PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24362325-0 2014 Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation. sinomenine 0-10 caspase 3 Mus musculus 80-89 30122899-11 2018 In addition, SIN treatment promoted the apoptosis of B16-F10 cells in a dose-dependent manner, as demonstrated by the increase in apoptotic cells, Bax/Bcl-2 ratio, and caspase-3 activity. sinomenine 13-16 caspase 3 Mus musculus 168-177 24362325-13 2014 CONCLUSION: Sinomenine inhibits osteoclast survival in vitro through caspase-3-mediated apoptosis, thus it is a potential agent for treating excessive bone resorption diseases. sinomenine 12-22 caspase 3 Mus musculus 69-78 17383204-5 2007 Finally, the immunosuppressive activity elicited by sinomenine in CD4(+) primary lymphocytes was found to be largely accounted for by caspase 3-dependent cells apoptosis. sinomenine 52-62 caspase 3 Mus musculus 134-143