PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30964927-0	2019	Retraction: Sinomenine Sensitizes Multidrug-Resistant Colon Cancer Cells (Caco-2) to Doxorubicin by Downregulation of MDR-1 Expression.	sinomenine	12-22	ATP binding cassette subfamily B member 1	Homo sapiens	118-123	
17063398-9	2006	Lastly, sinomenine was also shown to significantly increase the absorptive transport of digoxin (a prototypical p-glycoprotein substrate) and to significantly decrease its secretory transport.	sinomenine	8-18	ATP binding cassette subfamily B member 1	Homo sapiens	112-126	
30357956-4	2019	We also disclosed the possible action mechanism of sinomenine with a focus on P-glycoprotein function and glucocorticoid receptor (GR) translocation into nucleus.	sinomenine	51-61	ATP binding cassette subfamily B member 1	Homo sapiens	78-92	
24901713-0	2014	Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression.	sinomenine	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	106-111	
24901713-2	2014	Previous studies have indicated that sinomenine can enhance the absorption of various P-gp substrates.	sinomenine	37-47	ATP binding cassette subfamily B member 1	Homo sapiens	86-90	
24901713-6	2014	Importantly, we found that sinomenine enhances the sensitivity of MDR-Caco-2 cells towards doxorubicin by downregulating MDR-1 and COX-2 expression through inhibition of the NF-kappaB signaling pathway.	sinomenine	27-37	ATP binding cassette subfamily B member 1	Homo sapiens	121-126	
24601223-0	2014	Sinomenine reverses multidrug resistance in bladder cancer cells via P-glycoprotein-dependent and independent manners.	sinomenine	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	69-83	
24601223-5	2014	Mechanistically, the chemosensitive effect by sinomenine was mediated by down-regulating P-glycoprotein expression, as well as triggering apoptotic pathways.	sinomenine	46-56	ATP binding cassette subfamily B member 1	Homo sapiens	89-103