PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16856876-7 2006 Yeast phosphatidylinositol 4-phosphate 5-kinases Mss4 and Its3 are involved in resistance against disturbance of sphingolipid biosynthesis and maintenance of cell integrity through the synthesis of PtdIns(4,5)P2 and downstream signalling through the Rom2/Rho2 and Rgf1/Rho pathways. Sphingolipids 113-125 Rho family GTPase RHO2 Saccharomyces cerevisiae S288C 255-259