PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20054120-1 2009 Glycolate oxidase, a peroxisomal flavoenzyme, generates glyoxylate at the expense of oxygen. glyoxylic acid 56-66 hydroxyacid oxidase 2 Homo sapiens 0-17 3521736-6 1986 The midpoint potential of glycolate oxidase is more positive than that of the glyoxalate/glycolate couple, and two-electron reduction of glycolate oxidase is thermodynamically favorable. glyoxylic acid 78-88 hydroxyacid oxidase 2 Homo sapiens 26-43 3521736-6 1986 The midpoint potential of glycolate oxidase is more positive than that of the glyoxalate/glycolate couple, and two-electron reduction of glycolate oxidase is thermodynamically favorable. glyoxylic acid 78-88 hydroxyacid oxidase 2 Homo sapiens 137-154 35601556-3 2022 Oxidation of glycolate by glycolate oxidase (or hydroxy acid oxidase 1, HAO1) is a major cellular source of glyoxylate, and siRNA studies have shown phenotypic rescue of PH1 by the knockdown of HAO1, representing a promising inhibitor target. glyoxylic acid 108-118 hydroxyacid oxidase 2 Homo sapiens 26-43 16664240-5 1985 Under low oxygen (1.8%), or in the presence of alpha-hydroxy-2-pyridine methanesulfonic acid (an inhibitor of glycolate oxidase, a step in the photorespiratory formation of glyoxylate), there was a substantial (60-80%) decrease in transfer of label to glycine, serine, ammonia, and glutamine. glyoxylic acid 173-183 hydroxyacid oxidase 2 Homo sapiens 110-127 16657053-11 1969 In the peroxisomes, glycolate is oxidized with O(2) uptake to glyoxylate by glycolate oxidase, and the glyoxylate is converted to glycine by glutamate:glyoxylate aminotransferase. glyoxylic acid 62-72 hydroxyacid oxidase 2 Homo sapiens 76-93 33294491-8 2020 We have also generated an in vivo model of glycolate oxidase (GO) deficiency, which is an enzyme involved in the glyoxylate metabolism following the same strategy. glyoxylic acid 113-123 hydroxyacid oxidase 2 Homo sapiens 43-60 24263643-6 2013 In this assay, glycolic acid is converted to glyoxylic acid by glycolate oxidase, with the production of hydrogen peroxide, which is converted to a quinoneimine dye for spectrophotometric detection. glyoxylic acid 45-59 hydroxyacid oxidase 2 Homo sapiens 63-80 9144771-1 1997 A key step in plant photorespiration, the oxidation of glycolate to glyoxylate, is carried out by the peroxisomal flavoprotein glycolate oxidase (EC 1.1.3.15). glyoxylic acid 68-78 hydroxyacid oxidase 2 Homo sapiens 127-144 18215067-1 2008 Human glycolate oxidase (GO) catalyzes the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate, a key metabolite in kidney stone formation. glyoxylic acid 83-93 hydroxyacid oxidase 2 Homo sapiens 6-23 18215067-1 2008 Human glycolate oxidase (GO) catalyzes the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate, a key metabolite in kidney stone formation. glyoxylic acid 83-93 hydroxyacid oxidase 2 Homo sapiens 25-27 18215067-1 2008 Human glycolate oxidase (GO) catalyzes the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate, a key metabolite in kidney stone formation. glyoxylic acid 98-108 hydroxyacid oxidase 2 Homo sapiens 6-23 18215067-1 2008 Human glycolate oxidase (GO) catalyzes the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate, a key metabolite in kidney stone formation. glyoxylic acid 98-108 hydroxyacid oxidase 2 Homo sapiens 25-27 18215067-2 2008 We report herein the structures of recombinant GO complexed with sulfate, glyoxylate, and an inhibitor, 4-carboxy-5-dodecylsulfanyl-1,2,3-triazole (CDST), determined by X-ray crystallography. glyoxylic acid 74-84 hydroxyacid oxidase 2 Homo sapiens 47-49 18215067-8 2008 The kinetic parameters for the oxidation of glycolate, glyoxylate, and 2-hydroxy octanoate indicate that the oxidation of glycolate to glyoxylate is the primary reaction catalyzed by GO, while the oxidation of glyoxylate to oxalate is most likely not relevant under normal conditions. glyoxylic acid 55-65 hydroxyacid oxidase 2 Homo sapiens 183-185 18215067-8 2008 The kinetic parameters for the oxidation of glycolate, glyoxylate, and 2-hydroxy octanoate indicate that the oxidation of glycolate to glyoxylate is the primary reaction catalyzed by GO, while the oxidation of glyoxylate to oxalate is most likely not relevant under normal conditions. glyoxylic acid 135-145 hydroxyacid oxidase 2 Homo sapiens 183-185 18215067-8 2008 The kinetic parameters for the oxidation of glycolate, glyoxylate, and 2-hydroxy octanoate indicate that the oxidation of glycolate to glyoxylate is the primary reaction catalyzed by GO, while the oxidation of glyoxylate to oxalate is most likely not relevant under normal conditions. glyoxylic acid 135-145 hydroxyacid oxidase 2 Homo sapiens 183-185 18215067-9 2008 However, drugs that exploit the unique structural features of GO may ultimately prove to be useful for decreasing glycolate and glyoxylate levels in primary hyperoxaluria type 1 patients who have the inability to convert peroxisomal glyoxylate to glycine. glyoxylic acid 128-138 hydroxyacid oxidase 2 Homo sapiens 62-64 18215067-9 2008 However, drugs that exploit the unique structural features of GO may ultimately prove to be useful for decreasing glycolate and glyoxylate levels in primary hyperoxaluria type 1 patients who have the inability to convert peroxisomal glyoxylate to glycine. glyoxylic acid 233-243 hydroxyacid oxidase 2 Homo sapiens 62-64 10731695-2 2000 Glycolate was first converted to glyoxylate with glycolate oxidase, and the glyoxylate formed was condensed with phenylhydrazine. glyoxylic acid 33-43 hydroxyacid oxidase 2 Homo sapiens 49-66 10731695-4 2000 Since glycolate oxidase also acts on glyoxylate and L-lactate, the incubation of samples with glycolate oxidase was carried out in 120-170 mM Tris-HCl (pH 8.3) to obtain glyoxylate as its adduct with Tris. glyoxylic acid 37-47 hydroxyacid oxidase 2 Homo sapiens 6-23 10731695-4 2000 Since glycolate oxidase also acts on glyoxylate and L-lactate, the incubation of samples with glycolate oxidase was carried out in 120-170 mM Tris-HCl (pH 8.3) to obtain glyoxylate as its adduct with Tris. glyoxylic acid 170-180 hydroxyacid oxidase 2 Homo sapiens 94-111 2223823-5 1990 Among the three enzymes known to catalyze the oxidation of glyoxylate to oxalate, glycolate oxidase and XOD showed much lower activities (a higher Km and lower Vmax) toward glyoxylate than those with the respective primary substrates. glyoxylic acid 59-69 hydroxyacid oxidase 2 Homo sapiens 82-99 8000856-0 1994 Glyoxylic acid production using immobilized glycolate oxidase and catalase. glyoxylic acid 0-14 hydroxyacid oxidase 2 Homo sapiens 44-61 8000856-1 1994 A variety of methods for the immobilization of glycolate oxidase have been examined for the preparation of a catalyst for the oxidation of glycolic acid to glyoxylic acid. glyoxylic acid 156-170 hydroxyacid oxidase 2 Homo sapiens 47-64 2223823-5 1990 Among the three enzymes known to catalyze the oxidation of glyoxylate to oxalate, glycolate oxidase and XOD showed much lower activities (a higher Km and lower Vmax) toward glyoxylate than those with the respective primary substrates. glyoxylic acid 173-183 hydroxyacid oxidase 2 Homo sapiens 82-99