PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21679760-6	2011	RESULTS: Sinomenine was found to significantly inhibit TNF-alpha induced cell surface expression of vascular cell adhesion molecule (VCAM)-1 and release of inflammatory cytokine and chemokine IL-6, CCL2 and CXCL8 from both normal and RA-FLS (all p<0.05).	sinomenine	9-19	tumor necrosis factor	Homo sapiens	55-64	
21679760-7	2011	Moreover, the suppression of sinomenine on TNF-alpha induced VCAM-1 expression and IL-6 release of RA-FLS was significantly higher than that of normal FLS (p<0.05).	sinomenine	29-39	tumor necrosis factor	Homo sapiens	43-52	
21679760-9	2011	Further investigations showed that sinomenine and LMS could significantly suppress TNF-alpha-induced phosphorylation of inhibitor kappaBalpha and extracellular signal-regulated protein kinase, the central signaling molecules mediating TNF-alpha-induced VCAM-1 expression and chemokine production.	sinomenine	35-45	tumor necrosis factor	Homo sapiens	83-92	
21679760-9	2011	Further investigations showed that sinomenine and LMS could significantly suppress TNF-alpha-induced phosphorylation of inhibitor kappaBalpha and extracellular signal-regulated protein kinase, the central signaling molecules mediating TNF-alpha-induced VCAM-1 expression and chemokine production.	sinomenine	35-45	tumor necrosis factor	Homo sapiens	235-244	
21679760-10	2011	CONCLUSION: Our results therefore provide a new insight into the differential anti-inflammatory activities of sinomenine and LMS through the suppression of TNF-alpha-activated FLS by modulating distinct intracellular signaling pathways in RA.	sinomenine	110-120	tumor necrosis factor	Homo sapiens	156-165	
17869461-0	2007	Sinomenine suppresses TNF-alpha-induced VCAM-1 expression in human umbilical vein endothelial cells.	sinomenine	0-10	tumor necrosis factor	Homo sapiens	22-31	
17869461-13	2007	Our preliminary data indicates that SN has an inhibitory effect in vitro on TNF-alpha-induced VCAM-1 expression at both mRNA level and protein level in HUVECs, and suggests that SN may be a novel method of immunotherapy for rheumatic carditis or rheumatic heart disease.	sinomenine	36-38	tumor necrosis factor	Homo sapiens	76-85