PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32637407-1 2020 Sphingosine-1-phosphate (S1P) is a pleiotropic sphingolipid derived by the phosphorylation of sphingosine either by sphingosine kinase 1 (SPHK1) or SPHK2. Sphingolipids 47-59 sphingosine kinase 2 Homo sapiens 148-153 34826777-4 2022 We have previously shown that targeting sphingolipid metabolism with the sphingosine kinase 2 (SK2) inhibitor K145 in combination with bortezomib induces synergistic death of bortezomib-naive myeloma. Sphingolipids 40-52 sphingosine kinase 2 Homo sapiens 73-93 34826777-4 2022 We have previously shown that targeting sphingolipid metabolism with the sphingosine kinase 2 (SK2) inhibitor K145 in combination with bortezomib induces synergistic death of bortezomib-naive myeloma. Sphingolipids 40-52 sphingosine kinase 2 Homo sapiens 95-98 34826777-8 2022 Together, these findings indicate that targeting sphingolipid metabolism via SK2 inhibition may be effective in combination with a broad spectrum of proteasome inhibitors in the proteasome inhibitor resistant setting, and is an approach worth clinical exploration. Sphingolipids 49-61 sphingosine kinase 2 Homo sapiens 77-80 34419228-7 2021 Metabolomics analysis demonstrated that sphingosine-1-phosphate, which is regulated by sphingosine kinase 1 and sphingosine kinase 2, is a differential metabolite in plasma between the WJD-treated group and the control group, participating in the sphingolipid signaling. Sphingolipids 247-259 sphingosine kinase 2 Homo sapiens 112-132 35163559-11 2022 Many polymorphisms were identified in genes encoding enzymes of the sphingolipid pathway, including sphingosine kinase 2 (SK2), the S1P generating enzyme which is highly expressed in beta-cells. Sphingolipids 68-80 sphingosine kinase 2 Homo sapiens 100-120 35163559-11 2022 Many polymorphisms were identified in genes encoding enzymes of the sphingolipid pathway, including sphingosine kinase 2 (SK2), the S1P generating enzyme which is highly expressed in beta-cells. Sphingolipids 68-80 sphingosine kinase 2 Homo sapiens 122-125 31863815-2 2020 GI tumor and inflammatory cells contain activated sphingolipid-metabolizing enzymes, including sphingosine kinase 1 (SphK1) and SphK2, that generate sphingosine-1-phosphate (S1P), a highly bioactive compound. Sphingolipids 50-62 sphingosine kinase 2 Homo sapiens 128-133 31648078-3 2020 Sphingosine kinases 1 and 2 (SK1 and SK2) catalyze the conversion of the sphingolipid metabolite sphingosine into S1P. Sphingolipids 73-85 sphingosine kinase 2 Homo sapiens 37-40 32085881-6 2020 All GI tissues and circulating immune/blood cells contain activated sphingolipid-metabolizing enzymes, including sphingosine kinases (SphK1 and SphK2) that generate sphingosine-1-phosphate (S1P), a bioactive lipid and ligand for five G-protein coupled membrane S1P receptors (S1PRs). Sphingolipids 68-80 sphingosine kinase 2 Homo sapiens 144-149 30949409-1 2019 Sphingosine kinase 2 (SPHK2) is a key factor within sphingolipid metabolism, responsible for the conversion of pro-apoptotic sphingosine to the pro-survival sphingosine-1-phosphate. Sphingolipids 52-64 sphingosine kinase 2 Homo sapiens 0-20 30949409-1 2019 Sphingosine kinase 2 (SPHK2) is a key factor within sphingolipid metabolism, responsible for the conversion of pro-apoptotic sphingosine to the pro-survival sphingosine-1-phosphate. Sphingolipids 52-64 sphingosine kinase 2 Homo sapiens 22-27 30060814-1 2018 Sphingosine kinases (SK1 and SK2) are key, druggable targets within the sphingolipid metabolism pathway that promote tumor growth and pathologic inflammation. Sphingolipids 72-84 sphingosine kinase 2 Homo sapiens 29-32 29277894-5 2018 Sphingosine kinase 2 (SphK2) is one of the key enzymes in sphingolipid metabolism. Sphingolipids 58-70 sphingosine kinase 2 Homo sapiens 0-20 29277894-5 2018 Sphingosine kinase 2 (SphK2) is one of the key enzymes in sphingolipid metabolism. Sphingolipids 58-70 sphingosine kinase 2 Homo sapiens 22-27 29671030-8 2018 Next, we discovered eight gene polymorphisms (ORMDL3, SPHK2, B4GALNT1, SLC1A5, GALC, PPARD, PPARG and B4GALT1) involved in sphingolipid metabolism that contribute to the genetic predisposition to type 1 diabetes. Sphingolipids 123-135 sphingosine kinase 2 Homo sapiens 54-59 29130028-6 2017 Recent identification of the conjugated bile acid-induced activation of S1PR2 as a key regulator of SphK2 opened new directions for both the sphingolipid and bile acid research fields. Sphingolipids 141-153 sphingosine kinase 2 Homo sapiens 100-105 28950390-2 2018 Sphingosine kinase-2 (SphK2) a key regulator of sphingolipid signaling has been rationalized as an important therapeutic target. Sphingolipids 48-60 sphingosine kinase 2 Homo sapiens 22-27 28939554-2 2017 Sphingosine kinase 2 (SphK2) is a key factor within sphingolipid metabolism, responsible for the conversion of proapoptotic ceramides to antiapoptotic sphingosine-1-phosphate (S1P). Sphingolipids 52-64 sphingosine kinase 2 Homo sapiens 0-20 28939554-2 2017 Sphingosine kinase 2 (SphK2) is a key factor within sphingolipid metabolism, responsible for the conversion of proapoptotic ceramides to antiapoptotic sphingosine-1-phosphate (S1P). Sphingolipids 52-64 sphingosine kinase 2 Homo sapiens 22-27 28950390-2 2018 Sphingosine kinase-2 (SphK2) a key regulator of sphingolipid signaling has been rationalized as an important therapeutic target. Sphingolipids 48-60 sphingosine kinase 2 Homo sapiens 0-20 26271487-1 2015 UNLABELLED: The bioactive sphingolipid sphingosine-1-phosphate (S1P) drives several hallmark processes of cancer, making the enzymes that synthesize S1P, that is, sphingosine kinase 1 and 2 (SK1 and SK2), important molecular targets for cancer drug development. Sphingolipids 26-38 sphingosine kinase 2 Homo sapiens 199-202 26252351-2 2015 Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid metabolite produced by sphingosine kinases-1 and -2 (SPHK1 and SPHK2). Sphingolipids 52-64 sphingosine kinase 2 Homo sapiens 128-133 26054751-2 2015 Sphingosine kinase 2 (SphK2) is proposed to be the key regulator of sphingolipid signaling. Sphingolipids 68-80 sphingosine kinase 2 Homo sapiens 0-20 26054751-2 2015 Sphingosine kinase 2 (SphK2) is proposed to be the key regulator of sphingolipid signaling. Sphingolipids 68-80 sphingosine kinase 2 Homo sapiens 22-27 18485923-4 2008 The relative levels of these three interconvertible sphingolipid metabolites, and thus cell fate, are strongly influenced by the activity of sphingosine kinases, of which there are two isoforms, designated SphK1 and SphK2, the enzymes that phosphorylate sphingosine to produce S1P. Sphingolipids 52-64 sphingosine kinase 2 Homo sapiens 216-221 21896638-2 2011 Therefore, RNA interference was used to assess the individual roles of SK1 and SK2 in tumor cell sphingolipid metabolism, proliferation, and migration/invasion. Sphingolipids 97-109 sphingosine kinase 2 Homo sapiens 79-82 20110355-1 2010 Sphingosine 1-phosphate (S1P), a potent sphingolipid mediator produced by sphingosine kinase isoenzymes (SphK1 and SphK2), regulates diverse cellular processes important for breast cancer progression acting in an autocrine and/or paracrine manner. Sphingolipids 40-52 sphingosine kinase 2 Homo sapiens 115-120 25010828-1 2014 Phosphorylation of sphingosine by sphingosine kinases (SphK1 and SphK2) generates sphingosine-1-phosphate (S1P), a bioactive sphingolipid which promotes cancer cell survival and tumor progression in vivo. Sphingolipids 125-137 sphingosine kinase 2 Homo sapiens 65-70 23563649-1 2013 In this chapter, roles of bioactive sphingolipids, specifically sphingosine kinase 1 (SK1) and 2 (SK2) and their product-sphingosine 1-phosphate (S1P)-will be reviewed with respect to regulation of cancer growth, metastasis, chemotherapeutics, and drug resistance. Sphingolipids 36-49 sphingosine kinase 2 Homo sapiens 98-101 21906625-1 2011 The pleiotropic sphingolipid mediator, sphingosine-1-phosphate, produced in cells by two sphingosine kinase isoenzymes, SphK1 and SphK2, regulates many cellular and physiological processes important for homeostasis and development and pathophysiology. Sphingolipids 16-28 sphingosine kinase 2 Homo sapiens 130-135 17974990-1 2007 Sphingosine-1-phosphate is a potent lipid mediator formed by phosphorylation of sphingosine, a metabolite of sphingolipids, catalyzed by two sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2. Sphingolipids 109-122 sphingosine kinase 2 Homo sapiens 189-194 18511810-1 2008 The potent bioactive sphingolipid mediator, sphingosine-1-phosphate (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2. Sphingolipids 21-33 sphingosine kinase 2 Homo sapiens 133-138 17400555-0 2007 Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. Sphingolipids 52-64 sphingosine kinase 2 Homo sapiens 26-46 16118219-0 2005 SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. Sphingolipids 74-86 sphingosine kinase 2 Homo sapiens 10-15 16118219-1 2005 The potent sphingolipid metabolite sphingosine 1-phosphate is produced by phosphorylation of sphingosine catalyzed by sphingosine kinase (SphK) types 1 and 2. Sphingolipids 11-23 sphingosine kinase 2 Homo sapiens 118-157