PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6865913-13	1983	These data suggested a second site of interaction, thymidylate kinase, the enzyme responsible for the conversion of iododeoxyuridylate to the diphosphate.	Diphosphates	142-153	deoxythymidylate kinase	Homo sapiens	51-69	
2504244-4	1989	One microM zidovudine is sufficient for saturation of activation by TK and also of zidovudine monophosphate, by thymidylate kinase, to the diphosphate.	Diphosphates	139-150	deoxythymidylate kinase	Homo sapiens	112-130	
15855530-6	2005	To clarify the role of human TMPK in the phosphorylation of L-FMAUMP to the diphosphate metabolite in cells, a Tet-On inducible human TMPK cell line system was established.	Diphosphates	76-87	deoxythymidylate kinase	Homo sapiens	29-33	
32064397-2	2020	Human thymidylate kinase (hTMPK) conversion of the anti-HIV prodrug 3"-azido-3"-deoxythymidine (AZT or zidovudine) monophosphate to diphosphate is the rate-limiting step in the activation of AZT.	Diphosphates	132-143	deoxythymidylate kinase	Homo sapiens	6-24	
15855530-8	2005	When the cells were treated with L-FMAU or d4T, the amounts of the diphosphate and triphosphate metabolites of these analogs were increased, in accordance with an increase in human TMPK activity in cells.	Diphosphates	67-78	deoxythymidylate kinase	Homo sapiens	181-185	
12614151-3	2003	To gain further understanding of the determinants for efficient conversion by the enzyme thymidylate kinase (TMPK) of clinically important thymidine monophosphate analogues to the corresponding diphosphates, we solved the crystal structures of the enzyme, with either ADP or the ATP analogue AppNHp at the phosphoryl donor site, in complex with TMP, AZTMP (previous work), NH2TMP, d4TMP, ddTMP, and FLTMP (this work) at the phosphoryl acceptor site.	Diphosphates	194-206	deoxythymidylate kinase	Homo sapiens	109-113	
11923581-4	2002	TK and TMPK activities were determined by measuring the conversion of [3H] substrates (thymidine or AZT for TK and thymidine monophosphate for TMPK) to their respective monophosphate or diphosphate forms.	Diphosphates	186-197	deoxythymidylate kinase	Homo sapiens	7-11