PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27099776-11 2016 CONCLUSIONS: Initial combination therapy with methotrexate, sulfasalazine and prednisone, or methotrexate and infliximab, is the most effective treatment strategy for ACPA-negative patients, resulting in earlier functional improvement than when on initial methotrexate monotherapy. Prednisone 78-88 proteinase 3 Homo sapiens 167-171