PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15013450-2 2004 In this paper, it was shown that the deletion of the oxysterol binding protein homologue 3 (OSH3) gene confers hyper resistance against ISP-1, an inhibitor of sphingolipid biosynthesis, in the yeast Saccharomyces cerevisiae. Sphingolipids 159-171 oxysterol-binding protein related protein OSH3 Saccharomyces cerevisiae S288C 92-96 15013450-5 2004 Taken together, it is suggested that the expression levels of the OSH3 gene influence the ISP-1 sensitivity of S. cerevisiae, and the sphingolipids are necessary for normal mitotic spindle formation in which the Osh3p may play a pivotal role. Sphingolipids 134-147 oxysterol-binding protein related protein OSH3 Saccharomyces cerevisiae S288C 212-217