PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17611388-8	2007	Increased Beclin-1 levels and elevated autophagy were also observed in other sphingolipid storage diseases characterized by disrupted cholesterol and sphingolipid trafficking.	Sphingolipids	77-89	beclin 1	Homo sapiens	10-18	
17611388-9	2007	We propose a model in which the disordered cholesterol trafficking that occurs in many sphingolipid storages diseases results in upregulation of Beclin-1 and enhanced levels of autophagy.	Sphingolipids	87-99	beclin 1	Homo sapiens	145-153	
17468177-5	2007	Induction of cholesterol trafficking defects in wild-type fibroblasts by treatment with U18666A increased Beclin-1 and LC3-II expression, whereas treatment of NPC1-deficient fibroblasts with sphingolipid-lowering compound NB-DGJ failed to alter the expression of either Beclin-1 or LC3-II.	Sphingolipids	191-203	beclin 1	Homo sapiens	270-278	
17468177-6	2007	Primary fibroblasts from patients with two other sphingolipid storage diseases, NPC2 deficiency and Sandhoff disease, characterized by sphingolipid trafficking defects also showed elevation in Beclin-1 and LC3-II levels.	Sphingolipids	49-61	beclin 1	Homo sapiens	193-201