PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31154016-10	2019	Furthermore, ochratoxin A regulated the phosphorylation of AKT, ERK1/2, and JNK signal molecules of human astrocytes.	ochratoxin A	13-25	AKT serine/threonine kinase 1	Homo sapiens	59-62	
31653047-2	2019	We and others have previously shown that OTA causes sustained activation of PI3K/AKT and MAPK/ERK1-2 signaling pathways in different cell types and animal models.	ochratoxin A	41-44	AKT serine/threonine kinase 1	Homo sapiens	81-84	
31653047-3	2019	Given the close relationship between cellular signaling activity and protein stability, we were curious whether increased PI3K/AKT and MAPK/ERK1-2 signaling may be the result of OTA-stimulated alterations in proteolytic activity.	ochratoxin A	178-181	AKT serine/threonine kinase 1	Homo sapiens	127-130	
31653047-10	2019	Our results suggest that autophagy and subsequent UPS activation are responsible for sustained activation of PI3K/AKT and MAPK/ERK1-2 pathways through regulating the levels of critical phosphatases VHR/DUSP3, DUSP4, and PHLPP, which are known to be involved in OTA toxicity and carcinogenicity.	ochratoxin A	261-264	AKT serine/threonine kinase 1	Homo sapiens	114-117	
25002221-0	2015	Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells.	ochratoxin A	0-12	AKT serine/threonine kinase 1	Homo sapiens	43-46	
34936334-0	2022	Correction to Ochratoxin A Exposure Impairs Porcine Granulosa Cell Growth via the PI3K/AKT Signaling Pathway.	ochratoxin A	14-26	AKT serine/threonine kinase 1	Homo sapiens	87-90	
34116085-3	2021	OTA activates both MAPK/ERK and PI3K/Akt signaling pathways, which play role in apoptosis and cell survival, respectively.	ochratoxin A	0-3	AKT serine/threonine kinase 1	Homo sapiens	37-40	
34101318-0	2021	Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway.	ochratoxin A	0-12	AKT serine/threonine kinase 1	Homo sapiens	103-106