PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25982115-2	2015	Here, we show that a previously uncharacterized SCF(Ucc1) ubiquitin ligase mediates proteasomal degradation of citrate synthase in the glyoxylate cycle to maintain metabolic homeostasis in glucose-grown cells.	glyoxylic acid	135-145	citrate synthase	Homo sapiens	111-127	
7460950-0	1980	A deficiency of citrate synthase results in constitutive expression of the glyoxylate pathway in Arthrobacter pyridinolis.	glyoxylic acid	75-85	citrate synthase	Homo sapiens	16-32	
25982115-4	2015	Moreover, in vitro analysis demonstrates that oxaloacetate regenerated through the glyoxylate cycle induces a conformational change in citrate synthase and inhibits its recognition and ubiquitination by SCF(Ucc1), suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes citrate synthase.	glyoxylic acid	83-93	citrate synthase	Homo sapiens	135-151	
25982115-4	2015	Moreover, in vitro analysis demonstrates that oxaloacetate regenerated through the glyoxylate cycle induces a conformational change in citrate synthase and inhibits its recognition and ubiquitination by SCF(Ucc1), suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes citrate synthase.	glyoxylic acid	83-93	citrate synthase	Homo sapiens	307-323	
25982115-5	2015	We propose that SCF(Ucc1)-mediated regulation of citrate synthase acts as a metabolic switch for the glyoxylate cycle in response to changes in carbon source, thereby ensuring metabolic versatility and flexibility.	glyoxylic acid	101-111	citrate synthase	Homo sapiens	49-65