PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29377347-11	2018	The MEK/ERK inhibitor U0126 and TM inhibited hyaluronic acid-induced cell migration in HCC cells.	Hyaluronic Acid	45-60	mitogen-activated protein kinase 1	Homo sapiens	8-11	
32878463-0	2020	RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals.	Hyaluronic Acid	22-37	mitogen-activated protein kinase 1	Homo sapiens	144-147	
33024087-5	2020	Furthermore, the interaction of CD44 with the ligand hyaluronan (HA) initiated the Src-ERK signaling cascade, which subsequently maintained AKT and mTOR activity in the presence of a PI3Kalpha inhibitor.	Hyaluronic Acid	53-63	mitogen-activated protein kinase 1	Homo sapiens	87-90	
33024087-5	2020	Furthermore, the interaction of CD44 with the ligand hyaluronan (HA) initiated the Src-ERK signaling cascade, which subsequently maintained AKT and mTOR activity in the presence of a PI3Kalpha inhibitor.	Hyaluronic Acid	65-67	mitogen-activated protein kinase 1	Homo sapiens	87-90	
29128538-0	2018	Hyaluronan size alters chondrogenesis of adipose-derived stem cells via the CD44/ERK/SOX-9 pathway.	Hyaluronic Acid	0-10	mitogen-activated protein kinase 1	Homo sapiens	81-84	
25738334-0	2015	20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginsenoside Rb1, enhances the production of hyaluronic acid through the activation of ERK and Akt mediated by Src tyrosin kinase in human keratinocytes.	Hyaluronic Acid	110-125	mitogen-activated protein kinase 1	Homo sapiens	152-155	
28730511-0	2017	Intermediate Molecular Mass Hyaluronan and CD44 Receptor Interactions Enhance Neutrophil Phagocytosis and IL-8 Production via p38- and ERK1/2-MAPK Signalling Pathways.	Hyaluronic Acid	28-38	mitogen-activated protein kinase 1	Homo sapiens	126-129	
24845645-10	2014	These results demonstrate for the first time that cPA and LPA induce hyaluronic acid synthesis in human skin fibroblasts mainly through the activation of LPAR1-Gi/o followed by the PI3K, ERK, and CREB signaling pathway.	Hyaluronic Acid	69-84	mitogen-activated protein kinase 1	Homo sapiens	187-190	
25473211-0	2014	Synergistic effect of interleukin-6 and hyaluronic acid on cell migration and ERK activation in human keratinocytes.	Hyaluronic Acid	40-55	mitogen-activated protein kinase 1	Homo sapiens	78-81	
21059338-0	2010	High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1.	Hyaluronic Acid	22-37	mitogen-activated protein kinase 1	Homo sapiens	120-123	
17324121-9	2007	We conclude that the ERK MAPK and PI3K signalling pathways are necessary for the regulation of hyaluronan synthesis by PDGF-BB, and that prevention of its binding to CD44 inhibits PDGF-BB-induced cell growth.	Hyaluronic Acid	95-105	mitogen-activated protein kinase 1	Homo sapiens	21-24	
17324121-9	2007	We conclude that the ERK MAPK and PI3K signalling pathways are necessary for the regulation of hyaluronan synthesis by PDGF-BB, and that prevention of its binding to CD44 inhibits PDGF-BB-induced cell growth.	Hyaluronic Acid	95-105	mitogen-activated protein kinase 1	Homo sapiens	25-29	
15677552-9	2005	Inhibitors of the p38 and ERK1/2 mitogen-activated pathways but not JNK/SAPK blocked the IL-1beta-mediated induction of hyaluronan expression and the increase in HAS2 transcript expression.	Hyaluronic Acid	120-130	mitogen-activated protein kinase 1	Homo sapiens	18-21	
12093135-5	2002	Hyaluronan treatment mediated the rapid and transient phosphorylation of extracellular signal regulated kinases 1 and 2 (ERK1 and ERK2) in glioma cell lines.	Hyaluronic Acid	0-10	mitogen-activated protein kinase 1	Homo sapiens	73-119	
12093135-5	2002	Hyaluronan treatment mediated the rapid and transient phosphorylation of extracellular signal regulated kinases 1 and 2 (ERK1 and ERK2) in glioma cell lines.	Hyaluronic Acid	0-10	mitogen-activated protein kinase 1	Homo sapiens	130-134	
34628469-3	2021	Hyaluronan acts through the interaction with cell membrane receptors as CD44 and RHAMM and triggers signaling pathways as MEK/ERK.	Hyaluronic Acid	0-10	mitogen-activated protein kinase 1	Homo sapiens	126-129	
20706991-0	2011	Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38.	Hyaluronic Acid	0-10	mitogen-activated protein kinase 1	Homo sapiens	93-96	
15655247-0	2005	Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.	Hyaluronic Acid	0-10	mitogen-activated protein kinase 1	Homo sapiens	59-62