PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27169276-1	2015	Sphingolipids, especially ceramide and S1P, are structural components of biological membranes and bioactive molecules which participate in diverse cellular activities such as cell division, differentiation, gene expression and apoptosis.	Sphingolipids	0-13	membrane bound transcription factor peptidase, site 1	Homo sapiens	39-42	
26197437-3	2015	Both endothelial cells and astrocytes express the receptors for the bioactive sphingolipid S1P.	Sphingolipids	78-90	membrane bound transcription factor peptidase, site 1	Homo sapiens	91-94	
23563649-1	2013	In this chapter, roles of bioactive sphingolipids, specifically sphingosine kinase 1 (SK1) and 2 (SK2) and their product-sphingosine 1-phosphate (S1P)-will be reviewed with respect to regulation of cancer growth, metastasis, chemotherapeutics, and drug resistance.	Sphingolipids	36-49	membrane bound transcription factor peptidase, site 1	Homo sapiens	113-144	
26524900-6	2015	Sphingosine-1-phosphate(S1P), one of the biologically active sphingolipids, increases TNF-alpha production in NKT cells and induces the migration of NKT cells, suggesting that S1P can regulate inflammatory processes in atherogenesis.	Sphingolipids	61-74	membrane bound transcription factor peptidase, site 1	Homo sapiens	24-27	
26524900-6	2015	Sphingosine-1-phosphate(S1P), one of the biologically active sphingolipids, increases TNF-alpha production in NKT cells and induces the migration of NKT cells, suggesting that S1P can regulate inflammatory processes in atherogenesis.	Sphingolipids	61-74	membrane bound transcription factor peptidase, site 1	Homo sapiens	176-179	
23563649-1	2013	In this chapter, roles of bioactive sphingolipids, specifically sphingosine kinase 1 (SK1) and 2 (SK2) and their product-sphingosine 1-phosphate (S1P)-will be reviewed with respect to regulation of cancer growth, metastasis, chemotherapeutics, and drug resistance.	Sphingolipids	36-49	membrane bound transcription factor peptidase, site 1	Homo sapiens	146-149	
23563649-3	2013	Sphingolipid molecules such as ceramide and S1P have been shown to control cancer cell death and proliferation, respectively.	Sphingolipids	0-12	membrane bound transcription factor peptidase, site 1	Homo sapiens	44-47	
23563649-5	2013	Identification of novel intracellular SK/S1P targets has broadened the existing complex regulatory roles of bioactive sphingolipids in cancer pathogenesis and therapeutics.	Sphingolipids	118-131	membrane bound transcription factor peptidase, site 1	Homo sapiens	41-44	
18951299-5	2008	By studying changes in the metabolism of S1P and C1P in pathological conditions, it is hoped that altered sphingolipid-metabolizing enzymes and their metabolites can be used as therapeutic targets.	Sphingolipids	106-118	membrane bound transcription factor peptidase, site 1	Homo sapiens	41-52	
34679239-1	2022	S1P is a pleotropic sphingolipid signaling molecule that acts through binding to five high-affinity G-protein coupled receptors.	Sphingolipids	20-32	membrane bound transcription factor peptidase, site 1	Homo sapiens	0-3	
18644996-5	2008	In vivo, camptothecin and B-5354c alone display a limited effect on tumor growth in PC-3 cells, whereas in combination there is a synergy of effect on tumor size with a significant increase in the ceramide to S1P sphingolipid ratio.	Sphingolipids	213-225	membrane bound transcription factor peptidase, site 1	Homo sapiens	209-212	
17913601-2	2008	Particularly, the sphingolipid metabolites, ceramide and S1P, have emerged as a new class of potent bioactive molecules, implicated in a variety of cellular processes such as cell differentiation, apoptosis, and proliferation.	Sphingolipids	18-30	membrane bound transcription factor peptidase, site 1	Homo sapiens	57-60	
27825807-2	2017	These receptors are activated by the sphingolipid ligand, S1P, which is produced from the phosphorylation of sphingosine by sphingosine kinases.	Sphingolipids	37-49	membrane bound transcription factor peptidase, site 1	Homo sapiens	58-61