PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10454518-1 1999 We recently demonstrated that physiological induction of apoptosis by cytotoxic sphingolipid messengers proceeds via activating protein-1 (AP1)-dependent and AP1-independent mechanisms in U937 human monoblastic leukemia cells. Sphingolipids 80-92 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 139-142 10454518-1 1999 We recently demonstrated that physiological induction of apoptosis by cytotoxic sphingolipid messengers proceeds via activating protein-1 (AP1)-dependent and AP1-independent mechanisms in U937 human monoblastic leukemia cells. Sphingolipids 80-92 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 158-161 7592995-6 1995 These results suggest that the transcription factor AP-1 is critical for apoptosis in HL-60 cells and that an intracellular sphingolipid mediator, ceramide, modulates a signal transduction inducing apoptosis through AP-1 activation. Sphingolipids 124-136 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 216-220