PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20097954-2 2009 Recently, novel carboxymethylated pyridoindoles, structural analogues of the efficient chain-breaking antioxidant stobadine, were designed, synthesised and characterised as prospective aldose reductase inhibitors endowed with antioxidant activity. dicarbine 114-123 aldo-keto reductase family 1 member B1 Rattus norvegicus 185-201 18395454-1 2008 Starting from the efficient hexahydropyridoindole antioxidant stobadine, a series of carboxymethylated tetrahydro- and hexahydropyridoindole derivatives was synthesized and tested for the inhibition of aldose reductase, an enzyme involved in the etiology of diabetic complications. dicarbine 62-71 aldo-keto reductase family 1 member B1 Rattus norvegicus 202-218 20066176-1 2010 Recently novel carboxymethylated pyridoindoles, analogues of the efficient chain-breaking antioxidant stobadine, have been designed, synthesised and characterised as bifunctional compounds with joint antioxidant/aldose reductase inhibitory activities with the potential of preventing diabetic complications. dicarbine 102-111 aldo-keto reductase family 1 member B1 Rattus norvegicus 212-228