PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15763362-6	2005	In a definite concentration ranging from 30 to 120 microg/ml, SN showed inhibiting effect on the NF-kappaB activity and the expression of the mRNAs of TNF-alpha and IL-1beta in AA rats in a concentration-dependent manner (P<0.05).	sinomenine	62-64	interleukin 1 beta	Rattus norvegicus	165-173	
18782565-5	2008	Sinomenine suppressed the production of proinflammatory cytokines IL-1beta and IL-6 in serum, inhibited the protein expressions and activities of MMP-2 and MMP-9, and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues.	sinomenine	0-10	interleukin 1 beta	Rattus norvegicus	66-74	
9080247-10	1996	In vitro, sinomenine markedly inhibited proliferation of synovial fibroblasts from AIA or normal rats, both at rest and following activation with either transforming growth factor beta 2 (TGF-beta 2) or interleukin-1 beta (IL-1 beta).	sinomenine	10-20	interleukin 1 beta	Rattus norvegicus	203-221	
9080247-10	1996	In vitro, sinomenine markedly inhibited proliferation of synovial fibroblasts from AIA or normal rats, both at rest and following activation with either transforming growth factor beta 2 (TGF-beta 2) or interleukin-1 beta (IL-1 beta).	sinomenine	10-20	interleukin 1 beta	Rattus norvegicus	223-232	
26525983-11	2015	Compared with sinomenine, the derivatives significantly inhibited the expression of the inflammatory factors IL-1beta and IL-6 at the transcriptional and translational levels.	sinomenine	14-24	interleukin 1 beta	Rattus norvegicus	109-117	
31228805-6	2019	It was found that the SMH loaded ISH could benefit AA-rats by suppressing the level of IL-1beta in comparison to SMH solutions.	sinomenine	22-25	interleukin 1 beta	Rattus norvegicus	87-95	
29620048-8	2018	SIN administration decreased the levels of TNF-alpha, IL-1beta, and IL-6.	sinomenine	0-3	interleukin 1 beta	Rattus norvegicus	54-62	
29776417-13	2018	Finally, PTZ kindling increases the expression of NLRP1 inflammasome complexes and the levels of inflammatory cytokines IL-1beta, IL-18, IL-6, and TNF-alpha, which are all attenuated by SN in a dose- dependent manner.	sinomenine	186-188	interleukin 1 beta	Rattus norvegicus	120-128