PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12566438-0	2003	Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.	Sphingolipids	79-91	sphingomyelin phosphodiesterase 3	Homo sapiens	36-62	
17561096-3	2007	Incubation of SMC with serotonin or tyramine induced intracellular ROS generation, and a signaling cascade involving metalloproteases and the neutral sphingomyelinase-2 (nSMase2, the initial step of the sphingolipid pathway), ERK1/2 phosphorylation, and DNA synthesis.	Sphingolipids	203-215	sphingomyelin phosphodiesterase 3	Homo sapiens	142-168	
17561096-3	2007	Incubation of SMC with serotonin or tyramine induced intracellular ROS generation, and a signaling cascade involving metalloproteases and the neutral sphingomyelinase-2 (nSMase2, the initial step of the sphingolipid pathway), ERK1/2 phosphorylation, and DNA synthesis.	Sphingolipids	203-215	sphingomyelin phosphodiesterase 3	Homo sapiens	170-177	
33008902-5	2020	Oligodendrocytes express nSMase2 and exhibit a stress response to cytokine challenge that includes an overproduction of ceramide, a sphingolipid that forms negative curvatures in membranes.	Sphingolipids	132-144	sphingomyelin phosphodiesterase 3	Homo sapiens	25-32	
29321137-1	2018	We reported that amyloid beta peptide (Abeta42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes.	Sphingolipids	129-141	sphingomyelin phosphodiesterase 3	Homo sapiens	58-73	
29321137-1	2018	We reported that amyloid beta peptide (Abeta42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes.	Sphingolipids	129-141	sphingomyelin phosphodiesterase 3	Homo sapiens	75-82	
24960545-7	2014	We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women with corresponding increased GlcCer, decreased sphingomyelin levels, and decreased apoptosis in the endometrium.	Sphingolipids	34-46	sphingomyelin phosphodiesterase 3	Homo sapiens	116-121	
28479957-6	2017	The formation of tubes by 4-HNE involved the generation of reactive oxygen species and the activation of the sphingolipid pathway, namely, the neutral type 2 sphingomyelinase and sphingosine kinase-1 (nSMase2/SK-1) pathway, indicating a role for S1P in the angiogenic signaling of 4-HNE.	Sphingolipids	109-121	sphingomyelin phosphodiesterase 3	Homo sapiens	201-208	
27170180-7	2016	Among enzymes that experimentally remodel cellular sphingolipids, overexpression of glucosylceramide synthase to biosynthesize glycosylsphingolipids (GSLs) and neutral sphingomyelinase 2 to hydrolyze sphingomyelin (SM) additively enhanced psychosine-triggered multiploidy; almost all of the cells became polyploid.	Sphingolipids	51-64	sphingomyelin phosphodiesterase 3	Homo sapiens	160-186	
25555205-1	2015	The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis.	Sphingolipids	113-125	sphingomyelin phosphodiesterase 3	Homo sapiens	37-44	
23563653-14	2013	Furthermore, structural anomalies of the CS-activated EGFR appear to be supported by the excess ceramide produced by the CS-activated nSMase2 in the plasma membrane of lung epithelial cells.We present in this chapter the progression of the sphingolipid field in lung cancer using ceramide as an example.	Sphingolipids	240-252	sphingomyelin phosphodiesterase 3	Homo sapiens	134-141	
21303347-5	2011	Moreover, only overexpression of nSMase2, but not nSMase1 or nSMase3, had significant effects on cellular sphingolipid levels, increasing ceramide and decreasing sphingomyelin.	Sphingolipids	106-118	sphingomyelin phosphodiesterase 3	Homo sapiens	33-40	
22303002-6	2012	In addition, we demonstrated that secretion of neuron-derived exosomes was modulated by the activities of sphingolipid-metabolizing enzymes, including neutral sphingomyelinase 2 (nSMase2) and sphingomyelin synthase 2 (SMS2).	Sphingolipids	106-118	sphingomyelin phosphodiesterase 3	Homo sapiens	151-177	
22303002-6	2012	In addition, we demonstrated that secretion of neuron-derived exosomes was modulated by the activities of sphingolipid-metabolizing enzymes, including neutral sphingomyelinase 2 (nSMase2) and sphingomyelin synthase 2 (SMS2).	Sphingolipids	106-118	sphingomyelin phosphodiesterase 3	Homo sapiens	179-186	
21536668-4	2011	Notably, induction of nSMase2 was the primary effect of ATRA on the sphingolipid network and was both time- and dose-dependent.	Sphingolipids	68-80	sphingomyelin phosphodiesterase 3	Homo sapiens	22-29	
19735728-3	2009	We previously reported a role for the sphingolipid pathway in the mitogenic effect of plasminogen activators, but the signaling mechanisms involved in neutral sphingomyelinase-2 (NSMase-2) activation (the first step of the sphingolipid pathway) are poorly known.	Sphingolipids	223-235	sphingomyelin phosphodiesterase 3	Homo sapiens	151-177	
19735728-3	2009	We previously reported a role for the sphingolipid pathway in the mitogenic effect of plasminogen activators, but the signaling mechanisms involved in neutral sphingomyelinase-2 (NSMase-2) activation (the first step of the sphingolipid pathway) are poorly known.	Sphingolipids	223-235	sphingomyelin phosphodiesterase 3	Homo sapiens	179-187