PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22351758-0 2012 Constitutive expression of inter-alpha-inhibitor (IalphaI) family proteins and tumor necrosis factor-stimulated gene-6 (TSG-6) by human amniotic membrane epithelial and stromal cells supporting formation of the heavy chain-hyaluronan (HC-HA) complex. Hyaluronic Acid 223-233 TNF alpha induced protein 6 Homo sapiens 79-118 22922154-1 2012 TSG-6 is an ~35 kDa glycoprotein belonging to the hyaluronan binding family. Hyaluronic Acid 50-60 TNF alpha induced protein 6 Homo sapiens 0-5 22922154-4 2012 TSG-6 catalyzes cross-linking via heavy chains of trypsin alpha inhibitor and hyaluronan. Hyaluronic Acid 78-88 TNF alpha induced protein 6 Homo sapiens 0-5 22528482-2 2012 The complex is covalently held together by chondroitin sulfate but during inflammation IalphaI may interact with TNF-stimulated gene 6 protein (TSG-6), which supports transesterification of heavy chains to hyaluronan. Hyaluronic Acid 206-216 TNF alpha induced protein 6 Homo sapiens 113-142 22528482-2 2012 The complex is covalently held together by chondroitin sulfate but during inflammation IalphaI may interact with TNF-stimulated gene 6 protein (TSG-6), which supports transesterification of heavy chains to hyaluronan. Hyaluronic Acid 206-216 TNF alpha induced protein 6 Homo sapiens 144-149 22351758-0 2012 Constitutive expression of inter-alpha-inhibitor (IalphaI) family proteins and tumor necrosis factor-stimulated gene-6 (TSG-6) by human amniotic membrane epithelial and stromal cells supporting formation of the heavy chain-hyaluronan (HC-HA) complex. Hyaluronic Acid 223-233 TNF alpha induced protein 6 Homo sapiens 120-125 22351758-1 2012 Recently, we reported HC-HA, a covalent complex formed between heavy chains (HCs) of inter-alpha-inhibitor (IalphaI) and hyaluronan (HA) by the catalytic action of tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), is responsible for human amniotic membrane (AM) anti-inflammatory, anti-scarring, and anti-angiogenic actions. Hyaluronic Acid 121-131 TNF alpha induced protein 6 Homo sapiens 211-216 18448433-0 2008 The transfer of heavy chains from bikunin proteins to hyaluronan requires both TSG-6 and HC2. Hyaluronic Acid 54-64 TNF alpha induced protein 6 Homo sapiens 79-84 21619930-6 2011 We have previously demonstrated that PTX3 binds to HCs of IalphaI and TSG-6, which are essential for cumulus matrix formation and able to interact with hyaluronan. Hyaluronic Acid 152-162 TNF alpha induced protein 6 Homo sapiens 70-75 20463016-1 2010 The heavy chain (HC) subunits of the bikunin proteins are covalently attached to a single chondroitin sulfate (CS) chain originating from bikunin and can be transferred to different hyaluronan (HA) molecules by TSG-6/HC2. Hyaluronic Acid 182-192 TNF alpha induced protein 6 Homo sapiens 211-216 20463016-1 2010 The heavy chain (HC) subunits of the bikunin proteins are covalently attached to a single chondroitin sulfate (CS) chain originating from bikunin and can be transferred to different hyaluronan (HA) molecules by TSG-6/HC2. Hyaluronic Acid 194-196 TNF alpha induced protein 6 Homo sapiens 211-216 19389798-2 2009 TSG-6 is a hyaluronan-binding protein that is involved in ECM remodeling and has anti-inflammatory and chondroprotective functions. Hyaluronic Acid 11-21 TNF alpha induced protein 6 Homo sapiens 0-5 19389798-3 2009 PTX3 and TSG-6 are coregulated by growth differentiation factor-9 in granulosa cells, where they are produced during the periovulatory period and play essential roles in the incorporation of hyaluronan into the ECM during cumulus expansion. Hyaluronic Acid 191-201 TNF alpha induced protein 6 Homo sapiens 9-14 21596748-0 2011 The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers. Hyaluronic Acid 54-64 TNF alpha induced protein 6 Homo sapiens 36-41 21596748-0 2011 The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers. Hyaluronic Acid 54-64 TNF alpha induced protein 6 Homo sapiens 88-93 21596748-0 2011 The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers. Hyaluronic Acid 69-79 TNF alpha induced protein 6 Homo sapiens 36-41 21596748-0 2011 The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers. Hyaluronic Acid 69-79 TNF alpha induced protein 6 Homo sapiens 88-93 21239672-2 2011 The covalent modification of hyaluronan (HA) with the heavy chains (HC) of inter-alpha-inhibitor (IalphaI) has been identified as an important pathway in inflammation and tissue remodeling, where HC HA formation is catalyzed by TSG-6 (the protein product of tumor necrosis factor stimulated gene-6). Hyaluronic Acid 29-39 TNF alpha induced protein 6 Homo sapiens 228-233 20100602-2 2010 Tumor necrosis factor stimulated gene-6 protein (TSG-6)/heavy chain 2 (HC2) cleaves this unique cross-link and transfers the HCs to hyaluronan and other glycosaminoglycans via a covalent HC*TSG-6 intermediate. Hyaluronic Acid 132-142 TNF alpha induced protein 6 Homo sapiens 0-47 20100602-2 2010 Tumor necrosis factor stimulated gene-6 protein (TSG-6)/heavy chain 2 (HC2) cleaves this unique cross-link and transfers the HCs to hyaluronan and other glycosaminoglycans via a covalent HC*TSG-6 intermediate. Hyaluronic Acid 132-142 TNF alpha induced protein 6 Homo sapiens 49-54 20100602-2 2010 Tumor necrosis factor stimulated gene-6 protein (TSG-6)/heavy chain 2 (HC2) cleaves this unique cross-link and transfers the HCs to hyaluronan and other glycosaminoglycans via a covalent HC*TSG-6 intermediate. Hyaluronic Acid 132-142 TNF alpha induced protein 6 Homo sapiens 190-195 18806261-0 2008 Hyaluronan binding to link module of TSG-6 and to G1 domain of aggrecan is differently regulated by pH. Hyaluronic Acid 0-10 TNF alpha induced protein 6 Homo sapiens 37-42 18448433-1 2008 Tumor necrosis factor-stimulated gene-6 protein (TSG-6) is involved in the transfer of heavy chains (HCs) from inter-alpha-inhibitor (IalphaI), pre-alpha-inhibitor, and as shown here HC2.bikunin to hyaluronan through the formation of covalent HC.TSG-6 intermediates. Hyaluronic Acid 198-208 TNF alpha induced protein 6 Homo sapiens 0-47 18448433-1 2008 Tumor necrosis factor-stimulated gene-6 protein (TSG-6) is involved in the transfer of heavy chains (HCs) from inter-alpha-inhibitor (IalphaI), pre-alpha-inhibitor, and as shown here HC2.bikunin to hyaluronan through the formation of covalent HC.TSG-6 intermediates. Hyaluronic Acid 198-208 TNF alpha induced protein 6 Homo sapiens 49-54 17585936-2 2007 Previously NMR structures were calculated for the Link module of TSG-6 (Link_TSG6) in its free state and when bound to an octasaccharide of hyaluronan (HA(8)). Hyaluronic Acid 140-150 TNF alpha induced protein 6 Homo sapiens 65-70 17804111-6 2007 Hyaluronan crosslinking occurs through various proteins, such as tenascin, TSG-6, inter-alpha-trypsin inhibitor, pentraxin and TSP-1. Hyaluronic Acid 0-10 TNF alpha induced protein 6 Homo sapiens 75-80 17635118-1 2007 The inflammation-associated protein TSG-6 (the product of tumour necrosis factor-stimulated gene-6) can form covalent complexes with the heavy chains (HC1 and HC2) of IalphaI (inter-alpha-inhibitor); namely, TSG-6.HC1 and TSG-6.HC2, which act as intermediates in the covalent transfer of HCs on to the GAG (glycosaminoglycan) HA (hyaluronan). Hyaluronic Acid 330-340 TNF alpha induced protein 6 Homo sapiens 36-41 17635118-1 2007 The inflammation-associated protein TSG-6 (the product of tumour necrosis factor-stimulated gene-6) can form covalent complexes with the heavy chains (HC1 and HC2) of IalphaI (inter-alpha-inhibitor); namely, TSG-6.HC1 and TSG-6.HC2, which act as intermediates in the covalent transfer of HCs on to the GAG (glycosaminoglycan) HA (hyaluronan). Hyaluronic Acid 330-340 TNF alpha induced protein 6 Homo sapiens 58-98 17635118-1 2007 The inflammation-associated protein TSG-6 (the product of tumour necrosis factor-stimulated gene-6) can form covalent complexes with the heavy chains (HC1 and HC2) of IalphaI (inter-alpha-inhibitor); namely, TSG-6.HC1 and TSG-6.HC2, which act as intermediates in the covalent transfer of HCs on to the GAG (glycosaminoglycan) HA (hyaluronan). Hyaluronic Acid 330-340 TNF alpha induced protein 6 Homo sapiens 208-213 17635118-1 2007 The inflammation-associated protein TSG-6 (the product of tumour necrosis factor-stimulated gene-6) can form covalent complexes with the heavy chains (HC1 and HC2) of IalphaI (inter-alpha-inhibitor); namely, TSG-6.HC1 and TSG-6.HC2, which act as intermediates in the covalent transfer of HCs on to the GAG (glycosaminoglycan) HA (hyaluronan). Hyaluronic Acid 330-340 TNF alpha induced protein 6 Homo sapiens 208-213 12889811-0 2003 Fusion protein of the hyaluronan binding domain from human TSG-6 with luciferase for assay of hyaluronan. Hyaluronic Acid 22-32 TNF alpha induced protein 6 Homo sapiens 59-64 17307731-0 2007 Determining the molecular basis for the pH-dependent interaction between the link module of human TSG-6 and hyaluronan. Hyaluronic Acid 108-118 TNF alpha induced protein 6 Homo sapiens 98-103 26627146-0 2007 Using Molecular Dynamics Simulations To Provide New Insights into Protein Structure on the Nanosecond Timescale: Comparison with Experimental Data and Biological Inferences for the Hyaluronan-Binding Link Module of TSG-6. Hyaluronic Acid 182-192 TNF alpha induced protein 6 Homo sapiens 216-221 16771708-5 2006 TSG-6 has two functional domains, a Link domain (a hyaluronan binding domain) and a CUB domain implicated in protein interaction. Hyaluronic Acid 51-61 TNF alpha induced protein 6 Homo sapiens 0-5 16771708-7 2006 In addition, the inhibitory action of TSG-6 and the in vitro interaction of TSG-6 with BMP-2 were abolished by the addition of hyaluronan. Hyaluronic Acid 127-137 TNF alpha induced protein 6 Homo sapiens 38-43 16771708-7 2006 In addition, the inhibitory action of TSG-6 and the in vitro interaction of TSG-6 with BMP-2 were abolished by the addition of hyaluronan. Hyaluronic Acid 127-137 TNF alpha induced protein 6 Homo sapiens 76-81 15840581-0 2005 Characterization of complexes formed between TSG-6 and inter-alpha-inhibitor that act as intermediates in the covalent transfer of heavy chains onto hyaluronan. Hyaluronic Acid 149-159 TNF alpha induced protein 6 Homo sapiens 45-50 15718240-0 2005 Towards a structure for a TSG-6.hyaluronan complex by modeling and NMR spectroscopy: insights into other members of the link module superfamily. Hyaluronic Acid 32-42 TNF alpha induced protein 6 Homo sapiens 26-31 15718240-1 2005 The Link module from human TSG-6, a hyaladherin with roles in ovulation and inflammation, has a hyaluronan (HA)-binding groove containing two adjacent tyrosine residues that are likely to form CH-pi stacking interactions with sequential rings in the sugar. Hyaluronic Acid 96-106 TNF alpha induced protein 6 Homo sapiens 27-32 15718240-1 2005 The Link module from human TSG-6, a hyaladherin with roles in ovulation and inflammation, has a hyaluronan (HA)-binding groove containing two adjacent tyrosine residues that are likely to form CH-pi stacking interactions with sequential rings in the sugar. Hyaluronic Acid 108-110 TNF alpha induced protein 6 Homo sapiens 27-32 15060082-0 2004 TSG-6 modulates the interaction between hyaluronan and cell surface CD44. Hyaluronic Acid 40-50 TNF alpha induced protein 6 Homo sapiens 0-5 15060082-2 2004 Here we show that preincubation of hyaluronan with full-length recombinant TSG-6 or its Link module domain (Link_TSG6) enhances or induces the binding of hyaluronan to cell surface CD44 on constitutive and inducible cell backgrounds, respectively. Hyaluronic Acid 35-45 TNF alpha induced protein 6 Homo sapiens 75-80 15060082-2 2004 Here we show that preincubation of hyaluronan with full-length recombinant TSG-6 or its Link module domain (Link_TSG6) enhances or induces the binding of hyaluronan to cell surface CD44 on constitutive and inducible cell backgrounds, respectively. Hyaluronic Acid 154-164 TNF alpha induced protein 6 Homo sapiens 75-80 15060082-4 2004 Enhancement of CD44-mediated interactions of lymphoid cells with hyaluronan by TSG-6 proteins was seen under conditions of flow at shear forces that occur in post-capillary venules. Hyaluronic Acid 65-75 TNF alpha induced protein 6 Homo sapiens 79-84 15060082-5 2004 Increases in the number of rolling cells were observed on substrates comprising TSG-6-hyaluronan complexes as compared with a substrate containing hyaluronan alone. Hyaluronic Acid 86-96 TNF alpha induced protein 6 Homo sapiens 80-85 15060082-10 2004 The ability of TSG-6 to modulate the interaction of hyaluronan with CD44 has important implications for CD44-mediated cell activity at sites of inflammation, where TSG-6 is expressed. Hyaluronic Acid 52-62 TNF alpha induced protein 6 Homo sapiens 15-20 15060082-10 2004 The ability of TSG-6 to modulate the interaction of hyaluronan with CD44 has important implications for CD44-mediated cell activity at sites of inflammation, where TSG-6 is expressed. Hyaluronic Acid 52-62 TNF alpha induced protein 6 Homo sapiens 164-169 15110797-4 2004 TSG-6, which specifically binds to hyaluronan (HA) and to inter-alpha-inhibitor (I alpha I), shows potent anti-inflammatory activity in acute and chronic inflammation, notably in several models of autoimmune arthritis. Hyaluronic Acid 35-45 TNF alpha induced protein 6 Homo sapiens 0-5 14723873-0 2004 TSG-6 and calcium ions are essential for the coupling of inter-alpha-trypsin inhibitor to hyaluronan in human synovial fluid. Hyaluronic Acid 90-100 TNF alpha induced protein 6 Homo sapiens 0-5 14723873-1 2004 OBJECTIVE: To investigate the role of tumor necrosis factor stimulated gene 6 (TSG-6) and metal ions in the coupling of inter-alpha-trypsin inhibitor (ITI) to hyaluronan in human synovial fluid. Hyaluronic Acid 159-169 TNF alpha induced protein 6 Homo sapiens 79-84 14723873-7 2004 CONCLUSIONS: Tumor necrosis factor stimulated gene 6 (TSG-6) and calcium ions are both essential for the coupling of inter-alpha-trypsin inhibitor to hyaluronan in human synovial fluid. Hyaluronic Acid 150-160 TNF alpha induced protein 6 Homo sapiens 54-59 12972412-0 2003 The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding. Hyaluronic Acid 98-108 TNF alpha induced protein 6 Homo sapiens 68-73 12972412-1 2003 The solution structure of the Link module from human TSG-6, a hyaladherin with important roles in inflammation and ovulation, has been determined in both its free and hyaluronan-bound conformations. Hyaluronic Acid 167-177 TNF alpha induced protein 6 Homo sapiens 53-58 12889811-1 2003 The gene expression plasmid, pET-Lmluc, for the fusion protein of the hyaluronan binding domain from human TSG-6 [product of tumor necrosis factor (TNF)-stimulated gene-6] and luciferase from Renilla reniformis was constructed. Hyaluronic Acid 70-80 TNF alpha induced protein 6 Homo sapiens 107-112 14515153-7 2003 Hyaluronan-linked heavy chains in the extracellular matrix of this cellular complex have recently been shown to be tightly bound to TSG-6. Hyaluronic Acid 0-10 TNF alpha induced protein 6 Homo sapiens 132-137 12692188-4 2003 Growing evidence also indicates that TSG-6 acts as a crucial factor in ovulation by influencing the expansion of the hyaluronan-rich cumulus extracellular matrix in the preovulatory follicle. Hyaluronic Acid 117-127 TNF alpha induced protein 6 Homo sapiens 37-42 12692188-5 2003 TSG-6 is a member of the Link module superfamily and binds to hyaluronan (a vital component of extracellular matrix), as well as other glycosaminoglycans, via its Link module. Hyaluronic Acid 62-72 TNF alpha induced protein 6 Homo sapiens 0-5 14515153-8 2003 Since TSG-6 binds to hyaluronan, its complex with heavy chains could stabilize the extracellular matrix by cross-linking hyaluronan molecules. Hyaluronic Acid 21-31 TNF alpha induced protein 6 Homo sapiens 6-11 14515153-8 2003 Since TSG-6 binds to hyaluronan, its complex with heavy chains could stabilize the extracellular matrix by cross-linking hyaluronan molecules. Hyaluronic Acid 121-131 TNF alpha induced protein 6 Homo sapiens 6-11 12622693-5 2003 In the present study, an electrophoretic technique by which hyaluronan-bound ITI is immobilized was used to demonstrate that tumour necrosis factor stimulated gene 6 (TSG-6) is necessary for the coupling reaction. Hyaluronic Acid 60-70 TNF alpha induced protein 6 Homo sapiens 167-172 12622693-0 2003 Role of tumour necrosis factor stimulated gene 6 (TSG-6) in the coupling of inter-alpha-trypsin inhibitor to hyaluronan in human follicular fluid. Hyaluronic Acid 109-119 TNF alpha induced protein 6 Homo sapiens 50-55 12622693-8 2003 In conclusion, TSG-6 is necessary for the coupling of ITI to hyaluronan, but at least one additional component in follicular fluid is essential. Hyaluronic Acid 61-71 TNF alpha induced protein 6 Homo sapiens 15-20 12401803-0 2002 The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. Hyaluronic Acid 68-78 TNF alpha induced protein 6 Homo sapiens 27-32 34188166-6 2021 PTX3 organizes hyaluronan in conjunction with tumor necrosis factor-stimulated gene 6 (TSG-6) and facilitates stellate and cancer cell invasion. Hyaluronic Acid 15-25 TNF alpha induced protein 6 Homo sapiens 46-85 12011075-5 2002 Cells expressing the CD44/TSG-6 molecule bound hyaluronan with higher avidity than cells expressing CD44. Hyaluronic Acid 47-57 TNF alpha induced protein 6 Homo sapiens 26-31 10903951-0 2000 Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6. Hyaluronic Acid 41-51 TNF alpha induced protein 6 Homo sapiens 95-100 10903951-3 2000 RESULTS: Isothermal titration calorimetry was used to characterize the interaction of the Link module from human TSG-6 (Link_TSG6) with HA oligosaccharides of defined length (HA(4)-HA(16)). Hyaluronic Acid 136-138 TNF alpha induced protein 6 Homo sapiens 113-118 34909750-0 2021 Deletion of TNFAIP6 Gene in Human Keratinocytes Demonstrates a Role for TSG-6 to Retain Hyaluronan Inside Epidermis. Hyaluronic Acid 88-98 TNF alpha induced protein 6 Homo sapiens 72-77 12011075-0 2002 Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6. Hyaluronic Acid 0-10 TNF alpha induced protein 6 Homo sapiens 78-83 12011075-4 2002 Monoclonal antibodies raised against the CD44/TSG-6 chimera recognized recombinant human TSG-6 and native mouse TSG-6 and blocked hyaluronan binding to these proteins. Hyaluronic Acid 130-140 TNF alpha induced protein 6 Homo sapiens 46-51 11287417-0 2001 Mapping the hyaluronan-binding site on the link module from human tumor necrosis factor-stimulated gene-6 by site-directed mutagenesis. Hyaluronic Acid 12-22 TNF alpha induced protein 6 Homo sapiens 66-105 11287417-6 2001 Analysis of the sequences of TSG-6 and CD44 indicates that the molecular details of their association with hyaluronan are likely to be significantly different. Hyaluronic Acid 107-117 TNF alpha induced protein 6 Homo sapiens 29-34 9654129-0 1998 TSG-6 interacts with hyaluronan and aggrecan in a pH-dependent manner via a common functional element: implications for its regulation in inflamed cartilage. Hyaluronic Acid 21-31 TNF alpha induced protein 6 Homo sapiens 0-5 9237673-0 1997 Overlapping sites on the Link module of human TSG-6 mediate binding to hyaluronan and chrondroitin-4-sulphate. Hyaluronic Acid 71-81 TNF alpha induced protein 6 Homo sapiens 46-51 9237673-2 1997 We have examined the glycosaminoglycan specificity of the Link module from the arthritis-associated protein, human TSG-6, by microtitre plate-based assays employing biotinylated-hyaluronan or mono-biotinylated Link module. Hyaluronic Acid 178-188 TNF alpha induced protein 6 Homo sapiens 115-120 9237673-4 1997 Competition experiments indicate that C4S and hyaluronan have overlapping binding surfaces on the TSG-6 Link module. Hyaluronic Acid 46-56 TNF alpha induced protein 6 Homo sapiens 98-103 9244409-4 1997 TSG-6 protein consists of two structural domains: a hyaluronan-binding link module, the characteristic domain of the hyaladherin family of proteins, and a C-terminal CUB domain, present in a variety of diverse proteins. Hyaluronic Acid 52-62 TNF alpha induced protein 6 Homo sapiens 0-5 8797823-4 1996 The TSG-6 Link module was shown to interact with hyaluronan, and a putative binding surface was identified on the structure. Hyaluronic Acid 49-59 TNF alpha induced protein 6 Homo sapiens 4-9 34099638-1 2021 Hyaluronan (HA) cross-linking is a conformational state of HA, a covalent complex between HA and heavy chains (HCs) from inter-alpha-trypsin inhibitor (I-alpha-I) mediated by tumor necrosis factor-induced protein 6 (TSG6). Hyaluronic Acid 0-10 TNF alpha induced protein 6 Homo sapiens 216-220 34188166-6 2021 PTX3 organizes hyaluronan in conjunction with tumor necrosis factor-stimulated gene 6 (TSG-6) and facilitates stellate and cancer cell invasion. Hyaluronic Acid 15-25 TNF alpha induced protein 6 Homo sapiens 87-92 31484722-4 2019 Inflammation promotes the transfer of HCs from chondroitin 4-sulfate to hyaluronan by tumor necrosis factor stimulated gene 6 protein (TSG-6). Hyaluronic Acid 72-82 TNF alpha induced protein 6 Homo sapiens 86-133 31484722-4 2019 Inflammation promotes the transfer of HCs from chondroitin 4-sulfate to hyaluronan by tumor necrosis factor stimulated gene 6 protein (TSG-6). Hyaluronic Acid 72-82 TNF alpha induced protein 6 Homo sapiens 135-140 31484722-10 2019 After cleavage, free HC2, together with TSG-6, is able to catalyze the transfer of heavy chains to hyaluronan. Hyaluronic Acid 99-109 TNF alpha induced protein 6 Homo sapiens 40-45 31044513-7 2019 Besides, macrophages primed with high-molecular weight hyaluronan and inoculated in human breast cancer xenograft tumor increased blood vessel formation and diminished TSG-6 levels. Hyaluronic Acid 55-65 TNF alpha induced protein 6 Homo sapiens 168-173 31044513-0 2019 Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG-6 expression in a tumor type-specific manner. Hyaluronic Acid 0-10 TNF alpha induced protein 6 Homo sapiens 104-109 31044513-9 2019 Taken together, these results indicate that the effect of high-molecular weight hyaluronan as an inductor of the angiogenic behavior of macrophages in breast tumor context is in part consequence of the presence of TSG-6. Hyaluronic Acid 80-90 TNF alpha induced protein 6 Homo sapiens 214-219 25548183-7 2015 The observations were probably explained by the much lower expression of receptors for interleukin-1 and TGFbeta, downstream protumor factors, and hyaluronan and its cofactor TSG6, which all contribute to the protumor effects of BM-MSCs. Hyaluronic Acid 147-157 TNF alpha induced protein 6 Homo sapiens 175-179 26793973-7 2016 To address these problems, we added to the medium an inhibitor of hyaluronan synthesis and heparin to compete with the binding of TSG-6 to hyaluronan. Hyaluronic Acid 139-149 TNF alpha induced protein 6 Homo sapiens 130-135 26685054-2 2016 The Link module, one of the domains of TSG-6, is responsible for binding hyaluronan and other glycosaminoglycans found in the ECM. Hyaluronic Acid 73-83 TNF alpha induced protein 6 Homo sapiens 39-44 26769483-5 2016 HC-HA complex is covalently formed by hyaluronan (HA) and heavy chain 1 (HC1) of inter-alpha-trypsin inhibitor by the catalytic action of tumor necrosis factor-stimulated gene-6 (TSG-6) and are tightly associated with pentraxin 3 (PTX3) to form HC-HA/PTX3. Hyaluronic Acid 38-48 TNF alpha induced protein 6 Homo sapiens 138-177 26769483-5 2016 HC-HA complex is covalently formed by hyaluronan (HA) and heavy chain 1 (HC1) of inter-alpha-trypsin inhibitor by the catalytic action of tumor necrosis factor-stimulated gene-6 (TSG-6) and are tightly associated with pentraxin 3 (PTX3) to form HC-HA/PTX3. Hyaluronic Acid 38-48 TNF alpha induced protein 6 Homo sapiens 179-184 23166324-1 2013 The covalent transfer of heavy chains (HCs) from inter-alpha-inhibitor (IalphaI) to hyaluronan (HA) via the protein product of tumor necrosis factor-stimulated gene-6 (TSG-6) forms the HC-HA complex, a pathological form of HA that promotes the adhesion of leukocytes to HA matrices. Hyaluronic Acid 84-94 TNF alpha induced protein 6 Homo sapiens 127-166 25325979-1 2015 During inflammation and developmental processes, heavy chains (HCs) from inter-alpha-inhibitor (IalphaI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG-6) to form a HC-HA complex. Hyaluronic Acid 135-145 TNF alpha induced protein 6 Homo sapiens 166-205 25325979-1 2015 During inflammation and developmental processes, heavy chains (HCs) from inter-alpha-inhibitor (IalphaI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG-6) to form a HC-HA complex. Hyaluronic Acid 135-145 TNF alpha induced protein 6 Homo sapiens 207-212 25325979-1 2015 During inflammation and developmental processes, heavy chains (HCs) from inter-alpha-inhibitor (IalphaI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG-6) to form a HC-HA complex. Hyaluronic Acid 147-149 TNF alpha induced protein 6 Homo sapiens 166-205 25325979-1 2015 During inflammation and developmental processes, heavy chains (HCs) from inter-alpha-inhibitor (IalphaI) are covalently transferred to hyaluronan (HA) via the enzyme tumor-necrosis-factor-stimulated-gene 6 (TSG-6) to form a HC-HA complex. Hyaluronic Acid 147-149 TNF alpha induced protein 6 Homo sapiens 207-212 25135638-1 2014 We have recently demonstrated that the transfer of heavy chains (HCs) from inter-alpha-inhibitor, via the enzyme TSG-6 (tumor necrosis factor-stimulated gene 6), to hyaluronan (HA) oligosaccharides is an irreversible event in which subsequent swapping of HCs between HA molecules does not occur. Hyaluronic Acid 165-175 TNF alpha induced protein 6 Homo sapiens 113-118 25135638-1 2014 We have recently demonstrated that the transfer of heavy chains (HCs) from inter-alpha-inhibitor, via the enzyme TSG-6 (tumor necrosis factor-stimulated gene 6), to hyaluronan (HA) oligosaccharides is an irreversible event in which subsequent swapping of HCs between HA molecules does not occur. Hyaluronic Acid 165-175 TNF alpha induced protein 6 Homo sapiens 120-159 24213015-5 2014 TSG-6 is an inflammation-associated protein which acts as a potent inhibitor of neutrophil extravasation and also plays important roles in matrix remodeling, e.g., by promoting hyaluronan (HA) cross-linking and down-regulating the protease network. Hyaluronic Acid 177-187 TNF alpha induced protein 6 Homo sapiens 0-5 24005673-0 2013 Inter-alpha-inhibitor impairs TSG-6-induced hyaluronan cross-linking. Hyaluronic Acid 44-54 TNF alpha induced protein 6 Homo sapiens 30-35 23166324-1 2013 The covalent transfer of heavy chains (HCs) from inter-alpha-inhibitor (IalphaI) to hyaluronan (HA) via the protein product of tumor necrosis factor-stimulated gene-6 (TSG-6) forms the HC-HA complex, a pathological form of HA that promotes the adhesion of leukocytes to HA matrices. Hyaluronic Acid 84-94 TNF alpha induced protein 6 Homo sapiens 168-173