PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31929190-2 2020 ORMDL3 inhibits sphingolipid de novo synthesis. Sphingolipids 16-28 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 0-6 34931265-3 2021 Genome wide association studies (GWAS) initially identified a link between alleles within the 17q21 asthma-susceptibility locus, childhood asthma, and overexpression of the ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), an inhibitor of de novo sphingolipid synthesis. Sphingolipids 251-263 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 173-216 34931265-3 2021 Genome wide association studies (GWAS) initially identified a link between alleles within the 17q21 asthma-susceptibility locus, childhood asthma, and overexpression of the ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), an inhibitor of de novo sphingolipid synthesis. Sphingolipids 251-263 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 218-224 34560079-0 2021 Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways. Sphingolipids 81-93 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 18-24 34560079-3 2021 Previous studies have shown that ER membrane protein ORMDL3 inhibits the activity of SPT and subsequent sphingolipid synthesis. Sphingolipids 104-116 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 53-59 35503179-5 2022 ORMDL3 is an endoplasmic reticulum protein that stabilizes the serine palmitoyl transferase (SPT) complex that regulates sphingolipid de novo synthesis. Sphingolipids 121-133 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 0-6 33558761-2 2021 In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase holocomplex, which consists of catalytic components (SPTLC1 and SPTLC2) and regulatory components (ssSPTa and ORMDL3). Sphingolipids 47-59 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 228-234 33424845-0 2020 ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function. Sphingolipids 27-39 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 0-6 33424845-1 2020 Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme for sphingolipid biosynthesis in cells. Sphingolipids 178-190 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 0-18 33424845-1 2020 Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme for sphingolipid biosynthesis in cells. Sphingolipids 178-190 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 20-26 32078788-11 2020 Further, lipidomics analysis revealed opposing regulation of specific sphingolipid species (downstream of SPT) by myriocin and ORMDL3 siRNA, correlating with the effect of these treatments on RV replication. Sphingolipids 70-82 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 127-133 31929190-9 2020 These findings connect genetic 17q21 variations that are associated with asthma risk and higher ORMDL3 expression to lower sphingolipid synthesis in humans. Sphingolipids 123-135 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 96-102 31929192-2 2020 Polymorphisms in the endoplasmic reticular protein orosomucoid-like protein 3 (ORMDL3), which regulates sphingolipid homeostasis, have been strongly linked with childhood-onset asthma. Sphingolipids 104-116 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 79-85 31929192-3 2020 Despite extensive investigation, a link between ORMDL3 asthma-risk genotypes and altered sphingolipid synthesis has been lacking. Sphingolipids 89-101 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 48-54 31929192-6 2020 These results demonstrate that genetic variants in ORMDL3 may confer a risk of developing childhood asthma through dysregulation of sphingolipid synthesis. Sphingolipids 132-144 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 51-57 31439681-5 2019 In a cellular model, there was a significant difference in the induction of sphingosine-1-phosphate by vitamin D between a control human bronchial epithelial cell line and a cell line overexpressing ORMDL3 (p=0.002).Results suggest prenatal vitamin D supplementation may reduce the risk of early childhood asthma/wheeze via alterations of sphingolipid metabolism dependent on the 17q21 genotype. Sphingolipids 339-351 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 199-205 31330218-2 2019 Although the ORM homologues in yeast are well-known inhibitors of sphingolipid synthesis, it is still unclear whether and how mammalian ORMDL3 regulates sphingolipid metabolism and whether altered sphingolipid synthesis would be causally related to asthma risk. Sphingolipids 153-165 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 136-142 31376405-4 2019 We also suggest a potential unifying paradigm and discuss molecular mechanisms for the pathologic functions of ORMDL3 in asthma related to its evolutionarily conserved role in regulation of sphingolipid homeostasis. Sphingolipids 190-202 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 111-117 29671030-8 2018 Next, we discovered eight gene polymorphisms (ORMDL3, SPHK2, B4GALNT1, SLC1A5, GALC, PPARD, PPARG and B4GALT1) involved in sphingolipid metabolism that contribute to the genetic predisposition to type 1 diabetes. Sphingolipids 123-135 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 46-52 28826527-2 2017 ORMDL3 is localized to the endoplasmic reticulum and regulates downstream pathways including sphingolipids, metalloproteases, remodeling genes, and chemokines. Sphingolipids 93-106 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 0-6 28826527-3 2017 ORMDL3 inhibits serine palmitoyl-CoA transferase, the rate-limiting enzyme for sphingolipid biosynthesis. Sphingolipids 79-91 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 0-6 25691431-0 2015 ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis. Sphingolipids 91-103 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 70-76 25691431-3 2015 Here we test the notion that elevated levels of ORMDL3 decrease sphingolipid biosynthesis. Sphingolipids 64-76 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 48-54 25691431-8 2015 Although sphingolipid biosynthesis was not decreased by elevated ORMDL3 expression, the steady state mass levels of all major sphingolipids were marginally decreased by low level ORMDL3 over-expression in HBECs. Sphingolipids 126-139 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 179-185 25691431-9 2015 These data indicate that the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism, but that the connection is complex. Sphingolipids 90-102 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 45-51 20182505-2 2010 Here we reveal the function in sphingolipid metabolism of the ORM genes (known as ORMDL genes in humans)-a conserved gene family that includes ORMDL3, which has recently been identified as a potential risk factor for childhood asthma. Sphingolipids 31-43 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 143-149 31560728-3 2019 ORM sphingolipid biosynthesis regulator (ORMDL3) residing in this region is the most promising gene candidate for explaining association with disease. Sphingolipids 4-16 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 41-47 28030368-2 2017 ORMDL3 is one of three ORMDL proteins that integrate multiple signals to maintain sphingolipid homeostasis. Sphingolipids 82-94 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 0-6 28030368-8 2017 Universal overexpression of ORMDL3 decreases serum sphingolipids, increases inflammatory markers, airway remodeling and AHR in response to allergic stimuli. Sphingolipids 51-64 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 28-34 28030368-11 2017 ORMDL3 might have a critical role for smooth muscle contraction.Little is known about how the different ORMDL3 single nucleotide polymorphisms affect human blood and tissue sphingolipid profiles. Sphingolipids 173-185 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 0-6 28030368-11 2017 ORMDL3 might have a critical role for smooth muscle contraction.Little is known about how the different ORMDL3 single nucleotide polymorphisms affect human blood and tissue sphingolipid profiles. Sphingolipids 173-185 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 104-110 28030368-14 2017 SUMMARY: Possible mechanisms how ORMDL3 affects asthma include inhibition of sphingolipid synthesis, synergistic effects with known allergens and a combination of both. Sphingolipids 77-89 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 33-39 24165737-5 2014 This includes dysregulation of the unfolded protein response (UPR) associated with airway remodeling and also an effect of ORMDL3-dysregulated sphingolipid synthesis on bronchial hyperreactivity. Sphingolipids 143-155 ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens 123-129