PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33903744-2 2021 Here, we show that the release-through the implantation of a hyaluronic acid hydrogel-of CAR-T cells targeting the human chondroitin sulfate proteoglycan 4, polymer nanoparticles encapsulating the cytokine interleukin-15 and platelets conjugated with the checkpoint inhibitor programmed death-ligand 1 into the tumour cavity of mice with a resected subcutaneous melanoma tumour inhibits the local recurrence of the tumour as well as the growth of distant tumours, through the abscopal effect. Hyaluronic Acid 61-76 interleukin 15 Homo sapiens 206-220 10429666-0 1999 Interleukin 15 induces endothelial hyaluronan expression in vitro and promotes activated T cell extravasation through a CD44-dependent pathway in vivo. Hyaluronic Acid 35-45 interleukin 15 Homo sapiens 0-14 10429666-5 1999 Here, we examine the effect of IL-15 on hyaluronan expression by endothelial cells, and investigate its role in vivo in promoting the extravasation of antigen-activated T cells through a CD44-dependent pathway. Hyaluronic Acid 40-50 interleukin 15 Homo sapiens 31-36 10429666-6 1999 The expression of hyaluronan on primary endothelial cells and microvascular endothelial cell lines is induced by IL-15, whereas IL-2 has no such activity. Hyaluronic Acid 18-28 interleukin 15 Homo sapiens 113-118