PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25081536-0 2014 CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance. Hyaluronic Acid 20-30 basigin (Ok blood group) Homo sapiens 0-5 21518083-8 2011 Emmprin and stratifin were shown to stimulate fibroblast hyaluronan synthesis, and the hyaluronan-stimulating activity of KCM was removed following stratifin depletion and to a lesser extent by emmprin depletion. Hyaluronic Acid 57-67 basigin (Ok blood group) Homo sapiens 0-7 20483678-1 2010 AIM: Extracellular matrix metalloproteinase inducer (EMMPRIN) has been shown to promote tumor invasion and metastasis via stimulating matrix metalloproteinase synthesis in neighboring fibroblasts, to enhance angiogenesis via vascular endothelial growth factor, to induce chemoresistant tumor cells via the production of hyaluronan, and to confer resistance of cancer cells to anoikis through inhibition of Bim. Hyaluronic Acid 320-330 basigin (Ok blood group) Homo sapiens 5-51 20483678-1 2010 AIM: Extracellular matrix metalloproteinase inducer (EMMPRIN) has been shown to promote tumor invasion and metastasis via stimulating matrix metalloproteinase synthesis in neighboring fibroblasts, to enhance angiogenesis via vascular endothelial growth factor, to induce chemoresistant tumor cells via the production of hyaluronan, and to confer resistance of cancer cells to anoikis through inhibition of Bim. Hyaluronic Acid 320-330 basigin (Ok blood group) Homo sapiens 53-60 19176383-2 2009 Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in malignant cancer cells and stimulates hyaluronan production, as well as several downstream signaling pathways. Hyaluronic Acid 159-169 basigin (Ok blood group) Homo sapiens 0-7 19176383-2 2009 Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in malignant cancer cells and stimulates hyaluronan production, as well as several downstream signaling pathways. Hyaluronic Acid 159-169 basigin (Ok blood group) Homo sapiens 9-14 19176383-2 2009 Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in malignant cancer cells and stimulates hyaluronan production, as well as several downstream signaling pathways. Hyaluronic Acid 159-169 basigin (Ok blood group) Homo sapiens 16-23 19176383-6 2009 In the present study, we find that perturbation of endogenous hyaluronan, using small hyaluronan oligosaccharides, rapidly inhibits lactate efflux from breast carcinoma cells; down-regulation of emmprin, using emmprin small interfering RNA, also results in decreased efflux. Hyaluronic Acid 62-72 basigin (Ok blood group) Homo sapiens 195-202 19176383-6 2009 In the present study, we find that perturbation of endogenous hyaluronan, using small hyaluronan oligosaccharides, rapidly inhibits lactate efflux from breast carcinoma cells; down-regulation of emmprin, using emmprin small interfering RNA, also results in decreased efflux. Hyaluronic Acid 62-72 basigin (Ok blood group) Homo sapiens 210-217 18490190-4 2008 Emmprin, a cell surface glycoprotein of the Ig superfamily, stimulates hyaluronan production and downstream signaling consequences. Hyaluronic Acid 71-81 basigin (Ok blood group) Homo sapiens 0-7 17483329-11 2007 The synergistic activities of the MCT/CD147 complex could facilitate migration of tumor cells by CD147-mediated MMP induction and lactate-stimulated angiogenesis and hyaluronan production. Hyaluronic Acid 166-176 basigin (Ok blood group) Homo sapiens 38-43 15711733-5 2005 Emmprin induces angiogenesis via stimulation of VEGF production, invasiveness via stimulation of matrix metalloproteinase production and multidrug resistance via hyaluronan-mediated up-regulation of ErbB2 signaling and cell survival pathway activities. Hyaluronic Acid 162-172 basigin (Ok blood group) Homo sapiens 0-7 12738783-5 2003 Likewise, increased expression of emmprin, which is a glycoprotein that is present on the surface of most malignant cancer cells and that stimulates hyaluronan production, also induces increased resistance. Hyaluronic Acid 149-159 basigin (Ok blood group) Homo sapiens 34-41 25248362-5 2015 In the CKD that follows AKI, a molecular circuit involving CD147, MMPs and transforming growth factor-beta may be involved in the pathogenesis of progressive fibrosis through hyaluronan production and macrophage infiltration. Hyaluronic Acid 175-185 basigin (Ok blood group) Homo sapiens 59-64 21660043-4 2011 Interactions between hyaluronan and hyaluronan receptors on the cell surface also facilitate emmprin-mediated chemoresistance. Hyaluronic Acid 21-31 basigin (Ok blood group) Homo sapiens 93-100 15632176-5 2005 On the other hand, increasing hyaluronan production by overexpression of hyaluronan synthase 2 or emmprin causes elevated ErbB2 phosphorylation in MCF-7 mammary carcinoma cells, which normally exhibit low levels of ErbB2 activity. Hyaluronic Acid 30-40 basigin (Ok blood group) Homo sapiens 98-105 14983875-0 2004 Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Hyaluronic Acid 94-104 basigin (Ok blood group) Homo sapiens 0-7 14983875-4 2004 We also found that elevated emmprin expression stimulates hyaluronan production and that the effect of emmprin on anchorage-independent growth is dependent on hyaluronan. Hyaluronic Acid 58-68 basigin (Ok blood group) Homo sapiens 28-35 14983875-4 2004 We also found that elevated emmprin expression stimulates hyaluronan production and that the effect of emmprin on anchorage-independent growth is dependent on hyaluronan. Hyaluronic Acid 159-169 basigin (Ok blood group) Homo sapiens 103-110 14983875-5 2004 Furthermore, emmprin stimulates cell survival pathway signaling in a hyaluronan-dependent manner. Hyaluronic Acid 69-79 basigin (Ok blood group) Homo sapiens 13-20 31090215-6 2020 CD147 stimulates hyaluronan synthesis and interaction of hyaluronan with its receptors, in particular CD44 and LYVE-1, which in turn result in activation of multiprotein complexes containing members of the membrane-type matrix metalloproteinase, receptor tyrosine kinase, ABC drug transporter, or MCT families within lipid raft domains. Hyaluronic Acid 17-27 basigin (Ok blood group) Homo sapiens 0-5 23888049-6 2013 Here we found that CD147 induces breast epithelial cell invasiveness by promoting epidermal growth factor receptor (EGFR)-Ras-ERK signaling in a manner dependent on hyaluronan-CD44 interaction. Hyaluronic Acid 165-175 basigin (Ok blood group) Homo sapiens 19-24