PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16847337-0 2006 The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Sphingolipids 94-106 KH RNA binding domain containing, signal transduction associated 2 Homo sapiens 68-72 16847337-5 2006 Consistent with these data, we show that the previously characterized phosphoinositide effectors, Slm1 and Slm2, which regulate actin organization, are also necessary for normal sphingolipid metabolism, at least in part through regulation of the calcium/calmodulin-dependent phosphatase calcineurin, which binds directly to both proteins. Sphingolipids 178-190 KH RNA binding domain containing, signal transduction associated 2 Homo sapiens 98-102 16847337-7 2006 Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization. Sphingolipids 99-111 KH RNA binding domain containing, signal transduction associated 2 Homo sapiens 32-36