PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32349289-6	2020	Sinomenine decreases the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9, and the extracellular inducer of matrix metalloproteinase (EMMPRIN/CD147), but elevates the expression of reversion-inducing cysteine-rich proteins with kazal motifs (RECK) and the tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2.	sinomenine	0-10	matrix metallopeptidase 9	Homo sapiens	75-80	
33412412-9	2021	Western blot assay results showed that the upregulation of MMP-2 and MMP-9 by hypoxia was inversed by sinomenine.	sinomenine	102-112	matrix metallopeptidase 9	Homo sapiens	69-74	
31609766-5	2019	SIN and cisplatin further decreased the Bcl-2, procaspase-3, and beta-catenin, but increased Bax, cleaved dcaspase 3, MMP9, and MMP2 in combined group than in either alone group.	sinomenine	0-3	matrix metallopeptidase 9	Homo sapiens	118-122	
20473759-0	2011	Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147.	sinomenine	0-10	matrix metallopeptidase 9	Homo sapiens	182-187	
30784907-7	2019	Results Sinomenine significantly suppressed cell proliferation, promoted apoptosis and inhibited migration and invasion, as well as down-regulated Cyclin D1, CDK4, Bcl-2, MMP-2, MMP-9, Vimentin protein levels and up-regulated p16 and Bax protein levels in PC3 cells.	sinomenine	8-18	matrix metallopeptidase 9	Homo sapiens	178-183	
26983669-10	2016	Sinomenine inhibited invasion by suppressing CXCR4 and STAT3 phosphorylation then downregulating the expression of MMP-2, MMP-9, RANKL, VEGF downstream.	sinomenine	0-10	matrix metallopeptidase 9	Homo sapiens	122-127	
34804018-10	2021	Sin also inhibited MMP7, MMP9, and vimentin expression in 16HBE cells and respiratory epithelial cells from mice with asthma.	sinomenine	0-3	matrix metallopeptidase 9	Homo sapiens	25-29	
19305422-0	2009	Sinomenine influences capacity for invasion and migration in activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, and CD147.	sinomenine	0-10	matrix metallopeptidase 9	Homo sapiens	138-143