PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23085552-2	2013	The aryl hydrocarbon receptor (AhR) is involved in the regulation of T cell responses, and 3,3"-diindolylmethane (DIM) is a known ligand of AhR.	3,3'-diindolylmethane	91-112	aryl hydrocarbon receptor	Homo sapiens	140-143	
26377202-7	2015	The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3,3"-diindolylmethane (DIM) were used to activate Ahr in MDA-MB-231 and T47D breast cancer cells.	3,3'-diindolylmethane	51-72	aryl hydrocarbon receptor	Homo sapiens	101-104	
26377202-7	2015	The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3,3"-diindolylmethane (DIM) were used to activate Ahr in MDA-MB-231 and T47D breast cancer cells.	3,3'-diindolylmethane	74-77	aryl hydrocarbon receptor	Homo sapiens	101-104	
24527450-5	2014	Recently formed paradigm has shown that activation of Ahr by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3"-diindolylmethane (DIM) prompts the differentiation of CD4(+)Foxp3(+) regulatory T cells (Tregs) and inhibits T helper (Th)-17 suggesting that Ahr is an innovative therapeutic strategy for autoimmune inflammation.	3,3'-diindolylmethane	107-128	aryl hydrocarbon receptor	Homo sapiens	54-57	
24527450-5	2014	Recently formed paradigm has shown that activation of Ahr by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3"-diindolylmethane (DIM) prompts the differentiation of CD4(+)Foxp3(+) regulatory T cells (Tregs) and inhibits T helper (Th)-17 suggesting that Ahr is an innovative therapeutic strategy for autoimmune inflammation.	3,3'-diindolylmethane	107-128	aryl hydrocarbon receptor	Homo sapiens	254-257	
23085552-2	2013	The aryl hydrocarbon receptor (AhR) is involved in the regulation of T cell responses, and 3,3"-diindolylmethane (DIM) is a known ligand of AhR.	3,3'-diindolylmethane	114-117	aryl hydrocarbon receptor	Homo sapiens	140-143	
22592002-9	2012	CONCLUSION: Selective aryl hydrocarbon receptor modulator 3,3"-Diindolylmethane inhibits SGC7901 cell proliferation by inducing apoptosis and delaying cell cycle progression.	3,3'-diindolylmethane	58-79	aryl hydrocarbon receptor	Homo sapiens	22-47	
22592002-0	2012	A selective aryl hydrocarbon receptor modulator 3,3"-Diindolylmethane inhibits gastric cancer cell growth.	3,3'-diindolylmethane	48-69	aryl hydrocarbon receptor	Homo sapiens	12-37	
22592002-2	2012	3,3"-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator.	3,3'-diindolylmethane	0-21	aryl hydrocarbon receptor	Homo sapiens	64-67	
22592002-2	2012	3,3"-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator.	3,3'-diindolylmethane	23-26	aryl hydrocarbon receptor	Homo sapiens	64-67	
19056653-0	2009	Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3"-diindolylmethane in breast cancer cells.	3,3'-diindolylmethane	126-147	aryl hydrocarbon receptor	Homo sapiens	13-38	
19223575-3	2009	The AhR ligand 3,3"-diindolylmethane (DIM) is a beneficial dietary constituent that prevents breast tumors in rodents and is associated with decreased breast cancer risk in humans.	3,3'-diindolylmethane	15-36	aryl hydrocarbon receptor	Homo sapiens	4-7	
19223575-6	2009	We find that DIM and TCDD have differing abilities to activate the distinct AhR-controlled pathways.	3,3'-diindolylmethane	13-16	aryl hydrocarbon receptor	Homo sapiens	76-79	
19223575-10	2009	Our findings reveal that DIM and TCDD each elicit a unique pattern of change in pathways that control estrogen action; such patterns may determine if an AhR ligand has beneficial or adverse health effects.	3,3'-diindolylmethane	25-28	aryl hydrocarbon receptor	Homo sapiens	153-156	
19056653-1	2009	Ligands of the aryl hydrocarbon receptor (AhR) include the environmental xenobiotic 2,3,7,8 tetrachlorodibenzo(p)dioxin (TCDD), polycyclic aryl hydrocarbons, and the dietary compounds 3, 3"-diindolylmethane (DIM), a condensation product of indol-3-carbinol found in Brassica vegetables, and the phytoalexin resveratrol (RES).	3,3'-diindolylmethane	184-206	aryl hydrocarbon receptor	Homo sapiens	15-40	
19056653-1	2009	Ligands of the aryl hydrocarbon receptor (AhR) include the environmental xenobiotic 2,3,7,8 tetrachlorodibenzo(p)dioxin (TCDD), polycyclic aryl hydrocarbons, and the dietary compounds 3, 3"-diindolylmethane (DIM), a condensation product of indol-3-carbinol found in Brassica vegetables, and the phytoalexin resveratrol (RES).	3,3'-diindolylmethane	184-206	aryl hydrocarbon receptor	Homo sapiens	42-45	
11437101-2	2001	In this study, we have investigated the aryl hydrocarbon receptor (AhR) agonist activity and inhibitory AhR-estrogen receptor crosstalk induced by the following methyl-substituted DIMs: 1,1"-dimethyl-, 2,2"-dimethyl-, 5,5"-dimethyl-, 6,6"-dimethyl-, and 7,7"-dimethylDIM and 1,1",2,2"-tetramethylDIM.	3,3'-diindolylmethane	180-184	aryl hydrocarbon receptor	Homo sapiens	104-107	
16488130-8	2006	DIM is known to accumulate in the nucleus and is a preferred ligand for aryl hydrocarbon receptor (AhR) to I3C.	3,3'-diindolylmethane	0-3	aryl hydrocarbon receptor	Homo sapiens	72-97	
16488130-8	2006	DIM is known to accumulate in the nucleus and is a preferred ligand for aryl hydrocarbon receptor (AhR) to I3C.	3,3'-diindolylmethane	0-3	aryl hydrocarbon receptor	Homo sapiens	99-102	
16972788-3	2006	This study also shows that the AhR agonists benzo[a]pyrene, 3,3",4,4"-tetrachlorobiphenyl, chrysin, 6-methyl-1,3,8-trichlorodibenzofuran, and 3,3"-diindolylmethane also induce ERalpha-dependent transactivation.	3,3'-diindolylmethane	142-163	aryl hydrocarbon receptor	Homo sapiens	31-34	
14560034-5	2003	In contrast, the chemopreventative AHR ligand 3,3"-diindolylmethane promotes AHR nuclear translocation and p160 coactivator recruitment but, remarkably, fails to recruit Pol II or cause histone acetylation.	3,3'-diindolylmethane	46-67	aryl hydrocarbon receptor	Homo sapiens	35-38	
14560034-5	2003	In contrast, the chemopreventative AHR ligand 3,3"-diindolylmethane promotes AHR nuclear translocation and p160 coactivator recruitment but, remarkably, fails to recruit Pol II or cause histone acetylation.	3,3'-diindolylmethane	46-67	aryl hydrocarbon receptor	Homo sapiens	77-80	
12011988-5	2002	6-Alkyl-1,3,8-trichlorodibenzofurans and substituted diindolylmethanes represent two structural classes of selective AhR modulators (SAhRMs).	3,3'-diindolylmethane	53-70	aryl hydrocarbon receptor	Homo sapiens	117-120	
11294972-3	2001	DIM is a weak agonist for the aryl hydrocarbon (Ah) receptor and blocks the effects of estrogens via inhibitory Ah receptor-estrogen receptor cross-talk.	3,3'-diindolylmethane	0-3	aryl hydrocarbon receptor	Homo sapiens	30-60	
15992156-6	1999	Alternate-substituted (1,3,6,8- and 2,4,6,8-) alkyl polychlorinated dibenzofurans (PCDFs) and substituted diindolylmethanes (DIMs) bind the AhR and induce a pattern of AhR-oestrogen receptor (ER) inhibitory cross-talk similar to that observed for TCDD including inhibition of mammary tumour growth at doses < 1.0 mg/kg/day.	3,3'-diindolylmethane	106-123	aryl hydrocarbon receptor	Homo sapiens	140-143	
15992156-6	1999	Alternate-substituted (1,3,6,8- and 2,4,6,8-) alkyl polychlorinated dibenzofurans (PCDFs) and substituted diindolylmethanes (DIMs) bind the AhR and induce a pattern of AhR-oestrogen receptor (ER) inhibitory cross-talk similar to that observed for TCDD including inhibition of mammary tumour growth at doses < 1.0 mg/kg/day.	3,3'-diindolylmethane	106-123	aryl hydrocarbon receptor	Homo sapiens	168-171	
15992156-6	1999	Alternate-substituted (1,3,6,8- and 2,4,6,8-) alkyl polychlorinated dibenzofurans (PCDFs) and substituted diindolylmethanes (DIMs) bind the AhR and induce a pattern of AhR-oestrogen receptor (ER) inhibitory cross-talk similar to that observed for TCDD including inhibition of mammary tumour growth at doses < 1.0 mg/kg/day.	3,3'-diindolylmethane	125-129	aryl hydrocarbon receptor	Homo sapiens	140-143	
15992156-6	1999	Alternate-substituted (1,3,6,8- and 2,4,6,8-) alkyl polychlorinated dibenzofurans (PCDFs) and substituted diindolylmethanes (DIMs) bind the AhR and induce a pattern of AhR-oestrogen receptor (ER) inhibitory cross-talk similar to that observed for TCDD including inhibition of mammary tumour growth at doses < 1.0 mg/kg/day.	3,3'-diindolylmethane	125-129	aryl hydrocarbon receptor	Homo sapiens	168-171	
30009782-9	2018	Knockdown of Ahr reversed the TCDD/DIM-mediated proliferation and invasion.	3,3'-diindolylmethane	35-38	aryl hydrocarbon receptor	Homo sapiens	13-16	
34035125-13	2021	2-Ox-DIM exhibited significant AHR agonist activity emphasizing the need for characterization of pharmacological properties of DIM metabolites.	3,3'-diindolylmethane	5-8	aryl hydrocarbon receptor	Homo sapiens	31-34	
32546278-0	2020	3,3"-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway.	3,3'-diindolylmethane	0-21	aryl hydrocarbon receptor	Homo sapiens	32-57	
32546278-5	2020	METHODS: We used AHR selective modulator 3,3"-diindolylmethane (DIM) to treat ESCC cell lines TE1 and KYSE150 so as to examine alterations of migration and invasion by wound healing and Transwell assay.	3,3'-diindolylmethane	41-62	aryl hydrocarbon receptor	Homo sapiens	17-20	
32546278-5	2020	METHODS: We used AHR selective modulator 3,3"-diindolylmethane (DIM) to treat ESCC cell lines TE1 and KYSE150 so as to examine alterations of migration and invasion by wound healing and Transwell assay.	3,3'-diindolylmethane	64-67	aryl hydrocarbon receptor	Homo sapiens	17-20	
32546278-11	2020	DIM could inhibit COX2/PGE2 pathway by targeting AHR, and COX2 selective inhibitor Celecoxib could suppress EMT and metastasis.	3,3'-diindolylmethane	0-3	aryl hydrocarbon receptor	Homo sapiens	49-52	
9771935-0	1998	Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.	3,3'-diindolylmethane	82-98	aryl hydrocarbon receptor	Homo sapiens	0-25	
9771935-6	1998	Thus, DIM represents a new class of relatively non-toxic AhR-based antiestrogens that inhibit E2-dependent tumor growth in rodents and current studies are focused on development of analogs for clinical treatment of breast cancer.	3,3'-diindolylmethane	6-9	aryl hydrocarbon receptor	Homo sapiens	57-60	
8866829-0	1996	Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.	3,3'-diindolylmethane	22-38	aryl hydrocarbon receptor	Homo sapiens	42-72	
29735912-8	2018	Paradoxically, AHR agonists (2,3,7,8-tetrachlorodibenzo-p-dioxin and/or 3,3′-diindolylmethane) similarly inhibited irregular colony formation in Matrigel and blocked metastasis in vivo but accelerated migration.	3,3'-diindolylmethane	87-103	aryl hydrocarbon receptor	Homo sapiens	15-18	
28459113-3	2017	Successful clinical applications of AhR ligands will require the synthesis and development of selective AhR modulators (SAhRMs) with tumor-specific AhR agonist or antagonist activity, and some currently available compounds such as indole-3-carbinol and diindolylmethane-(DIM) and synthetic AhR antagonists are potential drug candidates.	3,3'-diindolylmethane	253-269	aryl hydrocarbon receptor	Homo sapiens	36-39	
29364159-0	2018	Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3"-Diindolylmethane.	3,3'-diindolylmethane	152-173	aryl hydrocarbon receptor	Homo sapiens	33-36