PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29262618-1 2017 Ceramide synthase 1 (CERS1) is the most highly expressed CERS in the central nervous system, and ceramide with an 18-carbon-containing fatty acid chain (C18-ceramide) in the brain plays important roles in signaling and sphingolipid development. Sphingolipids 219-231 Bardet-Biedl syndrome 9 Homo sapiens 153-156 744198-6 1978 Purified sphingolipids (cerebrosides, sulfatides and sphingomyelin) present a considerable diminution in very long chain fatty acids; the ratio of very long chain fatty acids (over C18) on shorter chains is 1% of the normal value for saturated fatty acids and 2% for the monounsaturated homologues. Sphingolipids 9-22 Bardet-Biedl syndrome 9 Homo sapiens 181-184 9458264-7 1997 The long chain bases in the neutral sphingolipid fraction were mainly C18 compounds and were identified as C18 dihydrosphingosine, C20 sphingosine, and isomers of C18 sphingosine. Sphingolipids 36-48 Bardet-Biedl syndrome 9 Homo sapiens 70-73 28030368-13 2017 Others evaluated sphingolipid profiles in 7-8-year old children with mild asthma and found significantly higher C18 and C20 ceramides in those with persistence of asthma symptoms 3 years later, suggesting that sphingolipid profiles might predict asthma persistence. Sphingolipids 210-222 Bardet-Biedl syndrome 9 Homo sapiens 112-115 21791630-8 2011 Remarkably, serum sphingolipid analysis revealed significant differences in patterns of C18-ceramide elevation in patients with CR/PR/SD in comparison with patients with PD, indicating the reconstitution of tumor suppressor ceramide generation by GEM/DOX treatment. Sphingolipids 18-30 Bardet-Biedl syndrome 9 Homo sapiens 88-91 9821869-7 1998 iii--A regulatory step in the biosynthesis of sphingolipid species differring long chain base content, C18 or C20 sphingosine, is in some way involved in the first steps of sphingolipid biosynthesis, and thus plays a decisive role in the availability of the long chain bases. Sphingolipids 46-58 Bardet-Biedl syndrome 9 Homo sapiens 103-106 9821869-7 1998 iii--A regulatory step in the biosynthesis of sphingolipid species differring long chain base content, C18 or C20 sphingosine, is in some way involved in the first steps of sphingolipid biosynthesis, and thus plays a decisive role in the availability of the long chain bases. Sphingolipids 173-185 Bardet-Biedl syndrome 9 Homo sapiens 103-106 22753704-2 2012 We previously observed that the knockdown of ceramide synthase 6, an enzyme from the de novo sphingolipid biosynthesis pathway, is associated with marked reduction in C18-dihydroceramide and makes cells resistant to apoptosis post-PDT. Sphingolipids 93-105 Bardet-Biedl syndrome 9 Homo sapiens 167-170 9458264-7 1997 The long chain bases in the neutral sphingolipid fraction were mainly C18 compounds and were identified as C18 dihydrosphingosine, C20 sphingosine, and isomers of C18 sphingosine. Sphingolipids 36-48 Bardet-Biedl syndrome 9 Homo sapiens 107-110 9458264-7 1997 The long chain bases in the neutral sphingolipid fraction were mainly C18 compounds and were identified as C18 dihydrosphingosine, C20 sphingosine, and isomers of C18 sphingosine. Sphingolipids 36-48 Bardet-Biedl syndrome 9 Homo sapiens 107-110