PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15486812-4 2004 The model simplifies purine nucleotide metabolism to four main steps: 1) de novo synthesis from PRPP to IMP; 2) the inosinic branch point from IMP to GMP or AMP; 3) catabolism of IMP, AMP and GMP to uric acid; 4) RNA and DNA formation from AMP and GMP. Inosine Monophosphate 143-146 inositol monophosphatase 2 Rattus norvegicus 104-110