) Homo sapiens 63-67 26038553-0 2015 Mechanical force effect on the two-state equilibrium of the hyaluronan-binding domain of CD44 in cell rolling. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 89-93 25923337-4 2015 In this arrangement, the nanoparticles enable the active targeting of tumor cells, due to the specific interaction of hyaluronic acid with the CD44 receptors. Hyaluronic Acid 118-133 CD44 molecule (Indian blood group) Homo sapiens 143-147 25818425-0 2015 Hyaluronic acid controls the uptake pathway and intracellular trafficking of an octaarginine-modified gene vector in CD44 positive- and CD44 negative-cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 117-121 25818425-0 2015 Hyaluronic acid controls the uptake pathway and intracellular trafficking of an octaarginine-modified gene vector in CD44 positive- and CD44 negative-cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 136-140 25515492-2 2015 Here we designed and characterized a hyaluronic acid (HA) based self-assembling nanoparticles that can target CD44 receptors overexpressed on multidrug resistance (MDR) ovarian cancer. Hyaluronic Acid 37-52 CD44 molecule (Indian blood group) Homo sapiens 110-114 25515492-2 2015 Here we designed and characterized a hyaluronic acid (HA) based self-assembling nanoparticles that can target CD44 receptors overexpressed on multidrug resistance (MDR) ovarian cancer. Hyaluronic Acid 54-56 CD44 molecule (Indian blood group) Homo sapiens 110-114 25596560-0 2015 Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts. Hyaluronic Acid 23-38 CD44 molecule (Indian blood group) Homo sapiens 132-136 26029210-1 2015 Hyaluronan (HA), the major extracellular matrix component, is often anchored to CD44, a family of structurally/functionally important cell surface receptors. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 80-84 32262851-2 2015 Herein, we developed one kind of water-soluble hyaluronic acid-hybridized polyaniline nanoparticles (HA-PANI NPs) as a nanoplatform for photothermal therapy (PTT) with targeted specificity of a CD44-mediated cancer cell. Hyaluronic Acid 47-62 CD44 molecule (Indian blood group) Homo sapiens 194-198 25809479-0 2015 Interleukin-1beta-induced Reduction of CD44 Ser-325 Phosphorylation in Human Epidermal Keratinocytes Promotes CD44 Homomeric Complexes, Binding to Ezrin, and Extended, Monocyte-adhesive Hyaluronan Coats. Hyaluronic Acid 186-196 CD44 molecule (Indian blood group) Homo sapiens 39-43 25809479-5 2015 Instead, we found that the increase in the hyaluronan-dependent monocyte binding was associated with the CD44 of the keratinocytes. Hyaluronic Acid 43-53 CD44 molecule (Indian blood group) Homo sapiens 105-109 25809479-10 2015 In conclusion, treatment of human keratinocytes with IL-1beta changes the structure of their hyaluronan coat by influencing the amount, post-translational modification, and cytoskeletal association of CD44, thus enhancing monocyte retention on keratinocytes. Hyaluronic Acid 93-103 CD44 molecule (Indian blood group) Homo sapiens 201-205 25999946-0 2015 Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 51-55 25901321-6 2015 To illustrate this, we show how the superselective targeting of the extracellular matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affinity of individual CD44-hyaluronan interactions. Hyaluronic Acid 104-114 CD44 molecule (Indian blood group) Homo sapiens 149-153 25901321-6 2015 To illustrate this, we show how the superselective targeting of the extracellular matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affinity of individual CD44-hyaluronan interactions. Hyaluronic Acid 104-114 CD44 molecule (Indian blood group) Homo sapiens 198-202 25901321-6 2015 To illustrate this, we show how the superselective targeting of the extracellular matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affinity of individual CD44-hyaluronan interactions. Hyaluronic Acid 203-213 CD44 molecule (Indian blood group) Homo sapiens 149-153 25901321-6 2015 To illustrate this, we show how the superselective targeting of the extracellular matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affinity of individual CD44-hyaluronan interactions. Hyaluronic Acid 203-213 CD44 molecule (Indian blood group) Homo sapiens 198-202 25596560-2 2015 Here, we report on reduction-sensitive reversibly crosslinked hyaluronic acid (HA) nanoparticles based on HA-Lys-LA conjugates (Lys: l-lysine methyl ester, LA: lipoic acid) for active targeting delivery of doxorubicin (DOX) to CD44+ breast cancers in vitro and in vivo, effectively overcoming drug resistance (ADR). Hyaluronic Acid 62-77 CD44 molecule (Indian blood group) Homo sapiens 227-231 25596560-2 2015 Here, we report on reduction-sensitive reversibly crosslinked hyaluronic acid (HA) nanoparticles based on HA-Lys-LA conjugates (Lys: l-lysine methyl ester, LA: lipoic acid) for active targeting delivery of doxorubicin (DOX) to CD44+ breast cancers in vitro and in vivo, effectively overcoming drug resistance (ADR). Hyaluronic Acid 79-81 CD44 molecule (Indian blood group) Homo sapiens 227-231 25596560-10 2015 The reversibly crosslinked hyaluronic acid nanoparticles with excellent biocompatibility, CD44-targetability, and effective reversal of drug resistance have a great potential in cancer therapy. Hyaluronic Acid 27-42 CD44 molecule (Indian blood group) Homo sapiens 90-94 25941526-1 2015 CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. Hyaluronic Acid 23-33 CD44 molecule (Indian blood group) Homo sapiens 0-4 26117979-4 2015 CD44 is a cell-surface glycoprotein, which binds to its ligand--hyaluronic acid (HA)--and regulates crucial processes such as cell differentiation, proliferation and migration. Hyaluronic Acid 64-79 CD44 molecule (Indian blood group) Homo sapiens 0-4 25892224-3 2015 We show that circulating CD8 TE arrest within liver sinusoids by docking onto platelets previously adhered to sinusoidal hyaluronan via CD44. Hyaluronic Acid 121-131 CD44 molecule (Indian blood group) Homo sapiens 136-140 25954275-4 2015 The extracellular matrix glycosaminoglycan hyaluronic acid (HA) is the principle ligand of CD44. Hyaluronic Acid 43-58 CD44 molecule (Indian blood group) Homo sapiens 91-95 25954275-4 2015 The extracellular matrix glycosaminoglycan hyaluronic acid (HA) is the principle ligand of CD44. Hyaluronic Acid 60-62 CD44 molecule (Indian blood group) Homo sapiens 91-95 25954275-5 2015 This review focuses both CD44-hyaluronan dependent and independent CD44 signaling and the role of CD44-HA interaction in various pathophysiologies. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 25-29 25753521-10 2015 Since hyaluronan is a ligand for CD44, formation of CD44-hyaluronan complex on the cell surface activates CD44 and this activation may explain why the tumor manifested aggressive invasion and metastasis throughout the clinical course. Hyaluronic Acid 6-16 CD44 molecule (Indian blood group) Homo sapiens 33-37 25753521-10 2015 Since hyaluronan is a ligand for CD44, formation of CD44-hyaluronan complex on the cell surface activates CD44 and this activation may explain why the tumor manifested aggressive invasion and metastasis throughout the clinical course. Hyaluronic Acid 6-16 CD44 molecule (Indian blood group) Homo sapiens 52-56 25753521-10 2015 Since hyaluronan is a ligand for CD44, formation of CD44-hyaluronan complex on the cell surface activates CD44 and this activation may explain why the tumor manifested aggressive invasion and metastasis throughout the clinical course. Hyaluronic Acid 6-16 CD44 molecule (Indian blood group) Homo sapiens 52-56 25753521-10 2015 Since hyaluronan is a ligand for CD44, formation of CD44-hyaluronan complex on the cell surface activates CD44 and this activation may explain why the tumor manifested aggressive invasion and metastasis throughout the clinical course. Hyaluronic Acid 57-67 CD44 molecule (Indian blood group) Homo sapiens 33-37 25753521-10 2015 Since hyaluronan is a ligand for CD44, formation of CD44-hyaluronan complex on the cell surface activates CD44 and this activation may explain why the tumor manifested aggressive invasion and metastasis throughout the clinical course. Hyaluronic Acid 57-67 CD44 molecule (Indian blood group) Homo sapiens 52-56 25753521-10 2015 Since hyaluronan is a ligand for CD44, formation of CD44-hyaluronan complex on the cell surface activates CD44 and this activation may explain why the tumor manifested aggressive invasion and metastasis throughout the clinical course. Hyaluronic Acid 57-67 CD44 molecule (Indian blood group) Homo sapiens 52-56 25941526-1 2015 CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. Hyaluronic Acid 35-37 CD44 molecule (Indian blood group) Homo sapiens 0-4 25361867-0 2015 Tunable CD44-specific cellular retargeting with hyaluronic acid nanoshells. Hyaluronic Acid 48-63 CD44 molecule (Indian blood group) Homo sapiens 8-12 25681725-0 2015 Hyaluronic acid conjugated beta-cyclodextrin-oligoethylenimine star polymer for CD44-targeted gene delivery. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 80-84 25600777-8 2015 Hyaluronan is colocalized with CD44 overexpression and infiltrating immune cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 31-35 25926830-10 2015 Likewise, naive T cells, which typically express low levels of the hyaluronan receptor, CD44, do not bind hyaluronan until they undergo antigen-stimulated T cell proliferation and upregulate CD44. Hyaluronic Acid 67-77 CD44 molecule (Indian blood group) Homo sapiens 88-92 25733665-0 2015 Extracellular processing of the cartilage proteoglycan aggregate and its effect on CD44-mediated internalization of hyaluronan. Hyaluronic Acid 116-126 CD44 molecule (Indian blood group) Homo sapiens 83-87 25733665-1 2015 In many cells hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes/lysosomes. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 34-38 25579786-1 2015 Hyaluronan (HA) in human milk mediates host responses to microbial infection via TLR4- and CD44-dependent signaling. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 91-95 25579786-1 2015 Hyaluronan (HA) in human milk mediates host responses to microbial infection via TLR4- and CD44-dependent signaling. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 91-95 25648974-0 2015 Hyaluronan-decorated polymer nanoparticles targeting the CD44 receptor for the combined photo/chemo-therapy of cancer. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 57-61 25648974-1 2015 In the attempt to develop novel concepts in designing targeted nanoparticles for combination therapy of cancer, we propose here CD44-targeted hyaluronan-decorated double-coated nanoparticles (dcNPs) delivering the lipophilic chemotherapeutic docetaxel (DTX) and an anionic porphyrin (TPPS4). Hyaluronic Acid 142-152 CD44 molecule (Indian blood group) Homo sapiens 128-132 25361867-1 2015 PURPOSE: In this work we specifically investigate the molecular weight (Mw) dependent combinatorial properties of hyaluronic acid (HA) for exhibiting stealth and targeting properties using different Mw HA nanoshells to tune nanoparticle retargeting to CD44-expressing cancer cells. Hyaluronic Acid 114-129 CD44 molecule (Indian blood group) Homo sapiens 252-256 25361867-1 2015 PURPOSE: In this work we specifically investigate the molecular weight (Mw) dependent combinatorial properties of hyaluronic acid (HA) for exhibiting stealth and targeting properties using different Mw HA nanoshells to tune nanoparticle retargeting to CD44-expressing cancer cells. Hyaluronic Acid 131-133 CD44 molecule (Indian blood group) Homo sapiens 252-256 25449802-0 2015 Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation. Hyaluronic Acid 22-37 CD44 molecule (Indian blood group) Homo sapiens 8-12 25693888-4 2015 Here, biocompatible hyaluronic acid (HA) was fabricated into nanoparticles to increase the target specificity by binding to CD44-over-expressed cancer cells. Hyaluronic Acid 20-35 CD44 molecule (Indian blood group) Homo sapiens 124-128 25693888-4 2015 Here, biocompatible hyaluronic acid (HA) was fabricated into nanoparticles to increase the target specificity by binding to CD44-over-expressed cancer cells. Hyaluronic Acid 37-39 CD44 molecule (Indian blood group) Homo sapiens 124-128 25549589-13 2015 Fluorescein-labeled hyaluronan bound regularly along fibronectin fibers and co-localized more with beta1 integrin and less with CD44. Hyaluronic Acid 20-30 CD44 molecule (Indian blood group) Homo sapiens 128-132 25499555-4 2015 As the model system to foreignize the tumors, we prepared a polymeric conjugate consisting of hyaluronic acid as the CD44(+) tumor-targeting ligand and ovalbumin (OVA) as a foreign antigen. Hyaluronic Acid 94-109 CD44 molecule (Indian blood group) Homo sapiens 117-121 32262257-2 2015 Hyaluronan (HA), as the target ligand for CD44, was bound to the CHI layer to selectively kill cancer cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 42-46 32262257-2 2015 Hyaluronan (HA), as the target ligand for CD44, was bound to the CHI layer to selectively kill cancer cells. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 42-46 25549589-12 2015 Time-lapse imaging of the immediate effects of hyaluronidase digestion showed that hyaluronan matrix primarily mediates attachment of membrane and cortical actin between focal contacts, suggesting that surface adhesion through hyaluronan and CD44 is distinct from focal adhesion through beta1 integrins and fibronectin. Hyaluronic Acid 83-93 CD44 molecule (Indian blood group) Homo sapiens 242-246 25558928-6 2015 LNP"s surface was functionalized with hyaluronan (HA), a naturally occurring glycosaminoglycan that specifically binds the CD44 receptor expressed on GBM cells. Hyaluronic Acid 38-48 CD44 molecule (Indian blood group) Homo sapiens 123-127 25242358-1 2014 The in vitro efficacy and selectivity of Hyaluronan-Doxorubicin complexes to affect the viability of overexpressing CD44 receptor cells. Hyaluronic Acid 41-51 CD44 molecule (Indian blood group) Homo sapiens 116-120 25445525-5 2014 Furthermore, the targeting potential of hyaluronic acid (HA) coated nanoparticles for CD44 receptors was investigated using the MCF7 cell line. Hyaluronic Acid 40-55 CD44 molecule (Indian blood group) Homo sapiens 86-90 25445525-5 2014 Furthermore, the targeting potential of hyaluronic acid (HA) coated nanoparticles for CD44 receptors was investigated using the MCF7 cell line. Hyaluronic Acid 57-59 CD44 molecule (Indian blood group) Homo sapiens 86-90 25116630-4 2014 CD44 is a single-pass transmembrane glycoprotein whose binding with its carbohydrate ligand hyaluronan (HA), an extracellular matrix component, mediates processes such as leukocyte homing, cell adhesion, and tumor metastasis. Hyaluronic Acid 92-102 CD44 molecule (Indian blood group) Homo sapiens 0-4 25126764-0 2014 Low molecular weight hyaluronan mediated CD44 dependent induction of IL-6 and chemokines in human dermal fibroblasts potentiates innate immune response. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 41-45 25262448-6 2014 Moreover, CD44 silencing resulted in induction of apoptosis in KG-1 cells, reduced adhesion of KG-1 and KG-1a cells to hyaluronic acid-coated cell culture plates and BM-MSC, and decreased adhesion of primary AML cells to BM-MSC. Hyaluronic Acid 119-134 CD44 molecule (Indian blood group) Homo sapiens 10-14 25116630-0 2014 Terminal sialic acids on CD44 N-glycans can block hyaluronan binding by forming competing intramolecular contacts with arginine sidechains. Hyaluronic Acid 50-60 CD44 molecule (Indian blood group) Homo sapiens 25-29 25342622-0 2014 Hyaluronic acid induces COX-2 expression via CD44 in orbital fibroblasts from patients with thyroid-associated ophthalmopathy. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 45-49 25342622-10 2014 CONCLUSIONS: Hyaluronic acid induced COX-2 expression in orbital fibroblasts from patients with TAO via CD44 through the MAPK and NF-kappaB-mediated signaling pathways. Hyaluronic Acid 13-28 CD44 molecule (Indian blood group) Homo sapiens 104-108 25299431-4 2014 In this study, we demonstrate that hyaluronan (HA)-conjugated cisplatin has highly selective and sensitive anticancer effects in NSCLC cells that overexpress the trans-membrane receptor, CD44, as HA is a specific ligand for CD44. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 187-191 25299431-4 2014 In this study, we demonstrate that hyaluronan (HA)-conjugated cisplatin has highly selective and sensitive anticancer effects in NSCLC cells that overexpress the trans-membrane receptor, CD44, as HA is a specific ligand for CD44. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 224-228 25454755-3 2014 Hyaluronic acid is a biocompatible, non-antigenic and hydrophilic, CD-44 ligand that can impart many useful features to the nanocarrier for anticancer drug delivery. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 67-72 25155464-0 2014 Blocking of HIV entry through CD44-hyaluronic acid interactions. Hyaluronic Acid 35-50 CD44 molecule (Indian blood group) Homo sapiens 30-34 25025570-1 2014 CD44 is a hyaluronan binding cell surface signal transducing receptor that influences motility, cell survival and proliferation as well as the formation of tumor microenvironment. Hyaluronic Acid 10-20 CD44 molecule (Indian blood group) Homo sapiens 0-4 24934231-3 2014 The expression of HAS genes encoding enzyme hyaluronan synthase 2 and 3, including CD44 gene which encodes the cell surface receptor of hyaluronan were upregulated in association with the activation of inflammation, along with an increase in hyaluronan level in the culture medium. Hyaluronic Acid 44-54 CD44 molecule (Indian blood group) Homo sapiens 83-87 25078298-2 2014 The aim of the present study is to fabricate cis-dichlorodiamminoplatinum (II) (CDDP) loaded glyconanoparticles using hyaluronic acid (HA) which is also known as the endogenous substrate for CD44 in vivo. Hyaluronic Acid 118-133 CD44 molecule (Indian blood group) Homo sapiens 191-195 25078298-2 2014 The aim of the present study is to fabricate cis-dichlorodiamminoplatinum (II) (CDDP) loaded glyconanoparticles using hyaluronic acid (HA) which is also known as the endogenous substrate for CD44 in vivo. Hyaluronic Acid 135-137 CD44 molecule (Indian blood group) Homo sapiens 191-195 24957217-3 2014 Hyaluronic acid (HA) is a major extracellular component of mucosa and the primary ligand for the cell surface receptor CD44. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 119-123 24957217-3 2014 Hyaluronic acid (HA) is a major extracellular component of mucosa and the primary ligand for the cell surface receptor CD44. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 119-123 24962319-0 2014 CD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motility. Hyaluronic Acid 26-41 CD44 molecule (Indian blood group) Homo sapiens 0-4 24637218-1 2014 UNLABELLED: In contrast with the conventional targeting of nanoparticles to cancer cells with antibody or peptide conjugates, a hyaluronic acid (HA) matrix nanoparticle with intrinsic-CD44-tropism was developed to deliver rapamycin for localized CD44-positive breast cancer treatment. Hyaluronic Acid 145-147 CD44 molecule (Indian blood group) Homo sapiens 184-188 25195884-0 2014 High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Hyaluronic Acid 72-82 CD44 molecule (Indian blood group) Homo sapiens 67-71 24643931-1 2014 PURPOSE: It is hypothesized that docetaxel (Doc)-loaded hyaluronic acid (HA)-polyethylene glycol/poly(epsilon-caprolactone)-grafted oily core nanocapsules (NCs) can enhance the drug cytotoxicity and uptake in CD44 expressing breast cancer (BC) cells (MDA-MB 231). Hyaluronic Acid 56-71 CD44 molecule (Indian blood group) Homo sapiens 209-213 24643931-1 2014 PURPOSE: It is hypothesized that docetaxel (Doc)-loaded hyaluronic acid (HA)-polyethylene glycol/poly(epsilon-caprolactone)-grafted oily core nanocapsules (NCs) can enhance the drug cytotoxicity and uptake in CD44 expressing breast cancer (BC) cells (MDA-MB 231). Hyaluronic Acid 73-75 CD44 molecule (Indian blood group) Homo sapiens 209-213 24892741-1 2014 BACKGROUND: Hyaluronan (HA) is a ligand for the CD44 receptor which is crucial to cancer cell proliferation and metastasis. Hyaluronic Acid 12-22 CD44 molecule (Indian blood group) Homo sapiens 48-52 24892741-1 2014 BACKGROUND: Hyaluronan (HA) is a ligand for the CD44 receptor which is crucial to cancer cell proliferation and metastasis. Hyaluronic Acid 24-26 CD44 molecule (Indian blood group) Homo sapiens 48-52 25013352-3 2014 Many studies have examined the effects of specific COX-2 and 5-LOX inhibitors on human colorectal cancer, but the role of isothiocyanates (ITSCs) as COX-LOX dual inhibitors engaged in hyaluronan-CD44 interaction has not been studied. Hyaluronic Acid 184-194 CD44 molecule (Indian blood group) Homo sapiens 195-199 24637218-1 2014 UNLABELLED: In contrast with the conventional targeting of nanoparticles to cancer cells with antibody or peptide conjugates, a hyaluronic acid (HA) matrix nanoparticle with intrinsic-CD44-tropism was developed to deliver rapamycin for localized CD44-positive breast cancer treatment. Hyaluronic Acid 128-143 CD44 molecule (Indian blood group) Homo sapiens 184-188 24798704-1 2014 INTRODUCTION: The CD44 transmembrane glycoprotein family mediates cellular responses to the microenvironment through binding of hyaluronic acid (HA) and other proteins of the extracellular matrix. Hyaluronic Acid 128-143 CD44 molecule (Indian blood group) Homo sapiens 18-22 24798704-1 2014 INTRODUCTION: The CD44 transmembrane glycoprotein family mediates cellular responses to the microenvironment through binding of hyaluronic acid (HA) and other proteins of the extracellular matrix. Hyaluronic Acid 145-147 CD44 molecule (Indian blood group) Homo sapiens 18-22 24269154-0 2014 Differences between healthy hematopoietic progenitors and leukemia cells with respect to CD44 mediated rolling versus adherence behavior on hyaluronic acid coated surfaces. Hyaluronic Acid 140-155 CD44 molecule (Indian blood group) Homo sapiens 89-93 24444042-0 2014 CD44-targeted docetaxel conjugate for cancer cells and cancer stem-like cells: a novel hyaluronic acid-based drug delivery system. Hyaluronic Acid 87-102 CD44 molecule (Indian blood group) Homo sapiens 0-4 24444042-1 2014 A CD44-targeted macromolecular conjugate of docetaxel was prepared via a pH-sensitive linkage to hyaluronic acid and was characterized using NMR, gel permeation chromatography, and differential scanning calorimetry. Hyaluronic Acid 97-112 CD44 molecule (Indian blood group) Homo sapiens 2-6 24444042-4 2014 Hyaluronic acid-docetaxel conjugates showed specific toxicity only in CD44-expressing cells in vitro, along with a decreased risk of neutropenia and dose-dependent mortality in vivo. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 70-74 24606718-0 2014 Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 24606718-2 2014 In this study we investigated matrix hyaluronan (HA)-CD44 (a primary HA receptor) interaction with c-Jun N-Terminal Kinase (JNK)/c-Jun signaling in MDA-MB-468 breast cancer cells [a triple-negative (estrogen receptor-negative/progesterone receptor-negative/HER2-negative) breast cancer cell line]. Hyaluronic Acid 37-47 CD44 molecule (Indian blood group) Homo sapiens 53-57 24406795-0 2014 Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 10-14 24439029-0 2014 Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronic acid interaction. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 58-62 24439029-2 2014 CD44, a cell-surface receptor for hyaluronic acid (HA), plays a key role in HA-mediated remodeling and degradation that triggers cancer cell invasion. Hyaluronic Acid 34-49 CD44 molecule (Indian blood group) Homo sapiens 0-4 24439029-2 2014 CD44, a cell-surface receptor for hyaluronic acid (HA), plays a key role in HA-mediated remodeling and degradation that triggers cancer cell invasion. Hyaluronic Acid 51-53 CD44 molecule (Indian blood group) Homo sapiens 0-4 24806526-1 2014 Hyaluronan-grafted liposomes (HA-liposomes) preferentially target CD44-overexpressing tumor cells in vitro via receptor-mediated endocytosis. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 66-70 24606063-1 2014 Selective inhibitors of hyaluronan (HA) binding to the cell surface receptor CD44 will have value as probes of CD44-mediated signaling and have potential as therapeutic agents in chronic inflammation, cardiovascular disease, and cancer. Hyaluronic Acid 24-34 CD44 molecule (Indian blood group) Homo sapiens 77-81 24606063-1 2014 Selective inhibitors of hyaluronan (HA) binding to the cell surface receptor CD44 will have value as probes of CD44-mediated signaling and have potential as therapeutic agents in chronic inflammation, cardiovascular disease, and cancer. Hyaluronic Acid 24-34 CD44 molecule (Indian blood group) Homo sapiens 111-115 24614402-6 2014 Furthermore, the interaction between CD44 and hyaluronan determines the adhesion of breast cancer cells. Hyaluronic Acid 46-56 CD44 molecule (Indian blood group) Homo sapiens 37-41 24269154-1 2014 We previously demonstrated that leukemia cell lines expressing CD44 and hematopoietic progenitor cells (HPC) from umbilical cord blood (CB) showed rolling on hyaluronic acid (HA)-coated surfaces under physiological shear stress. Hyaluronic Acid 158-173 CD44 molecule (Indian blood group) Homo sapiens 63-67 24269154-1 2014 We previously demonstrated that leukemia cell lines expressing CD44 and hematopoietic progenitor cells (HPC) from umbilical cord blood (CB) showed rolling on hyaluronic acid (HA)-coated surfaces under physiological shear stress. Hyaluronic Acid 175-177 CD44 molecule (Indian blood group) Homo sapiens 63-67 25081532-3 2014 The transmembrane protein CD44 contributes to the reception of a broad variety of microenvironmental components, including extracellular matrix constituents such as hyaluronic acid, as well as growth factors and cytokines. Hyaluronic Acid 165-180 CD44 molecule (Indian blood group) Homo sapiens 26-30 23760401-2 2014 Lenalidomide-resistant models were found to overexpress the hyaluronan (HA)-binding protein CD44, a downstream Wnt/beta-catenin transcriptional target. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 92-96 24482736-7 2014 In xenograft transplantation models with genetically engineered ESCC cells, IGFBP3 contributes to tumor progression with a concurrent induction of a subset of tumor cells showing high expression of CD44 (CD44H), a major cell surface receptor for hyaluronic acid, implicated in invasion, metastasis and drug resistance. Hyaluronic Acid 246-261 CD44 molecule (Indian blood group) Homo sapiens 198-202 24482736-7 2014 In xenograft transplantation models with genetically engineered ESCC cells, IGFBP3 contributes to tumor progression with a concurrent induction of a subset of tumor cells showing high expression of CD44 (CD44H), a major cell surface receptor for hyaluronic acid, implicated in invasion, metastasis and drug resistance. Hyaluronic Acid 246-261 CD44 molecule (Indian blood group) Homo sapiens 204-209 25278260-0 2014 Cationic conjugated polymer/fluoresceinamine-hyaluronan complex for sensitive fluorescence detection of CD44 and tumor-targeted cell imaging. Hyaluronic Acid 45-55 CD44 molecule (Indian blood group) Homo sapiens 104-108 25081533-0 2014 Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 25081534-0 2014 Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer. Hyaluronic Acid 76-86 CD44 molecule (Indian blood group) Homo sapiens 87-91 25081534-2 2014 Because of the intimate relationship between the hyaluronan-CD44 system and tumor cell survival and growth, it is an increasingly investigated area for applications to anticancer chemotherapeutics. Hyaluronic Acid 49-59 CD44 molecule (Indian blood group) Homo sapiens 60-64 25081534-3 2014 Interference with the hyaluronan-CD44 interaction by targeting drugs to CD44, targeting drugs to the hyaluronan matrix, or interfering with hyaluronan matrix/tumor cell-associated CD44 interactions is a viable strategy for cancer treatment. Hyaluronic Acid 22-32 CD44 molecule (Indian blood group) Homo sapiens 33-37 25081534-3 2014 Interference with the hyaluronan-CD44 interaction by targeting drugs to CD44, targeting drugs to the hyaluronan matrix, or interfering with hyaluronan matrix/tumor cell-associated CD44 interactions is a viable strategy for cancer treatment. Hyaluronic Acid 22-32 CD44 molecule (Indian blood group) Homo sapiens 72-76 25081534-3 2014 Interference with the hyaluronan-CD44 interaction by targeting drugs to CD44, targeting drugs to the hyaluronan matrix, or interfering with hyaluronan matrix/tumor cell-associated CD44 interactions is a viable strategy for cancer treatment. Hyaluronic Acid 22-32 CD44 molecule (Indian blood group) Homo sapiens 72-76 25081534-3 2014 Interference with the hyaluronan-CD44 interaction by targeting drugs to CD44, targeting drugs to the hyaluronan matrix, or interfering with hyaluronan matrix/tumor cell-associated CD44 interactions is a viable strategy for cancer treatment. Hyaluronic Acid 101-111 CD44 molecule (Indian blood group) Homo sapiens 33-37 25081536-2 2014 Hyaluronan (HA), a prominent constituent of the tumor microenvironment, not only provides structural support but also interacts with cell surface receptors, especially CD44, that influence cooperative signaling pathways leading to chemoresistance and invasiveness. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 168-172 25081536-2 2014 Hyaluronan (HA), a prominent constituent of the tumor microenvironment, not only provides structural support but also interacts with cell surface receptors, especially CD44, that influence cooperative signaling pathways leading to chemoresistance and invasiveness. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 168-172 24145190-8 2014 Finally, we discovered that c-Src kinase activity was required for the downregulation of miR-203 in HCT-15 cells, which was stimulated by the interaction between hyaluronan (HA) and CD44. Hyaluronic Acid 174-176 CD44 molecule (Indian blood group) Homo sapiens 182-186 24868467-3 2014 Sodium hyaluronate is a substance that binds to the CD44 receptors overexpressed in SK-OV-3 cells of epithelial ovarian carcinoma. Hyaluronic Acid 0-18 CD44 molecule (Indian blood group) Homo sapiens 52-56 24106105-1 2013 CD44, the main receptor of hyaluronic acid (HA), is overexpressed in several pathological conditions and therefore can be seen as an interesting target for therapeutic intervention. Hyaluronic Acid 27-42 CD44 molecule (Indian blood group) Homo sapiens 0-4 24106105-1 2013 CD44, the main receptor of hyaluronic acid (HA), is overexpressed in several pathological conditions and therefore can be seen as an interesting target for therapeutic intervention. Hyaluronic Acid 44-46 CD44 molecule (Indian blood group) Homo sapiens 0-4 24002934-3 2013 Therefore to improve efficacy, we have developed an ultra-small hyaluronic acid (HA) paclitaxel nanoconjugate (~5 kDa) that can passively diffuse across the leaky blood-tumor barrier and then be taken up into cancer cells (MDA-MB-231Br) via CD44 receptor-mediated endocytocis. Hyaluronic Acid 64-79 CD44 molecule (Indian blood group) Homo sapiens 241-245 32261192-0 2013 pi-Hyaluronan nanocarriers for CD44-targeted and pH-boosted aromatic drug delivery. Hyaluronic Acid 3-13 CD44 molecule (Indian blood group) Homo sapiens 31-35 32261192-2 2013 In this study, we developed a pi-hyaluronan nanocarrier (piHNC) for CD44-targeted and pH-boosted delivery of an aromatic anticancer drug to cancer cells. Hyaluronic Acid 33-43 CD44 molecule (Indian blood group) Homo sapiens 68-72 23791684-2 2013 Hyaluronic acid (HA) was selected as targeting agent since it is biodegradable, biocompatible, and can be chemically modified and its cell surface receptor CD44 is overexpressed on various tumors. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 156-160 23791684-2 2013 Hyaluronic acid (HA) was selected as targeting agent since it is biodegradable, biocompatible, and can be chemically modified and its cell surface receptor CD44 is overexpressed on various tumors. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 156-160 24002934-3 2013 Therefore to improve efficacy, we have developed an ultra-small hyaluronic acid (HA) paclitaxel nanoconjugate (~5 kDa) that can passively diffuse across the leaky blood-tumor barrier and then be taken up into cancer cells (MDA-MB-231Br) via CD44 receptor-mediated endocytocis. Hyaluronic Acid 81-83 CD44 molecule (Indian blood group) Homo sapiens 241-245 24135874-5 2013 Treatment of cells with cytochalasin D resulted in a loss of the microvilli projections and concomitantly abrogated CD44-mediated adhesion to its ligand hyaluronan. Hyaluronic Acid 153-163 CD44 molecule (Indian blood group) Homo sapiens 116-120 24091662-0 2013 Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44. Hyaluronic Acid 51-61 CD44 molecule (Indian blood group) Homo sapiens 106-110 24069351-0 2013 Hyaluronan-CD44 interaction promotes growth of decidual stromal cells in human first-trimester pregnancy. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 24010665-1 2013 The extracellular carbohydrate-binding domain of the Type I transmembrane receptor CD44 is known to undergo affinity switching, where change in conformation leads to enhanced binding of its carbohydrate ligand hyaluronan. Hyaluronic Acid 210-220 CD44 molecule (Indian blood group) Homo sapiens 83-87 22341413-6 2013 RESULTS: The paclitaxel-hyaluronan bioconjugate bound to UC tumor cells entered intracellular compartments through a saturable and energy-dependent mechanism that involved CD44, as assessed by blocking with specific antibody. Hyaluronic Acid 24-34 CD44 molecule (Indian blood group) Homo sapiens 172-176 23884413-4 2013 Using stable and transient overexpression of the cytoplasmic domain of CD44, we determined that the intracellular domain interfered with anchoring of the full-length CD44 to the cytoskeleton and disrupted the ability of the cells to bind hyaluronan and assemble a pericellular matrix. Hyaluronic Acid 238-248 CD44 molecule (Indian blood group) Homo sapiens 71-75 23884413-4 2013 Using stable and transient overexpression of the cytoplasmic domain of CD44, we determined that the intracellular domain interfered with anchoring of the full-length CD44 to the cytoskeleton and disrupted the ability of the cells to bind hyaluronan and assemble a pericellular matrix. Hyaluronic Acid 238-248 CD44 molecule (Indian blood group) Homo sapiens 166-170 23888049-6 2013 Here we found that CD147 induces breast epithelial cell invasiveness by promoting epidermal growth factor receptor (EGFR)-Ras-ERK signaling in a manner dependent on hyaluronan-CD44 interaction. Hyaluronic Acid 165-175 CD44 molecule (Indian blood group) Homo sapiens 176-180 24069351-1 2013 Hyaluronan (HA) and its receptor CD44 are expressed at the maternal-fetal interface, but its role in early pregnancy remains unclear. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 33-37 23826724-1 2013 CD44 is a transmembrane adhesion glycoprotein, functioning as a hyaluronan receptor and participating in the uptake and degradation of hyaluronan. Hyaluronic Acid 64-74 CD44 molecule (Indian blood group) Homo sapiens 0-4 23729731-0 2013 Membrane cholesterol modulates the hyaluronan-binding ability of CD44 in T lymphocytes and controls rolling under shear flow. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 65-69 23729731-3 2013 Here we show that the hyaluronan-binding ability of CD44 in T cells is upregulated by the depletion of membrane cholesterol with methyl-beta-cyclodextrin (MbetaCD), which disintegrates lipid rafts, i.e. cholesterol- and sphingolipid-enriched membrane microdomains. Hyaluronic Acid 22-32 CD44 molecule (Indian blood group) Homo sapiens 52-56 23817087-8 2013 Adhesive properties of ZK-1 were significantly inhibited by siRNA, and PDPN was shown to collaborate with CD44 in cell adhesion to tether SCC cells with hyaluronan-rich ECM of the narrow intercellular space as well as with the stromal ECM. Hyaluronic Acid 153-163 CD44 molecule (Indian blood group) Homo sapiens 106-110 23855374-9 2013 CD44, a transmembrane glycoprotein, acts as a major receptor for hyaluronan (HA). Hyaluronic Acid 65-75 CD44 molecule (Indian blood group) Homo sapiens 0-4 23900224-6 2013 We then demonstrated that the combination treatment of the selected siRNAs and cisplatin encapsulated in CD44-targeting hyaluronic acid (HA)-based self-assembling nanosystems reversed the resistance to cisplatin and delayed the tumor growth significantly (growth inhibition increased from 30 to 60%) in cisplatin-resistant tumors. Hyaluronic Acid 120-135 CD44 molecule (Indian blood group) Homo sapiens 105-109 23900224-6 2013 We then demonstrated that the combination treatment of the selected siRNAs and cisplatin encapsulated in CD44-targeting hyaluronic acid (HA)-based self-assembling nanosystems reversed the resistance to cisplatin and delayed the tumor growth significantly (growth inhibition increased from 30 to 60%) in cisplatin-resistant tumors. Hyaluronic Acid 137-139 CD44 molecule (Indian blood group) Homo sapiens 105-109 23441859-1 2013 In this study, we created a nanoscale layer of hyaluronic acid (HA) on the inactivated Hemagglutinating Virus of Japan envelope (HVJ-E) via a layer-by-layer (LbL) assembly technique for CD-44 targeted delivery. Hyaluronic Acid 47-62 CD44 molecule (Indian blood group) Homo sapiens 186-191 23441859-1 2013 In this study, we created a nanoscale layer of hyaluronic acid (HA) on the inactivated Hemagglutinating Virus of Japan envelope (HVJ-E) via a layer-by-layer (LbL) assembly technique for CD-44 targeted delivery. Hyaluronic Acid 64-66 CD44 molecule (Indian blood group) Homo sapiens 186-191 23529646-5 2013 To validate our hypothesis, in the first of two articles, we report the synthesis of doxorubicin (DOX)-loaded, hyaluronan (HA) coated silica nanoparticles (SNPs) containing a highly fluorescent core to target CD44, a receptor expressed on the cancer cell surface. Hyaluronic Acid 111-121 CD44 molecule (Indian blood group) Homo sapiens 209-213 23288481-9 2013 Co-localization of CD44 and ezrin, which might be a pathway of hyaluronan signaling, was abrogated by methylumbelliferone treatment. Hyaluronic Acid 63-73 CD44 molecule (Indian blood group) Homo sapiens 19-23 23449937-0 2013 Hyaluronan initiates chondrogenesis mainly via CD44 in human adipose-derived stem cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 47-51 23589287-0 2013 Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Hyaluronic Acid 115-125 CD44 molecule (Indian blood group) Homo sapiens 187-191 23589287-0 2013 Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Hyaluronic Acid 127-129 CD44 molecule (Indian blood group) Homo sapiens 187-191 23517721-5 2013 The signaling interaction between endogenous hyaluronan and CD44 has been shown to regulate COX-2 activities through ErbB2 receptor tyrosine kinase (RTK) activation. Hyaluronic Acid 45-55 CD44 molecule (Indian blood group) Homo sapiens 60-64 23529646-5 2013 To validate our hypothesis, in the first of two articles, we report the synthesis of doxorubicin (DOX)-loaded, hyaluronan (HA) coated silica nanoparticles (SNPs) containing a highly fluorescent core to target CD44, a receptor expressed on the cancer cell surface. Hyaluronic Acid 123-125 CD44 molecule (Indian blood group) Homo sapiens 209-213 23549322-3 2013 We synthesized hyaluronan (HA) coated silica nanoparticles (SNPs) containing a highly fluorescent core to target CD44 expressed on the cancer cell surface. Hyaluronic Acid 15-25 CD44 molecule (Indian blood group) Homo sapiens 113-117 23549322-3 2013 We synthesized hyaluronan (HA) coated silica nanoparticles (SNPs) containing a highly fluorescent core to target CD44 expressed on the cancer cell surface. Hyaluronic Acid 27-29 CD44 molecule (Indian blood group) Homo sapiens 113-117 23547842-0 2013 Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 110-114 23547842-1 2013 Many drug-resistant tumors and cancer stem cells (CSC) express elevated levels of CD44 receptor, a cellular glycoprotein binding hyaluronic acid (HA). Hyaluronic Acid 129-144 CD44 molecule (Indian blood group) Homo sapiens 82-86 23547842-1 2013 Many drug-resistant tumors and cancer stem cells (CSC) express elevated levels of CD44 receptor, a cellular glycoprotein binding hyaluronic acid (HA). Hyaluronic Acid 146-148 CD44 molecule (Indian blood group) Homo sapiens 82-86 24649196-3 2013 The ligation of CD44 with hyaluronan (HA) has been shown to contribute to the drug resistance of leukemic cells. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 16-20 24649196-3 2013 The ligation of CD44 with hyaluronan (HA) has been shown to contribute to the drug resistance of leukemic cells. Hyaluronic Acid 38-40 CD44 molecule (Indian blood group) Homo sapiens 16-20 23547716-0 2013 Efficient CD44-targeted magnetic resonance imaging (MRI) of breast cancer cells using hyaluronic acid (HA)-modified MnFe2O4 nanocrystals. Hyaluronic Acid 86-101 CD44 molecule (Indian blood group) Homo sapiens 10-14 23530247-1 2013 Chronic lymphocytic leukemia (CLL) cells express high levels of CD44, a cell-surface glycoprotein receptor for hyaluronic acid. Hyaluronic Acid 111-126 CD44 molecule (Indian blood group) Homo sapiens 64-68 23547716-0 2013 Efficient CD44-targeted magnetic resonance imaging (MRI) of breast cancer cells using hyaluronic acid (HA)-modified MnFe2O4 nanocrystals. Hyaluronic Acid 103-105 CD44 molecule (Indian blood group) Homo sapiens 10-14 23547716-1 2013 Targeted molecular imaging with hyaluronic acid (HA) has been highlighted in the diagnosis and treatment of CD44-overexpressing cancer. Hyaluronic Acid 32-47 CD44 molecule (Indian blood group) Homo sapiens 108-112 23547716-1 2013 Targeted molecular imaging with hyaluronic acid (HA) has been highlighted in the diagnosis and treatment of CD44-overexpressing cancer. Hyaluronic Acid 49-51 CD44 molecule (Indian blood group) Homo sapiens 108-112 23410679-0 2013 Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 54-58 23410679-3 2013 In the current study, we have engineered and screened a series of CD44 targeting hyaluronic acid (HA) based self-assembling nanosystems for targeted siRNA delivery. Hyaluronic Acid 81-96 CD44 molecule (Indian blood group) Homo sapiens 66-70 23410679-3 2013 In the current study, we have engineered and screened a series of CD44 targeting hyaluronic acid (HA) based self-assembling nanosystems for targeted siRNA delivery. Hyaluronic Acid 98-100 CD44 molecule (Indian blood group) Homo sapiens 66-70 23403616-2 2013 Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. Hyaluronic Acid 119-134 CD44 molecule (Indian blood group) Homo sapiens 6-10 22473523-2 2013 Hyaluronan (HA), a major component of the extracellular matrix, is the primary ligand for CD44 receptors. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 90-94 22473523-2 2013 Hyaluronan (HA), a major component of the extracellular matrix, is the primary ligand for CD44 receptors. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 90-94 23169460-4 2013 CD44 is a plasma membrane glycoprotein that binds to the extracellular matrix component hyaluronan (HA) and has been shown to be involved in metastasis formation in a variety of other tumors. Hyaluronic Acid 88-98 CD44 molecule (Indian blood group) Homo sapiens 0-4 23169460-4 2013 CD44 is a plasma membrane glycoprotein that binds to the extracellular matrix component hyaluronan (HA) and has been shown to be involved in metastasis formation in a variety of other tumors. Hyaluronic Acid 100-102 CD44 molecule (Indian blood group) Homo sapiens 0-4 23117883-0 2013 CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility. Hyaluronic Acid 105-115 CD44 molecule (Indian blood group) Homo sapiens 78-82 23419168-3 2013 CD44 is the binding site for hyaluronic acid, and CD24 is a receptor that interacts with P-selectin to induce metastasis and tumor progression. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 0-4 22927346-8 2013 Presence of hyaluronic acid promotes qualitative expression of CD44 surface markers and aggrecan (more visible in PCL-HA1s than PCL-HA2s), whereas in dedifferentiating conditions, expression of CD44 and aggrecan can hardly be detected in pure PCL scaffolds. Hyaluronic Acid 12-27 CD44 molecule (Indian blood group) Homo sapiens 63-67 23598979-3 2013 CD44 modulates signal transduction through post-translational modifications as well as interactions with hyaluronan, extracellular matrix molecules and growth factors and their cognate receptor tyrosine kinases. Hyaluronic Acid 105-115 CD44 molecule (Indian blood group) Homo sapiens 0-4 23117883-5 2013 CD44 has been implicated in cell activation, migration, and tissue retention via binding to its extracellular matrix ligand hyaluronan (HA). Hyaluronic Acid 124-134 CD44 molecule (Indian blood group) Homo sapiens 0-4 23117883-8 2013 However, CD40L stimulation promoted the firm, CD44-mediated adhesion of CLL cells to hyaluronan, antagonizing their motile behavior. Hyaluronic Acid 85-95 CD44 molecule (Indian blood group) Homo sapiens 46-50 24399703-7 2013 This review surveys recent data on hyaluronan biosynthesis, metabolism, and interactions with its binding proteins called hyaladherins (CD44, RHAMM), providing themolecular background underlying its differentiated biological activity. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 136-140 23076766-0 2013 Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 87-91 23113769-0 2012 Hyaluronic acid immobilized polyacrylamide nanoparticle sensors for CD44 receptor targeting and pH measurement in cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 68-72 22218639-1 2013 The aim of this study was to investigate the effect of hyaluronic acid (HA) on the expression of osteopontin (OPN) and CD44 mRNA of fibroblast-like synoviocytes (FLS) in the patients with osteoarthritis (OA) of the knee. Hyaluronic Acid 55-70 CD44 molecule (Indian blood group) Homo sapiens 119-123 22218639-1 2013 The aim of this study was to investigate the effect of hyaluronic acid (HA) on the expression of osteopontin (OPN) and CD44 mRNA of fibroblast-like synoviocytes (FLS) in the patients with osteoarthritis (OA) of the knee. Hyaluronic Acid 72-74 CD44 molecule (Indian blood group) Homo sapiens 119-123 23118219-0 2012 The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering. Hyaluronic Acid 43-53 CD44 molecule (Indian blood group) Homo sapiens 79-83 23118219-2 2012 Native high molecular weight hyaluronan (nHA) and oligosaccharides of hyaluronan (oHA) provoke distinct biological effects upon binding to CD44. Hyaluronic Acid 29-39 CD44 molecule (Indian blood group) Homo sapiens 139-143 23118219-2 2012 Native high molecular weight hyaluronan (nHA) and oligosaccharides of hyaluronan (oHA) provoke distinct biological effects upon binding to CD44. Hyaluronic Acid 70-80 CD44 molecule (Indian blood group) Homo sapiens 139-143 23118219-4 2012 In this study we investigated the effects of high and low molecular weight hyaluronan on CD44 clustering. Hyaluronic Acid 75-85 CD44 molecule (Indian blood group) Homo sapiens 89-93 23113769-4 2012 We used a polyacrylamide nanoparticle matrix bearing hyaluronic acid (HA) on the surface as a CD44 targeting ligand. Hyaluronic Acid 53-68 CD44 molecule (Indian blood group) Homo sapiens 94-98 23113769-4 2012 We used a polyacrylamide nanoparticle matrix bearing hyaluronic acid (HA) on the surface as a CD44 targeting ligand. Hyaluronic Acid 70-72 CD44 molecule (Indian blood group) Homo sapiens 94-98 22753358-1 2012 Cancer-cell-specific pH-activatable polymer nanogels consisting of CD44-receptor-targeting hyaluronic acid (HA), pH-sensitive poly(beta-amino ester) (PBAE), and near-infrared (NIR) fluorescent indocyanine green (ICG) were synthesized and used to detect cancer cells. Hyaluronic Acid 91-106 CD44 molecule (Indian blood group) Homo sapiens 67-71 23033492-5 2012 We also show that LOX is an essential component of the CD44-Twist signaling axis, in which extracellular hyaluronan causes nuclear translocation of CD44 in the cancer cells, thus triggering LOX transcription by associating with its promoter. Hyaluronic Acid 105-115 CD44 molecule (Indian blood group) Homo sapiens 55-59 23033492-5 2012 We also show that LOX is an essential component of the CD44-Twist signaling axis, in which extracellular hyaluronan causes nuclear translocation of CD44 in the cancer cells, thus triggering LOX transcription by associating with its promoter. Hyaluronic Acid 105-115 CD44 molecule (Indian blood group) Homo sapiens 148-152 22865879-4 2012 We demonstrate that sequential CD44 proteolysis is responsible for hyaluronan-mediated enhancement. Hyaluronic Acid 67-77 CD44 molecule (Indian blood group) Homo sapiens 31-35 22865879-10 2012 These data fit a model where the interaction of hyaluronan in vitreous and CD44 modulates transgene expression by initiating CD44 proteolysis and release of the cytoplasmic domain, resulting in increased transgene transcription. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Homo sapiens 125-129 22820451-0 2012 Hyaluronic acid-bearing lipoplexes: physico-chemical characterization and in vitro targeting of the CD44 receptor. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 100-104 22425026-3 2012 The bio-conjugated CS-MSNs with a PEGylated phospholipid compound and hyaluronic acid showed excellent dispersivity and could specifically target cancer cells overexpressing CD44, deliver insoluble drugs into these cells and consequently kill them effectively, and also fluorescently image them simultaneously in a unique and attractive NIR-to-Vis luminescence imaging fashion, providing a promising opportunity for cancer theranostics. Hyaluronic Acid 70-85 CD44 molecule (Indian blood group) Homo sapiens 174-178 22693353-1 2012 PURPOSE: Most primary human ovarian tumors and peritoneal implants, as well as tumor vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural ligand for which is hyaluronic acid. Hyaluronic Acid 200-215 CD44 molecule (Indian blood group) Homo sapiens 125-129 22564525-6 2012 Treatment with the HSP90 inhibitor 17-DMAG or ligation of CD44 with hyaluronan caused nuclear depletion of FRMD4A, nuclear accumulation of YAP and reduced SCC growth and metastasis. Hyaluronic Acid 68-78 CD44 molecule (Indian blood group) Homo sapiens 58-62 22777824-3 2012 CD44 receptor seems to function as the main receptor for hyaluronic acid and osteopontin, serving as coreceptor for growth factor pathways like cMet, EGFR, HER-2, and VEGFR and by cytoskeletal modulation via ERM and Rho kinase signaling. Hyaluronic Acid 57-72 CD44 molecule (Indian blood group) Homo sapiens 0-4 22694219-2 2012 Here we utilize a single, yet multifunctional, hyaluronic acid-based biosurfactant to simultaneously disperse nanocarbons and target single-walled carbon nanotubes (SWCNTs) to CD44 receptor positive tumor cells with prompt uptake. Hyaluronic Acid 47-62 CD44 molecule (Indian blood group) Homo sapiens 176-180 22491449-0 2012 CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptor 2 and hyaluronan. Hyaluronic Acid 146-156 CD44 molecule (Indian blood group) Homo sapiens 0-4 22525567-5 2012 The molecular patterns leading to cell activation have been substantially clarified and it is now widely accepted that cellular actions of hyaluronic acid are mediated by specific surface receptors, including CD44, RHAMM and toll like receptors. Hyaluronic Acid 139-154 CD44 molecule (Indian blood group) Homo sapiens 209-213 22610405-0 2012 Hyaluronic acid promotes angiogenesis by inducing RHAMM-TGFbeta receptor interaction via CD44-PKCdelta. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 89-93 22184056-5 2012 CD44 knock down also suggests that the role of hyaluronan in cranial NCC migration could be mediated, at least in part, by the activation of CD44. Hyaluronic Acid 47-57 CD44 molecule (Indian blood group) Homo sapiens 0-4 22418440-2 2012 Our previous in vitro studies suggested that the interaction between C. neoformans hyaluronic acid and human brain endothelial CD44 could be the initial step of brain invasion. Hyaluronic Acid 83-98 CD44 molecule (Indian blood group) Homo sapiens 127-131 22270319-12 2012 As hyaluronan is deposited within the pulmonary microvasculature, it may well serve as a ligand for its binding partner CD44, which is expressed by many tumour cells. Hyaluronic Acid 3-13 CD44 molecule (Indian blood group) Homo sapiens 120-124 22350800-0 2012 Hyaluronan oligomers-HPMA copolymer conjugates for targeting paclitaxel to CD44-overexpressing ovarian carcinoma. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 75-79 22350800-1 2012 PURPOSE: To evaluate the effect of the size of low molecular weight hyaluronan (LMW-HA) oligomers on the targeting ability of the HA-containing copolymers to the CD44-overexpressing cells for delivering Paclitaxel (PTX) to ovarian cancer. Hyaluronic Acid 68-78 CD44 molecule (Indian blood group) Homo sapiens 162-166 22566907-3 2012 As such, the interactions of CD44, primarily with its major ligand, the extracellular matrix (ECM) component hyaluronic acid (HA), can be crucial for the recruitment and function of effector and memory T cells into/within inflamed tissues. Hyaluronic Acid 109-124 CD44 molecule (Indian blood group) Homo sapiens 29-33 22566907-3 2012 As such, the interactions of CD44, primarily with its major ligand, the extracellular matrix (ECM) component hyaluronic acid (HA), can be crucial for the recruitment and function of effector and memory T cells into/within inflamed tissues. Hyaluronic Acid 126-128 CD44 molecule (Indian blood group) Homo sapiens 29-33 22184056-1 2012 BACKGROUND: Hyaluronan is a crucial glycosaminoglycan of the vertebrate embryonic extracellular matrix able to influence cell behaviour, both by assembling the pericellular matrices and by activating signal transducing receptors such as CD44. Hyaluronic Acid 12-22 CD44 molecule (Indian blood group) Homo sapiens 237-241 22095138-3 2012 We also aimed to determine if soluble CD44 (sCD44) was present in human tears, as it could have a role in the interaction of the tear fluid with hyaluronan. Hyaluronic Acid 145-155 CD44 molecule (Indian blood group) Homo sapiens 38-42 22184056-5 2012 CD44 knock down also suggests that the role of hyaluronan in cranial NCC migration could be mediated, at least in part, by the activation of CD44. Hyaluronic Acid 47-57 CD44 molecule (Indian blood group) Homo sapiens 141-145 22072421-2 2012 While most of these CD44 functions are supposed to involve hyaluronan, relatively little is known about the contribution of CD44 to hyaluronan maintenance and organization on cell surface, and the role of CD44 in hyaluronan synthesis and catabolism. Hyaluronic Acid 59-69 CD44 molecule (Indian blood group) Homo sapiens 20-24 21685938-3 2012 In this study, we investigated matrix hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with the stem cell markers, Nanog and Stat-3, in HNSCC cells (HSC-3 cells). Hyaluronic Acid 38-48 CD44 molecule (Indian blood group) Homo sapiens 62-66 21685938-3 2012 In this study, we investigated matrix hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with the stem cell markers, Nanog and Stat-3, in HNSCC cells (HSC-3 cells). Hyaluronic Acid 50-52 CD44 molecule (Indian blood group) Homo sapiens 62-66 22201835-1 2012 CD44 and RHAMM are two extracellar matrix receptors whose principle ligand is the polysaccharide hyaluronan (HA). Hyaluronic Acid 97-107 CD44 molecule (Indian blood group) Homo sapiens 0-4 22900150-4 2012 Accumulating evidence suggests that hyaluronan and its interaction with its cell surface receptor CD44 plays an important role in mediating pathogenic mechanisms in SLE. Hyaluronic Acid 36-46 CD44 molecule (Indian blood group) Homo sapiens 98-102 22900226-3 2012 Hyaluronan (HA) and its receptor CD44 are involved in cellular growth and tissue proliferation but have so far been less studied in myocardial hypertrophy. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 33-37 22072421-3 2012 Blocking hyaluronan binding either by CD44 antibodies, CD44-siRNA or hyaluronan decasaccharides (but not hexasaccharides) removed most of the hyaluronan from the surfaces of both human (HaCaT) and mouse keratinocytes, resembling results on cells from CD44-/- animals. Hyaluronic Acid 9-19 CD44 molecule (Indian blood group) Homo sapiens 38-42 22072421-3 2012 Blocking hyaluronan binding either by CD44 antibodies, CD44-siRNA or hyaluronan decasaccharides (but not hexasaccharides) removed most of the hyaluronan from the surfaces of both human (HaCaT) and mouse keratinocytes, resembling results on cells from CD44-/- animals. Hyaluronic Acid 9-19 CD44 molecule (Indian blood group) Homo sapiens 55-59 22072421-4 2012 In vitro, compromising CD44 function led to reduced and increased amounts, respectively, of intracellular and culture medium hyaluronan, and specific accumulation below the cells. Hyaluronic Acid 125-135 CD44 molecule (Indian blood group) Homo sapiens 23-27 22072421-6 2012 However, CD44-deficient tail skin challenged with retinoic acid or tape stripping revealed diffuse accumulation of hyaluronan in the superficial epidermal layers, normally negative for hyaluronan. Hyaluronic Acid 115-125 CD44 molecule (Indian blood group) Homo sapiens 9-13 22072421-6 2012 However, CD44-deficient tail skin challenged with retinoic acid or tape stripping revealed diffuse accumulation of hyaluronan in the superficial epidermal layers, normally negative for hyaluronan. Hyaluronic Acid 185-195 CD44 molecule (Indian blood group) Homo sapiens 9-13 22072421-7 2012 Our data indicate that CD44 retains hyaluronan in the keratinocyte pericellular matrix, a fact that has not been shown unambiguously before, and that hyaluronan abundance in the absence of CD44 can result in hyaluronan trapping in abnormal locations possibly interfering there with normal differentiation and epidermal barrier function. Hyaluronic Acid 36-46 CD44 molecule (Indian blood group) Homo sapiens 23-27 22916191-0 2012 Spatio-temporal patterns of pancreatic cancer cells expressing CD44 isoforms on supported membranes displaying hyaluronic acid oligomers arrays. Hyaluronic Acid 111-126 CD44 molecule (Indian blood group) Homo sapiens 63-67 22714418-0 2012 Hyaluronan-CD44 interaction promotes microRNA signaling and RhoGTPase activation leading to tumor progression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 22272243-1 2012 BACKGROUND: CD44 is a major cellular receptor for hyaluronic acids. Hyaluronic Acid 50-66 CD44 molecule (Indian blood group) Homo sapiens 12-16 21914806-1 2011 Hyaluronan (HA) modulates key cancer cell functions through interaction with its CD44 and receptor for hyaluronic acid-mediated motility (RHAMM) receptors. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 81-85 21745506-0 2011 Hyaluronan-coated nanoparticles: the influence of the molecular weight on CD44-hyaluronan interactions and on the immune response. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 74-78 21745506-0 2011 Hyaluronan-coated nanoparticles: the influence of the molecular weight on CD44-hyaluronan interactions and on the immune response. Hyaluronic Acid 79-89 CD44 molecule (Indian blood group) Homo sapiens 74-78 22031535-0 2011 Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NFkappaB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion. Hyaluronic Acid 36-46 CD44 molecule (Indian blood group) Homo sapiens 52-56 21978830-2 2011 The adhesion of sialyl-Lewis antigens to E-selectin is a key step in the development of metastasis and the glycosidic component of CD44 plays a key role in the binding to hyaluronic acid, a component of the extracellular matrix associated to tumor development and invasion. Hyaluronic Acid 171-186 CD44 molecule (Indian blood group) Homo sapiens 131-135 21914806-1 2011 Hyaluronan (HA) modulates key cancer cell functions through interaction with its CD44 and receptor for hyaluronic acid-mediated motility (RHAMM) receptors. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 81-85 21777976-0 2011 Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 59-63 21777976-1 2011 We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 83-87 21777976-3 2011 Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Hyaluronic Acid 15-25 CD44 molecule (Indian blood group) Homo sapiens 65-69 21777976-3 2011 Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Hyaluronic Acid 30-32 CD44 molecule (Indian blood group) Homo sapiens 65-69 21777976-3 2011 Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Hyaluronic Acid 98-108 CD44 molecule (Indian blood group) Homo sapiens 65-69 21743962-0 2011 Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane. Hyaluronic Acid 11-21 CD44 molecule (Indian blood group) Homo sapiens 95-99 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 124-128 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 124-128 21851104-17 2011 We also developed hyaluronic acid nanoparticles that can bind efficiently to the CD44 antigen receptors abundant in many tumor cells. Hyaluronic Acid 18-33 CD44 molecule (Indian blood group) Homo sapiens 81-85 21903450-4 2011 The cell surface proteoglycan, CD44, is expressed on most SCCHNs, and we hypothesized that it is an attractive candidate for targeted therapy via its natural ligand, hyaluronic acid (HA). Hyaluronic Acid 166-181 CD44 molecule (Indian blood group) Homo sapiens 31-35 21903450-4 2011 The cell surface proteoglycan, CD44, is expressed on most SCCHNs, and we hypothesized that it is an attractive candidate for targeted therapy via its natural ligand, hyaluronic acid (HA). Hyaluronic Acid 183-185 CD44 molecule (Indian blood group) Homo sapiens 31-35 21693704-4 2011 Human CD44 molecules from lipid rafts can directly interact with hyaluronic acid, the C. neoformans ligand. Hyaluronic Acid 65-80 CD44 molecule (Indian blood group) Homo sapiens 6-10 21570715-14 2011 CONCLUSION: Hyaluronan homeostasis is deranged in asthma, with increased production by fibroblasts and decreased CD44 expression on alveolar macrophages. Hyaluronic Acid 12-22 CD44 molecule (Indian blood group) Homo sapiens 113-117 21806926-0 2011 Shear stress regulates adhesion and rolling of CD44+ leukemic and hematopoietic progenitor cells on hyaluronan. Hyaluronic Acid 100-110 CD44 molecule (Indian blood group) Homo sapiens 47-51 21806926-1 2011 Leukemic cells and human hematopoietic progenitor cells expressing CD44 receptors have the ability to attach and roll on hyaluronan. Hyaluronic Acid 121-131 CD44 molecule (Indian blood group) Homo sapiens 67-71 21806926-3 2011 An applied flow enhances the interaction between CD44-positive cells and hyaluronan if a threshold shear stress of 0.2 dyn/cm(2) is exceeded. Hyaluronic Acid 73-83 CD44 molecule (Indian blood group) Homo sapiens 49-53 22184882-0 2011 [Two-state equilibrium of hyaluronan-binding domain is crucial for CD44-mediated cell rolling]. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 67-71 21649540-2 2011 Interactions between tumor cells and the extracellular matrix are in part mediated by CD44, whose principal ligand is hyaluronic acid. Hyaluronic Acid 118-133 CD44 molecule (Indian blood group) Homo sapiens 86-90 21471214-2 2011 In the immune system, the binding of hyaluronan to CD44 is tightly regulated, and exposure of human peripheral blood monocytes to inflammatory stimuli increases CD44 expression and induces hyaluronan binding. Hyaluronic Acid 37-47 CD44 molecule (Indian blood group) Homo sapiens 51-55 21673451-6 2011 Inhibition studies using LY294002 revealed the requirement of PI3K/Akt pathway for NO production and NF-kappaB activation by HBFN-f. Anti-CD44 treatment with anti-CD44 antibody and hyaluronan resulted in significant inhibition of HBFN-f actions on NO, NF-kappaB, and Akt. Hyaluronic Acid 181-191 CD44 molecule (Indian blood group) Homo sapiens 138-142 21696190-0 2011 Characterization of CD44-mediated cancer cell uptake and intracellular distribution of hyaluronan-grafted liposomes. Hyaluronic Acid 87-97 CD44 molecule (Indian blood group) Homo sapiens 20-24 21696190-1 2011 Hyaluronan (HA) is a biocompatible and biodegradable linear polysaccharide which is of interest for tumor targeting through cell surface CD44 receptors. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 137-141 21696190-1 2011 Hyaluronan (HA) is a biocompatible and biodegradable linear polysaccharide which is of interest for tumor targeting through cell surface CD44 receptors. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 137-141 20848284-0 2011 Hyaluronic acid-paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 78-82 21546828-2 2011 The integral membrane molecule CD44, known primarily for its role in binding hyaluronic acid, is characteristically expressed on HSPCs. Hyaluronic Acid 77-92 CD44 molecule (Indian blood group) Homo sapiens 31-35 21551360-7 2011 When osteopontin and hyaluronic acid, the two major ligands of CD44, were tested for their role in Th differentiation, osteopontin, but not hyaluronic acid, promoted Th1/Th17 differentiation. Hyaluronic Acid 21-36 CD44 molecule (Indian blood group) Homo sapiens 63-67 21471214-2 2011 In the immune system, the binding of hyaluronan to CD44 is tightly regulated, and exposure of human peripheral blood monocytes to inflammatory stimuli increases CD44 expression and induces hyaluronan binding. Hyaluronic Acid 189-199 CD44 molecule (Indian blood group) Homo sapiens 51-55 21471214-2 2011 In the immune system, the binding of hyaluronan to CD44 is tightly regulated, and exposure of human peripheral blood monocytes to inflammatory stimuli increases CD44 expression and induces hyaluronan binding. Hyaluronic Acid 37-47 CD44 molecule (Indian blood group) Homo sapiens 161-165 21454519-0 2011 Hyaluronan facilitates transforming growth factor-beta1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 84-88 21308480-12 2011 These results show that ROS depolymerizes hyaluronan into fragments, and these fragments bind their receptor CD44 to induce TK activation, which cleaves EGF precursors into mature EGF to activate its receptor EGFR. Hyaluronic Acid 42-52 CD44 molecule (Indian blood group) Homo sapiens 109-113 21308480-13 2011 Furthermore, we provide evidence that hyaluronan fragments are sufficient to induce CD44/EGFR interaction and EGFR signaling which lead to MUC5AC expression. Hyaluronic Acid 38-48 CD44 molecule (Indian blood group) Homo sapiens 84-88 21362138-0 2011 Hyaluronan-CD44 interactions as potential targets for cancer therapy. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 21362138-7 2011 CD44v-specific functions could be caused by their higher binding affinity than CD44s for hyaluronan. Hyaluronic Acid 89-99 CD44 molecule (Indian blood group) Homo sapiens 0-4 20799279-0 2011 Blood-derived human osteoclast resorption activity is impaired by Hyaluronan-CD44 engagement via a p38-dependent mechanism. Hyaluronic Acid 66-76 CD44 molecule (Indian blood group) Homo sapiens 77-81 21216252-3 2011 Here, all-atom explicit-solvent molecular dynamics simulations were used to characterize the dynamics and thermodynamics of oligomeric hyaluronan (oHA) and its two crystallographic complexes with the CD44 hyaluronan binding domain: the "A-form," which lacks arginine-HA close contact, and the "B-form," which has direct arginine side-chain-HA contact. Hyaluronic Acid 135-145 CD44 molecule (Indian blood group) Homo sapiens 200-204 21216252-3 2011 Here, all-atom explicit-solvent molecular dynamics simulations were used to characterize the dynamics and thermodynamics of oligomeric hyaluronan (oHA) and its two crystallographic complexes with the CD44 hyaluronan binding domain: the "A-form," which lacks arginine-HA close contact, and the "B-form," which has direct arginine side-chain-HA contact. Hyaluronic Acid 205-215 CD44 molecule (Indian blood group) Homo sapiens 200-204 21356346-0 2011 Role of hyaluronan-mediated CD44 signaling in head and neck squamous cell carcinoma progression and chemoresistance. Hyaluronic Acid 8-18 CD44 molecule (Indian blood group) Homo sapiens 28-32 21356346-4 2011 Hyaluronan (HA), a major extracellular matrix component is the primary ligand for CD44 receptors. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 82-86 21356346-4 2011 Hyaluronan (HA), a major extracellular matrix component is the primary ligand for CD44 receptors. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 82-86 21136024-2 2011 Binding to hyaluronan allows versican to indirectly interact with the hyaluronan cell surface receptor CD44. Hyaluronic Acid 11-21 CD44 molecule (Indian blood group) Homo sapiens 103-107 20706991-0 2011 Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 84-88 21541039-4 2011 ECM molecules including versican and hyaluronan (HA) which interacts with the HA receptor, CD44, have been shown to play critical roles in ovarian cancer metastasis. Hyaluronic Acid 37-47 CD44 molecule (Indian blood group) Homo sapiens 91-95 21087933-1 2011 CD44 is a cell surface adhesion molecule for hyaluronan and is implicated in tumor invasion and metastasis. Hyaluronic Acid 45-55 CD44 molecule (Indian blood group) Homo sapiens 0-4 21136024-7 2011 On the other hand, CD44 silencing caused a decrease in cell adhesion to vitronectin, fibronectin and hyaluronan. Hyaluronic Acid 101-111 CD44 molecule (Indian blood group) Homo sapiens 19-23 22022512-8 2011 The addition of anti-CD44 antibodies potentiates fibrocyte differentiation, suggesting that CD44 mediates at least some of the effect of hyaluronic acid on fibrocyte differentiation. Hyaluronic Acid 137-152 CD44 molecule (Indian blood group) Homo sapiens 21-25 20932561-2 2011 Binding of hyaluronan to one of its specific receptors, CD44, modulates transduction of intracellular signals which direct a variety of processes, including embryogenesis, wound healing, inflammation, and neoplasia. Hyaluronic Acid 11-21 CD44 molecule (Indian blood group) Homo sapiens 56-60 21078678-6 2011 Furthermore, CD44-dependent hyaluronan internalization was blocked by V3 expression and CD44 silencing, leading to an accumulation of this glycosaminoglycan in the pericellular matrix and to changes in cell migration on hyaluronan. Hyaluronic Acid 28-38 CD44 molecule (Indian blood group) Homo sapiens 13-17 21078678-6 2011 Furthermore, CD44-dependent hyaluronan internalization was blocked by V3 expression and CD44 silencing, leading to an accumulation of this glycosaminoglycan in the pericellular matrix and to changes in cell migration on hyaluronan. Hyaluronic Acid 28-38 CD44 molecule (Indian blood group) Homo sapiens 88-92 21144825-4 2011 Interestingly the reduced VCAM-1 expression could be restored by applying hyaluronan, a major glycosaminoglycan ligand of CD44, to the culture. Hyaluronic Acid 74-84 CD44 molecule (Indian blood group) Homo sapiens 122-126 21239738-0 2011 CD44 mediates oligosaccharides of hyaluronan-induced proliferation, tube formation and signal transduction in endothelial cells. Hyaluronic Acid 34-44 CD44 molecule (Indian blood group) Homo sapiens 0-4 22022512-8 2011 The addition of anti-CD44 antibodies potentiates fibrocyte differentiation, suggesting that CD44 mediates at least some of the effect of hyaluronic acid on fibrocyte differentiation. Hyaluronic Acid 137-152 CD44 molecule (Indian blood group) Homo sapiens 92-96 22022512-11 2011 CONCLUSIONS: We hypothesize that hyaluronic acid signals at least in part through CD44 to regulate fibrocyte differentiation, with a dominance hierarchy of SAP>LMWHA>=HMWHA>IL-4 or IL-13. Hyaluronic Acid 33-48 CD44 molecule (Indian blood group) Homo sapiens 82-86 20843027-1 2010 CD44, the primary receptor for hyaluronic acid, plays an important role in tumor growth and metastasis. Hyaluronic Acid 31-46 CD44 molecule (Indian blood group) Homo sapiens 0-4 20843787-0 2010 Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 20843787-3 2010 In this study, we investigated hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with c-Src kinase and the transcriptional factor, Twist, in breast tumor cells (MDA-MB-231 cells). Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 55-59 20843787-3 2010 In this study, we investigated hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with c-Src kinase and the transcriptional factor, Twist, in breast tumor cells (MDA-MB-231 cells). Hyaluronic Acid 43-45 CD44 molecule (Indian blood group) Homo sapiens 55-59 20709728-3 2010 We observed that binding of high-molecular-weight hyaluronan (HMW-HA) to its cognate receptor CD44 within caveolin-enriched microdomains (CEM) enhances human pulmonary EC barrier function. Hyaluronic Acid 50-60 CD44 molecule (Indian blood group) Homo sapiens 94-98 20665541-6 2010 Depolarization of the plasma membrane by hyaluronan represents an additional pathway of signal transduction to the classical CD44 signal transduction pathway, which links the extracellular matrix to intracellular metabolism. Hyaluronic Acid 41-51 CD44 molecule (Indian blood group) Homo sapiens 125-129 20843027-2 2010 CD44-hyaluronic acid interactions can be exploited for targeted delivery of anticancer agents specifically to cancer cells. Hyaluronic Acid 5-20 CD44 molecule (Indian blood group) Homo sapiens 0-4 20843027-3 2010 Although various splicing variants of CD44 are expressed on the plasma membrane of cancer cells, the hyaluronic acid binding domain (HABD) is highly conserved among the CD44 splicing variants. Hyaluronic Acid 101-116 CD44 molecule (Indian blood group) Homo sapiens 169-173 20663884-0 2010 Analysis of CD44-hyaluronan interactions in an artificial membrane system: insights into the distinct binding properties of high and low molecular weight hyaluronan. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Homo sapiens 12-16 20663884-0 2010 Analysis of CD44-hyaluronan interactions in an artificial membrane system: insights into the distinct binding properties of high and low molecular weight hyaluronan. Hyaluronic Acid 154-164 CD44 molecule (Indian blood group) Homo sapiens 12-16 20663884-10 2010 These findings provide new insight into the multivalent nature of CD44-HA interactions and suggest a molecular basis for the distinct biological properties of different size fractions of hyaluronan. Hyaluronic Acid 187-197 CD44 molecule (Indian blood group) Homo sapiens 66-70 20795701-2 2010 These films explore CD44-hyaluronate interactions and provide a method to make surface-bound B cell arrays without the need for nonselective covalent chemistry. Hyaluronic Acid 25-36 CD44 molecule (Indian blood group) Homo sapiens 20-24 20795701-4 2010 This work suggests two important conditions for successfully attaching B cells to hyaluronate-containing polyelectrolyte multilayer films: (1) hyaluronic acid is required for the proposed CD44-mediated binding mechanism, and (2) hyaluronic acid deposition conditions that favor loops and tails, such as low pH and with added salt, result in more available CD44 binding ligands and higher cell binding efficiency. Hyaluronic Acid 82-93 CD44 molecule (Indian blood group) Homo sapiens 188-192 20795701-4 2010 This work suggests two important conditions for successfully attaching B cells to hyaluronate-containing polyelectrolyte multilayer films: (1) hyaluronic acid is required for the proposed CD44-mediated binding mechanism, and (2) hyaluronic acid deposition conditions that favor loops and tails, such as low pH and with added salt, result in more available CD44 binding ligands and higher cell binding efficiency. Hyaluronic Acid 82-93 CD44 molecule (Indian blood group) Homo sapiens 356-360 20795701-4 2010 This work suggests two important conditions for successfully attaching B cells to hyaluronate-containing polyelectrolyte multilayer films: (1) hyaluronic acid is required for the proposed CD44-mediated binding mechanism, and (2) hyaluronic acid deposition conditions that favor loops and tails, such as low pH and with added salt, result in more available CD44 binding ligands and higher cell binding efficiency. Hyaluronic Acid 143-158 CD44 molecule (Indian blood group) Homo sapiens 188-192 20795701-4 2010 This work suggests two important conditions for successfully attaching B cells to hyaluronate-containing polyelectrolyte multilayer films: (1) hyaluronic acid is required for the proposed CD44-mediated binding mechanism, and (2) hyaluronic acid deposition conditions that favor loops and tails, such as low pH and with added salt, result in more available CD44 binding ligands and higher cell binding efficiency. Hyaluronic Acid 229-244 CD44 molecule (Indian blood group) Homo sapiens 356-360 20522558-3 2010 During inflammatory responses several cells produce hyaluronan matrices that promote monocyte/macrophage adhesion through interactions with the hyaluronan receptor CD44 present on inflammatory cell surfaces. Hyaluronic Acid 52-62 CD44 molecule (Indian blood group) Homo sapiens 164-168 20606732-3 2010 CD44, a transmembrane glycoprotein receptor for hyaluronic acid, and participates in cell-extracellular matrix interactions and migration. Hyaluronic Acid 48-63 CD44 molecule (Indian blood group) Homo sapiens 0-4 19957333-0 2010 Modulation of hyaluronan production by CD44 positive glioma cells. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 39-43 19957333-1 2010 This study examines the functional relationship between glioma cell production of hyaluronan (HA), known to play a role in glioma invasion, expression of its CD44 receptor, and glioma cell viability. Hyaluronic Acid 82-92 CD44 molecule (Indian blood group) Homo sapiens 158-162 20200161-0 2010 Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptor. Hyaluronic Acid 8-18 CD44 molecule (Indian blood group) Homo sapiens 47-51 20925198-2 2010 CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. Hyaluronic Acid 24-39 CD44 molecule (Indian blood group) Homo sapiens 0-4 20462498-0 2010 Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition. Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 66-70 20417561-2 2010 CD44 has a lectin domain that binds hyaluronan, a component of the extracellular matrix. Hyaluronic Acid 36-46 CD44 molecule (Indian blood group) Homo sapiens 0-4 20462498-2 2010 Our previous nuclear magnetic resonance (NMR) studies revealed that the CD44 hyaluronan-binding domain (HABD) alters its conformation upon HA binding, from the ordered (O) to the partially disordered (PD) conformation. Hyaluronic Acid 77-87 CD44 molecule (Indian blood group) Homo sapiens 72-76 20056122-3 2010 This study examines how CD44 regulates the motility and invasive growth of B35 neuroblastoma cells into a hyaluronan-rich environment. Hyaluronic Acid 106-116 CD44 molecule (Indian blood group) Homo sapiens 24-28 20479382-0 2010 Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling. Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 24-28 20479382-1 2010 OBJECTIVES: To investigate whether hyaluronan (HA), a ligand for the transmembrane receptor CD44, and CD44, which acts through multiple signaling pathways to influence cellular behavior, promote Rho kinase- and phosphatidylinositol 3 (PI-3) kinase-mediated oncogenic signaling to alter cisplatin sensitivity and stimulate tumor cell proliferation, migration, and matrix metalloproteinase secretion in head and neck squamous cell carcinoma (HNSCC). Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 92-96 20479382-1 2010 OBJECTIVES: To investigate whether hyaluronan (HA), a ligand for the transmembrane receptor CD44, and CD44, which acts through multiple signaling pathways to influence cellular behavior, promote Rho kinase- and phosphatidylinositol 3 (PI-3) kinase-mediated oncogenic signaling to alter cisplatin sensitivity and stimulate tumor cell proliferation, migration, and matrix metalloproteinase secretion in head and neck squamous cell carcinoma (HNSCC). Hyaluronic Acid 47-49 CD44 molecule (Indian blood group) Homo sapiens 92-96 20332234-5 2010 YB-1-transfected cells also bound to the CD44 ligand hyaluronan more than the control cells. Hyaluronic Acid 53-63 CD44 molecule (Indian blood group) Homo sapiens 41-45 19200980-1 2010 OBJECTIVE: We previously demonstrated that adherence of endometrial epithelial (EECs) and stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) is partly regulated by ESC/EEC CD44 interactions with PMC associated hyaluronan. Hyaluronic Acid 219-229 CD44 molecule (Indian blood group) Homo sapiens 181-185 19200980-2 2010 CD44, a transmembrane glycoprotein and major ligand for hyaluronan, has numerous splice variants which may impact hyaluronan binding. Hyaluronic Acid 56-66 CD44 molecule (Indian blood group) Homo sapiens 0-4 19200980-2 2010 CD44, a transmembrane glycoprotein and major ligand for hyaluronan, has numerous splice variants which may impact hyaluronan binding. Hyaluronic Acid 114-124 CD44 molecule (Indian blood group) Homo sapiens 0-4 20093489-0 2010 Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. Hyaluronic Acid 67-77 CD44 molecule (Indian blood group) Homo sapiens 88-92 20435253-7 2010 Hyaluronic acid is recognized by cell membrane receptors, notably CD44 which is the best known. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 66-70 20053435-10 2010 Results suggest that intracellular delivery of PolyDOX was depended on the CD44 expression level in cells due to presence of hyaluronic acid on the surface of polymersomes, and could be used as a self-targeting drug delivery cargo in over-expressed CD44 glycoprotein cells of breast cancer. Hyaluronic Acid 125-140 CD44 molecule (Indian blood group) Homo sapiens 75-79 20208419-0 2010 Hyaluronan inhibits prostaglandin E2 production via CD44 in U937 human macrophages. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 52-56 20056122-5 2010 We found that CD44-GFP fusion protein was localized in filopodia and in focal bleb-like protrusions where it provided binding sites for hyaluronan. Hyaluronic Acid 136-146 CD44 molecule (Indian blood group) Homo sapiens 14-18 19593781-6 2010 For an applied electric field of 10 V/m, the force transmitted to the CD44 receptor of a hyaluronan chain in cartilage is about 1 pN at 10 Hz and 7 pN at 1 Hz. Hyaluronic Acid 89-99 CD44 molecule (Indian blood group) Homo sapiens 70-74 20008845-0 2009 Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 20047150-2 2010 The principal ligand of CD44 is hyaluronan, and CD44 is involved in the metabolism of this compound. Hyaluronic Acid 32-42 CD44 molecule (Indian blood group) Homo sapiens 24-28 20001208-7 2010 Since both degradation and decrease of hyaluronan are often observed upon chronic inflammation, CD44 might be involved in modulation of local immune responses through regulation of cutaneous mast cell functions. Hyaluronic Acid 39-49 CD44 molecule (Indian blood group) Homo sapiens 96-100 19996211-4 2009 Treatment with small hyaluronan oligosaccharides, which dissociate constitutive hyaluronan polymer-CD44 interactions, was used to test the importance of hyaluronan-CD44 interaction in assembly of multidrug and monocarboxylate transporters and receptor tyrosine kinases in the plasma membrane of cells with high CD133 levels, and in the tumorigenic capacity of the CD133-high subpopulation. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 99-103 19996211-8 2009 CONCLUSIONS: We conclude that hyaluronan-CD44 interaction plays an important role in the properties of highly tumorigenic cells by stabilizing oncogenic complexes in their plasma membrane, and that treatment with hyaluronan-CD44 antagonists provides a logical therapeutic approach for abrogating the properties of these cells. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 41-45 19996211-8 2009 CONCLUSIONS: We conclude that hyaluronan-CD44 interaction plays an important role in the properties of highly tumorigenic cells by stabilizing oncogenic complexes in their plasma membrane, and that treatment with hyaluronan-CD44 antagonists provides a logical therapeutic approach for abrogating the properties of these cells. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 224-228 19996211-8 2009 CONCLUSIONS: We conclude that hyaluronan-CD44 interaction plays an important role in the properties of highly tumorigenic cells by stabilizing oncogenic complexes in their plasma membrane, and that treatment with hyaluronan-CD44 antagonists provides a logical therapeutic approach for abrogating the properties of these cells. Hyaluronic Acid 213-223 CD44 molecule (Indian blood group) Homo sapiens 41-45 19996211-8 2009 CONCLUSIONS: We conclude that hyaluronan-CD44 interaction plays an important role in the properties of highly tumorigenic cells by stabilizing oncogenic complexes in their plasma membrane, and that treatment with hyaluronan-CD44 antagonists provides a logical therapeutic approach for abrogating the properties of these cells. Hyaluronic Acid 213-223 CD44 molecule (Indian blood group) Homo sapiens 224-228 19996211-0 2009 Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 36-40 20008845-4 2009 Multivalent interactions of hyaluronan with CD44 collaborate in driving numerous tumor-promoting signaling pathways and transporter activities. Hyaluronic Acid 28-38 CD44 molecule (Indian blood group) Homo sapiens 44-48 20008845-5 2009 It is widely accepted that hyaluronan-CD44 interactions are crucial in both malignancy and resistance to therapy, but major challenges for future research in the field are the mechanism of activation of hyaluronan-CD44 signaling in cancer cells, the relative importance of variant forms of CD44 and other hyaluronan receptors, e.g., Rhamm, in different tumor contexts, and the role of stromal versus tumor cell production and turnover of hyaluronan. Hyaluronic Acid 27-37 CD44 molecule (Indian blood group) Homo sapiens 38-42 20008845-5 2009 It is widely accepted that hyaluronan-CD44 interactions are crucial in both malignancy and resistance to therapy, but major challenges for future research in the field are the mechanism of activation of hyaluronan-CD44 signaling in cancer cells, the relative importance of variant forms of CD44 and other hyaluronan receptors, e.g., Rhamm, in different tumor contexts, and the role of stromal versus tumor cell production and turnover of hyaluronan. Hyaluronic Acid 203-213 CD44 molecule (Indian blood group) Homo sapiens 214-218 20008845-5 2009 It is widely accepted that hyaluronan-CD44 interactions are crucial in both malignancy and resistance to therapy, but major challenges for future research in the field are the mechanism of activation of hyaluronan-CD44 signaling in cancer cells, the relative importance of variant forms of CD44 and other hyaluronan receptors, e.g., Rhamm, in different tumor contexts, and the role of stromal versus tumor cell production and turnover of hyaluronan. Hyaluronic Acid 203-213 CD44 molecule (Indian blood group) Homo sapiens 214-218 20008845-8 2009 In addition, hyaluronan is being used to tag drugs and delivery vehicles for targeting of anticancer agents to CD44-expressing tumor cells. Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 111-115 19633292-2 2009 In this study, we investigated the hyaluronan (HA)-induced interaction between CD44 (a primary HA receptor) and protein kinase Cepsilon (PKCepsilon), which regulates a number of human breast tumor cell functions. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 79-83 19606017-1 2009 As the interaction of hyaluronan (HA) with its receptor CD44 contributes to multidrug resistance (MDR) of tumor cells, HA oligosaccharides (o-HAs), as HA antagonists, may be useful to reverse the MDR. Hyaluronic Acid 22-32 CD44 molecule (Indian blood group) Homo sapiens 56-60 19703720-9 2009 CONCLUSIONS: CD34(+) populations use alpha4beta1, beta2 integrins and CD44 receptors to bind to the ligands VCAM-1/fibronectin, ICAM-1, and hyaluronic acid expressed on sinusoidal vessels in tissue sections and to primary human HSEC. Hyaluronic Acid 140-155 CD44 molecule (Indian blood group) Homo sapiens 70-74 19633292-2 2009 In this study, we investigated the hyaluronan (HA)-induced interaction between CD44 (a primary HA receptor) and protein kinase Cepsilon (PKCepsilon), which regulates a number of human breast tumor cell functions. Hyaluronic Acid 47-49 CD44 molecule (Indian blood group) Homo sapiens 79-83 19470767-0 2009 Abrogating drug resistance in malignant peripheral nerve sheath tumors by disrupting hyaluronan-CD44 interactions with small hyaluronan oligosaccharides. Hyaluronic Acid 85-95 CD44 molecule (Indian blood group) Homo sapiens 96-100 19635184-4 2009 In this study, we investigated the effect of CD44 monoclonal antibodies and hyaluronan, which is a ligand of CD44, on drug-induced apoptosis in human myeloid cell line KG1. Hyaluronic Acid 76-86 CD44 molecule (Indian blood group) Homo sapiens 109-113 19541937-8 2009 The present study demonstrates that the hyaluronan receptor CD44, the hyaluronidase HYAL 2, and the transforming growth factor beta(1)-receptor ALK5 all relocalized from raft to non-raft locations, which was reversed by the addition of exogenous hyaluronan. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 60-64 19470767-5 2009 Treatment of MPNST cells with the hyaluronan oligomers causes disassembly of CD44-transporter complexes and induces internalization of CD44, BCRP, and P-glycoprotein. Hyaluronic Acid 34-44 CD44 molecule (Indian blood group) Homo sapiens 77-81 19470767-5 2009 Treatment of MPNST cells with the hyaluronan oligomers causes disassembly of CD44-transporter complexes and induces internalization of CD44, BCRP, and P-glycoprotein. Hyaluronic Acid 34-44 CD44 molecule (Indian blood group) Homo sapiens 135-139 19470767-9 2009 These findings indicate that constitutive hyaluronan-CD44 interactions contribute to drug transporter localization and function at the plasma membrane, and that attenuating hyaluronan-CD44 interactions sensitizes MPNSTs to doxorubicin in vitro and in vivo. Hyaluronic Acid 42-52 CD44 molecule (Indian blood group) Homo sapiens 53-57 19470767-4 2009 Small hyaluronan oligosaccharides antagonize hyaluronan-CD44-mediated processes and inhibit hyaluronan production. Hyaluronic Acid 6-16 CD44 molecule (Indian blood group) Homo sapiens 56-60 19470767-4 2009 Small hyaluronan oligosaccharides antagonize hyaluronan-CD44-mediated processes and inhibit hyaluronan production. Hyaluronic Acid 45-55 CD44 molecule (Indian blood group) Homo sapiens 56-60 19374532-0 2009 Hyaluronic acid-modified DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 100-104 18971959-1 2009 CD44 proteins are cell surface receptors for hyaluronic acid (HA), a component of the extracellular matrix that has multiple effects on cell behavior. Hyaluronic Acid 45-60 CD44 molecule (Indian blood group) Homo sapiens 0-4 18971959-1 2009 CD44 proteins are cell surface receptors for hyaluronic acid (HA), a component of the extracellular matrix that has multiple effects on cell behavior. Hyaluronic Acid 62-64 CD44 molecule (Indian blood group) Homo sapiens 0-4 19350274-0 2009 Hyaluronan substratum induces multidrug resistance in human mesenchymal stem cells via CD44 signaling. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 87-91 19350274-6 2009 We have further found that PDMSCs treated with CD44 small interfering RNA (siRNA) and grown on a polystyrene surface coated with 30 microg/cm(2) hyaluronan have fewer P-glycoprotein(+) cells and lower CD44 expression levels (less than 60% in both cases) than PDMSCs not treated with CD44 siRNA and grown on the hyaluronan-coated surface. Hyaluronic Acid 145-155 CD44 molecule (Indian blood group) Homo sapiens 47-51 19350274-6 2009 We have further found that PDMSCs treated with CD44 small interfering RNA (siRNA) and grown on a polystyrene surface coated with 30 microg/cm(2) hyaluronan have fewer P-glycoprotein(+) cells and lower CD44 expression levels (less than 60% in both cases) than PDMSCs not treated with CD44 siRNA and grown on the hyaluronan-coated surface. Hyaluronic Acid 145-155 CD44 molecule (Indian blood group) Homo sapiens 201-205 19350274-6 2009 We have further found that PDMSCs treated with CD44 small interfering RNA (siRNA) and grown on a polystyrene surface coated with 30 microg/cm(2) hyaluronan have fewer P-glycoprotein(+) cells and lower CD44 expression levels (less than 60% in both cases) than PDMSCs not treated with CD44 siRNA and grown on the hyaluronan-coated surface. Hyaluronic Acid 145-155 CD44 molecule (Indian blood group) Homo sapiens 201-205 19350274-6 2009 We have further found that PDMSCs treated with CD44 small interfering RNA (siRNA) and grown on a polystyrene surface coated with 30 microg/cm(2) hyaluronan have fewer P-glycoprotein(+) cells and lower CD44 expression levels (less than 60% in both cases) than PDMSCs not treated with CD44 siRNA and grown on the hyaluronan-coated surface. Hyaluronic Acid 311-321 CD44 molecule (Indian blood group) Homo sapiens 47-51 19350274-7 2009 Moreover, treatment with CD44 siRNA suppresses the hyaluronan-substratum-induced doxorubicin resistance. Hyaluronic Acid 51-61 CD44 molecule (Indian blood group) Homo sapiens 25-29 19350274-8 2009 We conclude that a hyaluronan substratum induces MDR in PDMSCs through CD44 signaling. Hyaluronic Acid 19-29 CD44 molecule (Indian blood group) Homo sapiens 71-75 19243022-1 2009 CD44, a transmembrane receptor for hyaluronic acid, is implicated in various adhesion-dependent cellular processes, including cell migration, tumor cell metastasis and invasion. Hyaluronic Acid 35-50 CD44 molecule (Indian blood group) Homo sapiens 0-4 19374532-1 2009 Cationic hyaluronic acid (HA)-modified DOTAP/DOPE liposomes were designed for the targeted delivery of anti-telomerase siRNA to CD44 receptor-expressing lung cancer cells. Hyaluronic Acid 9-24 CD44 molecule (Indian blood group) Homo sapiens 128-132 19374532-1 2009 Cationic hyaluronic acid (HA)-modified DOTAP/DOPE liposomes were designed for the targeted delivery of anti-telomerase siRNA to CD44 receptor-expressing lung cancer cells. Hyaluronic Acid 26-28 CD44 molecule (Indian blood group) Homo sapiens 128-132 18757307-10 2009 In addition, we also provide evidence that hyaluronan fragments are sufficient to induce CD44/EGFR interaction and downstream signaling that results in MUC5B up-regulation, suggesting that hyaluronan depolymerization during inflammatory responses could be directly involved in the induction of mucus hypersecretion. Hyaluronic Acid 43-53 CD44 molecule (Indian blood group) Homo sapiens 89-93 19167378-1 2009 The interaction between the transmembrane receptor CD44 on epithelial tumor cells and its ligand hyaluronan in the surrounding extracellular matrix is important in tumor progression and metastasis. Hyaluronic Acid 97-107 CD44 molecule (Indian blood group) Homo sapiens 51-55 18757307-10 2009 In addition, we also provide evidence that hyaluronan fragments are sufficient to induce CD44/EGFR interaction and downstream signaling that results in MUC5B up-regulation, suggesting that hyaluronan depolymerization during inflammatory responses could be directly involved in the induction of mucus hypersecretion. Hyaluronic Acid 189-199 CD44 molecule (Indian blood group) Homo sapiens 89-93 19176383-1 2009 Interactions of hyaluronan with CD44 in tumor cells play important cooperative roles in various aspects of malignancy and drug resistance. Hyaluronic Acid 16-26 CD44 molecule (Indian blood group) Homo sapiens 32-36 18787423-3 2009 CD44 may mediate binding of calcium oxalate crystals to tubular epithelia via the ligands osteopontin (OPN) and hyaluronan. Hyaluronic Acid 112-122 CD44 molecule (Indian blood group) Homo sapiens 0-4 19033446-1 2009 The major lymphatic endothelial hyaluronan receptor LYVE-1, a Link superfamily glycoprotein similar to the hyaluronan-binding/inflammatory leukocyte homing receptor CD44, was initially implicated in hyaluronan (HA)-mediated cell adhesion and lymph-borne hyaluronan metabolism. Hyaluronic Acid 32-42 CD44 molecule (Indian blood group) Homo sapiens 165-169 19047049-0 2009 Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 20-24 19047049-1 2009 In this study we have investigated hyaluronan (HA)-mediated CD44 (an HA receptor) interactions with p300 (a histone acetyltransferase) and SIRT1 (a histone deacetylase) in human breast tumor cells (MCF-7 cells). Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 60-64 18805398-1 2008 Hyaluronan is a large glycosaminoglycan and is a major constituent of the extracellular matrix, interacting with cell surface receptors such as CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 144-148 18988207-0 2008 Efficient cellular labeling by CD44 receptor-mediated uptake of cationic liposomes functionalized with hyaluronic acid and loaded with MRI contrast agents. Hyaluronic Acid 103-118 CD44 molecule (Indian blood group) Homo sapiens 31-35 18805398-2 2008 We previously reported that fragmented hyaluronan, with the size frequently detected in cancer patients, induces CD44 cleavage and concomitantly enhances tumor cell migration. Hyaluronic Acid 39-49 CD44 molecule (Indian blood group) Homo sapiens 113-117 18952589-3 2008 Hyaluronan is a large extracellular glycosaminoglycan that enhances malignant glioma behaviors by interacting with CD44 receptors and by downstream activation of signaling proteins and transporters associated with malignancy. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 115-119 18981124-0 2008 Hyaluronan induces cell death in activated T cells through CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 59-63 18981124-1 2008 In the immune system, leukocyte activation induces CD44 to bind hyaluronan, a component of the extracellular matrix. Hyaluronic Acid 64-74 CD44 molecule (Indian blood group) Homo sapiens 51-55 18981124-2 2008 Here we used gain and loss of hyaluronan-binding mutants of CD44 to examine the consequence of hyaluronan binding in T cells. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 60-64 18981124-3 2008 Jurkat T cells transfected with CD44 mutated at S180, which prevented the addition of chondroitin sulfate, displayed constitutively high levels of hyaluronan binding. Hyaluronic Acid 147-157 CD44 molecule (Indian blood group) Homo sapiens 32-36 18981124-4 2008 These cells were more susceptible to activation-induced cell death, whereas cells expressing a CD44 mutant unable to bind hyaluronan (R41A) were resistant to cell death. Hyaluronic Acid 122-132 CD44 molecule (Indian blood group) Homo sapiens 95-99 18806267-2 2008 These different forms of hyaluronan bind to CD44 but elicit distinct effects on cellular function. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 44-48 18971636-2 2008 RHAMM can be exported to the cell surface where it binds hyaluronic acid (HA) and interacts with the HA receptor CD44. Hyaluronic Acid 1-3 CD44 molecule (Indian blood group) Homo sapiens 113-117 18574248-7 2008 Hyaluronan and the exclusion space were reduced, but did not disappear, by purified hyaluronan hexasaccharides that compete with hyaluronan attached to CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 152-156 18574248-7 2008 Hyaluronan and the exclusion space were reduced, but did not disappear, by purified hyaluronan hexasaccharides that compete with hyaluronan attached to CD44. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 152-156 18776204-7 2008 Hyaluronic acid (HA) was able to promote in vitro fibroblast adhesion, migration in a CD44-dependent manner, and survival in a serum-free culture condition. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 86-90 18776204-7 2008 Hyaluronic acid (HA) was able to promote in vitro fibroblast adhesion, migration in a CD44-dependent manner, and survival in a serum-free culture condition. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 86-90 18577517-0 2008 CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. Hyaluronic Acid 59-74 CD44 molecule (Indian blood group) Homo sapiens 0-4 18757435-2 2008 We previously reported that such HA oligosaccharides induce the proteolytic cleavage of an ECM-binding molecule CD44 from tumor cells and promote tumor cell migration in a CD44-dependent manner. Hyaluronic Acid 33-35 CD44 molecule (Indian blood group) Homo sapiens 112-116 18757435-2 2008 We previously reported that such HA oligosaccharides induce the proteolytic cleavage of an ECM-binding molecule CD44 from tumor cells and promote tumor cell migration in a CD44-dependent manner. Hyaluronic Acid 33-35 CD44 molecule (Indian blood group) Homo sapiens 172-176 18450475-0 2008 Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 20-24 18637056-2 2008 Hyaluronate is the main ligand for CD44 and this interaction was reported to promote tumor progression in in vitro or animal studies. Hyaluronic Acid 0-11 CD44 molecule (Indian blood group) Homo sapiens 35-39 18534864-6 2008 Antagonists of hyaluronan-CD44 interaction, especially small hyaluronan oligomers, may be useful in therapeutic strategies aimed at preventing tumor recurrence from these therapy-resistant sub-populations within malignant cancers. Hyaluronic Acid 15-25 CD44 molecule (Indian blood group) Homo sapiens 26-30 18412288-4 2008 Both HAAACB and HApACB turned out to be nontoxic for colorectal, ovarian and bladder tumor cell lines, to disclose a specific interaction with the CD44 antigen as the native hyaluronan moiety, and to deliver boron-atom concentrations largely sufficient for BNCT therapy when accumulated in cancer cells. Hyaluronic Acid 174-184 CD44 molecule (Indian blood group) Homo sapiens 147-151 18513329-0 2008 Hyaluronan-CD44 pathway regulates orientation of mitotic spindle in normal epithelial cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 18326857-3 2008 We now show for the first time a strong link between hyaluronan-CD44 interaction and cyclooxygenase-2 in colon cancer cells. Hyaluronic Acid 53-63 CD44 molecule (Indian blood group) Homo sapiens 64-68 18248627-3 2008 In this report, we demonstrate that C. neoformans hyaluronic acid interacts with CD44 on HBMEC. Hyaluronic Acid 50-65 CD44 molecule (Indian blood group) Homo sapiens 81-85 18490190-3 2008 Hyaluronan binds to several cell surface receptors, including CD44, thus leading to co-regulation of signaling pathways that are important in regulation of multidrug resistance to anticancer drugs, in particular anti-apoptotic pathways induced by activation of receptor tyrosine kinases. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 62-66 18490190-6 2008 Moreover, hyaluronan-CD44 interactions are critical to these properties in the highly malignant, chemotherapy-resistant cancer stem-like cells. Hyaluronic Acid 10-20 CD44 molecule (Indian blood group) Homo sapiens 21-25 18490190-7 2008 Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 32-36 18326857-7 2008 Fourth, perturbation of hyaluronan-CD44 interaction by hyaluronan oligomers or CD44-silencing RNA decreases cyclooxygenase-2 expression and enzyme activity, and inhibition of cyclooxygenase-2 decreases hyaluronan production suggesting the possibility of an amplifying positive feedback loop between hyaluronan and cyclooxygenase-2. Hyaluronic Acid 24-34 CD44 molecule (Indian blood group) Homo sapiens 35-39 18326857-7 2008 Fourth, perturbation of hyaluronan-CD44 interaction by hyaluronan oligomers or CD44-silencing RNA decreases cyclooxygenase-2 expression and enzyme activity, and inhibition of cyclooxygenase-2 decreases hyaluronan production suggesting the possibility of an amplifying positive feedback loop between hyaluronan and cyclooxygenase-2. Hyaluronic Acid 24-34 CD44 molecule (Indian blood group) Homo sapiens 79-83 18326857-7 2008 Fourth, perturbation of hyaluronan-CD44 interaction by hyaluronan oligomers or CD44-silencing RNA decreases cyclooxygenase-2 expression and enzyme activity, and inhibition of cyclooxygenase-2 decreases hyaluronan production suggesting the possibility of an amplifying positive feedback loop between hyaluronan and cyclooxygenase-2. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 35-39 18326857-7 2008 Fourth, perturbation of hyaluronan-CD44 interaction by hyaluronan oligomers or CD44-silencing RNA decreases cyclooxygenase-2 expression and enzyme activity, and inhibition of cyclooxygenase-2 decreases hyaluronan production suggesting the possibility of an amplifying positive feedback loop between hyaluronan and cyclooxygenase-2. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 35-39 18302264-0 2008 Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E(2) production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 125-129 18441325-0 2008 Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 18400745-2 2008 Intact hyaluronan molecules facilitate cell migration by acting as ligands for CD44. Hyaluronic Acid 7-17 CD44 molecule (Indian blood group) Homo sapiens 79-83 18326857-5 2008 Second, constitutive hyaluronan-CD44 interaction stimulates a signaling pathway involving ErbB2, phosphoinositide 3-kinase/AKT, beta-catenin, and cyclooxygenase-2/prostaglandin E(2) in HCA7 colon carcinoma cells. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 32-36 18326857-6 2008 Third, the HA/CD44-activated ErbB2 --> phosphoinositide 3-kinase/AKT --> beta-catenin pathway stimulates cell survival/cell proliferation through COX-2 induction in hyaluronan-overexpressing HIEC6 cells and in HCA7 cells. Hyaluronic Acid 171-181 CD44 molecule (Indian blood group) Homo sapiens 14-18 17919613-1 2008 The concentration of the soluble form of CD44, a competitive inhibitor for CD44 and hyaluronic acid binding, is higher in the peritoneal fluid of patients with endometriosis than in the peritoneal fluid of patients without endometriosis. Hyaluronic Acid 84-99 CD44 molecule (Indian blood group) Homo sapiens 41-45 18508558-3 2008 Interference with the association of hyaluronan and versican with the surface of ASMCs, either through short oliogosaccharides of hyaluronan or blocking antibodies to the hyaluronan receptor, CD44, blocks the proliferative and migratory response of these cells to growth factors, such as platelet derived growth factor (PDGF). Hyaluronic Acid 37-47 CD44 molecule (Indian blood group) Homo sapiens 192-196 18044795-0 2008 Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 76-80 18077444-0 2008 Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell motility during aging. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 18037227-3 2008 Here, we used a simple substrate of hyaluronic acid to investigate the specificity of CD44-mediated recruitment from human whole blood under shear conditions. Hyaluronic Acid 36-51 CD44 molecule (Indian blood group) Homo sapiens 86-90 18231653-3 2008 Among these molecules present on endothelial cells is hyaluronan (HA), a glycosaminoglycan that contributes to primary (rolling) interactions through binding to its main receptor CD44 expressed on leukocytes and tumor cells. Hyaluronic Acid 54-64 CD44 molecule (Indian blood group) Homo sapiens 179-183 19393131-6 2008 The adhesion percentages of CD44 siRNA1 and CD44 siRNA2 cells were significantly lower than those of the control siRNA cells in adhesion both to hyaluronan and to human peritoneal mesothelium. Hyaluronic Acid 145-155 CD44 molecule (Indian blood group) Homo sapiens 28-32 19393131-6 2008 The adhesion percentages of CD44 siRNA1 and CD44 siRNA2 cells were significantly lower than those of the control siRNA cells in adhesion both to hyaluronan and to human peritoneal mesothelium. Hyaluronic Acid 145-155 CD44 molecule (Indian blood group) Homo sapiens 44-48 18979165-8 2008 Hyaluronan (HA) and osteopontin (OPN), the ligands for CD44, were occasionally colocalized with CD44. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 55-59 18979165-8 2008 Hyaluronan (HA) and osteopontin (OPN), the ligands for CD44, were occasionally colocalized with CD44. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 96-100 18437074-2 2008 We investigated the antitumor effect of HA-But, a new histone deacetylase inhibitor, in which hyaluronic acid is esterified with butyric acid residues and selectively bind to CD44, overexpressed in most human cancers, including pancreatic cancer. Hyaluronic Acid 94-109 CD44 molecule (Indian blood group) Homo sapiens 175-179 18322236-1 2008 The cell adhesion molecule CD44, which is the major hyaluronan receptor, has been implicated in the binding, endocytosis, and metabolism of hyaluronan. Hyaluronic Acid 52-62 CD44 molecule (Indian blood group) Homo sapiens 27-31 18227732-2 2008 This interaction is best exemplified by the relationship of the receptor CD44 and the extracellular matrix component hyaluronan (HA). Hyaluronic Acid 117-127 CD44 molecule (Indian blood group) Homo sapiens 73-77 17625788-1 2008 Hyaluronic acid (HA) coated drug carriers (HCDCs) were successfully synthesized by chemical conjugation method for targeted delivery of doxorubicin (DOX) as a prototype anticancer drug to CD44 expressed human breast cancer cell. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 188-192 17625788-1 2008 Hyaluronic acid (HA) coated drug carriers (HCDCs) were successfully synthesized by chemical conjugation method for targeted delivery of doxorubicin (DOX) as a prototype anticancer drug to CD44 expressed human breast cancer cell. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 188-192 18274931-4 2008 HA-binding receptors, CD44 and receptor for hyaluronan-mediated motility have attracted much enthusiasm, mainly because they are believed to be involved in cancer metastasis. Hyaluronic Acid 44-54 CD44 molecule (Indian blood group) Homo sapiens 22-39 18661346-1 2008 Hyaluronan is an apparently simple polysaccharide that is responsible for tissue hydration but also stimulates cell proliferation, migration, and differentiation via binding to cell surface receptors, such as CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 209-213 18661347-1 2008 Carcinomas arising from colon epithelia develop or progress in a stromal microenvironment that is elevated in hyaluronan; interactions between elevated hyaluronan and the CD44 receptors on epithelial tumor cells activate an HA-receptor tyrosine kinase-mediated cell survival pathway. Hyaluronic Acid 110-120 CD44 molecule (Indian blood group) Homo sapiens 171-175 18661347-1 2008 Carcinomas arising from colon epithelia develop or progress in a stromal microenvironment that is elevated in hyaluronan; interactions between elevated hyaluronan and the CD44 receptors on epithelial tumor cells activate an HA-receptor tyrosine kinase-mediated cell survival pathway. Hyaluronic Acid 152-162 CD44 molecule (Indian blood group) Homo sapiens 171-175 18979165-8 2008 Hyaluronan (HA) and osteopontin (OPN), the ligands for CD44, were occasionally colocalized with CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 55-59 18979165-8 2008 Hyaluronan (HA) and osteopontin (OPN), the ligands for CD44, were occasionally colocalized with CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 96-100 18044795-1 2008 AIM: It was the aim of this study to prepare purified DNA/PEI polyplexes, which are coated with hyaluronan to facilitate CD44 receptor mediated uptake of the DNA/PEI polyplex and to reduce unspecific interactions of the complex with negatively charged extracellular matrix components on the ocular surface. Hyaluronic Acid 96-106 CD44 molecule (Indian blood group) Homo sapiens 121-125 18044795-6 2008 RESULTS: Coating of purified DNA/PEI polyplexes with low molecular weight hyaluronan (<10 kDa) facilitated receptor-mediated uptake via the CD44 receptor in HCE cells, increased complex stability in vitro, and effectively shielded the positive surface charges of the polyplex without decreasing its transfection efficiency. Hyaluronic Acid 74-84 CD44 molecule (Indian blood group) Homo sapiens 143-147 18044795-8 2008 CONCLUSIONS: Coating of polyplexes with low molecular weight hyaluronan is a promising strategy for gene delivery to the ocular surface, where CD44 receptor mediated uptake decreased cytotoxicity and reduced non-specific interactions with the negatively charged extracellular matrix components are considered beneficial for increased transfection efficiency of non-viral vectors. Hyaluronic Acid 61-71 CD44 molecule (Indian blood group) Homo sapiens 143-147 18090474-7 2007 The effect of hyaluronan on induced metalloproteinase activity was mediated partially by CD44, the principal cell surface receptor for hyaluronan. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 89-93 18039001-1 2007 Hyaluronic acid (HA) has a high affinity for the CD44 receptor present at the surface of articular cells, particularly of chondrocytes. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 49-53 18039001-1 2007 Hyaluronic acid (HA) has a high affinity for the CD44 receptor present at the surface of articular cells, particularly of chondrocytes. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 49-53 18090474-7 2007 The effect of hyaluronan on induced metalloproteinase activity was mediated partially by CD44, the principal cell surface receptor for hyaluronan. Hyaluronic Acid 135-145 CD44 molecule (Indian blood group) Homo sapiens 89-93 18090474-8 2007 Hyaluronan inhibited interleukin-1beta-induced metalloproteinase production from osteoarthritic synovial tissue by a process that was not solely dependent on hyaluronan molecular mass but that was partly mediated by hyaluronan binding to CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 238-242 18033205-9 2007 Through interaction with surface receptors (CD44, RHAMM, TLR4), hyaluronan fragments stimulate immune cells and enhance cytokine and reactive oxygen species production as well as other factors participating in inflammation. Hyaluronic Acid 64-74 CD44 molecule (Indian blood group) Homo sapiens 44-48 17945213-5 2007 Cell adhesion to hyaluronan was significantly lower with CD44(sol) cells compared to the control cells. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Homo sapiens 57-61 17911008-0 2007 Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 40-44 17804111-2 2007 Hyaluronan is extruded directly through the plasma membrane by one of three hyaluronan synthases and anchored to the cell surface by the synthase or cell surface receptors such as CD44 or RHAMM. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 180-184 17911008-7 2007 Our results point to the importance of the CD44-hyaluronan pathway in the escape of tumour cells from receptor-oriented therapy. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Homo sapiens 43-47 17252589-6 2007 The HOC313 cell line, which highly expresses CD44 v3-containing isoforms, demonstrated hyaluronan-mediated CD44-dependent promotion of tumor cell growth and migration. Hyaluronic Acid 87-97 CD44 molecule (Indian blood group) Homo sapiens 45-49 17909285-1 2007 CD44 is an important adhesion molecule that specifically binds hyaluronic acid and regulates cell-cell and cell-matrix interactions. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 0-4 17324121-8 2007 Importantly, inhibition of hyaluronan binding to its receptor CD44 by the monoclonal antibody Hermes-1, inhibited PDGF-BB-stimulated [3H]thymidine incorporation of dermal fibroblasts. Hyaluronic Acid 27-37 CD44 molecule (Indian blood group) Homo sapiens 62-66 17912438-3 2007 The ability of CD44 to bind hyaluronan has been shown to correlate with tumor cell invasiveness, and it is likely that this ability may enhance tumor cell migration at several points during metastasis. Hyaluronic Acid 28-38 CD44 molecule (Indian blood group) Homo sapiens 15-19 17687379-1 2007 Prevention of normal interactions between CD44 cell-surface receptors on cultured mesenchymal stem cells and hyaluronic acid in the renal interstitial matrix has been described as reducing the ability of these cells in vivo to localize to regions with acute tubular injury. Hyaluronic Acid 109-124 CD44 molecule (Indian blood group) Homo sapiens 42-46 17392272-3 2007 Here we describe an autocrine mechanism utilizing cell surface Rhamm-CD44 interactions to sustain rapid basal motility in invasive breast cancer cell lines that requires endogenous hyaluronan synthesis and the formation of Rhamm-CD44-ERK1,2 complexes. Hyaluronic Acid 181-191 CD44 molecule (Indian blood group) Homo sapiens 69-73 17392272-7 2007 Collectively, these results show that cell surface Rhamm and CD44 act together in a hyaluronan-dependent autocrine mechanism to coordinate sustained signaling through ERK1,2, leading to high basal motility of invasive breast cancer cells. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 61-65 17603630-2 2007 To develop tumor-targeted drugs, we have initially evaluated whether the CD44 ligand hyaluronic acid (HA) could serve as a backbone for paclitaxel (TXL) prodrugs. Hyaluronic Acid 85-100 CD44 molecule (Indian blood group) Homo sapiens 73-77 17603630-2 2007 To develop tumor-targeted drugs, we have initially evaluated whether the CD44 ligand hyaluronic acid (HA) could serve as a backbone for paclitaxel (TXL) prodrugs. Hyaluronic Acid 102-104 CD44 molecule (Indian blood group) Homo sapiens 73-77 17252589-6 2007 The HOC313 cell line, which highly expresses CD44 v3-containing isoforms, demonstrated hyaluronan-mediated CD44-dependent promotion of tumor cell growth and migration. Hyaluronic Acid 87-97 CD44 molecule (Indian blood group) Homo sapiens 107-111 17403031-0 2007 Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 17180679-2 2007 In the in vitro experiments with tumor cells, ADAM-17 is reported to cleave CD44, an adhesion molecule that interacts with hyaluronic acid, to promote tumor cell migration. Hyaluronic Acid 123-138 CD44 molecule (Indian blood group) Homo sapiens 76-80 17180120-6 2007 In this paper, we report data that implicate hyaluronan in the adenoviral infectious process and show that interference with the interaction between hyaluronan and its cellular receptor CD44 can block adenovirus transduction in vitro and in vivo. Hyaluronic Acid 149-159 CD44 molecule (Indian blood group) Homo sapiens 186-190 17170110-0 2007 CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2. Hyaluronic Acid 61-76 CD44 molecule (Indian blood group) Homo sapiens 0-4 17372087-1 2007 OBJECTIVE: To investigate the downstream molecular targets of hyaluronan (HA)-CD44 and phospholipase C (PLC)-mediated calcium ion (Ca(2+)) signaling in head and neck squamous cell carcinoma (HNSCC). Hyaluronic Acid 62-72 CD44 molecule (Indian blood group) Homo sapiens 78-82 17372087-1 2007 OBJECTIVE: To investigate the downstream molecular targets of hyaluronan (HA)-CD44 and phospholipase C (PLC)-mediated calcium ion (Ca(2+)) signaling in head and neck squamous cell carcinoma (HNSCC). Hyaluronic Acid 74-76 CD44 molecule (Indian blood group) Homo sapiens 78-82 17372087-2 2007 Hyaluronan is a ligand for the CD44 receptor, which interacts with multiple signaling pathways to influence cellular behavior. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 31-35 17293874-0 2007 Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Hyaluronic Acid 23-33 CD44 molecule (Indian blood group) Homo sapiens 18-22 17293874-3 2007 The molecular details of the Cd44-hyaluronan interaction and hence the structural basis for this activation are unknown. Hyaluronic Acid 34-44 CD44 molecule (Indian blood group) Homo sapiens 29-33 17293874-4 2007 Here we present the first crystal structure of Cd44 complexed with hyaluronan. Hyaluronic Acid 67-77 CD44 molecule (Indian blood group) Homo sapiens 47-51 17293874-5 2007 This reveals that the interaction with hyaluronan is dominated by shape and hydrogen-bonding complementarity and identifies two conformational forms of the receptor that differ in orientation of a crucial hyaluronan-binding residue (Arg45, equivalent to Arg41 in human CD44). Hyaluronic Acid 39-49 CD44 molecule (Indian blood group) Homo sapiens 269-273 17293874-5 2007 This reveals that the interaction with hyaluronan is dominated by shape and hydrogen-bonding complementarity and identifies two conformational forms of the receptor that differ in orientation of a crucial hyaluronan-binding residue (Arg45, equivalent to Arg41 in human CD44). Hyaluronic Acid 205-215 CD44 molecule (Indian blood group) Homo sapiens 269-273 17293874-6 2007 Measurements by NMR indicate that the conformational transition can be induced by hyaluronan binding, providing further insight into possible mechanisms for regulation of Cd44. Hyaluronic Acid 82-92 CD44 molecule (Indian blood group) Homo sapiens 171-175 17230576-1 2007 Hyaluronan (HA) and its major cell surface receptor, CD44, play an important role in tumor growth, proliferation, neovascularization, and invasion. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 53-57 17222331-5 2007 CD44 mediates hyaluronic acid (HA)-dependent cell adhesion: besides promoting invasion, this interaction also supports neoangiogenesis that indirectly stimulates tumour cell proliferation. Hyaluronic Acid 14-29 CD44 molecule (Indian blood group) Homo sapiens 0-4 17222331-5 2007 CD44 mediates hyaluronic acid (HA)-dependent cell adhesion: besides promoting invasion, this interaction also supports neoangiogenesis that indirectly stimulates tumour cell proliferation. Hyaluronic Acid 31-33 CD44 molecule (Indian blood group) Homo sapiens 0-4 17136494-6 2007 Furthermore, AICD induced by CD3 restimulation was inhibited by hyaluronidase as well as by soluble Fas, indicating an interaction between membrane-bound hyaluronan and the cell surface CD44 was involved in the up-regulation of FasL expression on T cells and subsequent AICD. Hyaluronic Acid 154-164 CD44 molecule (Indian blood group) Homo sapiens 186-190 17506690-6 2007 CD44 is the major cell-surface hyaluronan receptor and is required to clear hyaluronan degradation products produced during lung injury; impaired clearance of hyaluronan results in persistent inflammation. Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 0-4 17605420-1 2007 INTRODUCTION: The CD44 on lymphocytes binding to its ligand hyaluronan can mediate primary adhesion (rolling interactions) of lymphocytes on high endothelial venules (HEV). Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 18-22 17085435-0 2006 Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR. Hyaluronic Acid 46-56 CD44 molecule (Indian blood group) Homo sapiens 41-45 16652145-1 2006 Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis. Hyaluronic Acid 231-241 CD44 molecule (Indian blood group) Homo sapiens 112-116 17038319-9 2006 Anti-CD44 monoclonal antibody (Hermes-1) inhibited fragmented hyaluronan-induced YB-1 activation and P-glycoprotein expression in CD4+ T cells. Hyaluronic Acid 62-72 CD44 molecule (Indian blood group) Homo sapiens 5-9 17038319-10 2006 We provide the first evidence that binding of fragmented hyaluronan to CD44 induces YB-1 activation followed by P-glycoprotein expression in accordance with activation of CD4+ T cells. Hyaluronic Acid 57-67 CD44 molecule (Indian blood group) Homo sapiens 71-75 17323643-3 2006 In an attempt to obtain inhibitors of hyaluronic acid (HA) binding to its receptor, CD44, we established an efficient assay method to detect and quantify binding using fluorescein-labeled HA and HEK293 cells stably expressing CD44. Hyaluronic Acid 38-53 CD44 molecule (Indian blood group) Homo sapiens 84-88 17323643-3 2006 In an attempt to obtain inhibitors of hyaluronic acid (HA) binding to its receptor, CD44, we established an efficient assay method to detect and quantify binding using fluorescein-labeled HA and HEK293 cells stably expressing CD44. Hyaluronic Acid 38-53 CD44 molecule (Indian blood group) Homo sapiens 226-230 17076095-1 2006 OBJECTIVES: Expression of CD44 (a cell surface receptor for hyaluronic acid) and the distribution of hyaluronic acid were examined in the human vocal fold mucosa. Hyaluronic Acid 60-75 CD44 molecule (Indian blood group) Homo sapiens 26-30 17076095-9 2006 CONCLUSIONS: Stellate cells in the macula flava and CD44 cooperatively play important roles in maintaining hyaluronic acid in the human vocal fold mucosa as a vibrating tissue. Hyaluronic Acid 107-122 CD44 molecule (Indian blood group) Homo sapiens 52-56 16652145-1 2006 Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis. Hyaluronic Acid 231-241 CD44 molecule (Indian blood group) Homo sapiens 132-136 16652145-1 2006 Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis. Hyaluronic Acid 231-241 CD44 molecule (Indian blood group) Homo sapiens 132-136 16809345-5 2006 Our observations suggest that hyaluronan suppresses PDGF beta-receptor activation by recruiting a CD44-associated tyrosine phosphatase to the receptor. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 98-102 16809345-0 2006 Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44. Hyaluronic Acid 104-114 CD44 molecule (Indian blood group) Homo sapiens 129-133 16809345-2 2006 The suppressive effect of hyaluronan was neutralized by a monoclonal antibody that specifically inhibits hyaluronan binding to its receptor CD44. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 140-144 16809345-2 2006 The suppressive effect of hyaluronan was neutralized by a monoclonal antibody that specifically inhibits hyaluronan binding to its receptor CD44. Hyaluronic Acid 105-115 CD44 molecule (Indian blood group) Homo sapiens 140-144 16702221-0 2006 SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. Hyaluronic Acid 61-71 CD44 molecule (Indian blood group) Homo sapiens 21-25 16871244-3 2006 CD44 and its ligands, hyaluronic acid (HA) and osteopontin, were analyzed retrospectively by immunohistochemistry and, computer-aided, morphometric analysis. Hyaluronic Acid 22-37 CD44 molecule (Indian blood group) Homo sapiens 0-4 16871244-3 2006 CD44 and its ligands, hyaluronic acid (HA) and osteopontin, were analyzed retrospectively by immunohistochemistry and, computer-aided, morphometric analysis. Hyaluronic Acid 39-41 CD44 molecule (Indian blood group) Homo sapiens 0-4 16908592-7 2006 Our results revealed that TNF-alpha differentially modulates the expression of CD44 in TNF-alpha-resistant ovarian cancer cells, affecting their in vitro migration, invasion, and binding to hyaluronic acid. Hyaluronic Acid 190-205 CD44 molecule (Indian blood group) Homo sapiens 79-83 16702221-1 2006 CD44-hyaluronan (HA) interaction is involved in diverse physiological and pathological processes. Hyaluronic Acid 5-15 CD44 molecule (Indian blood group) Homo sapiens 0-4 16799081-4 2006 Hematopoietic CD44 is necessary to clear hyaluronan fragments that are produced after lung injury. Hyaluronic Acid 41-51 CD44 molecule (Indian blood group) Homo sapiens 14-18 16886606-7 2006 Re-expressing CD44s restored predominant hyaluronan binding. Hyaluronic Acid 41-51 CD44 molecule (Indian blood group) Homo sapiens 14-18 16449361-2 2006 We have previously shown that hyaluronan (HA) inhibits IL-1beta actions in RSF via CD44, the principal HA receptor. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 83-87 16449361-2 2006 We have previously shown that hyaluronan (HA) inhibits IL-1beta actions in RSF via CD44, the principal HA receptor. Hyaluronic Acid 42-44 CD44 molecule (Indian blood group) Homo sapiens 83-87 16847188-2 2006 Hyaluronan, a glycosaminoglycan component of the extracellular matrix, is a ligand for the transmembrane receptor CD44, which acts through multiple signaling pathways to influence cellular behavior. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 114-118 16565089-0 2006 Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 16497973-2 2006 In vitro studies using cell lines have previously demonstrated that rolling and adhesion of lymphocytes on endothelium requires CD44 interactions with hyaluronan (HA). Hyaluronic Acid 151-161 CD44 molecule (Indian blood group) Homo sapiens 128-132 16497973-2 2006 In vitro studies using cell lines have previously demonstrated that rolling and adhesion of lymphocytes on endothelium requires CD44 interactions with hyaluronan (HA). Hyaluronic Acid 163-165 CD44 molecule (Indian blood group) Homo sapiens 128-132 16554035-6 2006 We further show that hyaluronan mediates its effect through CD44. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 60-64 16554035-2 2006 Amongst them, hyaluronan, a glycosaminoglycan and ligand for the cell surface molecule CD44, and TGFbeta1, a cytokine particularly important in monocyte differentiation. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 87-91 16407205-0 2006 Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. Hyaluronic Acid 71-81 CD44 molecule (Indian blood group) Homo sapiens 30-34 16331675-0 2006 Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 141-145 16633060-4 2006 One important mechanism is the interaction between hyaluronic acid and the CD44 receptor with its submembrane linking complex. Hyaluronic Acid 51-66 CD44 molecule (Indian blood group) Homo sapiens 75-79 16407205-1 2006 Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that interacts with cell-surface receptors, including CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 115-119 16308159-0 2005 Expression of hyaluronic acid and its receptors, CD44s and CD44v6, in normal, hyperplastic, and neoplastic endometrium. Hyaluronic Acid 14-29 CD44 molecule (Indian blood group) Homo sapiens 49-53 16179372-3 2006 Here we show heterogeneity of suppressor activity among activated CD4CD25(+) Treg cells and that, within this population, the functionally active, hyaluronan-binding form of CD44 (CD44(act)) is strikingly correlated with superior suppressor activity. Hyaluronic Acid 147-157 CD44 molecule (Indian blood group) Homo sapiens 174-178 16179372-3 2006 Here we show heterogeneity of suppressor activity among activated CD4CD25(+) Treg cells and that, within this population, the functionally active, hyaluronan-binding form of CD44 (CD44(act)) is strikingly correlated with superior suppressor activity. Hyaluronic Acid 147-157 CD44 molecule (Indian blood group) Homo sapiens 180-189 16415424-0 2006 Hyaluronan-CD44 promotes phospholipase C-mediated Ca2+ signaling and cisplatin resistance in head and neck cancer. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 16415424-1 2006 OBJECTIVE: To investigate whether hyaluronan (HA)-CD44 promotes head and neck squamous cell carcinoma (HNSCC) cisplatin resistance and whether HA-CD44 promotes phospholipase C (PLC)-mediated Ca2+ signaling to alter cisplatin sensitivity in HNSCC. Hyaluronic Acid 34-44 CD44 molecule (Indian blood group) Homo sapiens 50-54 16394262-7 2006 Hyaluronan alternatively participates in leukocyte recruitment via interaction with CD44, while activating various inflammatory cells, such as macrophages, through CD44-dependent signaling. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 84-88 16394262-7 2006 Hyaluronan alternatively participates in leukocyte recruitment via interaction with CD44, while activating various inflammatory cells, such as macrophages, through CD44-dependent signaling. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 164-168 16325770-5 2006 Taken together, engagement of CD44 (e.g., hyaluronan) and glycated albumin induced the differentiation of resting monocytes into foam macrophages through the induction of MSRs, implying that CD44 could be involved in atherosclerotic lesions of those such as diabetic patients. Hyaluronic Acid 42-52 CD44 molecule (Indian blood group) Homo sapiens 30-34 16325770-5 2006 Taken together, engagement of CD44 (e.g., hyaluronan) and glycated albumin induced the differentiation of resting monocytes into foam macrophages through the induction of MSRs, implying that CD44 could be involved in atherosclerotic lesions of those such as diabetic patients. Hyaluronic Acid 42-52 CD44 molecule (Indian blood group) Homo sapiens 191-195 16181799-1 2006 Chondrocyte CD44 receptors anchor hyaluronan to the cell surface, enabling the assembly and retention of proteoglycan aggregates in the pericellular matrix. Hyaluronic Acid 34-44 CD44 molecule (Indian blood group) Homo sapiens 12-16 16181799-2 2006 Hyaluronan-CD44 interactions also provide signaling important for maintaining cartilage homeostasis. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 16181799-3 2006 Disruption of chondrocyte-hyaluronan contact alters CD44 occupancy, initiating alternative signaling cascades. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 52-56 16181799-4 2006 Treatment with hyaluronan oligosaccharides is one approach to uncouple CD44 receptors from its native ligand, hyaluronan. Hyaluronic Acid 15-25 CD44 molecule (Indian blood group) Homo sapiens 71-75 16308159-3 2005 One of these receptors, CD44, binds to extracellular matrix component hyaluronic acid (HA). Hyaluronic Acid 70-85 CD44 molecule (Indian blood group) Homo sapiens 24-28 16308159-3 2005 One of these receptors, CD44, binds to extracellular matrix component hyaluronic acid (HA). Hyaluronic Acid 87-89 CD44 molecule (Indian blood group) Homo sapiens 24-28 16219515-2 2005 CD44 is a receptor for hyaluronic acid. Hyaluronic Acid 23-38 CD44 molecule (Indian blood group) Homo sapiens 0-4 16234326-0 2005 Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding. Hyaluronic Acid 19-29 CD44 molecule (Indian blood group) Homo sapiens 46-50 16234326-0 2005 Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding. Hyaluronic Acid 19-29 CD44 molecule (Indian blood group) Homo sapiens 102-106 16234326-0 2005 Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding. Hyaluronic Acid 107-117 CD44 molecule (Indian blood group) Homo sapiens 102-106 16234326-3 2005 Moreover, chemotaxis towards hyaluronan, but not foetal bovine serum, can be abrogated following treatment of the cells with siRNA oligonucleotides to downregulate CD44 expression. Hyaluronic Acid 29-39 CD44 molecule (Indian blood group) Homo sapiens 164-168 16419149-7 2005 The function of CD44 surface receptors was assessed with specific receptor blocking monoclonal antibodies or removal of hyaluronan by digestion with hyaluronidase. Hyaluronic Acid 120-130 CD44 molecule (Indian blood group) Homo sapiens 16-20 16219515-10 2005 Accordingly, we deduce that the concentration of hyaluronic acid in the cervical tissue is increased because of the expression of CD44. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 130-134 15992376-1 2005 Glioma cell-surface binding to hyaluronan (HA), a major constituent of the brain extracellular matrix (ECM) environment, is regulated through a complex membrane type-1 matrix metalloproteinase (MT1-MMP)/CD44/caveolin interaction that takes place at the leading edges of invading cells. Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 203-207 16002044-0 2005 Chondroitin sulfate addition to CD44H negatively regulates hyaluronan binding. Hyaluronic Acid 59-69 CD44 molecule (Indian blood group) Homo sapiens 32-36 16002044-1 2005 CD44 is a widely expressed cell adhesion molecule that binds hyaluronan, an extracellular matrix glycosaminoglycan, in a tightly regulated manner. Hyaluronic Acid 61-71 CD44 molecule (Indian blood group) Homo sapiens 0-4 16002044-4 2005 Here, we identify serine 180 in human CD44H as the site of chondroitin sulfate addition and show that lack of chondroitin sulfate addition at this site enhances hyaluronan binding by CD44. Hyaluronic Acid 161-171 CD44 molecule (Indian blood group) Homo sapiens 38-42 16002044-6 2005 Mutation of serine 180 or glycine 181 in CD44H reduced chondroitin sulfate addition and increased hyaluronan binding, indicating that serine 180 is the site for chondroitin sulfate addition in CD44H and that this negatively regulates hyaluronan binding. Hyaluronic Acid 98-108 CD44 molecule (Indian blood group) Homo sapiens 41-45 16002044-6 2005 Mutation of serine 180 or glycine 181 in CD44H reduced chondroitin sulfate addition and increased hyaluronan binding, indicating that serine 180 is the site for chondroitin sulfate addition in CD44H and that this negatively regulates hyaluronan binding. Hyaluronic Acid 234-244 CD44 molecule (Indian blood group) Homo sapiens 41-45 16043857-1 2005 PURPOSE: The ectodomain of CD44, the principal receptor for hyaluronic acid (HA), is shed as a 32-kDa fragment-soluble CD44 (sCD44)-which is cytotoxic to trabecular meshwork (TM) cells and retinal ganglion cells (RGCs) in culture. Hyaluronic Acid 60-75 CD44 molecule (Indian blood group) Homo sapiens 27-31 16043857-1 2005 PURPOSE: The ectodomain of CD44, the principal receptor for hyaluronic acid (HA), is shed as a 32-kDa fragment-soluble CD44 (sCD44)-which is cytotoxic to trabecular meshwork (TM) cells and retinal ganglion cells (RGCs) in culture. Hyaluronic Acid 60-75 CD44 molecule (Indian blood group) Homo sapiens 119-123 16043857-1 2005 PURPOSE: The ectodomain of CD44, the principal receptor for hyaluronic acid (HA), is shed as a 32-kDa fragment-soluble CD44 (sCD44)-which is cytotoxic to trabecular meshwork (TM) cells and retinal ganglion cells (RGCs) in culture. Hyaluronic Acid 77-79 CD44 molecule (Indian blood group) Homo sapiens 27-31 16043857-1 2005 PURPOSE: The ectodomain of CD44, the principal receptor for hyaluronic acid (HA), is shed as a 32-kDa fragment-soluble CD44 (sCD44)-which is cytotoxic to trabecular meshwork (TM) cells and retinal ganglion cells (RGCs) in culture. Hyaluronic Acid 77-79 CD44 molecule (Indian blood group) Homo sapiens 119-123 15645431-7 2005 This enhanced migration is blocked when cells are preincubated with soluble hyaluronan, or anti-CD44 antibodies, suggesting that V3 acts by altering the hyaluronan-CD44 interaction. Hyaluronic Acid 153-163 CD44 molecule (Indian blood group) Homo sapiens 164-168 15954897-1 2005 BACKGROUND: Hyaluronan has diverse biologic functions in the body, varying from structural tasks to cell stress-induced CD44-mediated activation of intracellular signaling pathways. Hyaluronic Acid 12-22 CD44 molecule (Indian blood group) Homo sapiens 120-124 15746159-8 2005 CD44 expression on the tumour cells was confined to those invading cells and corresponded to cellular hyaluronan staining. Hyaluronic Acid 102-112 CD44 molecule (Indian blood group) Homo sapiens 0-4 15843382-0 2005 Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 66-70 15784621-4 2005 Data presented herein show that constitutive interaction of the pericellular polysaccharide, hyaluronan, with its receptor, CD44, regulates assembly and activation of an ErbB2-containing signaling complex, which in turn stimulates phosphoinositide 3-kinase activity in multidrug-resistant MCF-7/Adr human breast carcinoma cells. Hyaluronic Acid 93-103 CD44 molecule (Indian blood group) Homo sapiens 124-128 15728517-9 2005 The induction of IRAK-M by hyaluronan and tumor cells was abolished by incubation with anti-CD44 or anti-TLR4 blocking Abs. Hyaluronic Acid 27-37 CD44 molecule (Indian blood group) Homo sapiens 92-96 15762960-5 2005 Hyaluronan and its receptor CD44 were prominently expressed in IVL when compared to leiomyomas and associated with an elevation in bFGF expression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 28-32 15632176-4 2005 Dependence on hyaluronan-CD44 interaction was demonstrated by the administration of hyaluronan oligomers, experimentally induced expression of soluble CD44, and small interfering RNA knockdown of CD44 expression. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 25-29 15632176-4 2005 Dependence on hyaluronan-CD44 interaction was demonstrated by the administration of hyaluronan oligomers, experimentally induced expression of soluble CD44, and small interfering RNA knockdown of CD44 expression. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 151-155 15632176-4 2005 Dependence on hyaluronan-CD44 interaction was demonstrated by the administration of hyaluronan oligomers, experimentally induced expression of soluble CD44, and small interfering RNA knockdown of CD44 expression. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 151-155 15632176-4 2005 Dependence on hyaluronan-CD44 interaction was demonstrated by the administration of hyaluronan oligomers, experimentally induced expression of soluble CD44, and small interfering RNA knockdown of CD44 expression. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 25-29 15749731-3 2005 We demonstrate that engagement of CD44 using immobilized mAbs or hyaluronan-enriched extracellular matrix lattices induces active migration in T lymphocytes accompanied by cycles of cytoskeletal rearrangement and cell polarization. Hyaluronic Acid 65-75 CD44 molecule (Indian blood group) Homo sapiens 34-38 15655247-0 2005 Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 15655247-1 2005 In this study, we have examined the interaction of hyaluronan (HA)-CD44 with IQGAP1 (one of the binding partners for the Rho GTPase Cdc42) in SK-OV-3.ipl human ovarian tumor cells. Hyaluronic Acid 51-61 CD44 molecule (Indian blood group) Homo sapiens 67-71 15655247-1 2005 In this study, we have examined the interaction of hyaluronan (HA)-CD44 with IQGAP1 (one of the binding partners for the Rho GTPase Cdc42) in SK-OV-3.ipl human ovarian tumor cells. Hyaluronic Acid 63-65 CD44 molecule (Indian blood group) Homo sapiens 67-71 15725890-0 2005 Hyaluronic acid-CD44 interaction mediates the adhesion of lymphocytes by amniotic membrane stroma. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 16-20 15640281-1 2005 CD44 is a receptor for hyaluronic acid and is found on the surface of hematopoetic cells and in mesenchymal tissue. Hyaluronic Acid 23-38 CD44 molecule (Indian blood group) Homo sapiens 0-4 15640281-4 2005 Here we show that engagement of CD44 with signaling monoclonal antibodies (mAbs) or its natural ligand hyaluronic acid induces COX-2 and prostacyclin (PGI2) formation in human EC. Hyaluronic Acid 103-118 CD44 molecule (Indian blood group) Homo sapiens 32-36 15728517-11 2005 Altogether, our findings indicate that deactivation of human monocytes in the presence of tumor cells involves IRAK-M up-regulation, and this effect appears to be mediated by hyaluronan through the engagement of CD44 and TLR4. Hyaluronic Acid 175-185 CD44 molecule (Indian blood group) Homo sapiens 212-216 15652352-3 2005 In the myeloid progenitor cell line, KG1a, hyaluronan binding occurred in the pseudopod where CD44, P-ERM, and F-actin were highly localized. Hyaluronic Acid 43-53 CD44 molecule (Indian blood group) Homo sapiens 94-98 15828943-1 2005 It is well known that hyaluronic acid and its principal receptor, CD44, are implicated in the regulation of the tissue repair process, but their role in the formation of chronic diabetic ulcers has not been studied. Hyaluronic Acid 22-37 CD44 molecule (Indian blood group) Homo sapiens 66-70 15828943-6 2005 Fibroblasts of the diabetic group with ulcers, unlike those of the group without ulcers, showed significant increases in the high molecular weight hyaluronic acid accumulation in the pericellular matrix (30.5%, p < 0.01) and CD44 expression (27.0%, p < 0.05). Hyaluronic Acid 147-162 CD44 molecule (Indian blood group) Homo sapiens 228-232 15652352-4 2005 Hyaluronan binding correlated with high expression of both CD44 and P-ERM clustered in a single pseudopod. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 59-63 15652352-8 2005 Furthermore, expression of CD44 lacking the putative ERM binding site resulted in reduced hyaluronan binding. Hyaluronic Acid 90-100 CD44 molecule (Indian blood group) Homo sapiens 27-31 15652352-9 2005 Taken together, these data suggest that CD44-mediated hyaluronan binding in human myeloid cells is regulated by P-ERM and the actin cytoskeleton. Hyaluronic Acid 54-64 CD44 molecule (Indian blood group) Homo sapiens 40-44 15619667-4 2005 INTRODUCTION: Hyaluronan (HA), the major nonprotein glycosaminoglycan component of the extracellular matrix in mammalian bone marrow, functions in part through its receptor, CD44, to stimulate a series of intracellular signaling events that lead to cell migration, adhesion, and activation. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 174-178 16259720-13 2005 CONCLUSIONS: These results show that hyaluronan, at concentrations below those where intra-molecular associations occur, binds selectively to stimulated endothelial cells and inhibits neutrophil adhesion in vitro and in vivo via a mechanism which may involve molecules other than CD44, such as ICAM-1. Hyaluronic Acid 37-47 CD44 molecule (Indian blood group) Homo sapiens 280-284 15721147-1 2005 In previous studies, hyaluronan (HA) and its major cell surface receptor CD44 have been suggested to play an important role during tooth development. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 73-77 15705860-1 2005 Hyaluronic acid (HA) binds to cell-surface receptors such as CD44, and seems to be involved in cell adhesion, motility, and tumor progression in brain. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 61-65 15705860-1 2005 Hyaluronic acid (HA) binds to cell-surface receptors such as CD44, and seems to be involved in cell adhesion, motility, and tumor progression in brain. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 61-65 16101040-8 2005 Moreover, we found that hyaluronan-CD44 system during cumulus expansion induces the activation of maturation promoting factor, resulting in germinal vesicle breakdown of the oocytes, and the tyrosine-phosphorylation of Cx43 in the COCs. Hyaluronic Acid 24-34 CD44 molecule (Indian blood group) Homo sapiens 35-39 16101040-9 2005 The present results showed that the main component of cumulus expansion in the COCs is hyaluronan; the hyaluronan-CD44 system during cumulus expansion regulates the disruption of gap junctions in the COCs, and concurrently controls the incidence of meiotic resumption in the porcine oocytes. Hyaluronic Acid 87-97 CD44 molecule (Indian blood group) Homo sapiens 114-118 15619667-4 2005 INTRODUCTION: Hyaluronan (HA), the major nonprotein glycosaminoglycan component of the extracellular matrix in mammalian bone marrow, functions in part through its receptor, CD44, to stimulate a series of intracellular signaling events that lead to cell migration, adhesion, and activation. Hyaluronic Acid 26-28 CD44 molecule (Indian blood group) Homo sapiens 174-178 15231668-0 2004 Hyaluronan facilitates invasion of colon carcinoma cells in vitro via interaction with CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 87-91 15480059-7 2004 Disruption of chondrocyte CD44:hyaluronan interaction will induce a cascade of events resulting in the activation of both catabolic as well as anabolic gene products. Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 26-30 15480059-8 2004 Fragments of hyaluronan produced in free radical processes have the potential to augment the production of nitric oxide in a CD44-dependent mechanism. Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 125-129 15122068-2 2004 All new compounds exerted a dose-dependent inhibitory effect on both cell lines, which expressed CD44, the specific surface receptor for hyaluronic acid, in a very high percentage of cells (90%). Hyaluronic Acid 137-152 CD44 molecule (Indian blood group) Homo sapiens 97-101 15258184-1 2004 CD44 is a polymorphic transmembrane glycoprotein that binds hyaluronan and growth factors. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 0-4 15123640-12 2004 Taken together, these findings strongly suggest that hyaluronan-CD44 interaction with Rac1-PKNgamma plays a pivotal role in PLCgamma1-regulated Ca(2+) signaling and cortactin-cytoskeleton function required for keratinocyte cell-cell adhesion and differentiation. Hyaluronic Acid 53-63 CD44 molecule (Indian blood group) Homo sapiens 64-68 15596040-4 2004 CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and is implicated in a wide variety of physiological and pathological processes. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 0-4 15596040-4 2004 CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and is implicated in a wide variety of physiological and pathological processes. Hyaluronic Acid 66-68 CD44 molecule (Indian blood group) Homo sapiens 0-4 15313910-5 2004 Similarly, depletion of CD44 expression using RNA interference decreased the ability of PC3 cells and two CD44 +ve breast cancer cell lines (MDA-MB-231 and MDA-MB-157) to bind FITC-conjugated hyaluronan (FITC-HA) and to adhere to hBMECs. Hyaluronic Acid 192-202 CD44 molecule (Indian blood group) Homo sapiens 24-28 15313910-5 2004 Similarly, depletion of CD44 expression using RNA interference decreased the ability of PC3 cells and two CD44 +ve breast cancer cell lines (MDA-MB-231 and MDA-MB-157) to bind FITC-conjugated hyaluronan (FITC-HA) and to adhere to hBMECs. Hyaluronic Acid 192-202 CD44 molecule (Indian blood group) Homo sapiens 106-110 15123640-0 2004 Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 15123640-1 2004 In this study we have investigated hyaluronan (HA)-CD44 interaction with protein kinase N-gamma (PKNgamma), a small GTPase (Rac1)-activated serine/threonine kinase in human keratinocytes. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 51-55 15197174-1 2004 CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and undergoes sequential proteolytic cleavages in its ectodomain and intramembranous domain. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 0-4 15090545-7 2004 Finally, down-regulation of CD44 or Hyal-2 expression (by treating cells with CD44 or Hyal-2-specific small interfering RNAs) not only inhibits HA-mediated CD44 signaling (e.g. ROK-mediated Na(+)-H(+) exchanger reaction and cellular pH changes) but also impairs oncogenic events (e.g. Hyal-2 activity, hyaluronan modification, cathepsin B activation, and tumor cell invasion). Hyaluronic Acid 302-312 CD44 molecule (Indian blood group) Homo sapiens 28-32 15197174-1 2004 CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and undergoes sequential proteolytic cleavages in its ectodomain and intramembranous domain. Hyaluronic Acid 66-68 CD44 molecule (Indian blood group) Homo sapiens 0-4 15148219-2 2004 Sodium hyaluronate is the ligand for CD44, a cell surface adhesion molecule which has been found on normal human corneal epithelial cells. Hyaluronic Acid 0-18 CD44 molecule (Indian blood group) Homo sapiens 37-41 15060082-0 2004 TSG-6 modulates the interaction between hyaluronan and cell surface CD44. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 68-72 15060082-2 2004 Here we show that preincubation of hyaluronan with full-length recombinant TSG-6 or its Link module domain (Link_TSG6) enhances or induces the binding of hyaluronan to cell surface CD44 on constitutive and inducible cell backgrounds, respectively. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 181-185 15060082-2 2004 Here we show that preincubation of hyaluronan with full-length recombinant TSG-6 or its Link module domain (Link_TSG6) enhances or induces the binding of hyaluronan to cell surface CD44 on constitutive and inducible cell backgrounds, respectively. Hyaluronic Acid 154-164 CD44 molecule (Indian blood group) Homo sapiens 181-185 15060082-4 2004 Enhancement of CD44-mediated interactions of lymphoid cells with hyaluronan by TSG-6 proteins was seen under conditions of flow at shear forces that occur in post-capillary venules. Hyaluronic Acid 65-75 CD44 molecule (Indian blood group) Homo sapiens 15-19 15060082-9 2004 In turn, cross-linked hyaluronan could increase the binding avidity of CD44 by inducing receptor clustering. Hyaluronic Acid 22-32 CD44 molecule (Indian blood group) Homo sapiens 71-75 15060082-10 2004 The ability of TSG-6 to modulate the interaction of hyaluronan with CD44 has important implications for CD44-mediated cell activity at sites of inflammation, where TSG-6 is expressed. Hyaluronic Acid 52-62 CD44 molecule (Indian blood group) Homo sapiens 68-72 15060082-10 2004 The ability of TSG-6 to modulate the interaction of hyaluronan with CD44 has important implications for CD44-mediated cell activity at sites of inflammation, where TSG-6 is expressed. Hyaluronic Acid 52-62 CD44 molecule (Indian blood group) Homo sapiens 104-108 14977887-4 2004 Upon binding to cell surface CD44, proliferation of G1-, but not G3-, overexpressing cells were dose dependently inhibited by exogenous hyaluronan (HA) or HA fragments. Hyaluronic Acid 136-146 CD44 molecule (Indian blood group) Homo sapiens 29-33 15017146-0 2004 1H, 13C and 15N backbone resonance assignments of the hyaluronan-binding domain of CD44. Hyaluronic Acid 54-64 CD44 molecule (Indian blood group) Homo sapiens 83-87 15035676-5 2004 RESULTS: To demonstrate the use and advantages of this new spreadsheet method we have investigated the binding of the transmembrane adhesion receptor CD44 to its ligand hyaluronan. Hyaluronic Acid 169-179 CD44 molecule (Indian blood group) Homo sapiens 150-154 15084274-1 2004 CD44 on activated T cells can initiate contact and mediate rolling on hyaluronan on endothelial cells. Hyaluronic Acid 70-80 CD44 molecule (Indian blood group) Homo sapiens 0-4 15035676-10 2004 By this method it was demonstrated that hyaluronan binding requires a threshold expression of CD44 and that this threshold is higher for CD44-T. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 94-98 15035676-10 2004 By this method it was demonstrated that hyaluronan binding requires a threshold expression of CD44 and that this threshold is higher for CD44-T. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 137-141 14872494-0 2004 Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Hyaluronic Acid 86-96 CD44 molecule (Indian blood group) Homo sapiens 101-105 14992719-0 2004 Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Hyaluronic Acid 28-38 CD44 molecule (Indian blood group) Homo sapiens 100-104 14992719-3 2004 How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanking sequences peculiar to CD44 may be involved. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Homo sapiens 93-97 14992719-3 2004 How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanking sequences peculiar to CD44 may be involved. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Homo sapiens 179-183 14871402-7 2004 Hyaluronan-dependent enhanced migration was also abrogated by addition the CD44 blocking antibody, and by inhibition of MAPK kinase (MEK) activity. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 75-79 14871402-9 2004 CONCLUSION: We have demonstrated that hyaluronan activation of the MAPK pathway through binding to its receptor CD44, enhances proximal tubule cell (PTC) migration. Hyaluronic Acid 38-48 CD44 molecule (Indian blood group) Homo sapiens 112-116 14871815-1 2004 CD44 is a receptor for hyaluronan and mediates signaling that regulates complex cell behavior including cancer cell migration and invasion. Hyaluronic Acid 23-33 CD44 molecule (Indian blood group) Homo sapiens 0-4 15641700-1 2004 The effects of suppression of CD44 by CD44-specific antisense oligonucleotide on attachment of human trabecular meshwork cells to hyaluronic acid (HA) were observed and the possible relationship between CD44 and primary open-angle glaucoma (POAG) investigated. Hyaluronic Acid 147-149 CD44 molecule (Indian blood group) Homo sapiens 38-42 15009704-7 2004 CD44, a cell surface receptor known to bind hyaluronan, not infrequently exists as a proteoglycan, decorated with various glycosaminoglycan chains including heparan sulfate and chondroitin sulfate, and as such can bind fibronectin. Hyaluronic Acid 44-54 CD44 molecule (Indian blood group) Homo sapiens 0-4 15641700-1 2004 The effects of suppression of CD44 by CD44-specific antisense oligonucleotide on attachment of human trabecular meshwork cells to hyaluronic acid (HA) were observed and the possible relationship between CD44 and primary open-angle glaucoma (POAG) investigated. Hyaluronic Acid 130-145 CD44 molecule (Indian blood group) Homo sapiens 30-34 15641700-1 2004 The effects of suppression of CD44 by CD44-specific antisense oligonucleotide on attachment of human trabecular meshwork cells to hyaluronic acid (HA) were observed and the possible relationship between CD44 and primary open-angle glaucoma (POAG) investigated. Hyaluronic Acid 130-145 CD44 molecule (Indian blood group) Homo sapiens 38-42 15641700-1 2004 The effects of suppression of CD44 by CD44-specific antisense oligonucleotide on attachment of human trabecular meshwork cells to hyaluronic acid (HA) were observed and the possible relationship between CD44 and primary open-angle glaucoma (POAG) investigated. Hyaluronic Acid 130-145 CD44 molecule (Indian blood group) Homo sapiens 38-42 15641700-1 2004 The effects of suppression of CD44 by CD44-specific antisense oligonucleotide on attachment of human trabecular meshwork cells to hyaluronic acid (HA) were observed and the possible relationship between CD44 and primary open-angle glaucoma (POAG) investigated. Hyaluronic Acid 147-149 CD44 molecule (Indian blood group) Homo sapiens 30-34 14698847-1 2004 Lower molecular weight of hyaluronan (HA) fragments are capable of activating macrophages to express a number of inflammatory mediators through the interaction with the HA receptor CD44. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 181-185 14504094-0 2004 CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD. Hyaluronic Acid 5-20 CD44 molecule (Indian blood group) Homo sapiens 0-4 14504094-3 2004 We now identify the relevant adhesion molecule(s) directing this binding, showing that interactions between lymphocyte CD44 and hyaluronic acid (HA) expressed on dermal vessels in aGVHD alone confer this shear-resistant attachment. Hyaluronic Acid 128-143 CD44 molecule (Indian blood group) Homo sapiens 119-123 14504094-3 2004 We now identify the relevant adhesion molecule(s) directing this binding, showing that interactions between lymphocyte CD44 and hyaluronic acid (HA) expressed on dermal vessels in aGVHD alone confer this shear-resistant attachment. Hyaluronic Acid 145-147 CD44 molecule (Indian blood group) Homo sapiens 119-123 14706828-0 2004 Cytokines regulate the affinity of soluble CD44 for hyaluronan. Hyaluronic Acid 52-62 CD44 molecule (Indian blood group) Homo sapiens 43-47 14706828-4 2004 Release of soluble CD44 by proteolytic cleavage (shedding) of membrane-anchored CD44 is likely to alter cellular responses to the environment due to modification of the cell surface and the potential for soluble CD44 to influence CD44-mediated hyaluronan binding to cell surfaces. Hyaluronic Acid 244-254 CD44 molecule (Indian blood group) Homo sapiens 19-23 14706828-4 2004 Release of soluble CD44 by proteolytic cleavage (shedding) of membrane-anchored CD44 is likely to alter cellular responses to the environment due to modification of the cell surface and the potential for soluble CD44 to influence CD44-mediated hyaluronan binding to cell surfaces. Hyaluronic Acid 244-254 CD44 molecule (Indian blood group) Homo sapiens 80-84 14706828-4 2004 Release of soluble CD44 by proteolytic cleavage (shedding) of membrane-anchored CD44 is likely to alter cellular responses to the environment due to modification of the cell surface and the potential for soluble CD44 to influence CD44-mediated hyaluronan binding to cell surfaces. Hyaluronic Acid 244-254 CD44 molecule (Indian blood group) Homo sapiens 80-84 14706828-4 2004 Release of soluble CD44 by proteolytic cleavage (shedding) of membrane-anchored CD44 is likely to alter cellular responses to the environment due to modification of the cell surface and the potential for soluble CD44 to influence CD44-mediated hyaluronan binding to cell surfaces. Hyaluronic Acid 244-254 CD44 molecule (Indian blood group) Homo sapiens 80-84 14706828-5 2004 Cellular activation is typically required to induce hyaluronan binding to cell surface CD44 but the affinity of endogenous soluble CD44 for hyaluronan remains unknown. Hyaluronic Acid 140-150 CD44 molecule (Indian blood group) Homo sapiens 131-135 14706828-8 2004 In contrast, soluble CD44 released from TGF-beta1-treated HTB58 cells differed in its hyaluronan-binding capacity from cell surface CD44 expressed on TGF-beta1-stimulated cells. Hyaluronic Acid 86-96 CD44 molecule (Indian blood group) Homo sapiens 21-25 15641700-1 2004 The effects of suppression of CD44 by CD44-specific antisense oligonucleotide on attachment of human trabecular meshwork cells to hyaluronic acid (HA) were observed and the possible relationship between CD44 and primary open-angle glaucoma (POAG) investigated. Hyaluronic Acid 147-149 CD44 molecule (Indian blood group) Homo sapiens 38-42 15013310-4 2004 This deficiency is important since experimental studies have shown that blockade of the CD44-hyaluronic acid interaction may prolong allograft survival. Hyaluronic Acid 93-108 CD44 molecule (Indian blood group) Homo sapiens 88-92 15013310-1 2004 CD44 is a type I transmembrane glycoprotein serving as a cell adhesion receptor, whose main ligand is hyaluronic acid, but also may interact with collagen, laminin, fibronectin, and osteopontin. Hyaluronic Acid 102-117 CD44 molecule (Indian blood group) Homo sapiens 0-4 14712518-4 2003 RESULT: In vitro sodium hyaluronate enhanced proliferation of Colo205 cells, but it had no appreciable effect on SW620 growth under the same doses, Meantime, CD44 expression on cancer cells decreased compared with controls. Hyaluronic Acid 17-35 CD44 molecule (Indian blood group) Homo sapiens 158-162 12909589-3 2003 With the use of primary human bronchial epithelial cells and the bronchial epithelial cell line 16HBE 14o-, a CD44s antibody inhibited >95% (P < 0.01) of cell binding to hyaluronic acid (HA). Hyaluronic Acid 176-191 CD44 molecule (Indian blood group) Homo sapiens 110-114 12909589-3 2003 With the use of primary human bronchial epithelial cells and the bronchial epithelial cell line 16HBE 14o-, a CD44s antibody inhibited >95% (P < 0.01) of cell binding to hyaluronic acid (HA). Hyaluronic Acid 193-195 CD44 molecule (Indian blood group) Homo sapiens 110-114 14712518-5 2003 CONCLUSION: In vitro sodium hyaluronate has different effects on growth of different colorectal cancer cell lines, but can inhibit CD44 expression of colorectal cancer cells and influence their ability of adhesion. Hyaluronic Acid 21-39 CD44 molecule (Indian blood group) Homo sapiens 131-135 12748184-0 2003 Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 20-24 14614016-2 2003 EXPERIMENTAL DESIGN: We analyzed the expression of CD44 by immunohistochemistry in 307 epithelial ovarian cancers and evaluated its relation to hyaluronan, clinicopathological factors, and prognosis. Hyaluronic Acid 144-154 CD44 molecule (Indian blood group) Homo sapiens 51-55 14614016-8 2003 Thus, whereas CD44-expressing cancer cells may adhere and implant to the hyaluronan-positive mesothelium, at least in model systems, high expression of CD44 in the tumor does not bring about an unfavorable prognosis. Hyaluronic Acid 73-83 CD44 molecule (Indian blood group) Homo sapiens 14-18 12798349-0 2003 Regulation of proximal tubular epithelial cell CD44-mediated binding and internalisation of hyaluronan. Hyaluronic Acid 92-102 CD44 molecule (Indian blood group) Homo sapiens 47-51 14758731-7 2003 This behavior seems to be explained by the existing relationship between hyaluronan, a basic component of the extracellular matrix and CD44, which is its major cell surface receptor. Hyaluronic Acid 73-83 CD44 molecule (Indian blood group) Homo sapiens 135-139 12928429-0 2003 Hyaluronan recognition mode of CD44 revealed by cross-saturation and chemical shift perturbation experiments. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 31-35 12928429-1 2003 CD44 is the main cell surface receptor for hyaluronic acid (HA) and contains a functional HA-binding domain (HABD) composed of a Link module with N- and C-terminal extensions. Hyaluronic Acid 43-58 CD44 molecule (Indian blood group) Homo sapiens 0-4 12928429-1 2003 CD44 is the main cell surface receptor for hyaluronic acid (HA) and contains a functional HA-binding domain (HABD) composed of a Link module with N- and C-terminal extensions. Hyaluronic Acid 60-62 CD44 molecule (Indian blood group) Homo sapiens 0-4 12867430-0 2003 Tumor necrosis factor-alpha induces functionally active hyaluronan-adhesive CD44 by activating sialidase through p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated human monocytic cells. Hyaluronic Acid 56-66 CD44 molecule (Indian blood group) Homo sapiens 76-80 12867430-1 2003 Interaction of CD44, an adhesion molecule, with its ligand, hyaluronan (HA), in monocytic cells plays a critical role in cell migration, inflammation, and immune responses. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 15-19 12867430-1 2003 Interaction of CD44, an adhesion molecule, with its ligand, hyaluronan (HA), in monocytic cells plays a critical role in cell migration, inflammation, and immune responses. Hyaluronic Acid 72-74 CD44 molecule (Indian blood group) Homo sapiens 15-19 12702150-0 2003 CD44 variant isoform v10 is expressed on tumor-infiltrating lymphocytes and mediates hyaluronan-independent heterotypic cell-cell adhesion to melanoma cells. Hyaluronic Acid 85-95 CD44 molecule (Indian blood group) Homo sapiens 0-4 12689941-3 2003 It is also known that FN production is greatly enhanced by adhesion of HCs to hyaluronan (HA) via CD44. Hyaluronic Acid 78-88 CD44 molecule (Indian blood group) Homo sapiens 98-102 12689941-3 2003 It is also known that FN production is greatly enhanced by adhesion of HCs to hyaluronan (HA) via CD44. Hyaluronic Acid 90-92 CD44 molecule (Indian blood group) Homo sapiens 98-102 12883358-1 2003 Adhesion between the CD44s receptor and hyaluronic acid plays an important role in cell migration, tumour growth and progression. Hyaluronic Acid 40-55 CD44 molecule (Indian blood group) Homo sapiens 21-25 12848853-1 2003 Previous studies have shown that the antibody 7H9D6 identifies CD44, a glycoprotein receptor for hyaluronic acid. Hyaluronic Acid 97-112 CD44 molecule (Indian blood group) Homo sapiens 63-67 12848853-3 2003 The 7H9D6 antibody bound to the hyaluronic acid binding domain of CD44 and inhibited cell adhesion to immobilized hyaluronic acid. Hyaluronic Acid 32-47 CD44 molecule (Indian blood group) Homo sapiens 66-70 12848853-3 2003 The 7H9D6 antibody bound to the hyaluronic acid binding domain of CD44 and inhibited cell adhesion to immobilized hyaluronic acid. Hyaluronic Acid 114-129 CD44 molecule (Indian blood group) Homo sapiens 66-70 12796473-1 2003 CD44 was once thought to simply be a transmembrane adhesion molecule that also played a role in the metabolism of its principal ligand hyaluronan. Hyaluronic Acid 135-145 CD44 molecule (Indian blood group) Homo sapiens 0-4 12955860-6 2003 The spatial organization of CD44 at the cell surface may function to establish or regulate the structure of the pericellular matrix dependent on a hyaluronan scaffold. Hyaluronic Acid 147-157 CD44 molecule (Indian blood group) Homo sapiens 28-32 12650924-5 2003 Hyaluronan, the major ligand of CD44, also up-regulated ICAM-1 expression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 32-36 12723975-3 2003 The polymorphic nature of CD44 might explain its multifunctionality and its ability to interact with many cell-surface and extracellular ligands, the principal one being hyaluronic acid (HA). Hyaluronic Acid 170-185 CD44 molecule (Indian blood group) Homo sapiens 26-30 12623292-0 2003 The effect of hyaluronan on CD44-mediated survival of normal and hydroxyl radical-damaged chondrocytes. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 28-32 12623292-1 2003 OBJECTIVE: To identify the CD44-receptor-mediated effects of 5-7 x 10(5)MW hyaluronan (HA, Hyalgan) on cell viability in normal and damaged human chondrocyte primary cultures isolated from articular cartilage. Hyaluronic Acid 75-85 CD44 molecule (Indian blood group) Homo sapiens 27-31 12723975-3 2003 The polymorphic nature of CD44 might explain its multifunctionality and its ability to interact with many cell-surface and extracellular ligands, the principal one being hyaluronic acid (HA). Hyaluronic Acid 187-189 CD44 molecule (Indian blood group) Homo sapiens 26-30 12685559-1 2003 Low and high molecular weight hyaluronan (HA) was added to adult human fibroblasts grown in monolayer to assess its influence on CD44 expression, its internalisation and effect on cell growth. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 129-133 12469144-2 2003 The interactions of hyaluronic acid (HA) and its receptors, CD44 and RHAMM, on cancer cells can promote invasion and metastasis but parallel study on these two genes in TCCs has not been available. Hyaluronic Acid 20-35 CD44 molecule (Indian blood group) Homo sapiens 60-64 12506143-0 2003 Crystal retention capacity of cells in the human nephron: involvement of CD44 and its ligands hyaluronic acid and osteopontin in the transition of a crystal binding- into a nonadherent epithelium. Hyaluronic Acid 94-109 CD44 molecule (Indian blood group) Homo sapiens 73-77 12506143-5 2003 Confocal microscopy demonstrated the expression of the transmembrane receptor protein CD44 and its ligands osteopontin (OPN) and hyaluronic acid (HA) at the apical membrane of proliferating tubular cells; at confluence, CD44 was expressed at the basolateral membrane and OPN and HA were no longer detectable. Hyaluronic Acid 129-144 CD44 molecule (Indian blood group) Homo sapiens 86-90 12506143-5 2003 Confocal microscopy demonstrated the expression of the transmembrane receptor protein CD44 and its ligands osteopontin (OPN) and hyaluronic acid (HA) at the apical membrane of proliferating tubular cells; at confluence, CD44 was expressed at the basolateral membrane and OPN and HA were no longer detectable. Hyaluronic Acid 146-148 CD44 molecule (Indian blood group) Homo sapiens 86-90 12469144-2 2003 The interactions of hyaluronic acid (HA) and its receptors, CD44 and RHAMM, on cancer cells can promote invasion and metastasis but parallel study on these two genes in TCCs has not been available. Hyaluronic Acid 37-39 CD44 molecule (Indian blood group) Homo sapiens 60-64 12145287-0 2002 Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 50-54 12385018-4 2002 Hyaluronan interaction with its CD44 receptor and the resulting signal transduction events may be among the mechanisms for hyaluronan-associated cancer progression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 32-36 12385018-4 2002 Hyaluronan interaction with its CD44 receptor and the resulting signal transduction events may be among the mechanisms for hyaluronan-associated cancer progression. Hyaluronic Acid 123-133 CD44 molecule (Indian blood group) Homo sapiens 32-36 12385018-14 2002 Continuous hyaluronan binding to CD44 variant exon isoforms may also be required to stabilize inherently unstable isoforms that participate perhaps in tumor progression. Hyaluronic Acid 11-21 CD44 molecule (Indian blood group) Homo sapiens 33-37 12402308-0 2002 CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells. Hyaluronic Acid 31-46 CD44 molecule (Indian blood group) Homo sapiens 0-4 12145277-10 2002 We interpret these results to indicate that the oligomers competitively block binding of endogenous hyaluronan polymer to CD44, consequently giving rise to attenuated signaling. Hyaluronic Acid 100-110 CD44 molecule (Indian blood group) Homo sapiens 122-126 12145277-12 2002 We conclude that perturbation of hyaluronan-CD44 binding leads to suppression of the PI 3-kinase/Akt cell survival pathway and consequently to inhibition of anchorage-independent growth in culture and tumor growth in vivo. Hyaluronic Acid 33-43 CD44 molecule (Indian blood group) Homo sapiens 44-48 12297287-2 2002 Engagement of CD44 either by its natural ligand hyaluronan or a specific antibody on a cell line induced tyrosine phosphorylation and activation of focal adhesion kinase (FAK), which then associated with phosphatidylinositol 3-kinase (PI3K) and activated mitogen-activated protein kinase at its downstream. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Homo sapiens 14-18 11807784-6 2002 Interestingly, blocking of hyaluronan binding to CD44 receptors by the monoclonal antibody KM114 inhibited the effect of hyaluronidase, but not of bFGF, on endothelial cell tube formation. Hyaluronic Acid 27-37 CD44 molecule (Indian blood group) Homo sapiens 49-53 12011075-0 2002 Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 35-39 12011075-1 2002 CD44, a cell-surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, can mediate leukocyte rolling on hyaluronan substrates and has been implicated in leukocyte migration to sites of inflammation. Hyaluronic Acid 77-87 CD44 molecule (Indian blood group) Homo sapiens 0-4 12011075-2 2002 CD44-mediated binding to hyaluronan is of low affinity, and effective cell/matrix interaction depends on multiple interactions with the multivalent ligand. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 0-4 12011075-4 2002 Monoclonal antibodies raised against the CD44/TSG-6 chimera recognized recombinant human TSG-6 and native mouse TSG-6 and blocked hyaluronan binding to these proteins. Hyaluronic Acid 130-140 CD44 molecule (Indian blood group) Homo sapiens 41-45 12093135-2 2002 Although it is well established that glioma cells can bind hyaluronan to their surface via the expression of CD44, the cellular responses following ligand-receptor interaction remain poorly understood. Hyaluronic Acid 59-69 CD44 molecule (Indian blood group) Homo sapiens 109-113 12093135-11 2002 The capacity of CD44 to form stable complexes with receptor tyrosine kinases may provide a versatile system for the regulation of cellular invasion and proliferation that allows hyaluronan to activate signal transduction pathways and modulate gene expression via an EGFR-dependent manner. Hyaluronic Acid 178-188 CD44 molecule (Indian blood group) Homo sapiens 16-20 12093135-12 2002 These findings provide new insights into the mode by which hyaluronan regulates the malignant phenotype and also suggest a role for EGFR-CD44 interactions in glial tumorigenesis. Hyaluronic Acid 59-69 CD44 molecule (Indian blood group) Homo sapiens 137-141 11896210-4 2002 This prevalent distribution corroborates a role for CD44 in maintaining hyaluronan-filled spaces (J Histochem Cytochem 1998;46:241-248). Hyaluronic Acid 72-82 CD44 molecule (Indian blood group) Homo sapiens 52-56 12235127-0 2002 Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 12183053-0 2002 CD44 stimulation by fragmented hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells. Hyaluronic Acid 31-46 CD44 molecule (Indian blood group) Homo sapiens 0-4 12183053-2 2002 Since HGF/SF receptor, c-Met, is expressed by tumor cells, and since stimulation of CD44, a transmembrane glycoprotein known to bind hyaluronic acid (HA) in its extracellular domain, is involved in activation of c-Met, we have studied the effects of CD44 stimulation by ligation with HA upon the expression and tyrosine phosphorylation of c-Met on human chondrosarcoma cell line HCS-2/8. Hyaluronic Acid 133-148 CD44 molecule (Indian blood group) Homo sapiens 84-88 12183053-2 2002 Since HGF/SF receptor, c-Met, is expressed by tumor cells, and since stimulation of CD44, a transmembrane glycoprotein known to bind hyaluronic acid (HA) in its extracellular domain, is involved in activation of c-Met, we have studied the effects of CD44 stimulation by ligation with HA upon the expression and tyrosine phosphorylation of c-Met on human chondrosarcoma cell line HCS-2/8. Hyaluronic Acid 150-152 CD44 molecule (Indian blood group) Homo sapiens 84-88 12183053-2 2002 Since HGF/SF receptor, c-Met, is expressed by tumor cells, and since stimulation of CD44, a transmembrane glycoprotein known to bind hyaluronic acid (HA) in its extracellular domain, is involved in activation of c-Met, we have studied the effects of CD44 stimulation by ligation with HA upon the expression and tyrosine phosphorylation of c-Met on human chondrosarcoma cell line HCS-2/8. Hyaluronic Acid 150-152 CD44 molecule (Indian blood group) Homo sapiens 250-254 12222834-1 2002 Hyaluronan binding to its cellular receptors CD44 and ICAM-1 appears to enhance the malignant behavior of tumors, including astrocytomas. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 45-49 12011075-5 2002 Cells expressing the CD44/TSG-6 molecule bound hyaluronan with higher avidity than cells expressing CD44. Hyaluronic Acid 47-57 CD44 molecule (Indian blood group) Homo sapiens 21-25 12011075-6 2002 This resulted in changes in the hyaluronan binding properties characteristic of cells expressing CD44 such as requirements for threshold levels of receptor expression and for hyaluronan of high molecular mass. Hyaluronic Acid 32-42 CD44 molecule (Indian blood group) Homo sapiens 97-101 12124327-0 2002 Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 12015850-1 2002 OBJECTIVE: The interactions of CD44 with hyaluronan are thought to be crucial for tumor cell attachment to the extracellular matrix, migration, and invasion. Hyaluronic Acid 41-51 CD44 molecule (Indian blood group) Homo sapiens 31-35 11944887-10 2002 Differential expression of the somatic hyaluronidases and CD44-mediated hyaluronan turnover play a critical role in cartilage development from mesenchymal precursors. Hyaluronic Acid 72-82 CD44 molecule (Indian blood group) Homo sapiens 58-62 12090473-6 2002 Both cytokines enhanced the ability of the cells to adhere to the CD44-specific ligand hyaluronic acid, an effect that was specifically blocked by an anti-IL-8 antibody. Hyaluronic Acid 87-102 CD44 molecule (Indian blood group) Homo sapiens 66-70 11740562-2 2001 Because ligation of CD44 by hyaluronic acid can induce epithelial cell movement on extracellular matrix, we investigated whether molecular mimicry by the GAS hyaluronic acid capsule might induce similar cellular responses. Hyaluronic Acid 28-43 CD44 molecule (Indian blood group) Homo sapiens 20-24 12440825-1 2002 CD44 is an adhesion molecule, which binds hyaluronic acid and participates in a number of cell-cell interactions, including lymphocyte homing. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 0-4 12168806-4 2002 The interaction of CD44 with fragmented hyaluronan on rheumatoid synovial cells induces expression of VCAM-1 and Fas on the cells, which leads to Fas-mediated apoptosis of synovial cells by the interaction of T cells bearing FasL. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 19-23 11827788-0 2002 CD44-mediated uptake and degradation of hyaluronan. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 0-4 11827788-5 2002 In cells such as chondrocytes, anabolic and catabolic cytokines can alter the activity of CD44 toward hyaluronan internalization. Hyaluronic Acid 102-112 CD44 molecule (Indian blood group) Homo sapiens 90-94 12392154-0 2002 Low molecular weight hyaluronan induces malignant mesothelioma cell (MMC) proliferation and haptotaxis: role of CD44 receptor in MMC proliferation and haptotaxis. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 112-116 11710716-0 2001 Antisense inhibition of CD44 tailless splice variant in human articular chondrocytes promotes hyaluronan internalization. Hyaluronic Acid 94-104 CD44 molecule (Indian blood group) Homo sapiens 24-28 11737075-2 2001 Furthermore, alveolar macrophages could produce IL-8 subsequent to CD44-hyaluronic acid (HA) interaction. Hyaluronic Acid 72-87 CD44 molecule (Indian blood group) Homo sapiens 67-71 11721159-1 2001 An important function of CD44 is to act as a cellular receptor for hyaluronic acid and osteopontin. Hyaluronic Acid 67-82 CD44 molecule (Indian blood group) Homo sapiens 25-29 11721159-8 2001 The glomerular and interstitial deposition of hyaluronic acid correlated with the glomerular and interstitial expression of CD44. Hyaluronic Acid 46-61 CD44 molecule (Indian blood group) Homo sapiens 124-128 11721159-13 2001 In summary, this study suggests that CD44 participates in the progression of IgA nephropathy by binding hyaluronic acid and osteopontin. Hyaluronic Acid 104-119 CD44 molecule (Indian blood group) Homo sapiens 37-41 11710716-7 2001 Selective inhibition of CD44 exon 19 results in enhanced hyaluronan internalization and smaller cell-associated matrices. Hyaluronic Acid 57-67 CD44 molecule (Indian blood group) Homo sapiens 24-28 11698490-2 2001 Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Hyaluronic Acid 115-130 CD44 molecule (Indian blood group) Homo sapiens 40-44 11673554-0 2001 Role of sulfation in CD44-mediated hyaluronan binding induced by inflammatory mediators in human CD14(+) peripheral blood monocytes. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 21-25 11698490-2 2001 Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Hyaluronic Acid 132-134 CD44 molecule (Indian blood group) Homo sapiens 40-44 11451408-9 2001 The distribution of CD44 in the human tooth germ corresponds to that of hyaluronan in most locations, suggesting that during tooth development this transmembrane protein plays an important part in hyaluronan-mediated events. Hyaluronic Acid 72-82 CD44 molecule (Indian blood group) Homo sapiens 20-24 11287417-6 2001 Analysis of the sequences of TSG-6 and CD44 indicates that the molecular details of their association with hyaluronan are likely to be significantly different. Hyaluronic Acid 107-117 CD44 molecule (Indian blood group) Homo sapiens 39-43 11463356-0 2001 Ca(2+)/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan. Hyaluronic Acid 111-121 CD44 molecule (Indian blood group) Homo sapiens 75-79 11463356-1 2001 CD44 is the principal cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and binding to this ligand underlies CD44-mediated cell attachment and migration. Hyaluronic Acid 91-101 CD44 molecule (Indian blood group) Homo sapiens 0-4 11463356-1 2001 CD44 is the principal cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and binding to this ligand underlies CD44-mediated cell attachment and migration. Hyaluronic Acid 91-101 CD44 molecule (Indian blood group) Homo sapiens 140-144 11463356-4 2001 This modification is not required for efficient ligand binding, but is an essential component of CD44-dependent cell migration on a hyaluronan substratum. Hyaluronic Acid 132-142 CD44 molecule (Indian blood group) Homo sapiens 97-101 11506502-4 2001 HAS2-transfected cells with the ability to synthesize about 520 ng hyaluronan/5 x 10(4)cells/24 h exhibited about a 2-fold increase in the expression of the cell surface hyaluronan receptor CD44 and their locomotion increased compared to that of mock-transfected Mero-25 cells. Hyaluronic Acid 67-77 CD44 molecule (Indian blood group) Homo sapiens 190-194 11508432-0 2001 Anti-Fas-induced apoptosis in chondrocytes reduced by hyaluronan: evidence for CD44 and CD54 (intercellular adhesion molecule 1) invovement. Hyaluronic Acid 54-64 CD44 molecule (Indian blood group) Homo sapiens 79-83 11466334-4 2001 Based on these findings, we postulate a new concept: that interaction of CD44 on RA synovial cells with hyaluronan fragments present in the surrounding extracellular matrix augments Fas expression as well as Fas-mediated apoptosis of synovial cells. Hyaluronic Acid 104-114 CD44 molecule (Indian blood group) Homo sapiens 73-77 11377291-1 2001 Previous research into hyaluronan (HA) has focused on the role of this abundant tissue glycosaminoglycan in promoting cell migration through interactions with its transmembrane receptor CD44 on inflammatory leukocytes and tumor cells. Hyaluronic Acid 23-33 CD44 molecule (Indian blood group) Homo sapiens 186-190 11423990-0 2001 Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Hyaluronic Acid 85-100 CD44 molecule (Indian blood group) Homo sapiens 8-12 11423990-0 2001 Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Hyaluronic Acid 85-100 CD44 molecule (Indian blood group) Homo sapiens 69-73 11423990-5 2001 Soluble CD44s almost completely inhibited hyaluronic acid binding by melanoma cells, whereas soluble CD44 mutated in the HA binding domain had no effect. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 8-12 11423990-11 2001 These results provide strong evidence that direct solCD44 interactions with hyaluronic acid interfere competitively with processes induced by hyaluronic acid binding to surface CD44. Hyaluronic Acid 76-91 CD44 molecule (Indian blood group) Homo sapiens 53-57 11423990-11 2001 These results provide strong evidence that direct solCD44 interactions with hyaluronic acid interfere competitively with processes induced by hyaluronic acid binding to surface CD44. Hyaluronic Acid 142-157 CD44 molecule (Indian blood group) Homo sapiens 53-57 11325633-4 2001 CD44, a cell-adhesion molecule that is ubiquitously expressed on leukocytes and parenchymal cells, has been implicated, together with its ligand hyaluronan (HA), in several inflammatory diseases. Hyaluronic Acid 145-155 CD44 molecule (Indian blood group) Homo sapiens 0-4 11325633-4 2001 CD44, a cell-adhesion molecule that is ubiquitously expressed on leukocytes and parenchymal cells, has been implicated, together with its ligand hyaluronan (HA), in several inflammatory diseases. Hyaluronic Acid 157-159 CD44 molecule (Indian blood group) Homo sapiens 0-4 11171560-4 2001 PMN migration across model polarized intestinal epithelia was reduced (by 60%) if the CD44 receptor was activated by either a specific antibody (clone IM7) or the natural soluble ligand, hyaluronic acid. Hyaluronic Acid 187-202 CD44 molecule (Indian blood group) Homo sapiens 86-90 11084024-0 2001 CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration. Hyaluronic Acid 89-104 CD44 molecule (Indian blood group) Homo sapiens 0-4 11554683-9 2001 Hyaluronic acid significantly (p < .04) increased intracellular Ca2+ concentrations and this was inhibited by nifedipine and a monoclonal antibody to human CD44. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 159-163 11294894-7 2001 Layilin"s ability to bind hyaluronan, a ubiquitous extracellular matrix component, reveals an interesting parallel between layilin and CD44, because both can bind to cytoskeleton-membrane linker proteins through their cytoplasmic domains and to hyaluronan through their extracellular domains. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 135-139 11135041-4 2001 The intensity of CD44 expression was associated with the level of invasion and with hyaluronan expression, while the frequency of CD44 positive cells was not significantly related to any of the clinical or histological features of the tumours. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 17-21 11167875-7 2001 Sodium hyaluronate-induced tumour cell motility appeared to be CD44 receptor dependent, whereas sodium hyaluronate-induced tumour cell proliferation was CD44 receptor independent. Hyaluronic Acid 0-18 CD44 molecule (Indian blood group) Homo sapiens 63-67 11167875-7 2001 Sodium hyaluronate-induced tumour cell motility appeared to be CD44 receptor dependent, whereas sodium hyaluronate-induced tumour cell proliferation was CD44 receptor independent. Hyaluronic Acid 96-114 CD44 molecule (Indian blood group) Homo sapiens 153-157 11139477-0 2001 Hyaluronan enhances contraction of collagen by smooth muscle cells and adventitial fibroblasts: Role of CD44 and implications for constrictive remodeling. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 104-108 11512634-8 2001 In contrast to hyaluronan, in the first trimester CD44 was restricted to some of the Hofbauer cells which may be able to internalize hyaluronan, thus playing a significant role in its removal in early pregnancy. Hyaluronic Acid 133-143 CD44 molecule (Indian blood group) Homo sapiens 50-54 11123292-0 2001 Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. Hyaluronic Acid 33-43 CD44 molecule (Indian blood group) Homo sapiens 64-68 11168803-0 2001 CD44 is the principal mediator of hyaluronic-acid-induced melanoma cell proliferation. Hyaluronic Acid 34-49 CD44 molecule (Indian blood group) Homo sapiens 0-4 11168803-1 2001 Interactions of the extracellular matrix component hyaluronic acid and its cellular receptors CD44 and RHAMM/IHABP have been linked to tumor progression and metastasis formation. Hyaluronic Acid 51-66 CD44 molecule (Indian blood group) Homo sapiens 94-98 11168803-2 2001 We investigated the expression and hyaluronic-acid-dependent functions of CD44 and RHAMM/IHABP in human melanoma. Hyaluronic Acid 35-50 CD44 molecule (Indian blood group) Homo sapiens 74-78 11168803-7 2001 Binding and adhesion of melanoma cells to hyaluronic acid is mainly CD44 dependent as it was inhibited to 60%--80% by an anti-CD44 monoclonal antibody whereas anti-RHAMM/IHABP sera had no effect. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 68-72 11168803-7 2001 Binding and adhesion of melanoma cells to hyaluronic acid is mainly CD44 dependent as it was inhibited to 60%--80% by an anti-CD44 monoclonal antibody whereas anti-RHAMM/IHABP sera had no effect. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 126-130 11168803-8 2001 Culture of melanoma cells in the presence of hyaluronic acid resulted in a dose-dependent, CD44-mediated increase of melanoma cell proliferation and enhanced release of basic fibroblast growth factor and transforming growth factor beta 1. Hyaluronic Acid 45-60 CD44 molecule (Indian blood group) Homo sapiens 91-95 11168803-9 2001 We conclude that (i) the expression of CD44 and RHAMM/IHABP is increased during melanoma progression, (ii) CD44 is the principal hyaluronic acid surface receptor on melanoma cells, and (iii) the hyaluronic-acid-induced increase of the proliferative capacity of melanoma cells is mainly dependent on CD44--hyaluronic acid interactions. Hyaluronic Acid 195-210 CD44 molecule (Indian blood group) Homo sapiens 39-43 11168803-9 2001 We conclude that (i) the expression of CD44 and RHAMM/IHABP is increased during melanoma progression, (ii) CD44 is the principal hyaluronic acid surface receptor on melanoma cells, and (iii) the hyaluronic-acid-induced increase of the proliferative capacity of melanoma cells is mainly dependent on CD44--hyaluronic acid interactions. Hyaluronic Acid 195-210 CD44 molecule (Indian blood group) Homo sapiens 107-111 11168803-9 2001 We conclude that (i) the expression of CD44 and RHAMM/IHABP is increased during melanoma progression, (ii) CD44 is the principal hyaluronic acid surface receptor on melanoma cells, and (iii) the hyaluronic-acid-induced increase of the proliferative capacity of melanoma cells is mainly dependent on CD44--hyaluronic acid interactions. Hyaluronic Acid 195-210 CD44 molecule (Indian blood group) Homo sapiens 107-111 11168803-9 2001 We conclude that (i) the expression of CD44 and RHAMM/IHABP is increased during melanoma progression, (ii) CD44 is the principal hyaluronic acid surface receptor on melanoma cells, and (iii) the hyaluronic-acid-induced increase of the proliferative capacity of melanoma cells is mainly dependent on CD44--hyaluronic acid interactions. Hyaluronic Acid 129-144 CD44 molecule (Indian blood group) Homo sapiens 107-111 11168803-9 2001 We conclude that (i) the expression of CD44 and RHAMM/IHABP is increased during melanoma progression, (ii) CD44 is the principal hyaluronic acid surface receptor on melanoma cells, and (iii) the hyaluronic-acid-induced increase of the proliferative capacity of melanoma cells is mainly dependent on CD44--hyaluronic acid interactions. Hyaluronic Acid 129-144 CD44 molecule (Indian blood group) Homo sapiens 107-111 11190680-0 2001 Structure and function of CD44: characteristic molecular features and analysis of the hyaluronan binding site. Hyaluronic Acid 86-96 CD44 molecule (Indian blood group) Homo sapiens 26-30 11372773-13 2001 Hyaluronic acid adheres to CD44 around the stromal cells and retains water intermolecularly, finally forming the edematous matrix. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 27-31 11113870-7 2000 CD44 up-regulation was associated with a 50% increase in invasion through hyaluronan-supplemented Matrigel(trade mark), which was abrogated by ligating CD44 with the specific antibody KM201. Hyaluronic Acid 74-84 CD44 molecule (Indian blood group) Homo sapiens 0-4 11113870-7 2000 CD44 up-regulation was associated with a 50% increase in invasion through hyaluronan-supplemented Matrigel(trade mark), which was abrogated by ligating CD44 with the specific antibody KM201. Hyaluronic Acid 74-84 CD44 molecule (Indian blood group) Homo sapiens 152-156 10950950-6 2000 We also show that soluble L- and P-selectin directly bind to immobilized CS B, CS E, and HS and that soluble CD44 directly binds to immobilized hyaluronic acid, CH, and all the CS chains examined. Hyaluronic Acid 144-159 CD44 molecule (Indian blood group) Homo sapiens 109-113 11082285-7 2000 Myoepithelial-cell-conditioned medium and affinity-purified solubilized CD44 from this conditioned medium block hyaluronan adhesion and migration of both human carcinoma cell lines and human umbilical vein endothelial cells. Hyaluronic Acid 112-122 CD44 molecule (Indian blood group) Homo sapiens 72-76 10950950-4 2000 On the other hand, the binding to CD44 was inhibited by hyaluronic acid, chondroitin (CH), CS A, CS B, CS C, CS D, and CS E but not by HS or keratan sulfate. Hyaluronic Acid 56-71 CD44 molecule (Indian blood group) Homo sapiens 34-38 11049998-0 2000 Involvement of CD44-hyaluronan interaction in malignant cell homing and fibronectin synthesis in hairy cell leukemia. Hyaluronic Acid 20-30 CD44 molecule (Indian blood group) Homo sapiens 15-19 11035936-4 2000 Analysis of the in vivo growth properties of the transfectants revealed that the restoration of a functional CD44 receptor in nonamplified cells resulted in the suppression of in vivo cell growth, therefore linking the MYCN-related lack of hyaluronic acid-binding function of CD44 to the highly tumorigenic properties of a subset of neuroblastoma cells. Hyaluronic Acid 240-255 CD44 molecule (Indian blood group) Homo sapiens 109-113 11029494-1 2000 Interactions of hyaluronic acid (HA) with its binding proteins CD44 and RHAMM (receptor for HA-mediating motility) have been proposed to be important in promoting tumor progression and dissemination. Hyaluronic Acid 16-31 CD44 molecule (Indian blood group) Homo sapiens 63-67 11029494-1 2000 Interactions of hyaluronic acid (HA) with its binding proteins CD44 and RHAMM (receptor for HA-mediating motility) have been proposed to be important in promoting tumor progression and dissemination. Hyaluronic Acid 33-35 CD44 molecule (Indian blood group) Homo sapiens 63-67 10871609-0 2000 Hyaluronan binding by cell surface CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 35-39 10980134-1 2000 The cell surface glycoprotein CD44 and its ligand, hyaluronan (HA), enhance growth and metastatic capacity of melanoma cells in vitro, but their clinical significance in primary cutaneous melanoma is still unclear. Hyaluronic Acid 51-61 CD44 molecule (Indian blood group) Homo sapiens 30-34 10980134-1 2000 The cell surface glycoprotein CD44 and its ligand, hyaluronan (HA), enhance growth and metastatic capacity of melanoma cells in vitro, but their clinical significance in primary cutaneous melanoma is still unclear. Hyaluronic Acid 63-65 CD44 molecule (Indian blood group) Homo sapiens 30-34 10871609-1 2000 CD44 is the primary cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan. Hyaluronic Acid 89-99 CD44 molecule (Indian blood group) Homo sapiens 0-4 10871609-2 2000 Here we determined the relative avidities of unlabeled hyaluronan preparations for cell surface CD44 by their ability to block the binding of fluorescein-conjugated hyaluronan to a variety of cells. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 96-100 10871609-2 2000 Here we determined the relative avidities of unlabeled hyaluronan preparations for cell surface CD44 by their ability to block the binding of fluorescein-conjugated hyaluronan to a variety of cells. Hyaluronic Acid 165-175 CD44 molecule (Indian blood group) Homo sapiens 96-100 10871609-3 2000 We show that hyaluronan binding at the cell surface is a complex interplay of multivalent binding events affected by the size of the multivalent hyaluronan ligand, the quantity and density of cell surface CD44, and the activation state of CD44 as determined by cell-specific factors and/or treatment with CD44-specific monoclonal antibody (mAb). Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 205-209 10871609-3 2000 We show that hyaluronan binding at the cell surface is a complex interplay of multivalent binding events affected by the size of the multivalent hyaluronan ligand, the quantity and density of cell surface CD44, and the activation state of CD44 as determined by cell-specific factors and/or treatment with CD44-specific monoclonal antibody (mAb). Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 239-243 10871609-3 2000 We show that hyaluronan binding at the cell surface is a complex interplay of multivalent binding events affected by the size of the multivalent hyaluronan ligand, the quantity and density of cell surface CD44, and the activation state of CD44 as determined by cell-specific factors and/or treatment with CD44-specific monoclonal antibody (mAb). Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 239-243 10737894-0 2000 Interaction between CD44 and the repeat domain of ankyrin promotes hyaluronic acid-mediated ovarian tumor cell migration. Hyaluronic Acid 67-82 CD44 molecule (Indian blood group) Homo sapiens 20-24 11002457-0 2000 [The cytosolic hyaluronic acid level defines several clinico-biological properties of CD44v5-positive infiltrating ductal carcinoma of the breast]. Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Homo sapiens 86-90 11002457-1 2000 BACKGROUND: The hyaluronic acid (HA) is a ligand of CD44 adhesion molecule. Hyaluronic Acid 16-31 CD44 molecule (Indian blood group) Homo sapiens 52-56 11002457-1 2000 BACKGROUND: The hyaluronic acid (HA) is a ligand of CD44 adhesion molecule. Hyaluronic Acid 33-35 CD44 molecule (Indian blood group) Homo sapiens 52-56 10857790-10 2000 The regional loss of hyaluronan coincided with a regional up-regulation of CD44. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 75-79 10857790-13 2000 The net result is a loss of hyaluronan in areas of the articular cartilage where increases in CD44 expression are most prominent. Hyaluronic Acid 28-38 CD44 molecule (Indian blood group) Homo sapiens 94-98 10809739-0 2000 Hyaluronan anchoring and regulation on the surface of vascular endothelial cells is mediated through the functionally active form of CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 133-137 10809739-1 2000 CD44 on lymphocytes binding to its carbohydrate ligand hyaluronan can mediate primary adhesion (rolling interactions) of lymphocytes on vascular endothelial cells. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 0-4 10809739-7 2000 Hyaluronan binding activity was detected as a major species corresponding to the size of CD44, and this was confirmed to be the same by Western blotting and immunoprecipitation. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 89-93 10809739-8 2000 Moreover, alterations in the surface level of hyaluronan after tumor necrosis factor-alpha stimulation is regulated primarily by changes in the cell surface levels of the hyaluronan-binding form of CD44. Hyaluronic Acid 46-56 CD44 molecule (Indian blood group) Homo sapiens 198-202 10809739-9 2000 In laminar flow assays, lymphoid cells specifically roll on hyaluronan anchored by purified CD44 coated on glass tubes, indicating that the avidity of the endothelial CD44/hyaluronan interaction is sufficient to support rolling adhesions under conditions mimicking physiologic shear forces. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 92-96 10809739-9 2000 In laminar flow assays, lymphoid cells specifically roll on hyaluronan anchored by purified CD44 coated on glass tubes, indicating that the avidity of the endothelial CD44/hyaluronan interaction is sufficient to support rolling adhesions under conditions mimicking physiologic shear forces. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 167-171 10809739-9 2000 In laminar flow assays, lymphoid cells specifically roll on hyaluronan anchored by purified CD44 coated on glass tubes, indicating that the avidity of the endothelial CD44/hyaluronan interaction is sufficient to support rolling adhesions under conditions mimicking physiologic shear forces. Hyaluronic Acid 172-182 CD44 molecule (Indian blood group) Homo sapiens 167-171 10809739-10 2000 Together these studies show that CD44 serves to anchor hyaluronan on endothelial cell surfaces, that activation of CD44 is a major regulator of endothelial surface hyaluronan expression, and that the non-covalent interaction between CD44 and hyaluronan is sufficient to provide resistance to shear under physiologic conditions and thereby support the initial steps of lymphocyte extravasation. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 33-37 10943861-9 2000 The pretreatment of RASF with anti-CD44 monoclonal antibody (an adhesion molecule and receptor for hyaluronic acid) inhibited the destruction of the cartilaginous matrix by an average of 41% over 3 weeks. Hyaluronic Acid 99-114 CD44 molecule (Indian blood group) Homo sapiens 35-39 10929056-6 2000 This T-cell adhesion was manifested by polarization, spreading and co-localization of cell surface CD44 with a rearranged actin cytoskeleton in hyaluronan-bound T cells. Hyaluronic Acid 144-154 CD44 molecule (Indian blood group) Homo sapiens 99-103 10751416-0 2000 Oncostatin M and transforming growth factor-beta 1 induce post-translational modification and hyaluronan binding to CD44 in lung-derived epithelial tumor cells. Hyaluronic Acid 94-104 CD44 molecule (Indian blood group) Homo sapiens 116-120 10737894-1 2000 The adhesion molecule, CD44, interacts with ankyrin within its cytoplasmic domain and binds to hyaluronic acid (HA) at its extracellular domain. Hyaluronic Acid 95-110 CD44 molecule (Indian blood group) Homo sapiens 23-27 10737894-1 2000 The adhesion molecule, CD44, interacts with ankyrin within its cytoplasmic domain and binds to hyaluronic acid (HA) at its extracellular domain. Hyaluronic Acid 112-114 CD44 molecule (Indian blood group) Homo sapiens 23-27 10692236-0 2000 Human mast cells express the hyaluronic-acid-binding isoform of CD44 and adhere to hyaluronic acid. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 64-68 10805225-5 2000 Expression of CD44 and adhesion to hyaluronic acid (HA) are involved in glioma invasion. Hyaluronic Acid 52-54 CD44 molecule (Indian blood group) Homo sapiens 14-18 11100735-7 2000 Hyaluronidase, the hyaluronan-degrading enzyme, and CD44, the receptor for hyaluronan which also participates in the uptake and degradation of hyaluronan, were co-localized within the zone of ossification. Hyaluronic Acid 75-85 CD44 molecule (Indian blood group) Homo sapiens 52-56 11100735-8 2000 This pattern of expression suggests that cells in the early zone of ossification internalize and degrade hyaluronan through a CD44-mediated mechanism. Hyaluronic Acid 105-115 CD44 molecule (Indian blood group) Homo sapiens 126-130 10725329-0 2000 Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 32-36 10725329-0 2000 Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 32-36 10725329-1 2000 Both cell adhesion protein CD44 and its main ligand hyaluronic acid (HA) are thought to be involved in several processes ultimately requiring cytoskeleton rearrangements. Hyaluronic Acid 69-71 CD44 molecule (Indian blood group) Homo sapiens 27-31 10713114-1 2000 The CD44 glycoprotein is expressed in multiple isoforms on a variety of cell types where it functions as a receptor for hyaluronan-mediated motility. Hyaluronic Acid 120-130 CD44 molecule (Indian blood group) Homo sapiens 4-8 10737932-9 2000 On the basis of recent structural and mutagenesis studies, details of the CD44-hyaluronan interaction are beginning to be understood. Hyaluronic Acid 79-89 CD44 molecule (Indian blood group) Homo sapiens 74-78 10809384-9 2000 Although the HA receptor CD44 has been shown to mediate migration of cells over two-dimensional hyaluronan-coated surfaces in vitro, there is only little evidence that HA-binding to CD44 or other HA receptors has major impact on the locomotion of cells through three-dimensional matrices in vivo. Hyaluronic Acid 96-106 CD44 molecule (Indian blood group) Homo sapiens 25-29 10660111-4 2000 The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. Hyaluronic Acid 54-64 CD44 molecule (Indian blood group) Homo sapiens 46-50 10660111-5 2000 Interactions between CD44 and hyaluronan can mediate both cell-cell and cell-extracellular matrix adhesion. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 21-25 10660111-9 2000 In this commentary we have reviewed the molecular aspects of CD44 and the mechanisms that regulate its binding to hyaluronan. Hyaluronic Acid 114-124 CD44 molecule (Indian blood group) Homo sapiens 61-65 10911577-0 2000 Hyaluronic acid inhibits apoptosis in granulosa cells via CD44. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 58-62 10898120-0 2000 Expression of CD44 variants in lung cancer and its relationship to hyaluronan binding. Hyaluronic Acid 67-77 CD44 molecule (Indian blood group) Homo sapiens 14-18 10898120-1 2000 We examined the expression of CD44 variant forms and their binding to hyaluronan (HA) in lung cancer cell lines. Hyaluronic Acid 70-80 CD44 molecule (Indian blood group) Homo sapiens 30-34 10898120-1 2000 We examined the expression of CD44 variant forms and their binding to hyaluronan (HA) in lung cancer cell lines. Hyaluronic Acid 82-84 CD44 molecule (Indian blood group) Homo sapiens 30-34 10657658-0 2000 Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells. Hyaluronic Acid 130-145 CD44 molecule (Indian blood group) Homo sapiens 86-90 10692236-1 2000 CD44 is expressed in various isoforms on multiple cell lineages including those of hematopoietic origin and is believed in part to mediate cell adhesion to hyaluronic acid. Hyaluronic Acid 156-171 CD44 molecule (Indian blood group) Homo sapiens 0-4 10616194-1 1999 CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor. Hyaluronic Acid 44-59 CD44 molecule (Indian blood group) Homo sapiens 0-4 10714394-1 2000 Migration of some tumor cells, and their lodgment in target organs, is dependent on the activation of cell surface CD44 receptor, usually detected by its ability to bind hyaluronic acid (HA) or other ligands. Hyaluronic Acid 170-185 CD44 molecule (Indian blood group) Homo sapiens 115-119 10714394-1 2000 Migration of some tumor cells, and their lodgment in target organs, is dependent on the activation of cell surface CD44 receptor, usually detected by its ability to bind hyaluronic acid (HA) or other ligands. Hyaluronic Acid 187-189 CD44 molecule (Indian blood group) Homo sapiens 115-119 11206841-8 2000 Significant reduction of cell migration was observed with a monoclonal antibody against CD44 that blocks the hyaluronan-binding site of CD44, but not with an antibody that binds at an alternate site on CD44. Hyaluronic Acid 109-119 CD44 molecule (Indian blood group) Homo sapiens 88-92 11206841-8 2000 Significant reduction of cell migration was observed with a monoclonal antibody against CD44 that blocks the hyaluronan-binding site of CD44, but not with an antibody that binds at an alternate site on CD44. Hyaluronic Acid 109-119 CD44 molecule (Indian blood group) Homo sapiens 136-140 11206841-8 2000 Significant reduction of cell migration was observed with a monoclonal antibody against CD44 that blocks the hyaluronan-binding site of CD44, but not with an antibody that binds at an alternate site on CD44. Hyaluronic Acid 109-119 CD44 molecule (Indian blood group) Homo sapiens 136-140 11206841-9 2000 Intact hyaluronan and/or hyaluronan oligomers also inhibited cell migration, suggesting that the CD44-hyaluronan interaction provides an integrin-independent mechanism of control for ovarian carcinoma cell migration. Hyaluronic Acid 7-17 CD44 molecule (Indian blood group) Homo sapiens 97-101 11206841-9 2000 Intact hyaluronan and/or hyaluronan oligomers also inhibited cell migration, suggesting that the CD44-hyaluronan interaction provides an integrin-independent mechanism of control for ovarian carcinoma cell migration. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 97-101 11206841-9 2000 Intact hyaluronan and/or hyaluronan oligomers also inhibited cell migration, suggesting that the CD44-hyaluronan interaction provides an integrin-independent mechanism of control for ovarian carcinoma cell migration. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 97-101 10602047-0 2000 The role of the CD44 cytoplasmic and transmembrane domains in constitutive and inducible hyaluronan binding. Hyaluronic Acid 89-99 CD44 molecule (Indian blood group) Homo sapiens 16-20 10616194-5 1999 Briefly, we found that (a) rheumatoid synovial cells highly expressed CD44; (b) crosslinking of CD44 augmented IL-6 production and its mRNA transcription; (c) hyaluronan, especially when fragmented, also increased IL-6 production; and (d) CD44 activated the transcription factor activator protein-1 and CAMP-responsive element binding protein. Hyaluronic Acid 159-169 CD44 molecule (Indian blood group) Homo sapiens 96-100 10616194-5 1999 Briefly, we found that (a) rheumatoid synovial cells highly expressed CD44; (b) crosslinking of CD44 augmented IL-6 production and its mRNA transcription; (c) hyaluronan, especially when fragmented, also increased IL-6 production; and (d) CD44 activated the transcription factor activator protein-1 and CAMP-responsive element binding protein. Hyaluronic Acid 159-169 CD44 molecule (Indian blood group) Homo sapiens 96-100 10616194-6 1999 These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could activate transcription factor, resulting in cytokine production. Hyaluronic Acid 82-97 CD44 molecule (Indian blood group) Homo sapiens 106-110 10545519-5 1999 In vitro, human CD34(+) cells establish efficient rolling on P-selectin, E-selectin, and the CD44 ligand hyaluronic acid under physiological shear flow. Hyaluronic Acid 105-120 CD44 molecule (Indian blood group) Homo sapiens 93-97 10521464-0 1999 Mononuclear leukocytes preferentially bind via CD44 to hyaluronan on human intestinal mucosal smooth muscle cells after virus infection or treatment with poly(I.C). Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 47-51 10612197-2 1999 Hyaluronan (HYA) and its specific receptor CD44 play a central role in cell activation processes. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 43-47 10933060-0 1999 Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. Hyaluronic Acid 122-132 CD44 molecule (Indian blood group) Homo sapiens 39-43 10933060-0 1999 Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. Hyaluronic Acid 122-132 CD44 molecule (Indian blood group) Homo sapiens 85-89 10933060-3 1999 In the present study, we report the cloning of a novel, naturally occurring, differentially expressed, soluble CD44 isoform, designated CD44RC, which, in contrast to previously described soluble CD44 proteins, can dramatically enhance the hyaluronan binding activity of cell surface CD44. Hyaluronic Acid 239-249 CD44 molecule (Indian blood group) Homo sapiens 111-115 10933060-3 1999 In the present study, we report the cloning of a novel, naturally occurring, differentially expressed, soluble CD44 isoform, designated CD44RC, which, in contrast to previously described soluble CD44 proteins, can dramatically enhance the hyaluronan binding activity of cell surface CD44. Hyaluronic Acid 239-249 CD44 molecule (Indian blood group) Homo sapiens 136-140 10933060-3 1999 In the present study, we report the cloning of a novel, naturally occurring, differentially expressed, soluble CD44 isoform, designated CD44RC, which, in contrast to previously described soluble CD44 proteins, can dramatically enhance the hyaluronan binding activity of cell surface CD44. Hyaluronic Acid 239-249 CD44 molecule (Indian blood group) Homo sapiens 136-140 10933060-5 1999 Functional studies suggest that CD44RC enhances hyaluronan binding by adhering to chondroitin sulfate side-chains attached to cell surface CD44, generating a multivalent complex with increased avidity for hyaluronan. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Homo sapiens 32-36 10933060-5 1999 Functional studies suggest that CD44RC enhances hyaluronan binding by adhering to chondroitin sulfate side-chains attached to cell surface CD44, generating a multivalent complex with increased avidity for hyaluronan. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Homo sapiens 139-143 10933060-5 1999 Functional studies suggest that CD44RC enhances hyaluronan binding by adhering to chondroitin sulfate side-chains attached to cell surface CD44, generating a multivalent complex with increased avidity for hyaluronan. Hyaluronic Acid 205-215 CD44 molecule (Indian blood group) Homo sapiens 32-36 10933060-5 1999 Functional studies suggest that CD44RC enhances hyaluronan binding by adhering to chondroitin sulfate side-chains attached to cell surface CD44, generating a multivalent complex with increased avidity for hyaluronan. Hyaluronic Acid 205-215 CD44 molecule (Indian blood group) Homo sapiens 139-143 10521464-10 1999 Recognition of this virus-induced hyaluronan/CD44 mechanism of mesenchymal cell/leukocyte interaction introduces a new avenue in the research of gut inflammation. Hyaluronic Acid 34-44 CD44 molecule (Indian blood group) Homo sapiens 45-49 10459018-1 1999 CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 0-4 10493913-6 1999 The results also indicated that increased hyaluronan synthesis and shedding correlated with proteolysis of CD44 on the melanoma cell lines, which has been observed by others. Hyaluronic Acid 42-52 CD44 molecule (Indian blood group) Homo sapiens 107-111 10449175-2 1999 Although primary adhesion of lymphocytes to EC has been primarily attributed to the selectin family of receptors, CD44 can also mediate this function when activated to bind its ligand hyaluronan (HA). Hyaluronic Acid 184-194 CD44 molecule (Indian blood group) Homo sapiens 114-118 10449175-2 1999 Although primary adhesion of lymphocytes to EC has been primarily attributed to the selectin family of receptors, CD44 can also mediate this function when activated to bind its ligand hyaluronan (HA). Hyaluronic Acid 196-198 CD44 molecule (Indian blood group) Homo sapiens 114-118 10517181-8 1999 We hypothesize that hyaluronan binds aggrecan and link protein, forming stable ternary complexes, which interact with the chondrocyte surface, perhaps via CD44, and thus maintains a stable chondrocyte-matrix network. Hyaluronic Acid 20-30 CD44 molecule (Indian blood group) Homo sapiens 155-159 10694938-5 1999 The principal ligand of CD44 is hyaluronic acid, an integral component of the extracellular matrix. Hyaluronic Acid 32-47 CD44 molecule (Indian blood group) Homo sapiens 24-28 10388538-0 1999 Interferon-gamma inhibits CD44-hyaluronan interactions in normal human B lymphocytes. Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 26-30 10388538-1 1999 The interaction of CD44 with its ligand hyaluronan (HA) plays a vital role in lymphopoiesis, lymphocyte homing, T cell activation, and metastasis. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 19-23 10476048-5 1999 It is suggested that in analogy to carcinoma invasion where a tumour-induced production of hyaluronan was found in fibroblasts at the invasive margin of the tumour, in the brain reactive astrocytes may produce hyaluronan which would facilitate the adhesion of new CD44-positive astrocytic processes but which would also promote tumour invasion. Hyaluronic Acid 91-101 CD44 molecule (Indian blood group) Homo sapiens 264-268 10476048-5 1999 It is suggested that in analogy to carcinoma invasion where a tumour-induced production of hyaluronan was found in fibroblasts at the invasive margin of the tumour, in the brain reactive astrocytes may produce hyaluronan which would facilitate the adhesion of new CD44-positive astrocytic processes but which would also promote tumour invasion. Hyaluronic Acid 210-220 CD44 molecule (Indian blood group) Homo sapiens 264-268 10459018-1 1999 CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells. Hyaluronic Acid 59-61 CD44 molecule (Indian blood group) Homo sapiens 0-4 10354075-8 1999 CD44 has been proposed to play a part in lymphocyte homing, cell-matrix interaction (particularly with hyaluronic acid), lymphocyte activation and malignant progression of certain tumours. Hyaluronic Acid 103-118 CD44 molecule (Indian blood group) Homo sapiens 0-4 10362554-7 1999 As a control, we show that anti-CD44 (10 microg/ml) inhibited cell migration on a pure hyaluronan matrix using a two-dimensional Boyden chamber system. Hyaluronic Acid 87-97 CD44 molecule (Indian blood group) Homo sapiens 32-36 10383941-8 1999 In line with this possibility, we found that CD4 triggering by gp120, a natural ligand of CD4, potentiates CD44-mediated adhesion to hyaluronic acid. Hyaluronic Acid 133-148 CD44 molecule (Indian blood group) Homo sapiens 107-111 10371506-5 1999 Here, we report that ligation of CD44 with specific anti-CD44 monoclonal antibodies or with hyaluronan, its natural ligand, can reverse myeloid differentiation blockage in AML1/2 to AML5 subtypes. Hyaluronic Acid 92-102 CD44 molecule (Indian blood group) Homo sapiens 33-37 10465577-0 1999 CD44 variant isoform CD44v10 expression of human melanoma cell lines is upregulated by hyaluronate and correlates with migration. Hyaluronic Acid 87-98 CD44 molecule (Indian blood group) Homo sapiens 0-4 10209956-9 1999 These findings indicate that hyaluronic acid could offer an important advantage in drug delivery, in addition to its biocompatibility: the ability to bind to CD44, which are known to be frequently over-expressed on the tumor-cell surface. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 158-162 10357881-0 1999 Regulation of CD44-hyaluronan interactions in Burkitt"s lymphoma and Epstein-Barr virus-transformed lymphoblastoid B cells by PMA and interleukin-4. Hyaluronic Acid 19-29 CD44 molecule (Indian blood group) Homo sapiens 14-18 10357881-1 1999 In this study, we investigated the regulation of CD44-hyaluronan (HA) interactions in a panel of EBV+ Burkitt"s lymphoma (BL) and lymphoblastoid B cell lines (B-LCL) generated by in vitro EBV transformation of normal human B cells. Hyaluronic Acid 54-64 CD44 molecule (Indian blood group) Homo sapiens 49-53 10088720-7 1999 Our data show that although the CD44-hlg fusion proteins could interact with hyaluronic acid as expected, there was no interaction between CD44H, CD44E, CD44v3,v8-v10, or CD44v3 with osteopontin. Hyaluronic Acid 77-92 CD44 molecule (Indian blood group) Homo sapiens 32-36 10222064-0 1999 TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44. Hyaluronic Acid 32-42 CD44 molecule (Indian blood group) Homo sapiens 63-67 10222064-0 1999 TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44. Hyaluronic Acid 32-42 CD44 molecule (Indian blood group) Homo sapiens 111-115 10353740-2 1999 Standard CD44 (CD44S) is the principal receptor for hyaluronic acid, and in vitro and animal studies have suggested that the attachment of ovarian carcinoma cells to the peritoneal mesothelium involves the interaction between CD44S on ovarian carcinoma cells and hyaluronic acid on mesothelial surfaces. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 9-13 10353740-2 1999 Standard CD44 (CD44S) is the principal receptor for hyaluronic acid, and in vitro and animal studies have suggested that the attachment of ovarian carcinoma cells to the peritoneal mesothelium involves the interaction between CD44S on ovarian carcinoma cells and hyaluronic acid on mesothelial surfaces. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 15-20 10353740-2 1999 Standard CD44 (CD44S) is the principal receptor for hyaluronic acid, and in vitro and animal studies have suggested that the attachment of ovarian carcinoma cells to the peritoneal mesothelium involves the interaction between CD44S on ovarian carcinoma cells and hyaluronic acid on mesothelial surfaces. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 226-231 10353740-2 1999 Standard CD44 (CD44S) is the principal receptor for hyaluronic acid, and in vitro and animal studies have suggested that the attachment of ovarian carcinoma cells to the peritoneal mesothelium involves the interaction between CD44S on ovarian carcinoma cells and hyaluronic acid on mesothelial surfaces. Hyaluronic Acid 263-278 CD44 molecule (Indian blood group) Homo sapiens 9-13 10353740-2 1999 Standard CD44 (CD44S) is the principal receptor for hyaluronic acid, and in vitro and animal studies have suggested that the attachment of ovarian carcinoma cells to the peritoneal mesothelium involves the interaction between CD44S on ovarian carcinoma cells and hyaluronic acid on mesothelial surfaces. Hyaluronic Acid 263-278 CD44 molecule (Indian blood group) Homo sapiens 15-20 10353740-2 1999 Standard CD44 (CD44S) is the principal receptor for hyaluronic acid, and in vitro and animal studies have suggested that the attachment of ovarian carcinoma cells to the peritoneal mesothelium involves the interaction between CD44S on ovarian carcinoma cells and hyaluronic acid on mesothelial surfaces. Hyaluronic Acid 263-278 CD44 molecule (Indian blood group) Homo sapiens 226-231 10227973-0 1999 Cutting edge: an inducible sialidase regulates the hyaluronic acid binding ability of CD44-bearing human monocytes. Hyaluronic Acid 51-66 CD44 molecule (Indian blood group) Homo sapiens 86-90 10227973-1 1999 Previous studies established that variable degrees and types of glycosylation can account for differences in the ability of CD44 to function as a receptor for hyaluronic acid. Hyaluronic Acid 159-174 CD44 molecule (Indian blood group) Homo sapiens 124-128 10484683-0 1999 CD3-mediated T cell activation is inhibited by anti-CD44 monoclonal antibodies directed to the hyaluronan-binding region. Hyaluronic Acid 95-105 CD44 molecule (Indian blood group) Homo sapiens 52-56 10484683-7 1999 Interestingly, the ability of anti-CD44 MoAb to inhibit T cell activation was well correlated with their capability to block the binding of hyaluronan (HA) to CD44 molecules. Hyaluronic Acid 152-154 CD44 molecule (Indian blood group) Homo sapiens 35-39 10484683-7 1999 Interestingly, the ability of anti-CD44 MoAb to inhibit T cell activation was well correlated with their capability to block the binding of hyaluronan (HA) to CD44 molecules. Hyaluronic Acid 152-154 CD44 molecule (Indian blood group) Homo sapiens 159-163 10484683-7 1999 Interestingly, the ability of anti-CD44 MoAb to inhibit T cell activation was well correlated with their capability to block the binding of hyaluronan (HA) to CD44 molecules. Hyaluronic Acid 140-150 CD44 molecule (Indian blood group) Homo sapiens 35-39 10484683-7 1999 Interestingly, the ability of anti-CD44 MoAb to inhibit T cell activation was well correlated with their capability to block the binding of hyaluronan (HA) to CD44 molecules. Hyaluronic Acid 140-150 CD44 molecule (Indian blood group) Homo sapiens 159-163 10845557-0 1999 Membrane protein glycosylation and CD44 content in the adhesion of human ovarian cancer cells to hyaluronan. Hyaluronic Acid 97-107 CD44 molecule (Indian blood group) Homo sapiens 35-39 10037799-0 1999 LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. Hyaluronic Acid 83-93 CD44 molecule (Indian blood group) Homo sapiens 31-35 10048415-2 1999 More recently it has become apparent that CD44 antibodies cannot only inhibit CD44 mediated adhesion to hyaluronic acid and cellular ligands but can stimulate adhesion to these ligands. Hyaluronic Acid 104-119 CD44 molecule (Indian blood group) Homo sapiens 42-46 10048415-2 1999 More recently it has become apparent that CD44 antibodies cannot only inhibit CD44 mediated adhesion to hyaluronic acid and cellular ligands but can stimulate adhesion to these ligands. Hyaluronic Acid 104-119 CD44 molecule (Indian blood group) Homo sapiens 78-82 10048415-4 1999 While adhesion of T cells to keratinocytes is integrin mediated it appears that adhesion of hematopoietic progenitors to bone marrow stromal layers is the result of an antibody induced conformational change in the CD44 molecule similar to that seem for the augmentation of hyaluronic acid binding by some CD44 antibodies. Hyaluronic Acid 273-288 CD44 molecule (Indian blood group) Homo sapiens 214-218 9973520-1 1999 CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor. Hyaluronic Acid 44-59 CD44 molecule (Indian blood group) Homo sapiens 0-4 9973520-4 1999 Using synovial cells from rheumatoid arthritis (RA) patients, we demonstrated that CD44 cross-linking and binding to hyaluronan augmented VCAM-1 expression and subsequently VCAM-1-mediated cell adhesion. Hyaluronic Acid 117-127 CD44 molecule (Indian blood group) Homo sapiens 83-87 9973520-5 1999 Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking. Hyaluronic Acid 226-236 CD44 molecule (Indian blood group) Homo sapiens 95-99 9973520-5 1999 Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking. Hyaluronic Acid 226-236 CD44 molecule (Indian blood group) Homo sapiens 95-99 9973520-5 1999 Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking. Hyaluronic Acid 226-236 CD44 molecule (Indian blood group) Homo sapiens 95-99 9973520-6 1999 These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could up-regulate VCAM-1 expression and VCAM-1-mediated adhesion to T cells, which might in turn cause activation of T cells and synovial cells in RA synovitis. Hyaluronic Acid 82-97 CD44 molecule (Indian blood group) Homo sapiens 106-110 9634539-4 1998 This structural arrangement, which occurs within either the invariant region or the extracellular domain of the variant region, is important for CD44-mediated communication between extracellular matrix materials [ECM-hyaluronic acid (HA), collagen and fibronectin] and intracellular protein components (e.g cytoskeletal proteins and various regulatory enzymes). Hyaluronic Acid 217-232 CD44 molecule (Indian blood group) Homo sapiens 145-149 9634638-0 1998 Mechanisms regulating the binding activity of CD44 to hyaluronic acid. Hyaluronic Acid 54-69 CD44 molecule (Indian blood group) Homo sapiens 46-50 9634638-5 1998 One of the ligands for CD44 is hyaluronic acid (HA), a polymer consisting of repeat units of disaccharide; N-acetyl-D-glucosamine and N-acetyl-D-glucuronic acid. Hyaluronic Acid 31-46 CD44 molecule (Indian blood group) Homo sapiens 23-27 9634638-5 1998 One of the ligands for CD44 is hyaluronic acid (HA), a polymer consisting of repeat units of disaccharide; N-acetyl-D-glucosamine and N-acetyl-D-glucuronic acid. Hyaluronic Acid 48-50 CD44 molecule (Indian blood group) Homo sapiens 23-27 9887098-4 1999 Several distinct CD44 isoforms coprecipitate with MMP-9 and CD44/MMP-9 coclustering is observed to be dependent on the ability of CD44 to form hyaluronan-induced aggregates. Hyaluronic Acid 143-153 CD44 molecule (Indian blood group) Homo sapiens 17-21 9887098-4 1999 Several distinct CD44 isoforms coprecipitate with MMP-9 and CD44/MMP-9 coclustering is observed to be dependent on the ability of CD44 to form hyaluronan-induced aggregates. Hyaluronic Acid 143-153 CD44 molecule (Indian blood group) Homo sapiens 60-64 9887098-4 1999 Several distinct CD44 isoforms coprecipitate with MMP-9 and CD44/MMP-9 coclustering is observed to be dependent on the ability of CD44 to form hyaluronan-induced aggregates. Hyaluronic Acid 143-153 CD44 molecule (Indian blood group) Homo sapiens 60-64 9878114-0 1998 Identification of two regions in the cytoplasmic domain of CD44 through which PMA, calcium, and foskolin differentially regulate the binding of CD44 to hyaluronic acid. Hyaluronic Acid 152-167 CD44 molecule (Indian blood group) Homo sapiens 59-63 9878114-0 1998 Identification of two regions in the cytoplasmic domain of CD44 through which PMA, calcium, and foskolin differentially regulate the binding of CD44 to hyaluronic acid. Hyaluronic Acid 152-167 CD44 molecule (Indian blood group) Homo sapiens 144-148 9878114-5 1998 The effects of these mutations on the binding of CD44 to one of its ligands, hyaluronic acid (HA), were studied. Hyaluronic Acid 77-92 CD44 molecule (Indian blood group) Homo sapiens 49-53 9878114-5 1998 The effects of these mutations on the binding of CD44 to one of its ligands, hyaluronic acid (HA), were studied. Hyaluronic Acid 94-96 CD44 molecule (Indian blood group) Homo sapiens 49-53 9882571-0 1998 Characterization of a functional hyaluronan-binding domain from the human CD44 molecule expressed in Escherichia coli. Hyaluronic Acid 33-43 CD44 molecule (Indian blood group) Homo sapiens 74-78 9882571-7 1998 We show the method yields CD44 molecules that (1) retain reactivity with a panel of conformation-sensitive antibodies, (2) possess similar hyaluronan-binding characteristics to authentically folded CD44 molecules expressed in eukaryotic cells, and (3) display one-dimensional NMR spectra that indicate the presence of a single conformational species. Hyaluronic Acid 139-149 CD44 molecule (Indian blood group) Homo sapiens 26-30 9794764-4 1998 This posttranslational modification was required for CD44-mediated binding to the extracellular matrix component hyaluronan and to vascular endothelial cells. Hyaluronic Acid 113-123 CD44 molecule (Indian blood group) Homo sapiens 53-57 9751413-3 1998 The effects of the reintroduction of CD44s into PC3 cells on the ability to bind hyaluronic acid (HA) were analyzed by the cell adhesion assay and by the cell migration assay. Hyaluronic Acid 81-96 CD44 molecule (Indian blood group) Homo sapiens 37-41 9751413-3 1998 The effects of the reintroduction of CD44s into PC3 cells on the ability to bind hyaluronic acid (HA) were analyzed by the cell adhesion assay and by the cell migration assay. Hyaluronic Acid 98-100 CD44 molecule (Indian blood group) Homo sapiens 37-41 9842575-8 1998 Studies of cell cultures have shown that leukocyte adhesion and migration are inhibited by substances (antibodies, peptides, high levels of hyaluronate) that prevent hyaluronate from binding to CD44 and RHAMM. Hyaluronic Acid 140-151 CD44 molecule (Indian blood group) Homo sapiens 194-198 9842575-8 1998 Studies of cell cultures have shown that leukocyte adhesion and migration are inhibited by substances (antibodies, peptides, high levels of hyaluronate) that prevent hyaluronate from binding to CD44 and RHAMM. Hyaluronic Acid 166-177 CD44 molecule (Indian blood group) Homo sapiens 194-198 9842575-11 1998 Hyaluronate both stimulates SMC migration via an effect on RHAMM and enhances SMC division via an effect on CD44. Hyaluronic Acid 0-11 CD44 molecule (Indian blood group) Homo sapiens 108-112 9681695-11 1998 We presume that CD44 is involved in local binding, reuptake, and degradation of hyaluronan in the early stages of taste bud formation. Hyaluronic Acid 80-90 CD44 molecule (Indian blood group) Homo sapiens 16-20 9634543-5 1998 As such, hyaluronan may function as a ligand for CD44-mediated locomotion or assemble into a protective matrix coat surrounding the tumor cells. Hyaluronic Acid 9-19 CD44 molecule (Indian blood group) Homo sapiens 49-53 9634543-7 1998 The significance of tumor-associated hyaluronan accumulation as well as potential functions of CD44--hyaluronan interactions are reviewed. Hyaluronic Acid 101-111 CD44 molecule (Indian blood group) Homo sapiens 95-99 9634544-3 1998 The hyaluronan binding function of CD44 has been assayed in cell lines and in fusion proteins, termed CD44-Igs, consisting of the external domain of CD44 coupled to the hinge, CH2 and CH3 regions of human IgG1. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Homo sapiens 35-39 9634544-3 1998 The hyaluronan binding function of CD44 has been assayed in cell lines and in fusion proteins, termed CD44-Igs, consisting of the external domain of CD44 coupled to the hinge, CH2 and CH3 regions of human IgG1. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Homo sapiens 102-106 9634544-3 1998 The hyaluronan binding function of CD44 has been assayed in cell lines and in fusion proteins, termed CD44-Igs, consisting of the external domain of CD44 coupled to the hinge, CH2 and CH3 regions of human IgG1. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Homo sapiens 102-106 9634544-4 1998 These studies have shown that hyaluronan binding by CD44 is regulated by the cells in which it is expressed, and that at least part of this regulation is determined by cell specific posttranslational modifications, especially N-glycosylation, of CD44 itself. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 52-56 9634544-4 1998 These studies have shown that hyaluronan binding by CD44 is regulated by the cells in which it is expressed, and that at least part of this regulation is determined by cell specific posttranslational modifications, especially N-glycosylation, of CD44 itself. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 246-250 9634544-5 1998 Variant isoforms of CD44 determined by alternative splicing of 11 optional exons in the middle of the gene determine additional functions of CD44, as well as contributing to the regulation of hyaluronan binding. Hyaluronic Acid 192-202 CD44 molecule (Indian blood group) Homo sapiens 20-24 9634546-1 1998 CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified as hyaluronic acid (HA), a major component of the extracellular matrix (ECM). Hyaluronic Acid 101-116 CD44 molecule (Indian blood group) Homo sapiens 0-4 9634546-1 1998 CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified as hyaluronic acid (HA), a major component of the extracellular matrix (ECM). Hyaluronic Acid 118-120 CD44 molecule (Indian blood group) Homo sapiens 0-4 9634546-9 1998 For example, dysregulation in the interaction between activated cytotoxic lymphocytes expressing CD44 and endothelial cells bearing the appropriated ligand such as the hyaluronate (HA), could lead to endothelial cell lysis. Hyaluronic Acid 168-179 CD44 molecule (Indian blood group) Homo sapiens 97-101 9634546-9 1998 For example, dysregulation in the interaction between activated cytotoxic lymphocytes expressing CD44 and endothelial cells bearing the appropriated ligand such as the hyaluronate (HA), could lead to endothelial cell lysis. Hyaluronic Acid 181-183 CD44 molecule (Indian blood group) Homo sapiens 97-101 9541502-0 1998 Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 127-131 9580567-0 1998 Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 56-60 9573028-1 1998 CD44 is the major cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan and is implicated in a variety of biological events that include embryonic morphogenesis, lymphocyte recirculation, inflammation, and tumor metastasis. Hyaluronic Acid 87-97 CD44 molecule (Indian blood group) Homo sapiens 0-4 9417085-0 1998 Identification of CD44 residues important for hyaluronan binding and delineation of the binding site. Hyaluronic Acid 46-56 CD44 molecule (Indian blood group) Homo sapiens 18-22 9446831-6 1998 In contrast, CD44 was abundant on plasma membrane domains facing an open intercellular space, rich in hyaluronan. Hyaluronic Acid 102-112 CD44 molecule (Indian blood group) Homo sapiens 13-17 9417085-5 1998 The cartilage link protein-like domain of CD44 is important for hyaluronan binding. Hyaluronic Acid 64-74 CD44 molecule (Indian blood group) Homo sapiens 42-46 9519902-0 1998 The ankyrin-binding domain of CD44s is involved in regulating hyaluronic acid-mediated functions and prostate tumor cell transformation. Hyaluronic Acid 62-77 CD44 molecule (Indian blood group) Homo sapiens 30-34 9519902-1 1998 CD44 isoforms, such as CD44s (the standard form), contain at least one ankyrin-binding site within the 70-amino acid (aa) cytoplasmic domain and several hyaluronic acid (HA)-binding sites within the extracellular domain. Hyaluronic Acid 153-168 CD44 molecule (Indian blood group) Homo sapiens 23-27 9519902-1 1998 CD44 isoforms, such as CD44s (the standard form), contain at least one ankyrin-binding site within the 70-amino acid (aa) cytoplasmic domain and several hyaluronic acid (HA)-binding sites within the extracellular domain. Hyaluronic Acid 170-172 CD44 molecule (Indian blood group) Homo sapiens 0-4 9519902-1 1998 CD44 isoforms, such as CD44s (the standard form), contain at least one ankyrin-binding site within the 70-amino acid (aa) cytoplasmic domain and several hyaluronic acid (HA)-binding sites within the extracellular domain. Hyaluronic Acid 170-172 CD44 molecule (Indian blood group) Homo sapiens 23-27 9823466-3 1998 In order to mediate these diverse events, CD44 expressing cells must be able to regulate, and respond to, interactions with hyaluronan. Hyaluronic Acid 124-134 CD44 molecule (Indian blood group) Homo sapiens 42-46 9519902-1 1998 CD44 isoforms, such as CD44s (the standard form), contain at least one ankyrin-binding site within the 70-amino acid (aa) cytoplasmic domain and several hyaluronic acid (HA)-binding sites within the extracellular domain. Hyaluronic Acid 153-168 CD44 molecule (Indian blood group) Homo sapiens 0-4 9476059-1 1998 CD44 is an integral membrane glycoprotein, functioning as the receptor for hyaluronic acid. Hyaluronic Acid 75-90 CD44 molecule (Indian blood group) Homo sapiens 0-4 9683266-1 1997 Regulation of CD44-mediated binding to hyaluronan is critical in normal and diseased immune cell function. Hyaluronic Acid 39-49 CD44 molecule (Indian blood group) Homo sapiens 14-18 9550421-0 1997 Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13. Hyaluronic Acid 65-75 CD44 molecule (Indian blood group) Homo sapiens 52-56 9550421-1 1997 Ligation of CD44 by hyaluronan (HA) is a key proinflammatory event that regulates lymphocyte and monocyte adhesion and cytokine production. Hyaluronic Acid 20-30 CD44 molecule (Indian blood group) Homo sapiens 12-16 9704335-6 1998 CD44 may play a role in binding and turnover of hyaluronic acid in the trabecular meshwork, thereby regulating outflow facility. Hyaluronic Acid 48-63 CD44 molecule (Indian blood group) Homo sapiens 0-4 9511993-5 1997 The major ligand for CD44 is the extracellular matrix glycosaminoglycan, hyaluronic acid (HA). Hyaluronic Acid 73-88 CD44 molecule (Indian blood group) Homo sapiens 21-25 9417886-6 1997 The endothelial cell line, which does not synthesize hyaluronan, exhibited specific hyaluronan-binding sites, with about 3000 hyaluronan molecules (M(r) 3.85 x 10(6)) bound per cell at saturation and Kd was 0.05 x 10(-9) M. Furthermore, the cell line was stained with mAb IVd4 that recognizes a novel class of hyaluronan-binding proteins and mAb IM7 which recognizes CD44 molecules. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 367-371 9417886-6 1997 The endothelial cell line, which does not synthesize hyaluronan, exhibited specific hyaluronan-binding sites, with about 3000 hyaluronan molecules (M(r) 3.85 x 10(6)) bound per cell at saturation and Kd was 0.05 x 10(-9) M. Furthermore, the cell line was stained with mAb IVd4 that recognizes a novel class of hyaluronan-binding proteins and mAb IM7 which recognizes CD44 molecules. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 367-371 9417886-6 1997 The endothelial cell line, which does not synthesize hyaluronan, exhibited specific hyaluronan-binding sites, with about 3000 hyaluronan molecules (M(r) 3.85 x 10(6)) bound per cell at saturation and Kd was 0.05 x 10(-9) M. Furthermore, the cell line was stained with mAb IVd4 that recognizes a novel class of hyaluronan-binding proteins and mAb IM7 which recognizes CD44 molecules. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 367-371 9511993-5 1997 The major ligand for CD44 is the extracellular matrix glycosaminoglycan, hyaluronic acid (HA). Hyaluronic Acid 90-92 CD44 molecule (Indian blood group) Homo sapiens 21-25 9247577-1 1997 CD44 is a broadly expressed cell surface glycoprotein which is the major cell surface receptor for the glycosaminoglycan, hyaluronan. Hyaluronic Acid 122-132 CD44 molecule (Indian blood group) Homo sapiens 0-4 9330866-3 1997 A structural model is now available for the portion of CD44 that recognizes hyaluronan, but it is clear that all domains of the molecule influence CD44 functions. Hyaluronic Acid 76-86 CD44 molecule (Indian blood group) Homo sapiens 55-59 9300670-2 1997 The requirements for the "activation" of CD44 to bind its major ligand, hyaluronan (HA), and the in vivo role of this interaction remain unresolved. Hyaluronic Acid 72-82 CD44 molecule (Indian blood group) Homo sapiens 41-45 9300670-2 1997 The requirements for the "activation" of CD44 to bind its major ligand, hyaluronan (HA), and the in vivo role of this interaction remain unresolved. Hyaluronic Acid 84-86 CD44 molecule (Indian blood group) Homo sapiens 41-45 10462610-1 1997 Background: CD44, a major cell surface receptor for hyaluronic acid, is a family of ubiquitous cell surface glycoproteins. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 12-16 9298694-1 1997 CD44 is a major cell surface receptor for the glycosaminoglycan, hyaluronan (HA). Hyaluronic Acid 65-75 CD44 molecule (Indian blood group) Homo sapiens 0-4 9298694-1 1997 CD44 is a major cell surface receptor for the glycosaminoglycan, hyaluronan (HA). Hyaluronic Acid 77-79 CD44 molecule (Indian blood group) Homo sapiens 0-4 9298699-5 1997 The major ligand for CD44 is the extracellular matrix glycosaminoglycan, hyaluronic acid (HA). Hyaluronic Acid 73-88 CD44 molecule (Indian blood group) Homo sapiens 21-25 9298699-5 1997 The major ligand for CD44 is the extracellular matrix glycosaminoglycan, hyaluronic acid (HA). Hyaluronic Acid 90-92 CD44 molecule (Indian blood group) Homo sapiens 21-25 18372518-1 1997 CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan. Hyaluronic Acid 108-118 CD44 molecule (Indian blood group) Homo sapiens 0-4 9364462-2 1997 CD44 is one of the cell surface adhesion molecules responsible for interaction with hyaluronic acid, a component of the CNS extracellular matrix. Hyaluronic Acid 84-99 CD44 molecule (Indian blood group) Homo sapiens 0-4 9364462-8 1997 Invasion of cells derived from those gliomas carrying the rearranged CD44 gene locus was decreased by about 50% compared with gliomas without rearrangement, indicating that the altered hybridization patterns in the two glioma samples influenced CD44H mediated glioma cell invasion through hyaluronic acid in vitro. Hyaluronic Acid 289-304 CD44 molecule (Indian blood group) Homo sapiens 69-73 9364462-8 1997 Invasion of cells derived from those gliomas carrying the rearranged CD44 gene locus was decreased by about 50% compared with gliomas without rearrangement, indicating that the altered hybridization patterns in the two glioma samples influenced CD44H mediated glioma cell invasion through hyaluronic acid in vitro. Hyaluronic Acid 289-304 CD44 molecule (Indian blood group) Homo sapiens 245-249 9300690-3 1997 One of the ligands for CD44 is hyaluronic acid (HA). Hyaluronic Acid 31-46 CD44 molecule (Indian blood group) Homo sapiens 23-27 9300690-3 1997 One of the ligands for CD44 is hyaluronic acid (HA). Hyaluronic Acid 48-50 CD44 molecule (Indian blood group) Homo sapiens 23-27 9260564-2 1997 In addition to contributing to the unique structure of the pericellular matrix, hyaluronan interacts with cell surface receptors, such as RHAMM and CD44. Hyaluronic Acid 80-90 CD44 molecule (Indian blood group) Homo sapiens 148-152 9260564-4 1997 First, hyaluronan-CD44 interactions have been shown to mediate endocytic removal of hyaluronan at critical stages of embryonic development. Hyaluronic Acid 7-17 CD44 molecule (Indian blood group) Homo sapiens 18-22 9260564-4 1997 First, hyaluronan-CD44 interactions have been shown to mediate endocytic removal of hyaluronan at critical stages of embryonic development. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 18-22 9260564-6 1997 Thirdly, in-vitro studies suggest strongly that interactions of hyaluronan with RHAMM or CD44 are involved in cell movement and proliferation, which are critical events in morphogenesis. Hyaluronic Acid 64-74 CD44 molecule (Indian blood group) Homo sapiens 89-93 21590147-6 1997 We suggest that cancer cells expressing the CD44 molecule especially V6 may adhere to vascular endothelium and hyaluronic acid in the lung. Hyaluronic Acid 111-126 CD44 molecule (Indian blood group) Homo sapiens 44-48 9190898-6 1997 The induction of CD44V by TPA, IGF-1 or PDGF was correlated with an increased cellular binding to hyaluronic acid, a major counterreceptor for CD44. Hyaluronic Acid 98-113 CD44 molecule (Indian blood group) Homo sapiens 17-21 9190898-6 1997 The induction of CD44V by TPA, IGF-1 or PDGF was correlated with an increased cellular binding to hyaluronic acid, a major counterreceptor for CD44. Hyaluronic Acid 98-113 CD44 molecule (Indian blood group) Homo sapiens 143-147 9102228-8 1997 However, the ability of the CD44 receptor to bind immobilized hyaluronan was restricted to CD44H+ cell lines without NMYC amplification (SH-EP and ACN). Hyaluronic Acid 62-72 CD44 molecule (Indian blood group) Homo sapiens 28-32 9196442-0 1997 Glioma invasion in vitro is mediated by CD44-hyaluronan interactions. Hyaluronic Acid 45-55 CD44 molecule (Indian blood group) Homo sapiens 40-44 9058710-0 1997 CD44-mediated adhesiveness of human hematopoietic progenitors to hyaluronan is modulated by cytokines. Hyaluronic Acid 65-75 CD44 molecule (Indian blood group) Homo sapiens 0-4 9058710-2 1997 We have investigated whether cell surface proteoglycan CD44 can mediate adhesion of human CD34+ HPC to immobilized hyaluronan (HA), an abundant glycosaminoglycan of the bone marrow extracellular matrix. Hyaluronic Acid 115-125 CD44 molecule (Indian blood group) Homo sapiens 55-59 9058710-2 1997 We have investigated whether cell surface proteoglycan CD44 can mediate adhesion of human CD34+ HPC to immobilized hyaluronan (HA), an abundant glycosaminoglycan of the bone marrow extracellular matrix. Hyaluronic Acid 127-129 CD44 molecule (Indian blood group) Homo sapiens 55-59 9111868-12 1997 Hyaluronic acid (HA), an important component of the extracellular matrix (ECM), is the principal, but by no means the only, ligand of CD44. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 134-138 8922140-0 1997 The hyaluronan-binding adhesion molecule CD44: expression in normal and diseased kidneys and by cultured mesangial cells. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Homo sapiens 41-45 9111868-12 1997 Hyaluronic acid (HA), an important component of the extracellular matrix (ECM), is the principal, but by no means the only, ligand of CD44. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 134-138 8906846-6 1996 Lastly, PMN lyse target cells coated with hyaluronic acid (HA), the principal ligand for CD44, and this cytolytic activity is specifically blocked by the polyclonal anti-CD44 F(ab")2 and by an anti-CD44 mAb. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 89-93 9037387-10 1996 Considering the fact that CD44 is a receptor molecule for hyaluronic acid, the association of hyaluronic acid with the basal membrane and weakly or faintly with the lateral membrane of acinar and ductal cells may be attributed to the expression of CD44 on the baso-lateral membrane of the cells. Hyaluronic Acid 58-73 CD44 molecule (Indian blood group) Homo sapiens 26-30 9037387-10 1996 Considering the fact that CD44 is a receptor molecule for hyaluronic acid, the association of hyaluronic acid with the basal membrane and weakly or faintly with the lateral membrane of acinar and ductal cells may be attributed to the expression of CD44 on the baso-lateral membrane of the cells. Hyaluronic Acid 58-73 CD44 molecule (Indian blood group) Homo sapiens 248-252 9037387-10 1996 Considering the fact that CD44 is a receptor molecule for hyaluronic acid, the association of hyaluronic acid with the basal membrane and weakly or faintly with the lateral membrane of acinar and ductal cells may be attributed to the expression of CD44 on the baso-lateral membrane of the cells. Hyaluronic Acid 94-109 CD44 molecule (Indian blood group) Homo sapiens 26-30 9037387-10 1996 Considering the fact that CD44 is a receptor molecule for hyaluronic acid, the association of hyaluronic acid with the basal membrane and weakly or faintly with the lateral membrane of acinar and ductal cells may be attributed to the expression of CD44 on the baso-lateral membrane of the cells. Hyaluronic Acid 94-109 CD44 molecule (Indian blood group) Homo sapiens 248-252 8929456-0 1996 Binding of CD44 to hyaluronic acid can be induced by multiple signals and requires the CD44 cytoplasmic domain. Hyaluronic Acid 19-34 CD44 molecule (Indian blood group) Homo sapiens 11-15 8929456-0 1996 Binding of CD44 to hyaluronic acid can be induced by multiple signals and requires the CD44 cytoplasmic domain. Hyaluronic Acid 19-34 CD44 molecule (Indian blood group) Homo sapiens 87-91 8906846-6 1996 Lastly, PMN lyse target cells coated with hyaluronic acid (HA), the principal ligand for CD44, and this cytolytic activity is specifically blocked by the polyclonal anti-CD44 F(ab")2 and by an anti-CD44 mAb. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 170-174 8906846-6 1996 Lastly, PMN lyse target cells coated with hyaluronic acid (HA), the principal ligand for CD44, and this cytolytic activity is specifically blocked by the polyclonal anti-CD44 F(ab")2 and by an anti-CD44 mAb. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 170-174 8906846-6 1996 Lastly, PMN lyse target cells coated with hyaluronic acid (HA), the principal ligand for CD44, and this cytolytic activity is specifically blocked by the polyclonal anti-CD44 F(ab")2 and by an anti-CD44 mAb. Hyaluronic Acid 59-61 CD44 molecule (Indian blood group) Homo sapiens 89-93 8906846-6 1996 Lastly, PMN lyse target cells coated with hyaluronic acid (HA), the principal ligand for CD44, and this cytolytic activity is specifically blocked by the polyclonal anti-CD44 F(ab")2 and by an anti-CD44 mAb. Hyaluronic Acid 59-61 CD44 molecule (Indian blood group) Homo sapiens 170-174 8906846-6 1996 Lastly, PMN lyse target cells coated with hyaluronic acid (HA), the principal ligand for CD44, and this cytolytic activity is specifically blocked by the polyclonal anti-CD44 F(ab")2 and by an anti-CD44 mAb. Hyaluronic Acid 59-61 CD44 molecule (Indian blood group) Homo sapiens 170-174 8886879-10 1996 Since CD44 is known to act as a receptor for hyaluronic acid, which is a prominent stromal component and known to play an important role in cell mobility and tumor aggressiveness, its high expression in association with PFSR would suggest a role of CD44 overexpression in altered hyaluronate metabolism with accelerated tumor cell migration and subsequent distal spread. Hyaluronic Acid 45-60 CD44 molecule (Indian blood group) Homo sapiens 6-10 8878421-11 1996 Anti-CD44 antibody blocked fibroblast migration on the provisional matrix proteins fibronectin, fibrinogen, and hyaluronic acid. Hyaluronic Acid 112-127 CD44 molecule (Indian blood group) Homo sapiens 5-9 8892681-6 1996 As expected, >90% of cells in all primary normal and leukemic samples expressed high levels of CD44, as shown by their reactivity with an antibody specific for the CD44 hyaluronan-binding site. Hyaluronic Acid 172-182 CD44 molecule (Indian blood group) Homo sapiens 98-102 8892681-6 1996 As expected, >90% of cells in all primary normal and leukemic samples expressed high levels of CD44, as shown by their reactivity with an antibody specific for the CD44 hyaluronan-binding site. Hyaluronic Acid 172-182 CD44 molecule (Indian blood group) Homo sapiens 167-171 8892681-9 1996 Both the level and the hyaluronan-binding properties of CD44 could be stimulated in some, but not all, of these leukemic cell lines. Hyaluronic Acid 23-33 CD44 molecule (Indian blood group) Homo sapiens 56-60 21594498-3 1996 The binding was highly specific with a K-d of 0.48x10(-9) M. Most of the hyaluronan binding activity was blocked by mAbs against Hermes-l antigen indicating that the adhesion molecule CD44 is responsible for hyaluronan binding. Hyaluronic Acid 73-83 CD44 molecule (Indian blood group) Homo sapiens 184-188 21594498-3 1996 The binding was highly specific with a K-d of 0.48x10(-9) M. Most of the hyaluronan binding activity was blocked by mAbs against Hermes-l antigen indicating that the adhesion molecule CD44 is responsible for hyaluronan binding. Hyaluronic Acid 208-218 CD44 molecule (Indian blood group) Homo sapiens 184-188 8878421-12 1996 Additionally, fibroblast CD44 mediated adhesion to the provisional matrix proteins fibronectin, fibrin, and hyaluronic acid, but not to laminin, a component of the basement membrane. Hyaluronic Acid 108-123 CD44 molecule (Indian blood group) Homo sapiens 25-29 8886879-10 1996 Since CD44 is known to act as a receptor for hyaluronic acid, which is a prominent stromal component and known to play an important role in cell mobility and tumor aggressiveness, its high expression in association with PFSR would suggest a role of CD44 overexpression in altered hyaluronate metabolism with accelerated tumor cell migration and subsequent distal spread. Hyaluronic Acid 45-60 CD44 molecule (Indian blood group) Homo sapiens 249-253 8886879-10 1996 Since CD44 is known to act as a receptor for hyaluronic acid, which is a prominent stromal component and known to play an important role in cell mobility and tumor aggressiveness, its high expression in association with PFSR would suggest a role of CD44 overexpression in altered hyaluronate metabolism with accelerated tumor cell migration and subsequent distal spread. Hyaluronic Acid 280-291 CD44 molecule (Indian blood group) Homo sapiens 6-10 8886879-10 1996 Since CD44 is known to act as a receptor for hyaluronic acid, which is a prominent stromal component and known to play an important role in cell mobility and tumor aggressiveness, its high expression in association with PFSR would suggest a role of CD44 overexpression in altered hyaluronate metabolism with accelerated tumor cell migration and subsequent distal spread. Hyaluronic Acid 280-291 CD44 molecule (Indian blood group) Homo sapiens 249-253 9181059-7 1996 Glioma cell-derived laminin and hyaluronic acid may provide the most important substrates for invasion, cell adhesion to these substrates being achieved largely through integrin receptors (the function of which may be determined by interaction with cell surface gangliosides) and CD44, respectively. Hyaluronic Acid 32-47 CD44 molecule (Indian blood group) Homo sapiens 280-284 8878406-0 1996 Human ovarian tumour cells can bind hyaluronic acid via membrane CD44: a possible step in peritoneal metastasis. Hyaluronic Acid 36-51 CD44 molecule (Indian blood group) Homo sapiens 65-69 8878406-1 1996 Our previous studies have suggested that the interaction between hyaluronic acid (HA) on peritoneal mesothelial cells and the membrane adhesion molecule, CD44, on ovarian tumour cells could be important in ovarian cancer metastasis. Hyaluronic Acid 65-80 CD44 molecule (Indian blood group) Homo sapiens 154-158 8878406-1 1996 Our previous studies have suggested that the interaction between hyaluronic acid (HA) on peritoneal mesothelial cells and the membrane adhesion molecule, CD44, on ovarian tumour cells could be important in ovarian cancer metastasis. Hyaluronic Acid 82-84 CD44 molecule (Indian blood group) Homo sapiens 154-158 8798616-0 1996 The cell adhesion molecule, GP116, is a new CD44 variant (ex14/v10) involved in hyaluronic acid binding and endothelial cell proliferation. Hyaluronic Acid 80-95 CD44 molecule (Indian blood group) Homo sapiens 44-48 8769428-5 1996 A significant proportion of these rolling interactions were independent of divalent cations and were mediated by CD44 binding to hyaluronan, as shown by inhibition with mAb to CD44, soluble hyaluronan, as hyaluronidase treatment of the substrate, and O-glycoprotease treatment of the rolling cells. Hyaluronic Acid 129-139 CD44 molecule (Indian blood group) Homo sapiens 113-117 9239683-1 1996 Both hyaluronan and one of its receptors, CD44, can be demonstrated in the early human conceptus and in placental stroma. Hyaluronic Acid 5-15 CD44 molecule (Indian blood group) Homo sapiens 42-46 9239683-2 1996 The variants of CD44 resulting from variable exon splicing are found in metastasizing human malignancies and are also involved in hyaluronan uptake and degradation. Hyaluronic Acid 130-140 CD44 molecule (Indian blood group) Homo sapiens 16-20 8769428-5 1996 A significant proportion of these rolling interactions were independent of divalent cations and were mediated by CD44 binding to hyaluronan, as shown by inhibition with mAb to CD44, soluble hyaluronan, as hyaluronidase treatment of the substrate, and O-glycoprotease treatment of the rolling cells. Hyaluronic Acid 129-139 CD44 molecule (Indian blood group) Homo sapiens 176-180 8769428-5 1996 A significant proportion of these rolling interactions were independent of divalent cations and were mediated by CD44 binding to hyaluronan, as shown by inhibition with mAb to CD44, soluble hyaluronan, as hyaluronidase treatment of the substrate, and O-glycoprotease treatment of the rolling cells. Hyaluronic Acid 190-200 CD44 molecule (Indian blood group) Homo sapiens 113-117 8769428-11 1996 We propose that lymphocytes migrating through secondary lymphoid organs may use CD44 to bind to hyaluronan immobilized on stromal cells and reticular fibers. Hyaluronic Acid 96-106 CD44 molecule (Indian blood group) Homo sapiens 80-84 8805300-6 1996 We show that expression of wild-type CD44 enhances the ability of both cell lines to bind to, and migrate on, a hyaluronan-coated substratum. Hyaluronic Acid 112-122 CD44 molecule (Indian blood group) Homo sapiens 37-41 8642309-0 1996 A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid. Hyaluronic Acid 98-113 CD44 molecule (Indian blood group) Homo sapiens 58-62 8805127-1 1996 CD44 is a major receptor for hyaluronic acid, which is the most frequent route of malignant glioma invasion. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 0-4 8635860-1 1996 CD44 is a transmembrane glycoprotein that binds hyaluronan, extracellular matrix proteins and growth factors. Hyaluronic Acid 48-58 CD44 molecule (Indian blood group) Homo sapiens 0-4 9172805-1 1996 The CD44 cell surface molecule has been shown to be the principal cell surface receptor for hyaluronan (or hyaluronic acid), a glycosaminoglycan component of marrow extracellular matrix. Hyaluronic Acid 92-102 CD44 molecule (Indian blood group) Homo sapiens 4-8 9172805-1 1996 The CD44 cell surface molecule has been shown to be the principal cell surface receptor for hyaluronan (or hyaluronic acid), a glycosaminoglycan component of marrow extracellular matrix. Hyaluronic Acid 107-122 CD44 molecule (Indian blood group) Homo sapiens 4-8 9172805-2 1996 However, its affinity for hyaluronan is not constitutive, since it depends on the cell type, the stage of differentiation and on activation by external stimuli including certain anti-CD44 antibodies and phorbol esters. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 183-187 8832418-0 1996 Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 139-143 8832418-4 1996 With respect to one of the CD44-associated functions primarily involved in tumor progression we found that two highly metastatic tumor cell lines, MV3 and BLM, showed fivefold higher migration rates towards hyaluronate than melanomas with low metastatic potential and normal melanocytes. Hyaluronic Acid 207-218 CD44 molecule (Indian blood group) Homo sapiens 27-31 8832418-5 1996 Moreover, the highly metastatic cell lines expressed four- to sixfold higher levels of the CD44 epitope involved in hyaluronic acid-binding (monoclonal antibody Hermes-1) than less aggressive melanomas and melanocytes. Hyaluronic Acid 116-131 CD44 molecule (Indian blood group) Homo sapiens 91-95 8832418-8 1996 Differences in the accessibility of the hyaluronate-binding epitope defined by Hermes-1 correlated with the phosphorylation state of CD44s, probably reflecting different activation states of the receptor. Hyaluronic Acid 40-51 CD44 molecule (Indian blood group) Homo sapiens 133-137 9172805-7 1996 Recent experiments have shown that a very important feature of CD44 is its capacity to be rapidly activated by certain antibodies and cytokines (GM-CSF and KL) from a low affinity to a high affinity state for hyaluronan. Hyaluronic Acid 209-219 CD44 molecule (Indian blood group) Homo sapiens 63-67 9172805-11 1996 Considering that the production of cytokines is enhanced in this disease, we discuss whether CD44-hyaluronan interaction may have a role in the pathophysiology of this myeloproliferative syndrome. Hyaluronic Acid 98-108 CD44 molecule (Indian blood group) Homo sapiens 93-97 8642309-0 1996 A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid. Hyaluronic Acid 98-113 CD44 molecule (Indian blood group) Homo sapiens 90-94 8642309-6 1996 These transfectants were used to study whether these two cysteine residues are important in the binding of CD44(H) to fluorescein-conjugated hyaluronic acid (F-HA). Hyaluronic Acid 141-156 CD44 molecule (Indian blood group) Homo sapiens 107-111 8731670-2 1996 All BCCs studied displayed very low amounts of CD44std, a receptor for hyaluronic acid. Hyaluronic Acid 71-86 CD44 molecule (Indian blood group) Homo sapiens 47-51 8636151-0 1996 A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 38-42 8677750-2 1996 Ligands of CD44 include several extracellular matrix components, such as hyaluronic acid and fibronectin. Hyaluronic Acid 73-88 CD44 molecule (Indian blood group) Homo sapiens 11-15 8601595-0 1996 Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. Hyaluronic Acid 70-80 CD44 molecule (Indian blood group) Homo sapiens 17-21 8601595-0 1996 Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. Hyaluronic Acid 70-80 CD44 molecule (Indian blood group) Homo sapiens 39-43 8601595-1 1996 CD44-mediated cell adhesion to hyaluronate is controlled by mechanisms which are poorly understood. Hyaluronic Acid 31-42 CD44 molecule (Indian blood group) Homo sapiens 0-4 8601595-2 1996 In the present work we examine the role of N-linked glycosylation and Ser-Gly motifs in regulating CD44-hyaluronate interaction. Hyaluronic Acid 104-115 CD44 molecule (Indian blood group) Homo sapiens 99-103 8601595-3 1996 Our results show that treatment of a panel of human cell lines which constitutively express CD44 with the inhibitor of N-linked glycosylation tunicamycin results in the loss of attachment of these cells to hyaluronate-coated substrate. Hyaluronic Acid 206-217 CD44 molecule (Indian blood group) Homo sapiens 92-96 8601595-5 1996 Using human melanoma cells stably transfected with CD44 N-linked glycosylation site-specific mutants, we show that integrity of five potential N-linked glycosylation sites within the hyaluronate recognition domain of CD44 is critical for hyaluronate binding. Hyaluronic Acid 183-194 CD44 molecule (Indian blood group) Homo sapiens 51-55 8601595-5 1996 Using human melanoma cells stably transfected with CD44 N-linked glycosylation site-specific mutants, we show that integrity of five potential N-linked glycosylation sites within the hyaluronate recognition domain of CD44 is critical for hyaluronate binding. Hyaluronic Acid 183-194 CD44 molecule (Indian blood group) Homo sapiens 217-221 8601595-5 1996 Using human melanoma cells stably transfected with CD44 N-linked glycosylation site-specific mutants, we show that integrity of five potential N-linked glycosylation sites within the hyaluronate recognition domain of CD44 is critical for hyaluronate binding. Hyaluronic Acid 238-249 CD44 molecule (Indian blood group) Homo sapiens 51-55 8601595-5 1996 Using human melanoma cells stably transfected with CD44 N-linked glycosylation site-specific mutants, we show that integrity of five potential N-linked glycosylation sites within the hyaluronate recognition domain of CD44 is critical for hyaluronate binding. Hyaluronic Acid 238-249 CD44 molecule (Indian blood group) Homo sapiens 217-221 8601595-6 1996 Mutation of any one of these potential N-linked glycosylation sites abrogates CD44-mediated melanoma cell attachment to hyaluronate-coated surfaces, suggesting that all five sites are necessary to maintain the HA-recognition domain in the appropriate conformation. Hyaluronic Acid 120-131 CD44 molecule (Indian blood group) Homo sapiens 78-82 8601595-8 1996 Taken together, these observations indicate that changes in glycosylation of CD44 can have profound effects on its interaction with hyaluronic acid and suggest that glycosylation may provide an important regulatory mechanism of CD44 function. Hyaluronic Acid 132-147 CD44 molecule (Indian blood group) Homo sapiens 77-81 8601595-8 1996 Taken together, these observations indicate that changes in glycosylation of CD44 can have profound effects on its interaction with hyaluronic acid and suggest that glycosylation may provide an important regulatory mechanism of CD44 function. Hyaluronic Acid 132-147 CD44 molecule (Indian blood group) Homo sapiens 228-232 8609213-7 1996 Through binding to hyaluronic acid, CD44 augmented DNA synthesis in cultured human and rat smooth muscle cells by 48 +/- 7.8 and 100 +/- 12.5%, respectively, an effect inhibited by an anti-CD44 antibody that blocked hyaluronate binding. Hyaluronic Acid 19-34 CD44 molecule (Indian blood group) Homo sapiens 36-40 8609213-7 1996 Through binding to hyaluronic acid, CD44 augmented DNA synthesis in cultured human and rat smooth muscle cells by 48 +/- 7.8 and 100 +/- 12.5%, respectively, an effect inhibited by an anti-CD44 antibody that blocked hyaluronate binding. Hyaluronic Acid 216-227 CD44 molecule (Indian blood group) Homo sapiens 36-40 8621236-6 1996 Digestion of the CD44 ligand hyaluronic acid (HA) on RPMI-7951 cells significantly reduced adhesion to endothelial monolayers, while digestion of HUVEC HA had no effect. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 17-21 21594330-0 1996 Hyaluronic acid modulates glioma cell proliferation through its interaction with CD44H in vitro. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 81-85 8522617-0 1995 Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 14-18 8847140-8 1995 CD44 analysis revealed differential isoform banding for the MCF10A-HE cells compared to parental cells, MCF10A-H and MCF10A-E, accompanied by increased binding of hyaluronan by the double transformants. Hyaluronic Acid 163-173 CD44 molecule (Indian blood group) Homo sapiens 0-4 8750186-1 1995 CD44s (standard form of CD44) is a transmembrane glycoprotein whose external domain displays extracellular matrix adhesion properties by binding both hyaluronic acid (HA) and collagen. Hyaluronic Acid 150-165 CD44 molecule (Indian blood group) Homo sapiens 0-4 8750186-1 1995 CD44s (standard form of CD44) is a transmembrane glycoprotein whose external domain displays extracellular matrix adhesion properties by binding both hyaluronic acid (HA) and collagen. Hyaluronic Acid 150-165 CD44 molecule (Indian blood group) Homo sapiens 24-28 8750186-1 1995 CD44s (standard form of CD44) is a transmembrane glycoprotein whose external domain displays extracellular matrix adhesion properties by binding both hyaluronic acid (HA) and collagen. Hyaluronic Acid 167-169 CD44 molecule (Indian blood group) Homo sapiens 0-4 8750186-1 1995 CD44s (standard form of CD44) is a transmembrane glycoprotein whose external domain displays extracellular matrix adhesion properties by binding both hyaluronic acid (HA) and collagen. Hyaluronic Acid 167-169 CD44 molecule (Indian blood group) Homo sapiens 24-28 8522617-1 1995 The hyaluronan (HA)-binding function (lectin function) of the leukocyte homing receptor, CD44, is tightly regulated. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Homo sapiens 89-93 7545465-4 1995 The results show that CD44 engagement, either by hyaluronic acid (HA) or anti-CD44 MoAbs, inhibits DNA fragmentation and apoptosis induced by DEX and anti-CD3 MoAbs, whereas that induced by UV, a p53-dependent phenomenon, was not inhibited. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 22-26 7561101-0 1995 N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding. Hyaluronic Acid 98-108 CD44 molecule (Indian blood group) Homo sapiens 44-48 7561101-1 1995 CD44 molecules are cell surface receptors for hyaluronan (HA). Hyaluronic Acid 46-56 CD44 molecule (Indian blood group) Homo sapiens 0-4 7545465-4 1995 The results show that CD44 engagement, either by hyaluronic acid (HA) or anti-CD44 MoAbs, inhibits DNA fragmentation and apoptosis induced by DEX and anti-CD3 MoAbs, whereas that induced by UV, a p53-dependent phenomenon, was not inhibited. Hyaluronic Acid 66-68 CD44 molecule (Indian blood group) Homo sapiens 22-26 8564078-7 1995 The resulting hyaluronic-acid-rich, collagen-poor matrix may enhance infiltration of CD44/hyaluronate-receptor-bearing T-lymphocytes and monocytes into the vascular wall, an early event in atherogenesis. Hyaluronic Acid 14-29 CD44 molecule (Indian blood group) Homo sapiens 85-89 8564078-7 1995 The resulting hyaluronic-acid-rich, collagen-poor matrix may enhance infiltration of CD44/hyaluronate-receptor-bearing T-lymphocytes and monocytes into the vascular wall, an early event in atherogenesis. Hyaluronic Acid 14-29 CD44 molecule (Indian blood group) Homo sapiens 90-110 7543820-6 1995 The binding sites were saturated with about 19,700 hyaluronan molecules (Mr 1.4 x 10(6)) bound per cell with a Kd of 0.16 x 10(-9) M. CD44 molecules were responsible for the binding activity since Hermes-1 antibodies that block the binding of hyaluronan to CD44 blocked the binding of [3H]hyaluronan to U-1752 cells. Hyaluronic Acid 51-61 CD44 molecule (Indian blood group) Homo sapiens 134-138 8554897-6 1995 We tested CEMx174 cells, which are CD4-positive and HIV-susceptible for phorbol ester-inducible binding to hyaluronic acid through CD44. Hyaluronic Acid 107-122 CD44 molecule (Indian blood group) Homo sapiens 131-135 8554897-8 1995 Likewise, HIV from stimulated cells but not from unstimulated cells bound hyaluronic acid through acquired CD44 molecules. Hyaluronic Acid 74-89 CD44 molecule (Indian blood group) Homo sapiens 107-111 9166476-0 1995 High CD44 expression on human mesotheliomas mediates association with hyaluronan. Hyaluronic Acid 70-80 CD44 molecule (Indian blood group) Homo sapiens 5-9 9166476-4 1995 (3) What is the functional status of the CD44 expressed on mesotheliomas, with regard to hyaluronan anchorage? Hyaluronic Acid 89-99 CD44 molecule (Indian blood group) Homo sapiens 41-45 9166476-13 1995 Four of these cell lines exhibited strong attachment to hyaluronan in an in vitro attachment assay, indicating that their CD44 was functional with respect to hyaluronan anchorage. Hyaluronic Acid 56-66 CD44 molecule (Indian blood group) Homo sapiens 122-126 9166476-13 1995 Four of these cell lines exhibited strong attachment to hyaluronan in an in vitro attachment assay, indicating that their CD44 was functional with respect to hyaluronan anchorage. Hyaluronic Acid 158-168 CD44 molecule (Indian blood group) Homo sapiens 122-126 9166476-14 1995 Hyaluronan attachment was specific in that it could be abolished by preincubation with epitope-specific anti-CD44 antibodies or soluble substrate or by hyaluronidase treatment of attachment surfaces. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 109-113 9166476-15 1995 CONCLUSIONS: We conclude that CD44 is highly expressed on human mesotheliomas, that cell lines adequately represent tumor expression, and that CD44 mediates association with hyaluronan, a major component of pleural fluid. Hyaluronic Acid 174-184 CD44 molecule (Indian blood group) Homo sapiens 143-147 7543820-6 1995 The binding sites were saturated with about 19,700 hyaluronan molecules (Mr 1.4 x 10(6)) bound per cell with a Kd of 0.16 x 10(-9) M. CD44 molecules were responsible for the binding activity since Hermes-1 antibodies that block the binding of hyaluronan to CD44 blocked the binding of [3H]hyaluronan to U-1752 cells. Hyaluronic Acid 51-61 CD44 molecule (Indian blood group) Homo sapiens 257-261 7543820-6 1995 The binding sites were saturated with about 19,700 hyaluronan molecules (Mr 1.4 x 10(6)) bound per cell with a Kd of 0.16 x 10(-9) M. CD44 molecules were responsible for the binding activity since Hermes-1 antibodies that block the binding of hyaluronan to CD44 blocked the binding of [3H]hyaluronan to U-1752 cells. Hyaluronic Acid 243-253 CD44 molecule (Indian blood group) Homo sapiens 134-138 7543820-6 1995 The binding sites were saturated with about 19,700 hyaluronan molecules (Mr 1.4 x 10(6)) bound per cell with a Kd of 0.16 x 10(-9) M. CD44 molecules were responsible for the binding activity since Hermes-1 antibodies that block the binding of hyaluronan to CD44 blocked the binding of [3H]hyaluronan to U-1752 cells. Hyaluronic Acid 243-253 CD44 molecule (Indian blood group) Homo sapiens 134-138 7543820-9 1995 The fact that CD44 molecules are able to bind [3H]hyaluronan only on the SCLC line U-1752 but not on other lung carcinoma cell lines may be of value as a marker for squamous cell carcinoma differentiation. Hyaluronic Acid 50-60 CD44 molecule (Indian blood group) Homo sapiens 14-18 7544357-0 1995 Interaction of CD44 variant isoforms with hyaluronic acid and the cytoskeleton in human prostate cancer cells. Hyaluronic Acid 42-57 CD44 molecule (Indian blood group) Homo sapiens 15-19 7544357-9 1995 Functional characterization reveals that CD44 mediates prostate cell adhesion to extracellular hyaluronic acid (HA). Hyaluronic Acid 95-110 CD44 molecule (Indian blood group) Homo sapiens 41-45 7544357-9 1995 Functional characterization reveals that CD44 mediates prostate cell adhesion to extracellular hyaluronic acid (HA). Hyaluronic Acid 112-114 CD44 molecule (Indian blood group) Homo sapiens 41-45 7536236-1 1995 The cell-surface receptor for hyaluronic acid, CD44, is expressed by both normal and malignant cells. Hyaluronic Acid 30-45 CD44 molecule (Indian blood group) Homo sapiens 47-51 7542594-0 1995 Hyaluronan binding by CD44 is regulated by a phosphorylation-independent mechanism. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 22-26 7542594-1 1995 CD44 is an adhesion receptor for which the major characterized ligand is the extracellular matrix glycosaminoglycan, hyaluronan. Hyaluronic Acid 117-127 CD44 molecule (Indian blood group) Homo sapiens 0-4 7525525-13 1994 Since UDPGD activity is involved in hyaluronan synthesis, it is proposed that joint cavitation is facilitated by a rise in local hyaluronan concentration in an area of tissue where cohesion is dependent on the interaction between cellular CD44 and extracellular hyaluronan. Hyaluronic Acid 129-139 CD44 molecule (Indian blood group) Homo sapiens 239-243 7542258-1 1995 CD44 is a polymorphic cell surface glycoprotein, currently proposed to be the principal cell surface receptor for hyaluronan. Hyaluronic Acid 114-124 CD44 molecule (Indian blood group) Homo sapiens 0-4 7542258-2 1995 However, different isoforms of CD44, expressed in human lymphoid tumor cells, appear to have distinct effects on the ability of the cells to attach to hyaluronan-coated surfaces and on their capacity to form tumors in vivo. Hyaluronic Acid 151-161 CD44 molecule (Indian blood group) Homo sapiens 31-35 7542258-3 1995 In the present study, we address the mechanisms that may regulate CD44 isoform-dependent adhesion to hyaluronan. Hyaluronic Acid 101-111 CD44 molecule (Indian blood group) Homo sapiens 66-70 7542258-5 1995 We show that transfectants expressing CD44 splice variants that contain variable exons 6-10, 7-10 and 8-10 adhere to hyaluronan-coated surfaces weakly and that corresponding tumor formation in vivo is delayed with respect to CD44-negative parental cell-derived tumors. Hyaluronic Acid 117-127 CD44 molecule (Indian blood group) Homo sapiens 38-42 7533087-0 1995 Role of CD44 cytoplasmic domain in hyaluronan binding. Hyaluronic Acid 35-45 CD44 molecule (Indian blood group) Homo sapiens 8-12 7533087-1 1995 The hyaluronan (HA) binding activity of mutant CD44 constructs expressed in AKR1 T-lymphoma cells was evaluated by flow cytometry using fluorescein-conjugated HA (Fl-HA). Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Homo sapiens 47-51 7533087-1 1995 The hyaluronan (HA) binding activity of mutant CD44 constructs expressed in AKR1 T-lymphoma cells was evaluated by flow cytometry using fluorescein-conjugated HA (Fl-HA). Hyaluronic Acid 16-18 CD44 molecule (Indian blood group) Homo sapiens 47-51 7536764-1 1995 CD44 is thought to be a principal cell surface receptor for hyaluronic acid. Hyaluronic Acid 60-75 CD44 molecule (Indian blood group) Homo sapiens 0-4 7525818-1 1994 CD44 glycoproteins are present on the surfaces of many hematopoietic cells and in some cases can bind hyaluronan, a major component of the extracellular matrix. Hyaluronic Acid 102-112 CD44 molecule (Indian blood group) Homo sapiens 0-4 7525818-6 1994 In both case, the binding of [3H]hyaluronan was specifically inhibited by the addition of monoclonal antibody directed against CD44. Hyaluronic Acid 33-43 CD44 molecule (Indian blood group) Homo sapiens 127-131 7533172-5 1994 These results suggested that the osteoprogenitor cells may use CD44 to bind and internalize hyaluronan, and subsequently degrade it with lysosomal enzymes. Hyaluronic Acid 92-102 CD44 molecule (Indian blood group) Homo sapiens 63-67 7533172-8 1994 In addition, the binding of isotopically labeled hyaluronan to detergent extracts of these cells was blocked by a monoclonal antibody to CD44. Hyaluronic Acid 49-59 CD44 molecule (Indian blood group) Homo sapiens 137-141 7533172-9 1994 Similarly, the degradation of hyaluronan by these cultured cells was also inhibited by a monoclonal antibody to CD44. Hyaluronic Acid 30-40 CD44 molecule (Indian blood group) Homo sapiens 112-116 7533172-12 1994 The MG-63 cells removed significant amounts of hyaluronan present in the zone of hypertrophy, and this effect was blocked by an excess of soluble hyaluronan and by a monoclonal antibody to CD44. Hyaluronic Acid 47-57 CD44 molecule (Indian blood group) Homo sapiens 189-193 7519619-0 1994 Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function. Hyaluronic Acid 71-86 CD44 molecule (Indian blood group) Homo sapiens 26-30 7519619-2 1994 CD44(GP85) is known to contain at least one ankyrin-binding site within its 70 aa cytoplasmic domain and to bind hyaluronic acid (HA) with its extracellular domain. Hyaluronic Acid 130-132 CD44 molecule (Indian blood group) Homo sapiens 0-4 7519619-9 1994 These findings strongly suggest that ankyrin binding to the cytoplasmic domain of CD44(GP85) plays a pivotal role in regulating hyaluronic acid-mediated cell-cell and cell-extracellular matrix interactions. Hyaluronic Acid 128-143 CD44 molecule (Indian blood group) Homo sapiens 82-86 7521370-11 1994 High levels of fibronectin, hyaluronic acid, and collagen, all potential ligands for the CD44 adhesion molecule, have been reported in the circulation of IMF patients. Hyaluronic Acid 28-43 CD44 molecule (Indian blood group) Homo sapiens 89-93 7519123-7 1994 The hyaluronan receptor appeared to be related to CD44 (a cell surface glycoprotein previously suggested to function as a hyaluronan receptor) since Hermes-1 monoclonal antibodies which inhibit the binding of hyaluronan to CD44 blocked a major part of the binding of hyaluronan to the mesothelioma cells. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Homo sapiens 50-54 7519123-7 1994 The hyaluronan receptor appeared to be related to CD44 (a cell surface glycoprotein previously suggested to function as a hyaluronan receptor) since Hermes-1 monoclonal antibodies which inhibit the binding of hyaluronan to CD44 blocked a major part of the binding of hyaluronan to the mesothelioma cells. Hyaluronic Acid 4-14 CD44 molecule (Indian blood group) Homo sapiens 223-227 7519123-7 1994 The hyaluronan receptor appeared to be related to CD44 (a cell surface glycoprotein previously suggested to function as a hyaluronan receptor) since Hermes-1 monoclonal antibodies which inhibit the binding of hyaluronan to CD44 blocked a major part of the binding of hyaluronan to the mesothelioma cells. Hyaluronic Acid 122-132 CD44 molecule (Indian blood group) Homo sapiens 50-54 7519123-8 1994 However, there was no strict correlation between the hyaluronan-binding activity on the mesothelioma cell lines tested and the levels of CD44 molecules on their cell surface, suggesting that only a subfraction of the CD44 molecules bound hyaluronan or that other hyaluronan-binding proteins also exist on those cells. Hyaluronic Acid 238-248 CD44 molecule (Indian blood group) Homo sapiens 217-221 7518822-0 1994 Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: correlation with invasive potential. Hyaluronic Acid 27-37 CD44 molecule (Indian blood group) Homo sapiens 102-106 7518822-3 1994 In addition, the ability to bind and degrade hyaluronan was restricted to the cell lines expressing high levels of CD44, and both these functions were blocked by an antibody to CD44 (Hermes-1). Hyaluronic Acid 45-55 CD44 molecule (Indian blood group) Homo sapiens 115-119 7518822-3 1994 In addition, the ability to bind and degrade hyaluronan was restricted to the cell lines expressing high levels of CD44, and both these functions were blocked by an antibody to CD44 (Hermes-1). Hyaluronic Acid 45-55 CD44 molecule (Indian blood group) Homo sapiens 177-181 7518822-4 1994 Moreover, the rate of [3H]hyaluronan degradation was highly correlated with the amount of CD44 (r = 0.951, P < 0.0001), as well as with the invasive potential of the cells. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 90-94 7518822-9 1994 These results illustrate the diversity of CD44 molecules in invasive tumor cells, and suggest that one of their major functions is to degrade hyaluronan. Hyaluronic Acid 142-152 CD44 molecule (Indian blood group) Homo sapiens 42-46 7528901-9 1994 In an adhesion blocking assay it was found that ligation of CD44 with specific antibody resulted in reduced adhesion to hyaluronan, chondroitin sulphate, fibronectin, laminin, collagen IV and Matrigel. Hyaluronic Acid 120-130 CD44 molecule (Indian blood group) Homo sapiens 60-64 7519619-2 1994 CD44(GP85) is known to contain at least one ankyrin-binding site within its 70 aa cytoplasmic domain and to bind hyaluronic acid (HA) with its extracellular domain. Hyaluronic Acid 113-128 CD44 molecule (Indian blood group) Homo sapiens 0-4 7524689-0 1994 Biotinylated hyaluronic acid: a new tool for probing hyaluronate-receptor interactions. Hyaluronic Acid 13-28 CD44 molecule (Indian blood group) Homo sapiens 53-73 7524689-2 1994 Hyaluronate plays an important role in many biological processes as mediated by its interactions with a number of HA-binding proteins (the "hyaladherins") and with the cell surface HA-receptor, CD44. Hyaluronic Acid 0-11 CD44 molecule (Indian blood group) Homo sapiens 194-198 7511044-6 1994 GKW.A2 is a monoclonal antibody specific for human CD44 that can completely inhibit the binding of hyaluronic acid to SMMU-2 tumor cells in vitro. Hyaluronic Acid 99-114 CD44 molecule (Indian blood group) Homo sapiens 51-55 7516417-0 1994 Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. Hyaluronic Acid 29-40 CD44 molecule (Indian blood group) Homo sapiens 20-24 7516417-3 1994 We show that expression of a wild-type CD44 isoform that binds hyaluronic acid augments the rapidity of tumor formation by melanoma cells in vivo, whereas expression of a CD44 mutant, which does not mediate cell attachment to hyaluronate, fails to do so. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 39-43 7516417-4 1994 The importance of CD44-hyaluronate interaction in tumor development is underscored by the differential inhibitory effect of soluble wild-type and mutant CD44-Ig fusion proteins on melanoma growth in vivo. Hyaluronic Acid 23-34 CD44 molecule (Indian blood group) Homo sapiens 18-22 7516417-4 1994 The importance of CD44-hyaluronate interaction in tumor development is underscored by the differential inhibitory effect of soluble wild-type and mutant CD44-Ig fusion proteins on melanoma growth in vivo. Hyaluronic Acid 23-34 CD44 molecule (Indian blood group) Homo sapiens 153-157 7516417-6 1994 Taken together, these observations suggest that the tumor growth promoting property of CD44 is largely dependent on its ability to mediate cell attachment to hyaluronate. Hyaluronic Acid 158-169 CD44 molecule (Indian blood group) Homo sapiens 87-91 7510702-5 1994 CD44H, the major CD44 isoform expressed by most resting cell types, has been shown to function as a receptor for the glycosaminoglycan hyaluronan. Hyaluronic Acid 135-145 CD44 molecule (Indian blood group) Homo sapiens 0-4 7510702-9 1994 Both fusion proteins bound equally well to hyaluronan and in each case their attachment could be readily inhibited by monoclonal antibodies directed against the hyaluronan-binding domain of CD44. Hyaluronic Acid 43-53 CD44 molecule (Indian blood group) Homo sapiens 190-194 7510702-9 1994 Both fusion proteins bound equally well to hyaluronan and in each case their attachment could be readily inhibited by monoclonal antibodies directed against the hyaluronan-binding domain of CD44. Hyaluronic Acid 161-171 CD44 molecule (Indian blood group) Homo sapiens 190-194 7509720-1 1994 CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan. Hyaluronic Acid 108-118 CD44 molecule (Indian blood group) Homo sapiens 0-4 7520892-10 1994 Since one of the ligands of CD44 is hyaluronic acid (HA), we also analysed the tissue distribution of HA synthetase. Hyaluronic Acid 36-51 CD44 molecule (Indian blood group) Homo sapiens 28-32 7507730-0 1994 CD44 mediates hyaluronan binding by human myeloid KG1A and KG1 cells. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 0-4 7507730-1 1994 Hyaluronan-binding function of the CD44 molecule has not been so far detected in myeloid cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 35-39 7507730-2 1994 To study pure populations of primitive myeloid cells, we investigated the hyaluronan-binding function of the CD44 molecule from three myeloid cell lines: KG1a, KG1, and HL60. Hyaluronic Acid 74-84 CD44 molecule (Indian blood group) Homo sapiens 109-113 7507730-5 1994 Hyaluronan binding by KG1a and KG1 cells is mediated by CD44, because it is specifically abolished by monoclonal antibodies (MoAbs) to this molecule. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 56-60 7507730-8 1994 Binding of TPA-treated cells to hyaluronan is only partly inhibited by MoAb to CD44: this suggests that TPA may induce synthesis of a hyaluronan-binding protein distinct from CD44. Hyaluronic Acid 32-42 CD44 molecule (Indian blood group) Homo sapiens 79-83 7507730-9 1994 Considering the abundance of hyaluronan in human bone marrow, these results suggest that CD44 may be involved in mediating precursor-stroma interaction. Hyaluronic Acid 29-39 CD44 molecule (Indian blood group) Homo sapiens 89-93 7508860-0 1994 Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. Hyaluronic Acid 27-37 CD44 molecule (Indian blood group) Homo sapiens 94-98 7508860-0 1994 Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. Hyaluronic Acid 59-69 CD44 molecule (Indian blood group) Homo sapiens 94-98 7520892-10 1994 Since one of the ligands of CD44 is hyaluronic acid (HA), we also analysed the tissue distribution of HA synthetase. Hyaluronic Acid 53-55 CD44 molecule (Indian blood group) Homo sapiens 28-32 7504563-1 1993 CD44 is a cellular adhesion molecule expressed in many different types of cells that may be a receptor for hyaluronic acid, laminin, collagen or fibronectin. Hyaluronic Acid 107-122 CD44 molecule (Indian blood group) Homo sapiens 0-4 7505013-1 1993 Differential capacity for CD44-dependent binding to hyaluronic acid. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 26-30 7505013-2 1993 CD44 expression and the functional capacity for CD44-dependent binding of hyaluronic acid (HA) were analyzed on unstimulated B cells and on B cells stimulated with a variety of polyclonal B cell activators. Hyaluronic Acid 74-89 CD44 molecule (Indian blood group) Homo sapiens 48-52 7505013-2 1993 CD44 expression and the functional capacity for CD44-dependent binding of hyaluronic acid (HA) were analyzed on unstimulated B cells and on B cells stimulated with a variety of polyclonal B cell activators. Hyaluronic Acid 91-93 CD44 molecule (Indian blood group) Homo sapiens 48-52 7504022-0 1993 Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 20-24 7504022-0 1993 Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 30-34 7504563-2 1993 In this study, we determined whether CD44 participated in the adhesion of three human colorectal carcinoma cell lines (KM-12c, CCL 188 and MIP-101) to laminin, collagen and hyaluronic acid. Hyaluronic Acid 173-188 CD44 molecule (Indian blood group) Homo sapiens 37-41 7504563-6 1993 Only Hermes 1 completely abolished the binding to hyaluronic acid by a human B lymphoblastoid cell line, JY, that expressed the 90 kD haematopoietic form of CD44. Hyaluronic Acid 50-65 CD44 molecule (Indian blood group) Homo sapiens 157-161 8483916-5 1993 After transfection with CD44 cDNA, COS cells gained the capacity to assemble hyaluronan-dependent pericellular matrices in the presence of exogenously added hyaluronan and proteoglycan. Hyaluronic Acid 77-87 CD44 molecule (Indian blood group) Homo sapiens 24-28 8475990-10 1993 Exogenous hyaluronan induced a decline in measurable CD44 expression for normal skin fibroblasts but not for hypertrophic scar fibroblasts. Hyaluronic Acid 10-20 CD44 molecule (Indian blood group) Homo sapiens 53-57 8314845-0 1993 Identification of hyaluronic acid binding sites in the extracellular domain of CD44. Hyaluronic Acid 18-33 CD44 molecule (Indian blood group) Homo sapiens 79-83 8314845-3 1993 Because of the prominent role CD44 plays in diverse biological processes, we set out to identify the hyaluronic acid binding site(s) in the extracellular domain of CD44H. Hyaluronic Acid 101-116 CD44 molecule (Indian blood group) Homo sapiens 30-34 8492772-2 1993 The hyaluronic acid/CD44-receptor plays a key role in the binding and metabolism of hyaluronic acid, and affects numerous cellular functions of potential relevance to the pathogenesis of Graves" ophthalmopathy, including cell proliferation, migration, and adhesive interactions between connective tissue components and immunocompetent cells. Hyaluronic Acid 4-19 CD44 molecule (Indian blood group) Homo sapiens 20-24 8095961-8 1993 Pretreatment of T cells with hyaluronic acid, a ligand for CD44 and an extracellular matrix compound in the dermis and epidermis, did not affect T-cell/keratinocyte adhesion. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 59-63 8483916-5 1993 After transfection with CD44 cDNA, COS cells gained the capacity to assemble hyaluronan-dependent pericellular matrices in the presence of exogenously added hyaluronan and proteoglycan. Hyaluronic Acid 157-167 CD44 molecule (Indian blood group) Homo sapiens 24-28 1385154-9 1992 CD44, a receptor for hyaluronic acid and collagen, was expressed by most RA-SFL, RA-PBL and CO-PBL cells but at higher density on RA-SFL. Hyaluronic Acid 21-36 CD44 molecule (Indian blood group) Homo sapiens 0-4 8456087-0 1993 CD44 in human placenta: localization and binding to hyaluronic acid. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 0-4 8456087-1 1993 CD44, a receptor for hyaluronic acid (HA), has been identified in the stroma of stem and terminal chorionic villi of human term placenta. Hyaluronic Acid 21-36 CD44 molecule (Indian blood group) Homo sapiens 0-4 8456087-1 1993 CD44, a receptor for hyaluronic acid (HA), has been identified in the stroma of stem and terminal chorionic villi of human term placenta. Hyaluronic Acid 38-40 CD44 molecule (Indian blood group) Homo sapiens 0-4 8386563-2 1993 Moreover, CD44 has been shown to recognise the receptor for hyaluronic acid (HA), an extracellular matrix protein thought to be involved in tumour invasion. Hyaluronic Acid 60-75 CD44 molecule (Indian blood group) Homo sapiens 10-14 8386563-2 1993 Moreover, CD44 has been shown to recognise the receptor for hyaluronic acid (HA), an extracellular matrix protein thought to be involved in tumour invasion. Hyaluronic Acid 77-79 CD44 molecule (Indian blood group) Homo sapiens 10-14 8429233-0 1993 Migration of human melanoma cells on hyaluronate is related to CD44 expression. Hyaluronic Acid 37-48 CD44 molecule (Indian blood group) Homo sapiens 63-67 8429233-4 1993 Migration studies of CD44(+) cell lines on hyaluronic acid- and chondroitin-6-sulfate-coated substrates, using time-lapse video-microscopy, showed a dramatic dose-dependent increase in migration rate on hyaluronate but not on chondroitin-6-sulfate. Hyaluronic Acid 43-58 CD44 molecule (Indian blood group) Homo sapiens 21-25 8429233-4 1993 Migration studies of CD44(+) cell lines on hyaluronic acid- and chondroitin-6-sulfate-coated substrates, using time-lapse video-microscopy, showed a dramatic dose-dependent increase in migration rate on hyaluronate but not on chondroitin-6-sulfate. Hyaluronic Acid 203-214 CD44 molecule (Indian blood group) Homo sapiens 21-25 8429233-6 1993 Addition of soluble hyaluronate produced a dose-dependent inhibition of acceleration of CD44(+)cells on hyaluronate-coated substrates, whereas addition of chondroitin-6-sulfate had no effect. Hyaluronic Acid 20-31 CD44 molecule (Indian blood group) Homo sapiens 88-92 8429233-6 1993 Addition of soluble hyaluronate produced a dose-dependent inhibition of acceleration of CD44(+)cells on hyaluronate-coated substrates, whereas addition of chondroitin-6-sulfate had no effect. Hyaluronic Acid 104-115 CD44 molecule (Indian blood group) Homo sapiens 88-92 8429233-7 1993 Migration inhibition experiments with soluble CD44 (CD44 receptor globulin) also showed specific blocking of the migration of CD44(+) cells on hyaluronate. Hyaluronic Acid 143-154 CD44 molecule (Indian blood group) Homo sapiens 46-50 8429233-7 1993 Migration inhibition experiments with soluble CD44 (CD44 receptor globulin) also showed specific blocking of the migration of CD44(+) cells on hyaluronate. Hyaluronic Acid 143-154 CD44 molecule (Indian blood group) Homo sapiens 52-56 8429233-7 1993 Migration inhibition experiments with soluble CD44 (CD44 receptor globulin) also showed specific blocking of the migration of CD44(+) cells on hyaluronate. Hyaluronic Acid 143-154 CD44 molecule (Indian blood group) Homo sapiens 52-56 8429233-8 1993 Haptotactic invasion was increased in CD44(+) cell lines through hyaluronate-coated polycarbonate membranes, whereas no change was detected on chondroitin-6-sulfate-coated membranes. Hyaluronic Acid 65-76 CD44 molecule (Indian blood group) Homo sapiens 38-42 8429233-10 1993 In the melanoma cell lines tested, the expression of CD44 correlated with in vitro migration and invasiveness on hyaluronate substrates. Hyaluronic Acid 113-124 CD44 molecule (Indian blood group) Homo sapiens 53-57 8429233-11 1993 Taken together, our data are consistent with the suggestion that CD44 may play a role in stimulating in vivo aggressiveness of tumors through hyaluronate-rich stroma. Hyaluronic Acid 142-153 CD44 molecule (Indian blood group) Homo sapiens 65-69 33810348-2 2021 All CD44 isoforms share a common N-terminal domain that binds to hyaluronic acid (HA). Hyaluronic Acid 65-80 CD44 molecule (Indian blood group) Homo sapiens 4-8 1356634-9 1992 Ligands to three of these molecules have been identified; ICAM-1, LFA-3, and hyaluronic acid binding to LFA-1, LFA-2, and CD44, respectively. Hyaluronic Acid 77-92 CD44 molecule (Indian blood group) Homo sapiens 122-126 1730918-0 1992 Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody. Hyaluronic Acid 17-32 CD44 molecule (Indian blood group) Homo sapiens 44-48 33810348-2 2021 All CD44 isoforms share a common N-terminal domain that binds to hyaluronic acid (HA). Hyaluronic Acid 82-84 CD44 molecule (Indian blood group) Homo sapiens 4-8 34974860-5 2021 Afterwards, the PEI was further complexed with hyaluronic acid (HA) to give a cascade reaction platform (HP/UPB-Gox) for CD44 positive lung cancer therapy. Hyaluronic Acid 47-62 CD44 molecule (Indian blood group) Homo sapiens 121-125 34959425-4 2021 Herein, we explored a synergistic strategy by connecting MWNT and a kind of ICG derivate ICG-NH2 through hyaluronic acid (HA) that possesses CD44 receptor targeting ability, which largely enhanced the PTT effect of both MWNT and ICG-NH2. Hyaluronic Acid 105-120 CD44 molecule (Indian blood group) Homo sapiens 141-145 32797715-3 2020 This strategically framed TTNV is chemically conjugated with folic acid and hyaluronic acid as a dual-targeting entity to promote folate receptor (FR) mediated cancer cells and CD44 mediated CSC uptake, respectively. Hyaluronic Acid 76-91 CD44 molecule (Indian blood group) Homo sapiens 177-181 34752986-2 2022 In this study we evaluated the potential of an indocyanine green (ICG) and paclitaxel (PTX) loaded human serum albumin (HSA) nanoparticles that was conjugated with hyaluronic acid for use in image-guided drug delivery targeted to CD44-positive non-small cell lung cancer (NSCLC). Hyaluronic Acid 164-179 CD44 molecule (Indian blood group) Homo sapiens 230-234 33851564-2 2021 To achieve the optimum delivery for SN38, initially methoxy-polyethylene glycol (mPEG)-chitosan was synthesized and then nanoparticles were developed through ionic gelation between mPEG-chitosan and hyaluronic acid as a ligand for cell-surface glycoprotein CD44 receptor. Hyaluronic Acid 199-214 CD44 molecule (Indian blood group) Homo sapiens 257-261 34974860-5 2021 Afterwards, the PEI was further complexed with hyaluronic acid (HA) to give a cascade reaction platform (HP/UPB-Gox) for CD44 positive lung cancer therapy. Hyaluronic Acid 64-66 CD44 molecule (Indian blood group) Homo sapiens 121-125 34791576-5 2022 We found that human LAD2 mast cells spontaneously adhered to hyaluronic acid in a CD44-dependent manner and that reduced oxygen concentrations inhibited or even completely abolished this adhesion process. Hyaluronic Acid 61-76 CD44 molecule (Indian blood group) Homo sapiens 82-86 34560209-4 2021 This detection system also featured pH-responsive Eudragit S100, hyaluronic acid with high affinity to the CD44 receptor, and chitosan, and demonstrated improved loading efficiency and stability. Hyaluronic Acid 65-80 CD44 molecule (Indian blood group) Homo sapiens 107-111 34791576-6 2022 The mechanism of hypoxia downregulation of mast cell adhesion to hyaluronic acid did not involve a decrease in CD44 expression and hyaluronidase-mediated degradation of adhesion substrates but rather conformational changes in the avidity of CD44 to hyaluronic acid. Hyaluronic Acid 65-80 CD44 molecule (Indian blood group) Homo sapiens 241-245 34791576-6 2022 The mechanism of hypoxia downregulation of mast cell adhesion to hyaluronic acid did not involve a decrease in CD44 expression and hyaluronidase-mediated degradation of adhesion substrates but rather conformational changes in the avidity of CD44 to hyaluronic acid. Hyaluronic Acid 249-264 CD44 molecule (Indian blood group) Homo sapiens 241-245 34420747-3 2021 Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 103-107 34420747-3 2021 Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 103-107 34683858-1 2021 Hyaluronic acid-based nanoparticles (HA NPs) can be used to deliver a protein cargo to cells overexpressing HA receptors such as CD44 since they combine the low toxicity of the carrier and the retention of the protein integrity with the receptor-mediated internalization. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 129-133 34672138-5 2021 Hyaluronic acid (HA) was coated on PEI-PLGA-ICG nanoparticles to target CD44-positive cancer cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 72-76 34672138-5 2021 Hyaluronic acid (HA) was coated on PEI-PLGA-ICG nanoparticles to target CD44-positive cancer cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 72-76 34628469-3 2021 Hyaluronan acts through the interaction with cell membrane receptors as CD44 and RHAMM and triggers signaling pathways as MEK/ERK. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 72-76 34081254-0 2021 Downregulation of Hyaluronic acid-CD44 signaling pathway in cervical cancer cell by natural polyphenols Plumbagin, Pongapin and Karanjin. Hyaluronic Acid 18-33 CD44 molecule (Indian blood group) Homo sapiens 34-38 34081254-1 2021 Hyaluronic acid (HA)-CD44 pathway showed association with several malignancies. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 21-25 34081254-1 2021 Hyaluronic acid (HA)-CD44 pathway showed association with several malignancies. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 21-25 34698175-4 2021 The products" efficacy was quantified by measuring the following parameters: (1) water flux and direct moisturization by AQP3 immunohistochemical staining, and (2) maintenance of moisturization and elasticity of the mucosa by hyaluronic acid (CD44) immunofluorescence staining. Hyaluronic Acid 226-241 CD44 molecule (Indian blood group) Homo sapiens 243-247 34698175-7 2021 Furthermore, it demonstrated a significant increase of the expression of CD44, related to hyaluronic acid (HA) distribution in the extracellular matrix. Hyaluronic Acid 90-105 CD44 molecule (Indian blood group) Homo sapiens 73-77 34698175-7 2021 Furthermore, it demonstrated a significant increase of the expression of CD44, related to hyaluronic acid (HA) distribution in the extracellular matrix. Hyaluronic Acid 107-109 CD44 molecule (Indian blood group) Homo sapiens 73-77 34324894-5 2021 Moreover, the surface of nanomedicine was modified with hyaluronic acid, endowing not only excellent biocompatibilities but active tumor-targeting function due to its receptors (CD44) overexpressed on tumor cells. Hyaluronic Acid 56-71 CD44 molecule (Indian blood group) Homo sapiens 178-182 34439185-3 2021 SAHA encapsulation within F127 micelles functionalized with a surface hyaluronic acid moiety, was developed to target endometrial cancer cells expressing elevated levels of CD44. Hyaluronic Acid 70-85 CD44 molecule (Indian blood group) Homo sapiens 173-177 34119168-2 2021 We combined in a unique micelle-like superstructure the peculiar optical properties of CDs (NIR photothermal conversion and red fluorescence) with the ability of hyaluronic acid (HA) shell of stabilizing nanomedicines in aqueous environment and recognizing cancer cells overexpressing CD44 receptors on their membranes, thus giving rise to smart theranostic agents useful in cancer imaging and NIR-triggered chemo-phototherapy of solid tumors. Hyaluronic Acid 162-177 CD44 molecule (Indian blood group) Homo sapiens 285-289 34363352-3 2021 In this study, hyaluronic acid (HA) which could specifically bind to CD44 on the surface of tumor cells, was used to modify amine-caged platinum nanoclusters (Pt NCs-NH2 ) to obtain targeting HA-Pt NCs-NH2 . Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Homo sapiens 69-73 34364871-2 2021 The ubiquitous matrix polysaccharide hyaluronan (HA) is central to the fibrotic response through association with its primary receptor, CD44, which exists as standard CD44 (CD44s) or as multiple splice-variants. Hyaluronic Acid 49-51 CD44 molecule (Indian blood group) Homo sapiens 136-140 34364871-2 2021 The ubiquitous matrix polysaccharide hyaluronan (HA) is central to the fibrotic response through association with its primary receptor, CD44, which exists as standard CD44 (CD44s) or as multiple splice-variants. Hyaluronic Acid 49-51 CD44 molecule (Indian blood group) Homo sapiens 167-171 34364871-2 2021 The ubiquitous matrix polysaccharide hyaluronan (HA) is central to the fibrotic response through association with its primary receptor, CD44, which exists as standard CD44 (CD44s) or as multiple splice-variants. Hyaluronic Acid 49-51 CD44 molecule (Indian blood group) Homo sapiens 173-178 34286578-2 2021 To overcome these hurdles, we fabricated enzyme-responsive photo-cross-linked nanogels (EPNGs) through UV-triggered chemical cross-linking of cinnamyloxy groups in the side chain of PEGylation hyaluronic acid (HA) for CD44-targeted transport of cytochrome c (CC). Hyaluronic Acid 193-208 CD44 molecule (Indian blood group) Homo sapiens 218-222 34478583-2 2021 The major ligand for the CD44, hyaluronan (HA), binds to and interacts with CD44 which in turn triggers downstream signaling cascades, thereby promoting cellular behaviors such as proliferation, motility, invasiveness, and chemoresistance. Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 25-29 34478583-2 2021 The major ligand for the CD44, hyaluronan (HA), binds to and interacts with CD44 which in turn triggers downstream signaling cascades, thereby promoting cellular behaviors such as proliferation, motility, invasiveness, and chemoresistance. Hyaluronic Acid 31-41 CD44 molecule (Indian blood group) Homo sapiens 76-80 34478583-2 2021 The major ligand for the CD44, hyaluronan (HA), binds to and interacts with CD44 which in turn triggers downstream signaling cascades, thereby promoting cellular behaviors such as proliferation, motility, invasiveness, and chemoresistance. Hyaluronic Acid 43-45 CD44 molecule (Indian blood group) Homo sapiens 25-29 34478583-2 2021 The major ligand for the CD44, hyaluronan (HA), binds to and interacts with CD44 which in turn triggers downstream signaling cascades, thereby promoting cellular behaviors such as proliferation, motility, invasiveness, and chemoresistance. Hyaluronic Acid 43-45 CD44 molecule (Indian blood group) Homo sapiens 76-80 34146785-0 2021 Role of the interactions of soft hyaluronan nanomaterials with CD44 and supported bilayer membranes in the cellular uptake. Hyaluronic Acid 33-43 CD44 molecule (Indian blood group) Homo sapiens 63-67 34335086-6 2021 The main receptors for hyaluronic acid are CD44 and RHAMM. Hyaluronic Acid 23-38 CD44 molecule (Indian blood group) Homo sapiens 43-47 34082106-4 2021 Hyaluronic acid (HA) could selectively target cancer cells overexpressed CD44 protein. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 73-77 34082106-4 2021 Hyaluronic acid (HA) could selectively target cancer cells overexpressed CD44 protein. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 73-77 35450661-4 2022 Thereunto, hyaluronic acid modified transfersomes loaded with chlorogenic acid functioned to reverse M2 type into M1 type via CD44 mediated internalization, the nanomedicine was entrapped in Schiff-based crosslinked injectable hydrogel (fabricated with carboxymethyl chitosan and oxidized dextran) whose linkage was labile to the acidic TME for controlled drug release. Hyaluronic Acid 11-26 CD44 molecule (Indian blood group) Homo sapiens 126-130 34162396-2 2021 Thus, we fabricated a CD44-targeting and tumor microenvironment pH/redox-sensitive nanosystem composed of hyaluronic acid-vitamin E succinate and poly (beta-amino esters) (PBAEss) polymers to enhance the TPL-mediated suppression of breast cancer proliferation and lung metastasis. Hyaluronic Acid 106-121 CD44 molecule (Indian blood group) Homo sapiens 22-26 34162396-5 2021 Based on the hyaluronic acid coating, TPL/NPs exhibited selective tumor cellular uptake and high tumor tissue accumulation capacity by targeting CD44. Hyaluronic Acid 13-28 CD44 molecule (Indian blood group) Homo sapiens 145-149 34100170-3 2021 To address this, we developed CD44 receptor-targeted, novel hyaluronic acid (HA)-coated nanostructured lipid carriers (NLCs) of efavirenz via washless layer-by-layer (LbL) assembly of HA and polyallylamine hydrochloride (PAH). Hyaluronic Acid 77-79 CD44 molecule (Indian blood group) Homo sapiens 30-34 34100170-13 2021 The obtained results suggested preferential uptake of HA-coated NLCs via CD44-mediated uptake. Hyaluronic Acid 54-56 CD44 molecule (Indian blood group) Homo sapiens 73-77 34070901-2 2021 The secreted GAG and CD44 ligand hyaluronic acid (HA), and the cell surface PG syndecan-1 (Sdc-1) modulate the expression and activity of cytokines, chemokines, growth factors, and adhesion molecules, acting as critical regulators of tumor cell behavior. Hyaluronic Acid 33-48 CD44 molecule (Indian blood group) Homo sapiens 21-25 34070901-2 2021 The secreted GAG and CD44 ligand hyaluronic acid (HA), and the cell surface PG syndecan-1 (Sdc-1) modulate the expression and activity of cytokines, chemokines, growth factors, and adhesion molecules, acting as critical regulators of tumor cell behavior. Hyaluronic Acid 50-52 CD44 molecule (Indian blood group) Homo sapiens 21-25 35568119-2 2022 Here we constructed a dense and stretched low molecular weight hyaluronic acid (HA9.6k)-modified surface to selectively promote the rolling of CD44-high cancer cells. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 143-147 35568119-9 2022 To selectively promote the rolling of cancer stem cell marker CD44-high cancer cells, a surface with dense and stretched low molecular weight hyaluronic acid (HA9.6k) was constructed. Hyaluronic Acid 142-157 CD44 molecule (Indian blood group) Homo sapiens 62-66 35184000-6 2022 Furthermore, the outer layer hyaluronic acid can load doxorubicin and target overexpressed receptor CD44 of cancer cell, meanwhile, trigger release of DOX in photothermal condition and acidic tumor microenvironment. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 100-104 35613653-0 2022 Assessment of hyaluronic acid-modified imatinib mesylate cubosomes through CD44 targeted drug delivery in NDEA-induced hepatic carcinoma. Hyaluronic Acid 14-29 CD44 molecule (Indian blood group) Homo sapiens 75-79 35613653-1 2022 This study aimed at the development of hyaluronic acid-functionalised imatinib mesylate cubosomes (HA-IM-CBs) that might be useful in CD44 targeting against hepatic cancer. Hyaluronic Acid 39-54 CD44 molecule (Indian blood group) Homo sapiens 134-138 35470595-6 2022 A tumor-targeting nanomedicine is prepared by encapsulating indocyanine green into CD44 specifically binding material, a hyaluronic acid conjugated lipid poly(ethylene glycol). Hyaluronic Acid 121-136 CD44 molecule (Indian blood group) Homo sapiens 83-87 35389901-8 2022 The signal transduction of CD44-ankyrin-Akt-eNOS was significantly repressed in the ONFH group as compared with the control group after hyaluronic acid treatment. Hyaluronic Acid 136-151 CD44 molecule (Indian blood group) Homo sapiens 27-31 35244664-6 2022 Afterwards, nanoparticles were grafted with hyaluronic acid (HA), which specifically binds to CD44 on the surface of the OCs. Hyaluronic Acid 44-59 CD44 molecule (Indian blood group) Homo sapiens 94-98 35349634-3 2022 Here, we report the activation of adhesion molecules Lutheran/basal cell adhesion molecule (Lu/BCAM) and CD44 on uRBCs from Plasmodium falciparum in vitro cultures and malaria patients mediating the adherence to splenic extracellular-matrix (ECM) components laminin-alpha5 and hyaluronic acid (HA), respectively. Hyaluronic Acid 277-292 CD44 molecule (Indian blood group) Homo sapiens 105-109 35349634-3 2022 Here, we report the activation of adhesion molecules Lutheran/basal cell adhesion molecule (Lu/BCAM) and CD44 on uRBCs from Plasmodium falciparum in vitro cultures and malaria patients mediating the adherence to splenic extracellular-matrix (ECM) components laminin-alpha5 and hyaluronic acid (HA), respectively. Hyaluronic Acid 294-296 CD44 molecule (Indian blood group) Homo sapiens 105-109 35244664-6 2022 Afterwards, nanoparticles were grafted with hyaluronic acid (HA), which specifically binds to CD44 on the surface of the OCs. Hyaluronic Acid 61-63 CD44 molecule (Indian blood group) Homo sapiens 94-98 34058270-4 2021 The prepared polymersomal combinational formulation surrounded by hyaluronic acid brush as hydrophilic segment, could provide active targeting of the system against CD44 marker expressed on the surface of cancerous cells. Hyaluronic Acid 66-81 CD44 molecule (Indian blood group) Homo sapiens 165-169 35301389-2 2022 Herein, the AS/GOD@HAZnO NPs we proposed could be efficiently taken in by the affinity between hyaluronic acid and the CD44 receptors. Hyaluronic Acid 95-110 CD44 molecule (Indian blood group) Homo sapiens 119-123 35056160-0 2022 CD44-Targeted Carriers: The Role of Molecular Weight of Hyaluronic Acid in the Uptake of Hyaluronic Acid-Based Nanoparticles. Hyaluronic Acid 56-71 CD44 molecule (Indian blood group) Homo sapiens 0-4 35056160-0 2022 CD44-Targeted Carriers: The Role of Molecular Weight of Hyaluronic Acid in the Uptake of Hyaluronic Acid-Based Nanoparticles. Hyaluronic Acid 89-104 CD44 molecule (Indian blood group) Homo sapiens 0-4 3929769-4 1985 The ability of hyaluronic acid to compete with the labelled ligands for binding suggested that the binding site is identical with the recently described hyaluronate receptor on the liver endothelial cells [Smedsrod, Pertoft, Eriksson, Fraser & Laurent (1984) Biochem. Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Homo sapiens 153-173 33961871-2 2021 The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis, and expression of the chemoresistant phenotype. Hyaluronic Acid 29-39 CD44 molecule (Indian blood group) Homo sapiens 19-23 33957482-4 2021 Tumor cells actively internalized the complex through binding hyaluronan to CD44, overexpressed on the tumor cell surface. Hyaluronic Acid 62-72 CD44 molecule (Indian blood group) Homo sapiens 76-80 35408970-2 2022 The aim of this study is to investigate the CD44 receptor- and reactive oxygen species (ROS)-sensitive delivery of nanophotosensitizers of chlorin e6 (Ce6)-conjugated hyaluronic acid (HA) against HeLa human cervical cancer cells. Hyaluronic Acid 167-182 CD44 molecule (Indian blood group) Homo sapiens 44-48 35408970-2 2022 The aim of this study is to investigate the CD44 receptor- and reactive oxygen species (ROS)-sensitive delivery of nanophotosensitizers of chlorin e6 (Ce6)-conjugated hyaluronic acid (HA) against HeLa human cervical cancer cells. Hyaluronic Acid 184-186 CD44 molecule (Indian blood group) Homo sapiens 44-48 35350177-0 2022 Hyaluronic Acid Facilitates Angiogenesis of Endothelial Colony Forming Cell Combining With Mesenchymal Stem Cell via CD44/ MicroRNA-139-5p Pathway. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 117-121 35164326-2 2022 CD44 is a receptor for hyaluronic acid (HA) and is involved in HCC progression. Hyaluronic Acid 23-38 CD44 molecule (Indian blood group) Homo sapiens 0-4 35164326-2 2022 CD44 is a receptor for hyaluronic acid (HA) and is involved in HCC progression. Hyaluronic Acid 40-42 CD44 molecule (Indian blood group) Homo sapiens 0-4 35484752-2 2022 In this study, we developed high-efficiency nanotheranostic agent based on ferroferric oxide, manganese dioxide, hyaluronic acid and doxorubicin (FMDH-D NPs) for dual targeting and imaging guided synergetic photothermal-enhanced chemodynamic/chemotherapy for cancer, which improved the specific uptake of drugs at tumor site by the dual action of CD44 ligand hyaluronic acid and magnetic nanoparticles guided by magnetic force. Hyaluronic Acid 113-128 CD44 molecule (Indian blood group) Homo sapiens 347-351 35484752-2 2022 In this study, we developed high-efficiency nanotheranostic agent based on ferroferric oxide, manganese dioxide, hyaluronic acid and doxorubicin (FMDH-D NPs) for dual targeting and imaging guided synergetic photothermal-enhanced chemodynamic/chemotherapy for cancer, which improved the specific uptake of drugs at tumor site by the dual action of CD44 ligand hyaluronic acid and magnetic nanoparticles guided by magnetic force. Hyaluronic Acid 359-374 CD44 molecule (Indian blood group) Homo sapiens 347-351 35198956-0 2022 Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction. Hyaluronic Acid 12-27 CD44 molecule (Indian blood group) Homo sapiens 47-51 33895486-0 2021 Oxidative damage to hyaluronan-CD44 interactions as an underlying mechanism of action of oxidative stress-inducing cancer therapy. Hyaluronic Acid 20-30 CD44 molecule (Indian blood group) Homo sapiens 31-35 33895486-2 2021 Here we investigated the biological and molecular effect of oxidative stress on the interaction between CD44 and hyaluronan (HA), as interrupting their binding can hinder cancer progression. Hyaluronic Acid 113-123 CD44 molecule (Indian blood group) Homo sapiens 104-108 33881050-5 2021 Subsequently, ADA-tagged hyaluronic acid (ADA-HA) wrapped NGO-CB[7] non-covalently via CB[7]-ADA host-guest interactions to improve the physiological stability and overall biocompatibility of this supramolecular nanosystem, and to enable targeted delivery into cancer cells with CD44 receptors overexpressed. Hyaluronic Acid 25-40 CD44 molecule (Indian blood group) Homo sapiens 279-283 33890782-4 2021 The siRNA conjugate appeared to utilize the hyaluronan-specific receptors of CD44 for cell internalization, indicating similar functionalities to our hyaluronan-mimicking synthetic. Hyaluronic Acid 44-54 CD44 molecule (Indian blood group) Homo sapiens 77-81 34011362-3 2021 Moreover, CD44 can be effectively targeted by a specific hyaluronic acid analog, namely, chitosan oligosaccharide (CO). Hyaluronic Acid 57-72 CD44 molecule (Indian blood group) Homo sapiens 10-14 33719561-7 2021 Here we show that hyaluronan (HA) is present in the fibroblastic focus together with CD44 expressing MPCs and that ligation of CD44 by HA triggers S100A4 nuclear translocation to support IPF MPC self-renewal. Hyaluronic Acid 18-28 CD44 molecule (Indian blood group) Homo sapiens 127-131 34015513-2 2021 It consists of three active covalently bound components: (1) biocompatible nitrogen-doped graphene quantum dots (GQDs) as a multifunctional delivery and imaging platform, (2) hyaluronic acid (HA) unit targeted to the CD44 receptors on a variety of cancer cells, and (3) oxidative stress-based cancer-selective ferrocene (Fc) therapeutic. Hyaluronic Acid 175-190 CD44 molecule (Indian blood group) Homo sapiens 217-221 33738958-7 2021 Doxorubicin (DOX)-loaded TTP and CD44-specific hyaluronic acid (HA)-comodified NPs (DOX@TTP-HA) are designed as following drug-loaded NPs. Hyaluronic Acid 47-62 CD44 molecule (Indian blood group) Homo sapiens 33-37 33719561-8 2021 The mechanism involves HA-mediated formation of a CD44/S100A4/transportin1 complex, which promotes S100A4 nuclear import. Hyaluronic Acid 23-25 CD44 molecule (Indian blood group) Homo sapiens 50-54 33932249-10 2021 The results showed that the synthesized nanocarrier is completely biocompatible and the drug nanocarriers reduce HeLa cell viability significantly, due to the mediation of hyaluronic acid-CD44 for drug cell uptake. Hyaluronic Acid 172-187 CD44 molecule (Indian blood group) Homo sapiens 188-192 33603365-1 2021 Purpose: Development of hyaluronic acid conjugated metformin-phospholipid sonocomplexes (HA-MPS), a biphasic complexation product compiled for enhancing both the lipophilicity and targeting potential of Metformin (MET) to CD44 receptors on pancreatic cancer. Hyaluronic Acid 24-39 CD44 molecule (Indian blood group) Homo sapiens 222-226 33675612-3 2021 Breast cancer cells have greater uptake of hyaluronic acid compared to normal cells as it binds to their overexpressed CD44 receptors. Hyaluronic Acid 43-58 CD44 molecule (Indian blood group) Homo sapiens 119-123 33675612-7 2021 In vitro investigation with hypoxia-elevated CD44 MDA-MB-231 cells showed that hyaluronic acid-targeted nanoparticles maintained their efficacy despite hypoxia-induced drug resistance unlike free DOX and nontargeted nanoparticles. Hyaluronic Acid 79-94 CD44 molecule (Indian blood group) Homo sapiens 45-49 33637851-5 2021 Accumulated hyaluronic acid shed by tumor cells subsequently mediates adhesion to the endothelium via the glycoprotein CD44. Hyaluronic Acid 12-27 CD44 molecule (Indian blood group) Homo sapiens 119-123 33637851-7 2021 Targeting of the hyaluronic acid-CD44 glycocalyx complex results in significant reduction in the extravasation of tumor cells. Hyaluronic Acid 17-32 CD44 molecule (Indian blood group) Homo sapiens 33-37 33924987-4 2021 Interestingly, Kaplan-Meier analyses showed longer recurrence-free survival in combination with strong CD44 expression, which is thought to mediate ITIH-hyaluronan (HA) binding functions. Hyaluronic Acid 153-163 CD44 molecule (Indian blood group) Homo sapiens 103-107 33649828-3 2021 A feature for the "activated" state of CD44 is that it can bind to its principal ligand hyaluronan (HA). Hyaluronic Acid 88-98 CD44 molecule (Indian blood group) Homo sapiens 39-43 33649828-3 2021 A feature for the "activated" state of CD44 is that it can bind to its principal ligand hyaluronan (HA). Hyaluronic Acid 100-102 CD44 molecule (Indian blood group) Homo sapiens 39-43 33745427-4 2021 OBJECTIVE: Designing tumor targeted PLGA nanoparticles of tamoxifen by attaching hyaluronic acid (HA) as ligand to actively target the CD44 receptors present at breast cancer cells surface. Hyaluronic Acid 81-96 CD44 molecule (Indian blood group) Homo sapiens 135-139 33745427-4 2021 OBJECTIVE: Designing tumor targeted PLGA nanoparticles of tamoxifen by attaching hyaluronic acid (HA) as ligand to actively target the CD44 receptors present at breast cancer cells surface. Hyaluronic Acid 98-100 CD44 molecule (Indian blood group) Homo sapiens 135-139 33687952-5 2021 Interestingly, we identified CD44, the receptor for hyaluronic acid, a potent biomarker and driver of progressive disease in multiple tumor types, as significantly associated with androgen stimulation. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 29-33 33664400-2 2021 As a prime example of the significance of glycans, the ability of the cell surface receptor CD44 to bind its ligand, hyaluronan, is modulated by N-glycosylation. Hyaluronic Acid 117-127 CD44 molecule (Indian blood group) Homo sapiens 92-96 33664400-5 2021 We find that non-glycosylated CD44 favors the canonical sub-micromolar binding site, while glycosylated CD44 binds hyaluronan with an entirely different micromolar binding site. Hyaluronic Acid 115-125 CD44 molecule (Indian blood group) Homo sapiens 104-108 33035113-1 2021 Poly(amido-amine) (PAMAM), one of the most widely studied dendrimers in the field of drug and gene delivery, can enhance the stability of DNA and deliver it to cell cytosol; hyaluronic acid (HA), a simple disaccharide unit, can polymerize and is considered a polymer of non-immunogenicity, which has an intrinsic targeting property for many cancer cells by interacting with CD 44. Hyaluronic Acid 191-193 CD44 molecule (Indian blood group) Homo sapiens 374-379 33557143-2 2021 CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA). Hyaluronic Acid 61-76 CD44 molecule (Indian blood group) Homo sapiens 0-4 33533018-0 2021 The effect of hyaluronic acid on nucleus pulposus extracellular matrix production through hypoxia-inducible factor-1alpha transcriptional activation of CD44 under hypoxia. Hyaluronic Acid 14-29 CD44 molecule (Indian blood group) Homo sapiens 152-156 33183436-7 2021 Hyaluronic acid is a natural polysaccharide, which has excellent biocompatibility and biodegradability, and has a good ability to actively target malignant tumor cells overexpressing the CD44 receptor. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 187-191 33525717-6 2021 Cellular uptake experiments demonstrated that AuNPs modified with hyaluronic acid were more readily ingested by HepG2 and HCT-116 cells, as they have a large number of CD44 receptors. Hyaluronic Acid 66-81 CD44 molecule (Indian blood group) Homo sapiens 168-172 33355448-3 2021 To facilitate targeted internalization by cancer cells, hyaluronic acid, a natural ligand of CD44 receptors, was covalently grafted on nCQDs. Hyaluronic Acid 56-71 CD44 molecule (Indian blood group) Homo sapiens 93-97 32472122-5 2021 The levels of hyaluronan and its capacity to counteract the effects of 4MU and the expression of RHAMM and CD44 were also determined. Hyaluronic Acid 14-24 CD44 molecule (Indian blood group) Homo sapiens 107-111 33334200-1 2021 Purpose: In our previous study, we demonstrated that hyaluronan induces odontoblastic differentiation of dental pulp stem cells via interactions with CD44. Hyaluronic Acid 53-63 CD44 molecule (Indian blood group) Homo sapiens 150-154 33091531-3 2021 Here, we synthesized a redox-sensitive nano-micelle formed by hyaluronic acid (HA) conjugated with d-alpha-tocopherol succinate (TOS) using a disulfide bond as the linker (HA-SS-TOS, HSST), which could actively accumulate to the tumor sites and metastasis cancer cells with high expression of CD44. Hyaluronic Acid 79-81 CD44 molecule (Indian blood group) Homo sapiens 293-297 32513906-2 2021 Binding of hyaluronic acid (HA) to CD44 activates cell signaling pathways, inducing cell proliferation, cell survival, and invasion. Hyaluronic Acid 11-26 CD44 molecule (Indian blood group) Homo sapiens 35-39 33159986-0 2021 Preparation of hyaluronic acid-decorated mixed nanomicelles for targeted delivery of hydrophobic drugs to CD44-overexpressing cancer cells. Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Homo sapiens 106-110 33159986-2 2021 The present research was aimed to develop a facile method for preparation of hyaluronic acid (HA)-decorated mixed nanomicelles loaded with curcumin (as a hydrophobic drug model) to provide an efficient drug delivery system for targeted therapy of breast cancer cells with high expression of CD44 receptor. Hyaluronic Acid 77-92 CD44 molecule (Indian blood group) Homo sapiens 291-295 33159986-2 2021 The present research was aimed to develop a facile method for preparation of hyaluronic acid (HA)-decorated mixed nanomicelles loaded with curcumin (as a hydrophobic drug model) to provide an efficient drug delivery system for targeted therapy of breast cancer cells with high expression of CD44 receptor. Hyaluronic Acid 94-96 CD44 molecule (Indian blood group) Homo sapiens 291-295 33091477-4 2021 The advantage of this nanosystem is that the anticancer drug MTX can be used as a tumor-targeted ligand for folate acid receptors (FA), and hyaluronic acid (HA) can be used as another tumor targeted ligand for CD44 receptors. Hyaluronic Acid 140-155 CD44 molecule (Indian blood group) Homo sapiens 210-214 32311697-10 2021 IMPACT: The interplay between CD44 and RHAMM, two receptors of hyaluronic acid, can be dependent on the lung developmental stage at birth.This is the second study that analyzes the distribution pattern of CD44 in the human lung during development and the first study performed with quantitative analysis of CD44 expression together with RHAMM expression in the human lung.Our results suggest a relationship in a subset of infants between CD44 and RHAMM expression, which appears at birth during the late saccular stage but not during the earlier stages of lung development. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 30-34 33070673-4 2021 By incorporating a reactive oxygen species (ROS)-responsive hydrophobic group into the backbone structure of hyaluronic acid - a natural ligand for the highly expressed CD44 receptor on tumor surfaces, a novel ROS-responsive and CD44-targeting nano-carriers was constructed. Hyaluronic Acid 109-124 CD44 molecule (Indian blood group) Homo sapiens 169-173 33070673-4 2021 By incorporating a reactive oxygen species (ROS)-responsive hydrophobic group into the backbone structure of hyaluronic acid - a natural ligand for the highly expressed CD44 receptor on tumor surfaces, a novel ROS-responsive and CD44-targeting nano-carriers was constructed. Hyaluronic Acid 109-124 CD44 molecule (Indian blood group) Homo sapiens 229-233 32311697-10 2021 IMPACT: The interplay between CD44 and RHAMM, two receptors of hyaluronic acid, can be dependent on the lung developmental stage at birth.This is the second study that analyzes the distribution pattern of CD44 in the human lung during development and the first study performed with quantitative analysis of CD44 expression together with RHAMM expression in the human lung.Our results suggest a relationship in a subset of infants between CD44 and RHAMM expression, which appears at birth during the late saccular stage but not during the earlier stages of lung development. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 205-209 32311697-10 2021 IMPACT: The interplay between CD44 and RHAMM, two receptors of hyaluronic acid, can be dependent on the lung developmental stage at birth.This is the second study that analyzes the distribution pattern of CD44 in the human lung during development and the first study performed with quantitative analysis of CD44 expression together with RHAMM expression in the human lung.Our results suggest a relationship in a subset of infants between CD44 and RHAMM expression, which appears at birth during the late saccular stage but not during the earlier stages of lung development. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 205-209 32311697-10 2021 IMPACT: The interplay between CD44 and RHAMM, two receptors of hyaluronic acid, can be dependent on the lung developmental stage at birth.This is the second study that analyzes the distribution pattern of CD44 in the human lung during development and the first study performed with quantitative analysis of CD44 expression together with RHAMM expression in the human lung.Our results suggest a relationship in a subset of infants between CD44 and RHAMM expression, which appears at birth during the late saccular stage but not during the earlier stages of lung development. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 205-209 32768983-0 2020 Dopamine-functionalized hyaluronic acid microspheres for effective capture of CD44-overexpressing circulating tumor cells. Hyaluronic Acid 24-39 CD44 molecule (Indian blood group) Homo sapiens 78-82 32768983-3 2020 In present work, we developed novel dopamine-functionalized hyaluronic acid microspheres (HA-DA microspheres) to capture CD44-overexpressing CTCs. Hyaluronic Acid 60-75 CD44 molecule (Indian blood group) Homo sapiens 121-125 32452217-5 2020 Hyaluronic acid (HA), a natural polysaccharide has been demonstrated to have the abilities such as good biocompatibility and targeting CD44 overexpressed receptors on non-small cell lung cancer (NSCLC) cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 135-139 33294730-4 2021 Additionally, a hyaluronic acid (HA) layer was coated on the surface of PAAVB NPs to target the CD44-overexpressed tumor cells. Hyaluronic Acid 16-31 CD44 molecule (Indian blood group) Homo sapiens 96-100 33294730-4 2021 Additionally, a hyaluronic acid (HA) layer was coated on the surface of PAAVB NPs to target the CD44-overexpressed tumor cells. Hyaluronic Acid 33-35 CD44 molecule (Indian blood group) Homo sapiens 96-100 32919536-3 2020 The cellular uptake of HA-DP4, HA-DP6 and HA-DP8-decorated fluorescently labelled liposomes was significantly higher (12 to 14-fold) in lung cancer cell lines with high CD44 expression than in those with low CD44 expression, suggesting a receptor-mediated entry of HA-conjugated formulations. Hyaluronic Acid 23-26 CD44 molecule (Indian blood group) Homo sapiens 169-173 32956582-5 2020 Meanwhile, equipping ZIF-90 with a SAD shell not only substantially improved the pH-responsive drug releasing of ZIF-90, but also enabled the post-formation conjugation of ZIF-90 with hyaluronic acid for specific CD44 recognition, thereby facilitating precise drug delivery to CD44-overexpressed tumor. Hyaluronic Acid 184-199 CD44 molecule (Indian blood group) Homo sapiens 213-217 32956582-5 2020 Meanwhile, equipping ZIF-90 with a SAD shell not only substantially improved the pH-responsive drug releasing of ZIF-90, but also enabled the post-formation conjugation of ZIF-90 with hyaluronic acid for specific CD44 recognition, thereby facilitating precise drug delivery to CD44-overexpressed tumor. Hyaluronic Acid 184-199 CD44 molecule (Indian blood group) Homo sapiens 277-281 33024087-5 2020 Furthermore, the interaction of CD44 with the ligand hyaluronan (HA) initiated the Src-ERK signaling cascade, which subsequently maintained AKT and mTOR activity in the presence of a PI3Kalpha inhibitor. Hyaluronic Acid 53-63 CD44 molecule (Indian blood group) Homo sapiens 32-36 33024087-5 2020 Furthermore, the interaction of CD44 with the ligand hyaluronan (HA) initiated the Src-ERK signaling cascade, which subsequently maintained AKT and mTOR activity in the presence of a PI3Kalpha inhibitor. Hyaluronic Acid 65-67 CD44 molecule (Indian blood group) Homo sapiens 32-36 32870819-4 2020 The glomerular homing of T cells was mediated via the direct binding of their CD44 to the hyaluronic acid (HA) component of the endothelial glycocalyx, and glycocalyx-degrading enzymes efficiently disrupted it. Hyaluronic Acid 90-105 CD44 molecule (Indian blood group) Homo sapiens 78-82 32870819-4 2020 The glomerular homing of T cells was mediated via the direct binding of their CD44 to the hyaluronic acid (HA) component of the endothelial glycocalyx, and glycocalyx-degrading enzymes efficiently disrupted it. Hyaluronic Acid 107-109 CD44 molecule (Indian blood group) Homo sapiens 78-82 32372344-0 2020 Correction to: a facile approach for fabricating CD44-targeted delivery of hyaluronic acid-functionalized PCL nanoparticles in urethane-induced lung cancer: Bcl-2, MMP-9, caspase-9, and BAX as potential markers. Hyaluronic Acid 75-90 CD44 molecule (Indian blood group) Homo sapiens 49-53 32779670-2 2020 Herein, we report active-targeting, enzyme- and ROS-dual responsive nanoparticles (HPGBCA) consisting of CD44-targeting hyaluronic acid (HA) shells and afatinib (AFT)-loaded, ROS-sensitive poly(l-lysine)-conjugated chlorin e6 (Ce6) derivative nanoparticle cores (PGBCA). Hyaluronic Acid 120-135 CD44 molecule (Indian blood group) Homo sapiens 105-109 32851998-1 2020 A tumor redox-activatable micellar nanoplatform based on the naturally occurring biomacromolecule hyaluronic acid (HA) was developed for complementary photodynamic/chemotherapy against CD44-positive tumors. Hyaluronic Acid 98-113 CD44 molecule (Indian blood group) Homo sapiens 185-189 32851998-1 2020 A tumor redox-activatable micellar nanoplatform based on the naturally occurring biomacromolecule hyaluronic acid (HA) was developed for complementary photodynamic/chemotherapy against CD44-positive tumors. Hyaluronic Acid 115-117 CD44 molecule (Indian blood group) Homo sapiens 185-189 32919536-3 2020 The cellular uptake of HA-DP4, HA-DP6 and HA-DP8-decorated fluorescently labelled liposomes was significantly higher (12 to 14-fold) in lung cancer cell lines with high CD44 expression than in those with low CD44 expression, suggesting a receptor-mediated entry of HA-conjugated formulations. Hyaluronic Acid 23-26 CD44 molecule (Indian blood group) Homo sapiens 208-212 32919536-3 2020 The cellular uptake of HA-DP4, HA-DP6 and HA-DP8-decorated fluorescently labelled liposomes was significantly higher (12 to 14-fold) in lung cancer cell lines with high CD44 expression than in those with low CD44 expression, suggesting a receptor-mediated entry of HA-conjugated formulations. Hyaluronic Acid 23-25 CD44 molecule (Indian blood group) Homo sapiens 169-173 32919536-3 2020 The cellular uptake of HA-DP4, HA-DP6 and HA-DP8-decorated fluorescently labelled liposomes was significantly higher (12 to 14-fold) in lung cancer cell lines with high CD44 expression than in those with low CD44 expression, suggesting a receptor-mediated entry of HA-conjugated formulations. Hyaluronic Acid 23-25 CD44 molecule (Indian blood group) Homo sapiens 208-212 32919536-3 2020 The cellular uptake of HA-DP4, HA-DP6 and HA-DP8-decorated fluorescently labelled liposomes was significantly higher (12 to 14-fold) in lung cancer cell lines with high CD44 expression than in those with low CD44 expression, suggesting a receptor-mediated entry of HA-conjugated formulations. Hyaluronic Acid 31-34 CD44 molecule (Indian blood group) Homo sapiens 169-173 32379519-1 2020 CD44 is a type I transmembrane glycoprotein interacting with a number of extracellular components, including hyaluronic acid (HA). Hyaluronic Acid 109-124 CD44 molecule (Indian blood group) Homo sapiens 0-4 32379519-1 2020 CD44 is a type I transmembrane glycoprotein interacting with a number of extracellular components, including hyaluronic acid (HA). Hyaluronic Acid 126-128 CD44 molecule (Indian blood group) Homo sapiens 0-4 33014359-3 2020 Here, we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle (5K-HA-HPPS) loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast cancer. Hyaluronic Acid 70-85 CD44 molecule (Indian blood group) Homo sapiens 18-22 32995671-0 2021 Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer. Hyaluronic Acid 28-43 CD44 molecule (Indian blood group) Homo sapiens 73-77 32428448-0 2020 Hyaluronic acid binding to CD44S is indiscriminate of molecular weight. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 27-31 32645383-5 2020 DOPE-conjugated hyaluronic acid (HA) was coated on the surface of MDMs to shield the exposed positive charge on PAMAM and to increase the cellular association with CD44+ cancer cells. Hyaluronic Acid 16-31 CD44 molecule (Indian blood group) Homo sapiens 164-168 32645383-5 2020 DOPE-conjugated hyaluronic acid (HA) was coated on the surface of MDMs to shield the exposed positive charge on PAMAM and to increase the cellular association with CD44+ cancer cells. Hyaluronic Acid 33-35 CD44 molecule (Indian blood group) Homo sapiens 164-168 32878305-4 2020 The targeting abilities of CD44 binding were increased as the hyaluronan concentration increased and decreased by adding a competitor CD44 antibody. Hyaluronic Acid 62-72 CD44 molecule (Indian blood group) Homo sapiens 27-31 32878305-4 2020 The targeting abilities of CD44 binding were increased as the hyaluronan concentration increased and decreased by adding a competitor CD44 antibody. Hyaluronic Acid 62-72 CD44 molecule (Indian blood group) Homo sapiens 134-138 32452217-5 2020 Hyaluronic acid (HA), a natural polysaccharide has been demonstrated to have the abilities such as good biocompatibility and targeting CD44 overexpressed receptors on non-small cell lung cancer (NSCLC) cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 135-139 32679746-5 2020 The synthesis and plasma membrane binding of hyaluronan were manipulated with hyaluronan synthase 3 (HAS3) and hyaluronan receptor CD44 overexpression, and treatments with mannose, 4-methylumbelliferone (4-MU), and glucosamine. Hyaluronic Acid 45-55 CD44 molecule (Indian blood group) Homo sapiens 131-135 32638804-1 2020 Hyaluronic acid (HA) is a ubiquitous glycosaminoglycan in the extracellular matrix and a ligand of CD44, a transmembrane glycoprotein that is important in cell migration. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 99-103 32638804-1 2020 Hyaluronic acid (HA) is a ubiquitous glycosaminoglycan in the extracellular matrix and a ligand of CD44, a transmembrane glycoprotein that is important in cell migration. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 99-103 32437163-3 2020 Inspired by special CD44 binding capability from hyaluronic acid(HA), in this study, novel HA coated CPT nanocrystals were successfully prepared by an anti-solvent precipitation method for tumor targeted delivery of hydrophobic drug CPT. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 20-24 32616529-4 2021 In primary AML BM samples from patients and the OCI-AML3 cell line, CD44 engagement by hyaluronan induced inside-out activation of VLA-4 resulting in enhanced leukemia cell adhesion on VCAM-1. Hyaluronic Acid 87-97 CD44 molecule (Indian blood group) Homo sapiens 68-72 32656449-6 2020 idoBR1 and cucumber extract reduced the binding of hyaluronic acid (HA) to CD44 in LPS-stimulated THP-1 cells and may function as an anti-inflammatory agent by inhibiting induced sialidase involved in the production of functionally active HA adhesive CD44. Hyaluronic Acid 51-66 CD44 molecule (Indian blood group) Homo sapiens 75-79 33102192-4 2020 Hyaluronan is a versatile bio-polymer and ligand of the receptor (CD44) on cancer cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 66-70 32617404-0 2020 Sulfation modulates the targeting properties of hyaluronic acid to P-selectin and CD44. Hyaluronic Acid 48-63 CD44 molecule (Indian blood group) Homo sapiens 82-86 32617404-4 2020 Hyaluronic acid (HA) was regioselectivity modified using a multi-step synthetic approach to alter binding specificities for CD44 and P-selectin to tumor cell interaction. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 124-128 32617404-4 2020 Hyaluronic acid (HA) was regioselectivity modified using a multi-step synthetic approach to alter binding specificities for CD44 and P-selectin to tumor cell interaction. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 124-128 32112841-1 2020 The present study was intended to develop a papain grafted S-protected hyaluronic acid-lithocholic acid co-block (PAP-HA-ss-LCA) polymeric excipient as an amphiphilic muco permeating stabilizer for targeting breast cancer epithelial cells overexpressed with CD44 receptors. Hyaluronic Acid 71-86 CD44 molecule (Indian blood group) Homo sapiens 258-262 31090215-6 2020 CD147 stimulates hyaluronan synthesis and interaction of hyaluronan with its receptors, in particular CD44 and LYVE-1, which in turn result in activation of multiprotein complexes containing members of the membrane-type matrix metalloproteinase, receptor tyrosine kinase, ABC drug transporter, or MCT families within lipid raft domains. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Homo sapiens 102-106 32193421-0 2020 IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent Manner. Hyaluronic Acid 15-25 CD44 molecule (Indian blood group) Homo sapiens 26-30 32193421-2 2020 We previously found that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan-CD44 interactions. Hyaluronic Acid 136-146 CD44 molecule (Indian blood group) Homo sapiens 147-151 32193421-5 2020 In a manner comparable to that of the IGFBP-3 protein, the peptide blocked hyaluronan-CD44 signaling, and more effectively inhibited viability of A549 cells than viability of either H1299 or HFL1 cell lines. Hyaluronic Acid 75-85 CD44 molecule (Indian blood group) Homo sapiens 86-90 32193421-8 2020 Taken together, our results show that IGFBP-3 or its peptide blocks hyaluronan-CD44 signaling via a mechanism that depends on both p53 and acetylcholinesterase. Hyaluronic Acid 68-78 CD44 molecule (Indian blood group) Homo sapiens 79-83 32222753-0 2020 Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44. Hyaluronic Acid 40-55 CD44 molecule (Indian blood group) Homo sapiens 84-88 31276783-5 2020 Extra- and intra-cellular hyaluronan binds to hyaluronan binding proteins, such as CD44, RHAMM, CDC37 and USP17, affecting cellular behavior. Hyaluronic Acid 26-36 CD44 molecule (Indian blood group) Homo sapiens 83-87 32183027-0 2020 On-Chip Synthesis of Hyaluronic Acid-Based Nanoparticles for Selective Inhibition of CD44+ Human Mesenchymal Stem Cell Proliferation. Hyaluronic Acid 21-36 CD44 molecule (Indian blood group) Homo sapiens 85-89 33463200-0 2020 CD44-Mediated Methotrexate Delivery by Hyaluronan-Coated Nanoparticles Composed of a Branched Cell-Penetrating Peptide. Hyaluronic Acid 39-49 CD44 molecule (Indian blood group) Homo sapiens 0-4 32148519-6 2020 Herein, microarray-based transcriptomic analysis shows that G-CSF stimulation in vitro results in modulation of various signaling pathways including ones related with the metabolism of hyaluronan (HA), conferring a profile of cell mobilization to ADSCs, mediated in a cell-intrinsic fashion in part by reducing CD44 expression and HA synthesis-related genes. Hyaluronic Acid 185-195 CD44 molecule (Indian blood group) Homo sapiens 311-315 31532629-0 2020 CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors in Vivo. Hyaluronic Acid 72-87 CD44 molecule (Indian blood group) Homo sapiens 0-4 31532629-8 2020 These multifunctional nanoformulations based on a single and all-natural hyaluronic acid conjugate emerge as a potential nanoplatform for targeted treatment of CD44-positive metastatic tumors. Hyaluronic Acid 73-88 CD44 molecule (Indian blood group) Homo sapiens 160-164 33463200-4 2020 The HA-coated nanoparticles provide targetability for the CD44 cell surface receptor. Hyaluronic Acid 4-6 CD44 molecule (Indian blood group) Homo sapiens 58-62 31582066-0 2019 Tumor acidity and CD44 dual targeting hyaluronic acid-coated gold nanorods for combined chemo- and photothermal cancer therapy. Hyaluronic Acid 38-53 CD44 molecule (Indian blood group) Homo sapiens 18-22 31654718-4 2020 Dysregulation of hyaluronan-CD44 interactions is seen in diseases, such as inflammation and cancer. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Homo sapiens 28-32 31654718-5 2020 In the present communication, we discuss the mechanism of hyaluronan-induced signaling via CD44, as well as the involvement of hyaluronan-engaged CD44 in malignancies and in viral infections. Hyaluronic Acid 58-68 CD44 molecule (Indian blood group) Homo sapiens 91-95 31742323-3 2019 The GNR was surface functionalized with poly-glutamic acid (PGA) and poly-l-Lysine (PLL) with a final layer of hyaluronic acid (HA) that could also serve as a targeting ligand toward the overexpressed CD44 receptors in ovarian cancer cells. Hyaluronic Acid 128-130 CD44 molecule (Indian blood group) Homo sapiens 201-205 33051414-0 2020 Effect of ligand-receptor interaction of osteopontin-CD44 on the expression of hyaluronic acid in human knee osteoarthritic chondrocytes in vitro. Hyaluronic Acid 79-94 CD44 molecule (Indian blood group) Homo sapiens 53-57 33051414-1 2020 OBJECTIVES: To investigate the effect of ligand-receptor interaction of osteopontin (OPN)-CD44 on the expression of hyaluronic acid (HA) in the cultured human knee osteoarthritis (OA) chondrocytes via interfering the reaction between OPN and CD44 ligand-receptor. Hyaluronic Acid 116-131 CD44 molecule (Indian blood group) Homo sapiens 90-94 31742323-3 2019 The GNR was surface functionalized with poly-glutamic acid (PGA) and poly-l-Lysine (PLL) with a final layer of hyaluronic acid (HA) that could also serve as a targeting ligand toward the overexpressed CD44 receptors in ovarian cancer cells. Hyaluronic Acid 111-126 CD44 molecule (Indian blood group) Homo sapiens 201-205 31582066-1 2019 In this work, tumor acidity and CD44 dual targeting hyaluronic acid-coated gold nanorods (AuNRs) are investigated for combined chemo- and photothermal cancer therapy. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 32-36 31229434-0 2019 Synergistic Enhancement of Cellular Uptake With CD44-Expressing Malignant Pleural Mesothelioma by Combining Cationic Liposome and Hyaluronic Acid-Lipid Conjugate. Hyaluronic Acid 130-145 CD44 molecule (Indian blood group) Homo sapiens 48-52 30676222-0 2019 Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 30676222-1 2019 The role of hyaluronan (HA) in periodontal healing has been speculated via its interaction with the CD44 receptor. Hyaluronic Acid 12-22 CD44 molecule (Indian blood group) Homo sapiens 100-104 30676222-1 2019 The role of hyaluronan (HA) in periodontal healing has been speculated via its interaction with the CD44 receptor. Hyaluronic Acid 24-26 CD44 molecule (Indian blood group) Homo sapiens 100-104 31357900-0 2019 Mucopenetrating lipoplexes modified with PEG and hyaluronic acid for CD44-targeted local siRNA delivery to the lungs. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 69-73 31227170-2 2019 This was functionalized with hyaluronic acid to permit active targeting of CD44-overexpressing human breast cancer cells. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 75-79 31125725-3 2019 CD44 is a cell surface receptor for hyaluronic acid (HA) and has been reported as an important CSC marker. Hyaluronic Acid 36-51 CD44 molecule (Indian blood group) Homo sapiens 0-4 31509965-2 2019 Hyaluronic acid (HA) plays a key role in fibrosis with its specific receptor, CD44, overexpressed by CTD-ILD and BOS cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 78-82 31509965-2 2019 Hyaluronic acid (HA) plays a key role in fibrosis with its specific receptor, CD44, overexpressed by CTD-ILD and BOS cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 78-82 29589805-0 2019 Hyaluronan impairs the barrier integrity of brain microvascular endothelial cells through a CD44-dependent pathway. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 92-96 30935974-6 2019 Silencing HAS2 and CD44 partly inhibited the inflammatory response, suggesting that hyaluronan coat is involved in the process. Hyaluronic Acid 84-94 CD44 molecule (Indian blood group) Homo sapiens 19-23 31389968-1 2019 Hyaluronic acid (HA)-based nanocarriers are of great interest in the drug delivery field due to the tumor targetability via CD44-mediated recognition and endocytosis. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 124-128 31389968-1 2019 Hyaluronic acid (HA)-based nanocarriers are of great interest in the drug delivery field due to the tumor targetability via CD44-mediated recognition and endocytosis. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 124-128 31290616-3 2019 In this study, Bi2 Se3 hollow nanocubes (HNCs) are first fabricated based on a mild cation exchange way and Kirkendall effect and then modified with hyaluronic acid (HA) through redox-cleavable linkage (-s-s-), thus enabling the HNC to target cancer cells overexpressing CD-44 and control the cargo release profile. Hyaluronic Acid 149-164 CD44 molecule (Indian blood group) Homo sapiens 271-276 31290616-3 2019 In this study, Bi2 Se3 hollow nanocubes (HNCs) are first fabricated based on a mild cation exchange way and Kirkendall effect and then modified with hyaluronic acid (HA) through redox-cleavable linkage (-s-s-), thus enabling the HNC to target cancer cells overexpressing CD-44 and control the cargo release profile. Hyaluronic Acid 166-168 CD44 molecule (Indian blood group) Homo sapiens 271-276 30773699-0 2019 Hyaluronic Acid-Based Activatable Nanomaterials for Stimuli-Responsive Imaging and Therapeutics: Beyond CD44-Mediated Drug Delivery. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 104-108 30773699-6 2019 Recent advances in designing hyaluronic acid-based, actively targeted, hyaluronidase- or reactive-oxygen-species-responsive nanomaterials for both diagnostic imaging and therapeutic delivery, which go beyond merely the classical targeting of CD44, are summarized. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 242-246 31125725-3 2019 CD44 is a cell surface receptor for hyaluronic acid (HA) and has been reported as an important CSC marker. Hyaluronic Acid 53-55 CD44 molecule (Indian blood group) Homo sapiens 0-4 31047947-3 2019 In order to increase the active delivery to tumor cells, we produced hyaluronic acid (HA)-conjugated liposomes containing Sdox (HA-Lsdox), exploiting the abundance of the HA receptor CD44 in osteosarcoma. Hyaluronic Acid 69-84 CD44 molecule (Indian blood group) Homo sapiens 183-187 31047947-3 2019 In order to increase the active delivery to tumor cells, we produced hyaluronic acid (HA)-conjugated liposomes containing Sdox (HA-Lsdox), exploiting the abundance of the HA receptor CD44 in osteosarcoma. Hyaluronic Acid 86-88 CD44 molecule (Indian blood group) Homo sapiens 183-187 31293964-3 2019 Hyaluronan (HA), one of the major ECM (extracellular matrix) components have been identified as a physiological ligand for surface CD44 isoforms which are frequently overexpressed in malignant tumor cells during cancer progression. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 131-135 31257854-0 2019 Photoelectrochemical Biosensor for Sensitive Detection of Soluble CD44 Based on the Facile Construction of a Poly(ethylene glycol)/Hyaluronic Acid Hybrid Antifouling Interface. Hyaluronic Acid 131-146 CD44 molecule (Indian blood group) Homo sapiens 66-70 31198046-2 2019 Herein, dual-acting MTX (not only targeting folate receptors but also killing cells via inhibition of intracellular folate metabolism) and hyaluronic acid (HA, targeting CD44 receptors) were selected to be covalently linked by the redox-responsive disulfide bond. Hyaluronic Acid 139-154 CD44 molecule (Indian blood group) Homo sapiens 170-174 31293964-3 2019 Hyaluronan (HA), one of the major ECM (extracellular matrix) components have been identified as a physiological ligand for surface CD44 isoforms which are frequently overexpressed in malignant tumor cells during cancer progression. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 131-135 30908865-6 2019 Further modification by hyaluronic acid (HA) bestowed the Si-Dox@HA nanoparticles with the ability to target CD44-overexpressing cancer cells. Hyaluronic Acid 24-39 CD44 molecule (Indian blood group) Homo sapiens 109-113 30908865-6 2019 Further modification by hyaluronic acid (HA) bestowed the Si-Dox@HA nanoparticles with the ability to target CD44-overexpressing cancer cells. Hyaluronic Acid 41-43 CD44 molecule (Indian blood group) Homo sapiens 109-113 30633963-4 2019 Our approach is demonstrated with the interaction between hyaluronan (HA, a key component of the endothelial glycocalyx) and its cell receptor CD44. Hyaluronic Acid 58-68 CD44 molecule (Indian blood group) Homo sapiens 143-147 31013093-0 2019 Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44. Hyaluronic Acid 29-44 CD44 molecule (Indian blood group) Homo sapiens 69-73 31013093-2 2019 Currently, one of the most investigated agents for cancer targeting is hyaluronic acid (HA), since its receptor, CD44, is overexpressed in many cancers. Hyaluronic Acid 71-86 CD44 molecule (Indian blood group) Homo sapiens 113-117 31013093-2 2019 Currently, one of the most investigated agents for cancer targeting is hyaluronic acid (HA), since its receptor, CD44, is overexpressed in many cancers. Hyaluronic Acid 88-90 CD44 molecule (Indian blood group) Homo sapiens 113-117 31044197-4 2019 The obtained tetracycline (Tet)@ZIF-8@ hyaluronic acid (HA) system (abbreviated to TZH) can be taken up by cells owing to the presence of CD44 receptors on the cell surface via an HA-mediated pathway. Hyaluronic Acid 39-54 CD44 molecule (Indian blood group) Homo sapiens 138-142 31044197-4 2019 The obtained tetracycline (Tet)@ZIF-8@ hyaluronic acid (HA) system (abbreviated to TZH) can be taken up by cells owing to the presence of CD44 receptors on the cell surface via an HA-mediated pathway. Hyaluronic Acid 56-58 CD44 molecule (Indian blood group) Homo sapiens 138-142 30077625-0 2019 Hyaluronan-CD44 interaction promotes HPV 16 E6 oncogene-mediated oropharyngeal cell carcinoma survival and chemoresistance. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 30077625-4 2019 Importantly, interaction between matrix hyaluronan (HA) and CD44 (an HA receptor) promotes c-Jun phosphorylation followed by phospho-c-Jun nuclear translocation and co-localization with HPV16 E6 in the nucleus of both UMSCC-104 and UMSCC-47 cells. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 60-64 30844454-1 2019 Hyaluronic acid (HA) is a natural biopolymer that can target to tumor cells due to CD44 receptors overexpressed in tumor cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 83-87 30844454-1 2019 Hyaluronic acid (HA) is a natural biopolymer that can target to tumor cells due to CD44 receptors overexpressed in tumor cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 83-87 31080060-3 2019 Mechanistically, clustering of the CD44 extracellular domain by high-molecular-weight hyaluronan leads to recruitment of the polarity-regulating kinase PAR1b by the CD44 intracellular domain, which results in disruption of the Hippo signaling-inhibitory PAR1b-MST complex. Hyaluronic Acid 86-96 CD44 molecule (Indian blood group) Homo sapiens 35-39 31080060-3 2019 Mechanistically, clustering of the CD44 extracellular domain by high-molecular-weight hyaluronan leads to recruitment of the polarity-regulating kinase PAR1b by the CD44 intracellular domain, which results in disruption of the Hippo signaling-inhibitory PAR1b-MST complex. Hyaluronic Acid 86-96 CD44 molecule (Indian blood group) Homo sapiens 165-169 31080060-5 2019 Conversely, low-molecular-weight hyaluronan, which is produced by hyaluronidase-mediated degradation of high-molecular-weight hyaluronan, inhibits Hippo signaling by competing with high-molecular-weight hyaluronan for CD44 binding. Hyaluronic Acid 33-43 CD44 molecule (Indian blood group) Homo sapiens 218-222 29425696-9 2019 Signaling events driven by changes in hyaluronan-chondrocyte interactions may involve a chaperone function of CD44 with other receptors/cofactors as well as the changes in hyaluronan production functioning as a metabolic rheostat. Hyaluronic Acid 38-48 CD44 molecule (Indian blood group) Homo sapiens 110-114 30644653-7 2019 We found that combining MSC-S and HA/CS increased the expression of CD44 receptors colocalized with HA, suggesting that the observed therapeutic effects between the MSC-S and HA/CS are in part mediated by CD44 receptor upregulation and activation by HA. Hyaluronic Acid 34-36 CD44 molecule (Indian blood group) Homo sapiens 68-72 30644653-7 2019 We found that combining MSC-S and HA/CS increased the expression of CD44 receptors colocalized with HA, suggesting that the observed therapeutic effects between the MSC-S and HA/CS are in part mediated by CD44 receptor upregulation and activation by HA. Hyaluronic Acid 34-36 CD44 molecule (Indian blood group) Homo sapiens 205-209 30633963-4 2019 Our approach is demonstrated with the interaction between hyaluronan (HA, a key component of the endothelial glycocalyx) and its cell receptor CD44. Hyaluronic Acid 70-72 CD44 molecule (Indian blood group) Homo sapiens 143-147 31079324-7 2019 HA supplementation promoted the expression of GSC markers and CD44 in GBM cells cultured in serum-free media. Hyaluronic Acid 0-2 CD44 molecule (Indian blood group) Homo sapiens 62-66 30822503-5 2019 In this study we developed ternary nanocomplexes to deliver an anti-KRAS siRNA to colorectal cancer cells, exploiting the interaction of hyaluronic acid (HA) with CD44 as a means to achieve selective targeting of CD44-positive cancer cells. Hyaluronic Acid 137-152 CD44 molecule (Indian blood group) Homo sapiens 163-167 30822503-5 2019 In this study we developed ternary nanocomplexes to deliver an anti-KRAS siRNA to colorectal cancer cells, exploiting the interaction of hyaluronic acid (HA) with CD44 as a means to achieve selective targeting of CD44-positive cancer cells. Hyaluronic Acid 137-152 CD44 molecule (Indian blood group) Homo sapiens 213-217 30822503-5 2019 In this study we developed ternary nanocomplexes to deliver an anti-KRAS siRNA to colorectal cancer cells, exploiting the interaction of hyaluronic acid (HA) with CD44 as a means to achieve selective targeting of CD44-positive cancer cells. Hyaluronic Acid 154-156 CD44 molecule (Indian blood group) Homo sapiens 163-167 30822503-5 2019 In this study we developed ternary nanocomplexes to deliver an anti-KRAS siRNA to colorectal cancer cells, exploiting the interaction of hyaluronic acid (HA) with CD44 as a means to achieve selective targeting of CD44-positive cancer cells. Hyaluronic Acid 154-156 CD44 molecule (Indian blood group) Homo sapiens 213-217 30909497-0 2019 CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells. Hyaluronic Acid 16-26 CD44 molecule (Indian blood group) Homo sapiens 0-4 30456933-7 2019 Using gas-phase electrophoretic molecular mobility analysis, we uncover a shift towards high molecular mass hyaluronan in pancreatic cancer tissue compared to normal pancreas and at a transcriptional level, we find that hyaluronan synthesising HAS2 correlates positively with CD44. Hyaluronic Acid 220-230 CD44 molecule (Indian blood group) Homo sapiens 276-280 30456933-2 2019 Secreted hyaluronan, osteopontin and type IV collagen sustain oncogenic signalling by interactions with CD44s and its variant isoform CD44v6 on cancer cell membranes. Hyaluronic Acid 9-19 CD44 molecule (Indian blood group) Homo sapiens 104-108 29658360-0 2019 Hyaluronic acid promotes proliferation and migration of human meniscus cells via a CD44-dependent mechanism. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 83-87 30972285-1 2019 Hyaluronic acid (HA) is a natural ligand of tumor-targeted drug delivery systems (DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 107-111 30972285-1 2019 Hyaluronic acid (HA) is a natural ligand of tumor-targeted drug delivery systems (DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 107-111 30365189-0 2019 Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 11-15 30365189-1 2019 Although members of the hyaluronan (HA)-CD44/HA-mediated motility receptor (RHAMM) signaling pathway have been shown to be overexpressed in lung cancer, their role in lung tumorigenesis is unclear. Hyaluronic Acid 24-34 CD44 molecule (Indian blood group) Homo sapiens 40-44 30396062-1 2019 The cell-surface protein CD44, a primary receptor for hyaluronic acid (HA), is one of the most promising targets for cancer therapies. Hyaluronic Acid 54-69 CD44 molecule (Indian blood group) Homo sapiens 25-29 30396062-1 2019 The cell-surface protein CD44, a primary receptor for hyaluronic acid (HA), is one of the most promising targets for cancer therapies. Hyaluronic Acid 71-73 CD44 molecule (Indian blood group) Homo sapiens 25-29 30178279-0 2019 A facile approach for fabricating CD44-targeted delivery of hyaluronic acid-functionalized PCL nanoparticles in urethane-induced lung cancer: Bcl-2, MMP-9, caspase-9, and BAX as potential markers. Hyaluronic Acid 60-75 CD44 molecule (Indian blood group) Homo sapiens 34-38 30554119-4 2019 Hyaluronic acid (HA), an endogenous anionic polysaccharide was coated on cationic liposomes for targeting CD44 receptors over expressed on CSCs. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 106-110 30554119-4 2019 Hyaluronic acid (HA), an endogenous anionic polysaccharide was coated on cationic liposomes for targeting CD44 receptors over expressed on CSCs. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 106-110 30957871-2 2019 In monocytes, CD44H is implicated in phagocytosis of particles coated by hyaluronan (HA). Hyaluronic Acid 73-83 CD44 molecule (Indian blood group) Homo sapiens 14-18 30960121-1 2019 In this study, hyaluronic acid (HA), a natural polysaccharide that can specifically bind to CD44 receptors, was conjugated onto laponite (LAP) nanodisks for the encapsulation and specific delivery of the anti-cancer drug doxorubicin (DOX) to CD44-overexpressed cancer cells. Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Homo sapiens 92-96 30960121-1 2019 In this study, hyaluronic acid (HA), a natural polysaccharide that can specifically bind to CD44 receptors, was conjugated onto laponite (LAP) nanodisks for the encapsulation and specific delivery of the anti-cancer drug doxorubicin (DOX) to CD44-overexpressed cancer cells. Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Homo sapiens 243-247 30960121-1 2019 In this study, hyaluronic acid (HA), a natural polysaccharide that can specifically bind to CD44 receptors, was conjugated onto laponite (LAP) nanodisks for the encapsulation and specific delivery of the anti-cancer drug doxorubicin (DOX) to CD44-overexpressed cancer cells. Hyaluronic Acid 32-34 CD44 molecule (Indian blood group) Homo sapiens 92-96 30960121-1 2019 In this study, hyaluronic acid (HA), a natural polysaccharide that can specifically bind to CD44 receptors, was conjugated onto laponite (LAP) nanodisks for the encapsulation and specific delivery of the anti-cancer drug doxorubicin (DOX) to CD44-overexpressed cancer cells. Hyaluronic Acid 32-34 CD44 molecule (Indian blood group) Homo sapiens 243-247 30267751-4 2019 METHODS: Hyaluronic acid (HA) decorated liposomes, containing diethyldithiocarbamate-copper (Cu(DDC)2), able to target the specific CSC marker CD44 receptor were prepared by ion gradient technique and fully characterized. Hyaluronic Acid 9-24 CD44 molecule (Indian blood group) Homo sapiens 143-147 30267751-4 2019 METHODS: Hyaluronic acid (HA) decorated liposomes, containing diethyldithiocarbamate-copper (Cu(DDC)2), able to target the specific CSC marker CD44 receptor were prepared by ion gradient technique and fully characterized. Hyaluronic Acid 26-28 CD44 molecule (Indian blood group) Homo sapiens 143-147 30957871-2 2019 In monocytes, CD44H is implicated in phagocytosis of particles coated by hyaluronan (HA). Hyaluronic Acid 85-87 CD44 molecule (Indian blood group) Homo sapiens 14-18 30375477-0 2018 Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells. Hyaluronic Acid 40-55 CD44 molecule (Indian blood group) Homo sapiens 67-71 29183161-0 2018 Macrophage repolarization using CD44-targeting hyaluronic acid-polylactide nanoparticles containing curcumin. Hyaluronic Acid 47-62 CD44 molecule (Indian blood group) Homo sapiens 32-36 30245385-4 2018 The obtained results indicated that 3D microspheres provided proper support for cells to self-assemble into compact 3D microtissues and promoted an increase in CD44 expression, emulating the presence of native-ECM hyaluronan. Hyaluronic Acid 214-224 CD44 molecule (Indian blood group) Homo sapiens 160-164 30838615-6 2019 Finally, the NPs are functionalized with hyaluronic acid, a polysaccharide which targets the CD44 receptor. Hyaluronic Acid 41-56 CD44 molecule (Indian blood group) Homo sapiens 93-97 31458417-3 2018 Here, we report the synthesis of IL-4-loaded hyaluronic acid (HA) particle for the targeted delivery of cytokines through the high affinity of HA to CD44 receptors of macrophages. Hyaluronic Acid 45-60 CD44 molecule (Indian blood group) Homo sapiens 149-153 31458417-3 2018 Here, we report the synthesis of IL-4-loaded hyaluronic acid (HA) particle for the targeted delivery of cytokines through the high affinity of HA to CD44 receptors of macrophages. Hyaluronic Acid 62-64 CD44 molecule (Indian blood group) Homo sapiens 149-153 29183161-1 2018 The aim of this study was to evaluate the efficiency of using a natural substance, curcumin, encapsulated in CD44-targeting hyaluronate-polylactide (HA-PLA) nanoparticles (NPs) for the modulation of macrophage polarity from the pro-inflammatory M1 to anti-inflammatory M2 phenotype. Hyaluronic Acid 124-135 CD44 molecule (Indian blood group) Homo sapiens 109-113 30025377-0 2018 Hyaluronan magnetic nanoparticle for mitoxantrone delivery toward CD44-positive cancer cells. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 66-70 30201431-10 2018 The hyaluronic acid (HA) coating over the MTNst surface served a dual purpose of first, stabilizing DOX inside the MTNst (capping agent), and second, directing the nanoplatform device to CD44 receptors that are highly expressed in MDA-MB-231 cells (targeting ligand). Hyaluronic Acid 21-23 CD44 molecule (Indian blood group) Homo sapiens 187-191 30259937-4 2018 Hyaluronic acid (HA)-functionalized Au@Cu-PbCQD nanoprobes were labelled on MCF-7 cells via specific recognition to the CD44 receptor, which served as the research model. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 120-124 30259937-4 2018 Hyaluronic acid (HA)-functionalized Au@Cu-PbCQD nanoprobes were labelled on MCF-7 cells via specific recognition to the CD44 receptor, which served as the research model. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 120-124 30201431-10 2018 The hyaluronic acid (HA) coating over the MTNst surface served a dual purpose of first, stabilizing DOX inside the MTNst (capping agent), and second, directing the nanoplatform device to CD44 receptors that are highly expressed in MDA-MB-231 cells (targeting ligand). Hyaluronic Acid 4-19 CD44 molecule (Indian blood group) Homo sapiens 187-191 30375477-1 2018 The physiological importance of the interactions between hyaluronic acid (HA) and its main membrane receptor, CD44, in pathological processes, e.g. cancer, is well recognized. Hyaluronic Acid 57-72 CD44 molecule (Indian blood group) Homo sapiens 110-114 30375477-1 2018 The physiological importance of the interactions between hyaluronic acid (HA) and its main membrane receptor, CD44, in pathological processes, e.g. cancer, is well recognized. Hyaluronic Acid 74-76 CD44 molecule (Indian blood group) Homo sapiens 110-114 30297743-0 2018 Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 16-20 30254460-1 2018 Background: This study investigated the effect of hyaluronic acid (HA)-CD44st on the invasive ability of human breast cancer MCF-7 cells and the correlation between the expression of CD44st and human epidermal growth factor receptor-2 (HER-2) in postoperative breast cancer patients. Hyaluronic Acid 50-65 CD44 molecule (Indian blood group) Homo sapiens 71-75 29030990-0 2018 Novel nanohydrogel of hyaluronic acid loaded with quercetin alone and in combination with temozolomide as new therapeutic tool, CD44 targeted based, of glioblastoma multiforme. Hyaluronic Acid 22-37 CD44 molecule (Indian blood group) Homo sapiens 128-132 30254460-1 2018 Background: This study investigated the effect of hyaluronic acid (HA)-CD44st on the invasive ability of human breast cancer MCF-7 cells and the correlation between the expression of CD44st and human epidermal growth factor receptor-2 (HER-2) in postoperative breast cancer patients. Hyaluronic Acid 67-69 CD44 molecule (Indian blood group) Homo sapiens 71-75 30090893-2 2018 A fusion peptide containing the tuftsin sequence that can interact with Fc receptors and neuropilin-1, and hyaluronic acid (HA) that can interact with CD44 were introduced into the delivery system by self-assembly to form peptide/hyaluronic acid/protamine/CaCO3/DNA nanoparticles (PHNP) with both macrophage targeting and tumor targeting capabilities. Hyaluronic Acid 107-122 CD44 molecule (Indian blood group) Homo sapiens 151-155 29773381-0 2018 CD44-targeted hyaluronic acid-curcumin prodrug protects renal tubular epithelial cell survival from oxidative stress damage. Hyaluronic Acid 14-29 CD44 molecule (Indian blood group) Homo sapiens 0-4 30087241-0 2018 Hyaluronic Acid-Decorated Chitosan Nanoparticles for CD44-Targeted Delivery of Everolimus. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 53-57 30087241-3 2018 Rationale was the selective delivery of everolimus into lung allograft-derived mesenchymal cells; these cells are characterized by the CD44-overexpressing feature, and hyaluronic acid has proven to be a natural selective CD44-targeting moiety. Hyaluronic Acid 168-183 CD44 molecule (Indian blood group) Homo sapiens 221-225 30087241-5 2018 The everolimus was successfully loaded into hyaluronic acid-decorated chitosan-based nanoparticles (95.94 +- 13.68 mug/100 mg nanoparticles) and in vitro released in 24 h. The hyaluronic acid decoration on the nanoparticles provided targetability to CD44-overexpressing mesenchymal cells isolated from bronchoalveolar lavage of BOS-affected patients. Hyaluronic Acid 44-59 CD44 molecule (Indian blood group) Homo sapiens 250-254 29456044-2 2018 Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH2) and then with hyaluronic acid, a biocompatible biopolymer which can be recognized by CD44 receptors in tumor cells, to obtain a targeting drug delivery system. Hyaluronic Acid 101-116 CD44 molecule (Indian blood group) Homo sapiens 172-176 29655990-5 2018 Through hyaluronan-mediated CD44 targeting, the constructed vesicles can specifically carry STAT3-decoy ODNs into TRAZ-resistant breast cancer cells and then regulate TRAZ-induced apoptosis. Hyaluronic Acid 8-18 CD44 molecule (Indian blood group) Homo sapiens 28-32 29915821-2 2018 Herein, we prepared CD44-targeted dual-stimuli responsive human hair keratin and hyaluronic acid nanogels (KHA-NGs) through a simple crosslinking method. Hyaluronic Acid 81-96 CD44 molecule (Indian blood group) Homo sapiens 20-24 30100720-0 2018 Reduction-sensitive CD44 receptor-targeted hyaluronic acid derivative micelles for doxorubicin delivery. Hyaluronic Acid 43-58 CD44 molecule (Indian blood group) Homo sapiens 20-24 30100720-1 2018 Introduction: A reduction-sensitive CD44-positive tumor-targetable drug delivery system for doxorubicin (DOX) delivery was developed based on hyaluronic acid (HA)-grafted polymers. Hyaluronic Acid 142-157 CD44 molecule (Indian blood group) Homo sapiens 36-40 30100720-1 2018 Introduction: A reduction-sensitive CD44-positive tumor-targetable drug delivery system for doxorubicin (DOX) delivery was developed based on hyaluronic acid (HA)-grafted polymers. Hyaluronic Acid 159-161 CD44 molecule (Indian blood group) Homo sapiens 36-40 29898364-0 2018 Hyaluronic Acid Surface Modified Liposomes Prepared via Orthogonal Aminoxy Coupling: Synthesis of Nontoxic Aminoxylipids Based on Symmetrically alpha-Branched Fatty Acids, Preparation of Liposomes by Microfluidic Mixing, and Targeting to Cancer Cells Expressing CD44. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 262-266 29898364-4 2018 In vitro experiments on cell lines expressing CD44 receptors demonstrate selective internalization of fluorochrome-labeled hyaluronic acid-liposomes, while cells with down regulated CD44 receptor levels exhibit very low internalization of hyaluronic acid-liposomes. Hyaluronic Acid 123-138 CD44 molecule (Indian blood group) Homo sapiens 46-50 29898364-4 2018 In vitro experiments on cell lines expressing CD44 receptors demonstrate selective internalization of fluorochrome-labeled hyaluronic acid-liposomes, while cells with down regulated CD44 receptor levels exhibit very low internalization of hyaluronic acid-liposomes. Hyaluronic Acid 239-254 CD44 molecule (Indian blood group) Homo sapiens 182-186 29898364-6 2018 These hyaluronic acid-liposomes represent a potentially new drug delivery platform for CD44-targeted anticancer drugs as well as for immunotherapeutics and vaccines. Hyaluronic Acid 6-21 CD44 molecule (Indian blood group) Homo sapiens 87-91 29946991-0 2018 Hyaluronic acid-grafted three-dimensional MWCNT array as biosensing interface for chronocoulometric detection and fluorometric imaging of CD44-overexpressing cancer cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 138-142 29934525-0 2018 Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions. Hyaluronic Acid 96-106 CD44 molecule (Indian blood group) Homo sapiens 91-95 29934525-5 2018 This producer cell dependence, which was also observed for virus spread in secondary lymphoid tissues ex vivo, is accounted for by CD44 incorporated into virus particles and hyaluronan bound to such CD44 molecules. Hyaluronic Acid 174-184 CD44 molecule (Indian blood group) Homo sapiens 199-203 29934525-6 2018 This virus-associated hyaluronan interacts with CD44 expressed on FRCs, thereby promoting virus capture by FRCs. Hyaluronic Acid 22-32 CD44 molecule (Indian blood group) Homo sapiens 48-52 29524557-4 2018 Hyaluronic acid (HA), which targets the CD44-overexpressing cancer cells, was modified on the nanocarrier surface to enhance the selective killing of melanoma cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 40-44 29524557-4 2018 Hyaluronic acid (HA), which targets the CD44-overexpressing cancer cells, was modified on the nanocarrier surface to enhance the selective killing of melanoma cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 40-44 29183110-4 2018 In this study, hyaluronic acid (HA)-based pH-sensitive polymers were designed as multifunctional polymers having not only pH-sensitivity but also targeting properties to cells expressing CD44, which is known as a cancer cell surface marker. Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Homo sapiens 187-191 29415537-0 2018 A Microfluidic Chip Integrated with Hyaluronic Acid-Functionalized Electrospun Chitosan Nanofibers for Specific Capture and Nondestructive Release of CD44-Overexpressing Circulating Tumor Cells. Hyaluronic Acid 36-51 CD44 molecule (Indian blood group) Homo sapiens 150-154 29277856-1 2018 Preclinical studies in small cell lung cancer (SCLC) have shown that hyaluronic acid (HA) can be effectively used to deliver chemotherapy and selectively decrease CD44 expressing (stem cell-like) tumour cells. Hyaluronic Acid 69-84 CD44 molecule (Indian blood group) Homo sapiens 163-167 29277856-1 2018 Preclinical studies in small cell lung cancer (SCLC) have shown that hyaluronic acid (HA) can be effectively used to deliver chemotherapy and selectively decrease CD44 expressing (stem cell-like) tumour cells. Hyaluronic Acid 86-88 CD44 molecule (Indian blood group) Homo sapiens 163-167 29323913-5 2018 Hyaluronic acid (HA), a ligand for CD44 receptors was also modified onto the outer shell of the 3s-PLGA-PEG nanoparticles to promote immune cell uptake. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 35-39 29323913-5 2018 Hyaluronic acid (HA), a ligand for CD44 receptors was also modified onto the outer shell of the 3s-PLGA-PEG nanoparticles to promote immune cell uptake. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 35-39 29441466-1 2018 To promote the specific targeting and elimination of CD44-positive cancer cells, berberine chloride (BRB)-encapsulated hyaluronic acid-grafted poly(lactic-co-glycolic acid) copolymer (BRB-d(HA)-g-PLGA) nanoparticles (NPs) were prepared. Hyaluronic Acid 119-134 CD44 molecule (Indian blood group) Homo sapiens 53-57 29678787-3 2018 Herein, we have developed a CD44 targeting Hyaluronic Acid (HA) decorated biocompatible oligomer, containing FDA approved vitamin E TPGS and Styrene Maleic Anhydride (SMA) (HA-SMA-TPGS) for targeting TNBC. Hyaluronic Acid 43-58 CD44 molecule (Indian blood group) Homo sapiens 28-32 29678787-3 2018 Herein, we have developed a CD44 targeting Hyaluronic Acid (HA) decorated biocompatible oligomer, containing FDA approved vitamin E TPGS and Styrene Maleic Anhydride (SMA) (HA-SMA-TPGS) for targeting TNBC. Hyaluronic Acid 60-62 CD44 molecule (Indian blood group) Homo sapiens 28-32 28503952-1 2018 Hyaluronic acid (HA) has inherent ability to target the CD44 receptors and internalize into tumour cells via receptor-mediated endocytosis. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 56-60 28503952-1 2018 Hyaluronic acid (HA) has inherent ability to target the CD44 receptors and internalize into tumour cells via receptor-mediated endocytosis. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 56-60 28503952-6 2018 Also, computational molecular docking was employed to study in detail the active site residues and the critical interactions between HA-EDA-PEG-EDA-MTX NPs and CD44 receptor. Hyaluronic Acid 133-135 CD44 molecule (Indian blood group) Homo sapiens 160-164 29421063-2 2018 In this work, an innovative GO-based carrier was developed by modifying GO with chitosan (CHI) to improve the biocompatibility, and followed by the conjugation of hyaluronic acid (HA), the target ligand for CD44, to realize the specific recognition of tumor cells and improve the efficiency of anti-tumor drug delivery. Hyaluronic Acid 163-178 CD44 molecule (Indian blood group) Homo sapiens 207-211 29421063-2 2018 In this work, an innovative GO-based carrier was developed by modifying GO with chitosan (CHI) to improve the biocompatibility, and followed by the conjugation of hyaluronic acid (HA), the target ligand for CD44, to realize the specific recognition of tumor cells and improve the efficiency of anti-tumor drug delivery. Hyaluronic Acid 180-182 CD44 molecule (Indian blood group) Homo sapiens 207-211 29352038-2 2018 We have previously found that in vitro reconstitution of this microenvironment induces specific variant isoforms of the adhesion molecule CD44, which confer human CLL with high affinity to hyaluronan (HA). Hyaluronic Acid 189-199 CD44 molecule (Indian blood group) Homo sapiens 138-142 29269686-3 2018 Meanwhile, hyaluronic acid (HA) is known as a promising tumor targeting ligand, because various cancer cells overexpress CD44, a HA-binding glycoprotein. Hyaluronic Acid 11-26 CD44 molecule (Indian blood group) Homo sapiens 121-125 29269686-3 2018 Meanwhile, hyaluronic acid (HA) is known as a promising tumor targeting ligand, because various cancer cells overexpress CD44, a HA-binding glycoprotein. Hyaluronic Acid 28-30 CD44 molecule (Indian blood group) Homo sapiens 121-125 29483847-2 2018 Exon 2 is one of the important exons to bind CD44 protein to hyaluronan. Hyaluronic Acid 61-71 CD44 molecule (Indian blood group) Homo sapiens 45-49 29483847-3 2018 Experimental evidences show that hyaluronan-CD44 interaction intensifies the proliferation, migration, and invasion of breast cancer cells. Hyaluronic Acid 33-43 CD44 molecule (Indian blood group) Homo sapiens 44-48 29284258-0 2018 pH-Sensitive Coiled-Coil Peptide-Cross-Linked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells. Hyaluronic Acid 46-61 CD44 molecule (Indian blood group) Homo sapiens 129-133 29284258-2 2018 Here, pH-sensitive coiled-coil peptide-cross-linked hyaluronic acid nanogels (HA-cNGs) were designed and investigated for targeted intracellular protein delivery to CD44 overexpressing MCF-7 breast cancer cells. Hyaluronic Acid 52-67 CD44 molecule (Indian blood group) Homo sapiens 165-169 29396830-1 2018 In this work, novel mitochondrial and CD44 receptor dual-targeting redox-sensitive multifunctional nanoparticles (micelles) based on oligomeric hyaluronic acid (oHA) were proposed. Hyaluronic Acid 144-159 CD44 molecule (Indian blood group) Homo sapiens 38-42 29253923-1 2018 In this study, we propose using IR 780-loaded, CD44-targeted hyaluronic acid-based micelles (HA-IR 780) for enhanced photothermal therapy (PTT) effects in tumors. Hyaluronic Acid 61-76 CD44 molecule (Indian blood group) Homo sapiens 47-51 29272095-0 2018 Hyaluronic Acid-Shelled Disulfide-Cross-Linked Nanopolymersomes for Ultrahigh-Efficiency Reactive Encapsulation and CD44-Targeted Delivery of Mertansine Toxin. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 116-120 29272095-2 2018 Here, we report on novel hyaluronic acid-shelled disulfide-cross-linked biodegradable polymersomes (HA-XPS) self-assembled from hyaluronic acid-b-poly(trimethylene carbonate-co-dithiolane trimethylene carbonate) diblock copolymer for ultrahigh-efficiency reactive encapsulation and CD44-targeted delivery of mertansine (DM1) toxin, a highly potent warhead for clinically used antibody-drug conjugates. Hyaluronic Acid 25-40 CD44 molecule (Indian blood group) Homo sapiens 282-286 29128538-0 2018 Hyaluronan size alters chondrogenesis of adipose-derived stem cells via the CD44/ERK/SOX-9 pathway. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 76-80 29328918-8 2018 CD44 binds hyaluronan, anchoring a pericellular coat that also limits receptor displacement and obstructs access to phagocytic targets. Hyaluronic Acid 11-21 CD44 molecule (Indian blood group) Homo sapiens 0-4 29239219-5 2018 The nanomedicine had natural anti-tumour drugs (CUR) as the hydrophobic kernel, and targeting CD44 receptor oligosaccharides of hyaluronan (oHA) and other anti-tumour drugs (ALN) as hydrophilic shell, named ALN-oHA-S-S-CUR conjugates, which could self-assemble into micelle-like nano-spheres in water via a dialysis method with hydrodynamic diameters of 179 +- 23 nm. Hyaluronic Acid 128-138 CD44 molecule (Indian blood group) Homo sapiens 94-98 29183110-4 2018 In this study, hyaluronic acid (HA)-based pH-sensitive polymers were designed as multifunctional polymers having not only pH-sensitivity but also targeting properties to cells expressing CD44, which is known as a cancer cell surface marker. Hyaluronic Acid 32-34 CD44 molecule (Indian blood group) Homo sapiens 187-191 28939108-5 2017 Doxorubicin accumulated and penetrated similarly in both cell lines while the NP accumulated more in MDA-MB-231 than MCF-7 potentially due to binding of hyaluronic acid to CD44 expressed by MDA-MB-231. Hyaluronic Acid 153-168 CD44 molecule (Indian blood group) Homo sapiens 172-176 28986884-4 2018 CD44, as a transmembrane receptor for hyaluronic acid (HA) and many other ECM components and a coreceptor for growth factors and cytokines, is a critical cell surface molecule that can sense, integrate, and transduce cellular microenvironmental signals to membrane-associated cytoskeletal proteins or to cell nucleus to regulate a variety of gene expressions that govern cell behaviors. Hyaluronic Acid 38-53 CD44 molecule (Indian blood group) Homo sapiens 0-4 28986884-4 2018 CD44, as a transmembrane receptor for hyaluronic acid (HA) and many other ECM components and a coreceptor for growth factors and cytokines, is a critical cell surface molecule that can sense, integrate, and transduce cellular microenvironmental signals to membrane-associated cytoskeletal proteins or to cell nucleus to regulate a variety of gene expressions that govern cell behaviors. Hyaluronic Acid 55-57 CD44 molecule (Indian blood group) Homo sapiens 0-4 28994324-4 2017 Hyaluronic acid (HA) was introduced to shield the PEI/dsRNA-p21 binary complexes (BC-dsRNA-p21) for reducing the cytotoxicity of PEI and for increasing the tumor-targeted intracellular uptake by cancer cells through HA-CD44 mediated endocytosis. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 219-223 29162741-3 2017 We identified an unexpected function for the ubiquitous hyaluronan-degrading enzyme, hyaluronidase 2 (HYAL2), as a regulator of CD44 splicing. Hyaluronic Acid 56-66 CD44 molecule (Indian blood group) Homo sapiens 128-132 28958164-10 2017 This study provides a proof-of-concept that lipoic acid-crosslinked hyaluronic acid nanoparticulate drugs may offer a more safe and effective treatment modality for CD44 positive hematological malignancies. Hyaluronic Acid 68-83 CD44 molecule (Indian blood group) Homo sapiens 165-169 28994324-4 2017 Hyaluronic acid (HA) was introduced to shield the PEI/dsRNA-p21 binary complexes (BC-dsRNA-p21) for reducing the cytotoxicity of PEI and for increasing the tumor-targeted intracellular uptake by cancer cells through HA-CD44 mediated endocytosis. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 219-223 28875691-4 2017 Here, we developed a CD44-targeted nanophotodynamic agent by physically encapsulating a photosensitizer, Ce6, into a hyaluronic acid nanoparticle (HANP), which was hereby denoted HANP/Ce6. Hyaluronic Acid 117-132 CD44 molecule (Indian blood group) Homo sapiens 21-25 28743090-0 2017 NIR and UV-responsive degradable hyaluronic acid nanogels for CD44-targeted and remotely triggered intracellular doxorubicin delivery. Hyaluronic Acid 33-48 CD44 molecule (Indian blood group) Homo sapiens 62-66 28743090-1 2017 Hyaluronic acid (HA) is an endogenous polysaccharide that shows intrinsic targetability to CD44+ cancer cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 91-95 28743090-1 2017 Hyaluronic acid (HA) is an endogenous polysaccharide that shows intrinsic targetability to CD44+ cancer cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 91-95 28730511-2 2017 Hyaluronan (HA), the natural ligand of CD44, is a simple repeated disaccharide with variable molecular mass that is widely distributed on cell surfaces and the connective tissue matrix. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 39-43 28730511-2 2017 Hyaluronan (HA), the natural ligand of CD44, is a simple repeated disaccharide with variable molecular mass that is widely distributed on cell surfaces and the connective tissue matrix. Hyaluronic Acid 12-14 CD44 molecule (Indian blood group) Homo sapiens 39-43 29190904-4 2017 CD44 is the receptor for hyaluronic acid and is a Type I transmembrane protein. Hyaluronic Acid 25-40 CD44 molecule (Indian blood group) Homo sapiens 0-4 28837080-0 2017 Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells. Hyaluronic Acid 21-31 CD44 molecule (Indian blood group) Homo sapiens 41-45 28666726-3 2017 Hyaluronic acid (HA, MW 20-40kDa), a ligand to CD44, was non-covalently coated on the cationic liposomes. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 47-51 27874296-0 2017 CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan. Hyaluronic Acid 86-96 CD44 molecule (Indian blood group) Homo sapiens 0-4 27874296-2 2017 The cell surface receptor CD44 is capable of binding to hyaluronan (HA) produced by tumor cells and by cells of the tumor microenvironment, including blood endothelial cells. Hyaluronic Acid 56-66 CD44 molecule (Indian blood group) Homo sapiens 26-30 28633290-1 2017 Exciting discoveries in many diverse fields of hyaluronan (HA) biology over the last 40 years have centered around the ability of HA to bind cell surface HA receptors (e.g., CD44, Layilin, LYVE-1, HARE/Stab2 and RHAMM) and sometimes also to activate intracellular signal transduction pathways, frequently involving ERK1/2. Hyaluronic Acid 47-57 CD44 molecule (Indian blood group) Homo sapiens 174-178 28684419-7 2017 These data implicate versican G1 in enhancing adenoviral vector transgene expression in a hyaluronic acid-CD44 independent manner that is down-regulated by inhibitors of the JAK/STAT pathway and enhanced by inhibitors of the Src kinase pathway. Hyaluronic Acid 90-105 CD44 molecule (Indian blood group) Homo sapiens 106-110 28627617-2 2017 Although the hyaluronan (HA)-binding CD44 is responsible for enhanced cellular motility, the mechanism underlying its actions in various cell types and clinical conditions have yet to be elucidated. Hyaluronic Acid 13-23 CD44 molecule (Indian blood group) Homo sapiens 37-41 28675028-0 2017 EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo. Hyaluronic Acid 44-59 CD44 molecule (Indian blood group) Homo sapiens 9-13 28675028-9 2017 EGFR and CD44 dual-targeted multifunctional hyaluronic acid nanogels have appeared as a safe and efficacious platform for cancer protein therapy. Hyaluronic Acid 44-59 CD44 molecule (Indian blood group) Homo sapiens 9-13 28675028-3 2017 Here, we report that epidermal growth factor receptor (EGFR) and CD44 dual-targeted multifunctional hyaluronic acid nanogels (EGFR/CD44-NGs) boost protein delivery to ovarian and breast cancers in vitro and in vivo. Hyaluronic Acid 100-115 CD44 molecule (Indian blood group) Homo sapiens 65-69 28675028-3 2017 Here, we report that epidermal growth factor receptor (EGFR) and CD44 dual-targeted multifunctional hyaluronic acid nanogels (EGFR/CD44-NGs) boost protein delivery to ovarian and breast cancers in vitro and in vivo. Hyaluronic Acid 100-115 CD44 molecule (Indian blood group) Homo sapiens 131-135 28675028-4 2017 EGFR/CD44-NGs obtained via nanoprecipitation and photoclick chemistry from hyaluronic acid derivatives with tetrazole, GE11 peptide/tetrazole, and cystamine methacrylate groups had nearly quantitative loading of therapeutic proteins like cytochrome C (CC) and GrB, a small size of ca. Hyaluronic Acid 75-90 CD44 molecule (Indian blood group) Homo sapiens 5-9 28569787-0 2017 Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression. Hyaluronic Acid 49-59 CD44 molecule (Indian blood group) Homo sapiens 126-130 28740384-4 2017 Hyaluronic acid (HA) was an enzyme-responsive shell which could protect the core and enhance the co-delivery efficiency through CD44-mediated endocytosis. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 128-132 28740384-4 2017 Hyaluronic acid (HA) was an enzyme-responsive shell which could protect the core and enhance the co-delivery efficiency through CD44-mediated endocytosis. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 128-132 28715483-0 2017 Atomistic fingerprint of hyaluronan-CD44 binding. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 36-40 28715483-1 2017 Hyaluronan is a polyanionic, megadalton-scale polysaccharide, which initiates cell signaling by interacting with several receptor proteins including CD44 involved in cell-cell interactions and cell adhesion. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 149-153 28715483-2 2017 Previous studies of the CD44 hyaluronan binding domain have identified multiple widespread residues to be responsible for its recognition capacity. Hyaluronic Acid 29-39 CD44 molecule (Indian blood group) Homo sapiens 24-28 28715483-4 2017 In this study, we show through atomistic molecular dynamics simulations that hyaluronan can bind CD44 with three topographically different binding modes that in unison define an interaction fingerprint, thus providing a plausible explanation for the disagreement between the earlier studies. Hyaluronic Acid 77-87 CD44 molecule (Indian blood group) Homo sapiens 97-101 28533273-5 2017 The HAS2 product hyaluronan further stimulated CD44s-mediated Akt signaling, creating a feed-forward signaling circuit that promoted tumor cell survival. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Homo sapiens 47-51 28605176-3 2017 To develop CD44-targetable, pH-, and reduction-responsive drug delivery systems for Ir(III) drugs, the amphiphilic hyaluronan (HA)-based conjugates of HA-cystamin-pyrenyl (HA-ss-Py) containing disulfide bonds and HA-pyrenyl (HA-Py) were designed. Hyaluronic Acid 115-125 CD44 molecule (Indian blood group) Homo sapiens 11-15 28605176-3 2017 To develop CD44-targetable, pH-, and reduction-responsive drug delivery systems for Ir(III) drugs, the amphiphilic hyaluronan (HA)-based conjugates of HA-cystamin-pyrenyl (HA-ss-Py) containing disulfide bonds and HA-pyrenyl (HA-Py) were designed. Hyaluronic Acid 127-129 CD44 molecule (Indian blood group) Homo sapiens 11-15 28569787-2 2017 Known that CD44 has the specific binding sites for a natural ligand hyaluronan (HA), we investigated biological effects of HA with different molecular sizes on MLL+ALL cell lines, and found that the addition of ultra-low-molecular-weight (ULMW)-HA strongly suppressed their thymidine uptakes. Hyaluronic Acid 68-78 CD44 molecule (Indian blood group) Homo sapiens 11-15 28481500-3 2017 Hyaluronic acid (HA)-functionalized solid-state probes were used to label a single breast cancer cell by the specific recognition of HA with CD44 on the cell surface, revealing more stable, sensitive, and effective tagging in comparison with the water-soluble CQDs. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 141-145 28489348-0 2017 Novel Curcumin Liposome Modified with Hyaluronan Targeting CD44 Plays an Anti-Leukemic Role in Acute Myeloid Leukemia in Vitro and in Vivo. Hyaluronic Acid 38-48 CD44 molecule (Indian blood group) Homo sapiens 59-63 28489348-3 2017 To address these issues, we developed a novel curcumin liposome modified with hyaluronan (HA-Cur-LPs) to specifically deliver curcumin to AML by targeting CD44 on AML cell surface. Hyaluronic Acid 78-88 CD44 molecule (Indian blood group) Homo sapiens 155-159 28481500-3 2017 Hyaluronic acid (HA)-functionalized solid-state probes were used to label a single breast cancer cell by the specific recognition of HA with CD44 on the cell surface, revealing more stable, sensitive, and effective tagging in comparison with the water-soluble CQDs. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 141-145 28392690-3 2017 Drugs conjugated with hyaluronic acid (HA) are innovative carrier-mediated drug delivery systems characterized by CD44-mediated endocytosis of HA and intracellular drug release. Hyaluronic Acid 22-37 CD44 molecule (Indian blood group) Homo sapiens 114-118 28274742-0 2017 A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis. Hyaluronic Acid 2-17 CD44 molecule (Indian blood group) Homo sapiens 42-46 27746219-1 2017 Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44 are crucial events that regulate the onset and progression of tumors. Hyaluronic Acid 43-53 CD44 molecule (Indian blood group) Homo sapiens 86-90 28403901-6 2017 The interaction of CD44 with its ligand, hyaluronan (HA) has demonstrated an important role in modulating cell proliferation and invasiveness in MPM. Hyaluronic Acid 41-51 CD44 molecule (Indian blood group) Homo sapiens 19-23 28403901-6 2017 The interaction of CD44 with its ligand, hyaluronan (HA) has demonstrated an important role in modulating cell proliferation and invasiveness in MPM. Hyaluronic Acid 53-55 CD44 molecule (Indian blood group) Homo sapiens 19-23 28213097-5 2017 We developed self-assembled tumor-targeting hyaluronic acid-IR-780 nanoparticles for photothermal ablation in over-expressing CD44 (the receptor for HA) bladder cancer, which show high tumor selectivity, high treatment efficacy, good bioavailability, and excellent biocompatibility. Hyaluronic Acid 44-59 CD44 molecule (Indian blood group) Homo sapiens 126-130 28213097-20 2017 2) We developed self-assembled tumor-targeting hyaluronic acid-IR-780 nanoparticles for photothermal ablation in over-expressing CD44 (the receptor for HA) bladder cancer. Hyaluronic Acid 47-62 CD44 molecule (Indian blood group) Homo sapiens 129-133 33465938-3 2017 The developed LAP-PLA-PEG-PEI nanoparticles were used as templates for the embedding of gold nanoparticles (Au NPs), followed by modification with hyaluronic acid (HA) as a targeting ligand for cancer cells overexpressing CD44 receptors. Hyaluronic Acid 164-166 CD44 molecule (Indian blood group) Homo sapiens 222-226 27965172-0 2017 Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 74-78 27965172-1 2017 Hyaluronan (HA) and its principal receptor CD44 are known to be involved in regulating tumor cell dissemination and metastasis. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 43-47 32264632-0 2017 Minimum hyaluronic acid (HA) modified magnetic nanocrystals with less facilitated cancer migration and drug resistance for targeting CD44 abundant cancer cells by MR imaging. Hyaluronic Acid 8-23 CD44 molecule (Indian blood group) Homo sapiens 133-137 28107631-1 2017 In this study, we developed a general method to decorate plasmonic gold nanorods (GNRs) with a CD44-targeting functional polymer, containing a hyaluronic acid (HA)-targeting moiety and a small molecule Glut1 inhibitor of diclofenac (DC), to obtain GNR/HA-DC. Hyaluronic Acid 143-158 CD44 molecule (Indian blood group) Homo sapiens 95-99 28107631-1 2017 In this study, we developed a general method to decorate plasmonic gold nanorods (GNRs) with a CD44-targeting functional polymer, containing a hyaluronic acid (HA)-targeting moiety and a small molecule Glut1 inhibitor of diclofenac (DC), to obtain GNR/HA-DC. Hyaluronic Acid 160-162 CD44 molecule (Indian blood group) Homo sapiens 95-99 27987832-0 2017 Dual pH/redox responsive and CD44 receptor targeting hybrid nano-chrysalis based on new oligosaccharides of hyaluronan conjugates. Hyaluronic Acid 108-118 CD44 molecule (Indian blood group) Homo sapiens 29-33 27987832-2 2017 The nano-chrysalis has an inner core composed of specially designed oligosaccharides of hyaluronan (oHA) targeting CD44 receptor. Hyaluronic Acid 88-98 CD44 molecule (Indian blood group) Homo sapiens 115-119 32264632-1 2017 We report minimal amount of hyaluronic acid (HA) conjugated magnetic nanocrystals (mHMs) for targeted imaging of CD44 abundant breast cancer cells via MRI. Hyaluronic Acid 28-43 CD44 molecule (Indian blood group) Homo sapiens 113-117 32264632-1 2017 We report minimal amount of hyaluronic acid (HA) conjugated magnetic nanocrystals (mHMs) for targeted imaging of CD44 abundant breast cancer cells via MRI. Hyaluronic Acid 45-47 CD44 molecule (Indian blood group) Homo sapiens 113-117 27990775-0 2017 The CD44-Mediated Uptake of Hyaluronic Acid-Based Carriers in Macrophages. Hyaluronic Acid 28-43 CD44 molecule (Indian blood group) Homo sapiens 4-8 27990775-2 2017 In this study, we have established quantitative relationships between CD44 expression in differently polarized macrophages (M0, M1, and M2-polarized THP-1 human macrophages) and the uptake of hyaluronic acid (HA)-based materials, which are potentially usable for CD44 targeting. Hyaluronic Acid 192-207 CD44 molecule (Indian blood group) Homo sapiens 70-74 27990775-2 2017 In this study, we have established quantitative relationships between CD44 expression in differently polarized macrophages (M0, M1, and M2-polarized THP-1 human macrophages) and the uptake of hyaluronic acid (HA)-based materials, which are potentially usable for CD44 targeting. Hyaluronic Acid 192-207 CD44 molecule (Indian blood group) Homo sapiens 263-267 27990775-2 2017 In this study, we have established quantitative relationships between CD44 expression in differently polarized macrophages (M0, M1, and M2-polarized THP-1 human macrophages) and the uptake of hyaluronic acid (HA)-based materials, which are potentially usable for CD44 targeting. Hyaluronic Acid 209-211 CD44 molecule (Indian blood group) Homo sapiens 70-74 27990775-2 2017 In this study, we have established quantitative relationships between CD44 expression in differently polarized macrophages (M0, M1, and M2-polarized THP-1 human macrophages) and the uptake of hyaluronic acid (HA)-based materials, which are potentially usable for CD44 targeting. Hyaluronic Acid 209-211 CD44 molecule (Indian blood group) Homo sapiens 263-267 27989859-0 2017 Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells. Hyaluronic Acid 73-88 CD44 molecule (Indian blood group) Homo sapiens 117-121 28091588-0 2017 High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy. Hyaluronic Acid 22-37 CD44 molecule (Indian blood group) Homo sapiens 98-102 27989859-2 2017 Herein, we developed hyaluronic acid-modified poly(dl-lactic-co-glycolic acid)-poly (ethylene glycol) nanoparticles (PLGA-PEG-HA NPs) for targeted delivery of TTQ (thio-tetrazolyl analog of a clinical candidate, IC87114) to CD44 overexpressing cancer cells. Hyaluronic Acid 21-36 CD44 molecule (Indian blood group) Homo sapiens 224-228 28068992-0 2017 Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 150-154 28068992-3 2017 METHODS: We reported that hyaluronic acid (HA)-coated chitosan NPs promoted the drug delivery of 5-fluorouracil (5-Fu) into tumor cells that highly expressed CD44. Hyaluronic Acid 26-41 CD44 molecule (Indian blood group) Homo sapiens 158-162 28068992-3 2017 METHODS: We reported that hyaluronic acid (HA)-coated chitosan NPs promoted the drug delivery of 5-fluorouracil (5-Fu) into tumor cells that highly expressed CD44. Hyaluronic Acid 43-45 CD44 molecule (Indian blood group) Homo sapiens 158-162 27999837-2 2017 After crosslinking the natural polysaccharide hyaluronan, a ligand for CD44, cisplatin could be removed by simple dialysis in a salt solution while the withheld drug remains entrapped. Hyaluronic Acid 46-56 CD44 molecule (Indian blood group) Homo sapiens 71-75 28255343-3 2017 The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 37-41 28255343-3 2017 The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field. Hyaluronic Acid 49-64 CD44 molecule (Indian blood group) Homo sapiens 134-138 29354263-0 2017 Impact of structurally modifying hyaluronic acid on CD44 interaction. Hyaluronic Acid 33-48 CD44 molecule (Indian blood group) Homo sapiens 52-56 27702492-0 2017 Hyaluronic acid conjugated micelles possessing CD44 targeting potential for gene delivery. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 47-51 27702492-1 2017 The high- and low-molecular weight hyaluronic acid (HHA and LHA) were used to conjugate with PLGA-PEG copolymers which were applied to encapsulate DOTAP/pDNA (D/P) lipoplex as a CD44-targeted micelle delivery system. Hyaluronic Acid 35-50 CD44 molecule (Indian blood group) Homo sapiens 178-182 28552066-2 2017 Hyaluronic acid is a type of polysaccharide that has been extensively studied as a selective targeting ligand to cancerous cells that overexpress its specific receptor CD44. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 168-172 29354263-1 2017 CD44 is a widely-distributed type I transmembrane glycoprotein that binds hyaluronic acid (HA) in most cell types, including primary tumor cells and cancer-initiating cells and has roles in cell migration, cell-cell, and cell-matrix adhesion. Hyaluronic Acid 74-89 CD44 molecule (Indian blood group) Homo sapiens 0-4 29354263-3 2017 Altering crucial interactions of HA with CD44 active sites holds significant importance in modulating targeting ability of hyaluronic acid to other cancer types that do not express the CD44 receptor or minimizing the interaction with CD44+ cells that are not target cells. Hyaluronic Acid 123-138 CD44 molecule (Indian blood group) Homo sapiens 41-45 27885422-3 2017 CD44 was stimulated with hyaluronan treatment, and the accompanying changes in FOXP3 mRNA expression in breast cancer cell lines representing breast cancer subtype were assessed. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 0-4 27577897-4 2016 Herein we present a "top-down" method to coat liposomes in situ with tumor (CD44 receptor) targeting polymer, hyaluronan (HA), by taking advantages of "click" type chemistries and enzymatic degradation. Hyaluronic Acid 110-120 CD44 molecule (Indian blood group) Homo sapiens 76-80 27640754-2 2016 The role of CD44 in tumorigenesis is due to its binding to extracellular matrix components, including hyaluronan (HA) and osteopontin (OPN), and to messenger molecules, such as growth factors present in the tumor microenvironment. Hyaluronic Acid 102-112 CD44 molecule (Indian blood group) Homo sapiens 12-16 27980406-0 2016 Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells. Hyaluronic Acid 6-21 CD44 molecule (Indian blood group) Homo sapiens 116-120 27507056-2 2016 Interactions between CD44 and hyaluronic acid are associated with poor prognosis, making CD44 an attractive therapeutic target. Hyaluronic Acid 30-45 CD44 molecule (Indian blood group) Homo sapiens 89-93 27929475-4 2016 Both enhanced permeability and retention (EPR) effect-based passive targeting and hyaluronic-acid-CD44 interaction-based active targeting were applied. Hyaluronic Acid 82-97 CD44 molecule (Indian blood group) Homo sapiens 98-102 27545604-2 2016 The interaction between hyaluronan (HA) and its primary receptor CD44 maintains the homeostasis of articular chondrocytes. Hyaluronic Acid 24-34 CD44 molecule (Indian blood group) Homo sapiens 65-69 27786455-3 2016 In the study, we produced negatively charged and biocompatible hyaluronic acid-based nanoparticles as a therapeutic system for targeting CD44-positive cancer cells. Hyaluronic Acid 63-78 CD44 molecule (Indian blood group) Homo sapiens 137-141 27786455-5 2016 In this study, hyaluronic acid-based nanoparticles successfully encapsulated epigallocatechin-3-gallate and were efficiently internalized into cancer cells via CD44 ligand receptor recognition, induced cell cycle arrest at G2/M phase, and inhibited prostate cancer cell growth. Hyaluronic Acid 15-30 CD44 molecule (Indian blood group) Homo sapiens 160-164 27599396-1 2016 CD44, a major surface receptor for hyaluronic acid, has multiple isoforms and represents a major cancer stem cell marker for various epithelial tumors. Hyaluronic Acid 35-50 CD44 molecule (Indian blood group) Homo sapiens 0-4 27653258-3 2016 Herein, we present the preparation and characterization of hyaluronic acid (HA)-modified, multifunctional nanoparticles (NPs) targeting CD44 receptor-expressing cancer cells for computed tomography (CT)/magnetic resonance (MR) dual-mode imaging. Hyaluronic Acid 59-74 CD44 molecule (Indian blood group) Homo sapiens 136-140 27653258-3 2016 Herein, we present the preparation and characterization of hyaluronic acid (HA)-modified, multifunctional nanoparticles (NPs) targeting CD44 receptor-expressing cancer cells for computed tomography (CT)/magnetic resonance (MR) dual-mode imaging. Hyaluronic Acid 76-78 CD44 molecule (Indian blood group) Homo sapiens 136-140 27651223-0 2016 Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 79-83 27651223-4 2016 In this study, we investigated the effects of hyaluronan-a known CD44 ligand-on dental pulp stem cells (DPSCs). Hyaluronic Acid 46-56 CD44 molecule (Indian blood group) Homo sapiens 65-69 27651223-12 2016 Moreover, the odontoblastic differentiation induced by hyaluronan was mediated by CD44-but not by Akt, Smad1 or MAPK signaling. Hyaluronic Acid 55-65 CD44 molecule (Indian blood group) Homo sapiens 82-86 27651223-13 2016 CONCLUSIONS: Our results indicate that hyaluronan induces odontoblastic differentiation of DPSCs via CD44. Hyaluronic Acid 39-49 CD44 molecule (Indian blood group) Homo sapiens 101-105 27463610-4 2016 Moreover, a targeting ligand, hyaluronic acid (HA), was conjugated to ZnO QDs for specifically binding to the overexpressed glycoprotein CD44 by cancer cells. Hyaluronic Acid 30-45 CD44 molecule (Indian blood group) Homo sapiens 137-141 27463610-4 2016 Moreover, a targeting ligand, hyaluronic acid (HA), was conjugated to ZnO QDs for specifically binding to the overexpressed glycoprotein CD44 by cancer cells. Hyaluronic Acid 47-49 CD44 molecule (Indian blood group) Homo sapiens 137-141 28335277-0 2016 Receptor-Meditated Endocytosis by Hyaluronic Acid@Superparamagnetic Nanovetor for Targeting of CD44-Overexpressing Tumor Cells. Hyaluronic Acid 34-49 CD44 molecule (Indian blood group) Homo sapiens 95-99 27473554-0 2016 Fabrication and biological evaluation of chitosan coated hyaluronic acid-docetaxel conjugate nanoparticles in CD44(+) cancer cells. Hyaluronic Acid 57-72 CD44 molecule (Indian blood group) Homo sapiens 110-114 27162075-2 2016 We developed a novel C60 fullerene-silica nanoparticle system surface-decorated with hyaluronan (HA) to target the variant CD44 overexpressed on breast CSCs. Hyaluronic Acid 85-95 CD44 molecule (Indian blood group) Homo sapiens 123-127 27162075-2 2016 We developed a novel C60 fullerene-silica nanoparticle system surface-decorated with hyaluronan (HA) to target the variant CD44 overexpressed on breast CSCs. Hyaluronic Acid 97-99 CD44 molecule (Indian blood group) Homo sapiens 123-127 27107383-1 2016 In this paper, a CD44-targeted and redox-responsive drug delivery system based on mesoporous silica nanoparticles (MSNs) was synthesized by conjugating tumor-shedable hyaluronic acid (HA) on the surface of MSNs via disulfide bonds. Hyaluronic Acid 167-182 CD44 molecule (Indian blood group) Homo sapiens 17-21 27107383-1 2016 In this paper, a CD44-targeted and redox-responsive drug delivery system based on mesoporous silica nanoparticles (MSNs) was synthesized by conjugating tumor-shedable hyaluronic acid (HA) on the surface of MSNs via disulfide bonds. Hyaluronic Acid 184-186 CD44 molecule (Indian blood group) Homo sapiens 17-21 27193782-6 2016 The CD44-hyaluronan-dependent interactions are Janus-faced: on one side, they have been shown to be crucial in both malignancy and resistance to therapy; on the other, they represent a potential value for future therapies, as disturbing the CD44-hyaluronan axis would not only impair the pericellular matrix but also the subpopulation of self-renewing oncogenic cells. Hyaluronic Acid 9-19 CD44 molecule (Indian blood group) Homo sapiens 4-8 27193782-6 2016 The CD44-hyaluronan-dependent interactions are Janus-faced: on one side, they have been shown to be crucial in both malignancy and resistance to therapy; on the other, they represent a potential value for future therapies, as disturbing the CD44-hyaluronan axis would not only impair the pericellular matrix but also the subpopulation of self-renewing oncogenic cells. Hyaluronic Acid 9-19 CD44 molecule (Indian blood group) Homo sapiens 241-245 27193782-6 2016 The CD44-hyaluronan-dependent interactions are Janus-faced: on one side, they have been shown to be crucial in both malignancy and resistance to therapy; on the other, they represent a potential value for future therapies, as disturbing the CD44-hyaluronan axis would not only impair the pericellular matrix but also the subpopulation of self-renewing oncogenic cells. Hyaluronic Acid 246-256 CD44 molecule (Indian blood group) Homo sapiens 4-8 27193782-6 2016 The CD44-hyaluronan-dependent interactions are Janus-faced: on one side, they have been shown to be crucial in both malignancy and resistance to therapy; on the other, they represent a potential value for future therapies, as disturbing the CD44-hyaluronan axis would not only impair the pericellular matrix but also the subpopulation of self-renewing oncogenic cells. Hyaluronic Acid 246-256 CD44 molecule (Indian blood group) Homo sapiens 241-245 27193782-8 2016 Thus, a better understanding of the hyaluronan-CD44 interactions holds the potential for ameliorating current cancer therapies and eradicating CSC. Hyaluronic Acid 36-46 CD44 molecule (Indian blood group) Homo sapiens 47-51 27473554-1 2016 BACKGROUND: Hyaluronic acid (HA) has been used for target-specific drug delivery because of strong affinity to CD44, a marker in which overexpressed in cancer cells and cancer stem cells. Hyaluronic Acid 12-27 CD44 molecule (Indian blood group) Homo sapiens 111-115 27473554-1 2016 BACKGROUND: Hyaluronic acid (HA) has been used for target-specific drug delivery because of strong affinity to CD44, a marker in which overexpressed in cancer cells and cancer stem cells. Hyaluronic Acid 29-31 CD44 molecule (Indian blood group) Homo sapiens 111-115 27473554-8 2016 Chitosan coated hyaluronic acid-docetaxel conjugate nanoparticles fabricated and evaluated in CD44+ cancer cells. Hyaluronic Acid 16-31 CD44 molecule (Indian blood group) Homo sapiens 94-98 27045981-7 2016 Hyaluronic acid (HA) was coated onto the surface of SLM nanoparticles for targeting CD44 receptors over expressed on cancer stem cells and they showed the highest cytotoxicity with minimum IC50 on breast cancer cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 84-88 27045981-7 2016 Hyaluronic acid (HA) was coated onto the surface of SLM nanoparticles for targeting CD44 receptors over expressed on cancer stem cells and they showed the highest cytotoxicity with minimum IC50 on breast cancer cells. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 84-88 27389568-1 2016 Extensive experimental evidence demonstrates the important role of hyaluronic acid (HA)-CD44 interaction in cell proliferation and migration, inflammation and tumor growth. Hyaluronic Acid 67-82 CD44 molecule (Indian blood group) Homo sapiens 88-92 27342250-2 2016 There is evidence that the interaction between CD44 and hyaluronan promotes breast cancer metastasis. Hyaluronic Acid 56-66 CD44 molecule (Indian blood group) Homo sapiens 47-51 27342250-3 2016 Recently, the molecule F-19848A was shown to inhibit hyaluronan binding to receptor CD44 in a cell-based assay. Hyaluronic Acid 53-63 CD44 molecule (Indian blood group) Homo sapiens 84-88 27265514-2 2016 Because of the specific affinity between the hyaluronic acid (HA) on MSNs and the CD44 antigen overexpressed on tumor cells, the MSNs can selectively attach to tumor cells. Hyaluronic Acid 45-60 CD44 molecule (Indian blood group) Homo sapiens 82-86 26946213-0 2016 Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 54-58 27389568-1 2016 Extensive experimental evidence demonstrates the important role of hyaluronic acid (HA)-CD44 interaction in cell proliferation and migration, inflammation and tumor growth. Hyaluronic Acid 84-86 CD44 molecule (Indian blood group) Homo sapiens 88-92 27098318-2 2016 Thus, we have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. Hyaluronic Acid 88-103 CD44 molecule (Indian blood group) Homo sapiens 72-76 27120809-0 2016 Hyaluronic acid-conjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 75-79 26954089-3 2016 Moreover, these microspheres could be specifically targeted to HeLa tumor cells, since hyaluronic acid can specifically recognize and bind to CD44, a receptor overexpressed on many tumor cells. Hyaluronic Acid 87-102 CD44 molecule (Indian blood group) Homo sapiens 142-146 26530693-1 2016 OBJECTIVE: Most primary human ovarian tumors and peritoneal implants, as well as tumor vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural ligand for which is hyaluronic acid (HA). Hyaluronic Acid 202-217 CD44 molecule (Indian blood group) Homo sapiens 127-131 26530693-1 2016 OBJECTIVE: Most primary human ovarian tumors and peritoneal implants, as well as tumor vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural ligand for which is hyaluronic acid (HA). Hyaluronic Acid 219-221 CD44 molecule (Indian blood group) Homo sapiens 127-131 27148749-0 2016 MicroRNA-223 Induced Repolarization of Peritoneal Macrophages Using CD44 Targeting Hyaluronic Acid Nanoparticles for Anti-Inflammatory Effects. Hyaluronic Acid 83-98 CD44 molecule (Indian blood group) Homo sapiens 68-72 27144715-5 2016 Nonetheless, we further report that a fragment-screening campaign, with solution NMR spectroscopy as the detection method, identified a viable fragment hit that bound in a potentially functional pocket on the surface of CD44, opposite to the hyaluronic acid binding site. Hyaluronic Acid 242-257 CD44 molecule (Indian blood group) Homo sapiens 220-224 27163367-4 2016 Hyaluronan is the main component of ECM in the brain, where its major receptor protein CD44 is expressed by a subset of astrocytes. Hyaluronic Acid 0-10 CD44 molecule (Indian blood group) Homo sapiens 87-91 27163367-7 2016 Moreover, as a dynamic reorganization of the actin cytoskeleton is supposed to be responsible for morphological changes of cells, and this reorganization is controlled by small GTPases of the Rho family, we hypothesized that GTPase Rac1 acts as a downstream effector for hyaluronan and CD44 in astrocytes. Hyaluronic Acid 271-281 CD44 molecule (Indian blood group) Homo sapiens 286-290 25613026-0 2016 In vivo evaluation of novel ketal-based oligosaccharides of hyaluronan micelles as multifunctional CD44 receptor-targeting and tumor pH-responsive carriers. Hyaluronic Acid 60-70 CD44 molecule (Indian blood group) Homo sapiens 99-103 25613026-1 2016 In this report, the oligosaccharides of hyaluronan (oHA)-histidine-menthone 1,2-glycerol ketal (MGK) (oHM) carried pH-sensitive MGK as hydrophobic moieties and oHA as the target of the CD44 receptor. Hyaluronic Acid 40-50 CD44 molecule (Indian blood group) Homo sapiens 185-189 26724540-2 2016 We developed new hyaluronan-based nanoparticles targeting CD44 receptors of two different sizes and compared their lung cancer cells targeting efficacy in vitro and in vivo. Hyaluronic Acid 17-27 CD44 molecule (Indian blood group) Homo sapiens 58-62 26975415-0 2016 Mineralization Effect of Hyaluronan on Dental Pulp Cells via CD44. Hyaluronic Acid 25-35 CD44 molecule (Indian blood group) Homo sapiens 61-65 26975415-3 2016 Hyaluronic acid (HA) is the principal ligand for receptor CD44. Hyaluronic Acid 0-15 CD44 molecule (Indian blood group) Homo sapiens 58-62 26975415-3 2016 Hyaluronic acid (HA) is the principal ligand for receptor CD44. Hyaluronic Acid 17-19 CD44 molecule (Indian blood group) Homo sapiens 58-62 26724540-10 2016 In this study, the authors investigated the ability of two hyaluronan-based nanoparticles targeting CD44 receptors to home in on lung cancer cells in an in-vivo orthotropic model. Hyaluronic Acid 59-69 CD44 molecule (Indian blood group) Homo sapiens 100-104