PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17449793-0 2007 Effect of intravenous albumin infusion on brain salicylate concentration. Salicylates 48-58 albumin Sus scrofa 22-29 17449793-2 2007 The binding of salicylate to albumin is saturable; free plasma salicylate concentrations rise disproportionately to total drug levels. Salicylates 15-25 albumin Sus scrofa 29-36 17449793-4 2007 infusion of albumin would cause a redistribution of salicylate from the brain back into the plasma, which might allow enough time for hemodialysis to be instituted. Salicylates 52-62 albumin Sus scrofa 12-19 17449793-6 2007 albumin infusion would lower brain salicylate concentrations through redistribution in a porcine model of acute salicylate poisoning. Salicylates 35-45 albumin Sus scrofa 0-7 17449793-14 2007 RESULTS: Average peak serum total salicylate concentrations of 105.5 and 109 mg/dL were achieved in control and albumin-treated animals, respectively. Salicylates 34-44 albumin Sus scrofa 112-119 17449793-15 2007 Albumin infusion was accompanied by statistically significant increases in serum total salicylate concentrations (median from 79.5 to 86.9 mg/dL at 75 minutes), while levels decreased slightly in control animals. Salicylates 87-97 albumin Sus scrofa 0-7 17449793-16 2007 Serum free salicylate concentrations decreased slightly in albumin-treated animals, but the difference was not statistically significant. Salicylates 11-21 albumin Sus scrofa 59-66 17449793-17 2007 Median brain salicylate concentrations were about 14% lower in the albumin treatment group (17.8 mg/100 g brain) compared with controls (20.5 mg/100 g brain); this approached statistical significance (p = 0.075). Salicylates 13-23 albumin Sus scrofa 67-74 17449793-18 2007 Median urinary salicylate excretion was higher in the albumin-treated group (0.83 vs. 0.48 g; p = 0.072), with similar urinary pH and volumes in both groups. Salicylates 15-25 albumin Sus scrofa 54-61 17449793-20 2007 infusion of 1.25 g/kg albumin was accompanied by a 14% decline in median brain salicylate concentrations, which approached statistical significance. Salicylates 79-89 albumin Sus scrofa 22-29