PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29488603-8 2018 Flow cytometry assays indicated that miR-124 transfection attenuated apoptosis resistance of osteosarcoma to tunicamycin, potentially via the downregulation of P53 and Bcl-2 apoptosis regulator expression. Tunicamycin 109-120 tumor protein p53 Homo sapiens 160-163 19699254-4 2009 Capsaicin also induced degradation of tumor suppressor p53; this effect was enhanced by the ER stressor tunicamycin. Tunicamycin 104-115 tumor protein p53 Homo sapiens 55-58 30637701-14 2018 Interestingly, nano-formulated tunicamycin is three times more potent in inhibiting the cell cycle progression than the native tunicamycin and is supported by downregulation of the ratio of phospho-p53 to total-p53 as well as phospho-Rb to total Rb. Tunicamycin 31-42 tumor protein p53 Homo sapiens 198-201 30637701-14 2018 Interestingly, nano-formulated tunicamycin is three times more potent in inhibiting the cell cycle progression than the native tunicamycin and is supported by downregulation of the ratio of phospho-p53 to total-p53 as well as phospho-Rb to total Rb. Tunicamycin 31-42 tumor protein p53 Homo sapiens 211-214 28720827-9 2017 In the SH-SY5Y human cells, tunicamycin (TM), a PERK activator, promoted transcription of hsp27; and necrosis induced by glutamate could be rescued by TM, associated with reduced p53 accumulation. Tunicamycin 28-39 tumor protein p53 Homo sapiens 179-182 29130967-6 2017 The mutant p53 cell lines were treated with tunicamycin to induce ERS and rapamycin in order to inhibit mTOR. Tunicamycin 44-55 tumor protein p53 Homo sapiens 11-14 24008518-9 2013 Protein levels of both p53 and glucosidase II were increased in response to UV irradiation but decreased in response to tunicamycin-induced ER stress. Tunicamycin 120-131 tumor protein p53 Homo sapiens 23-26 22859938-6 2012 Tunicamycin or brefeldin A, two ER stress inducers, increased p53 expression in MCF-7 and Hela cells. Tunicamycin 0-11 tumor protein p53 Homo sapiens 62-65 19242657-0 2009 Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export. Tunicamycin 0-11 tumor protein p53 Homo sapiens 76-79 19242657-4 2009 In order to further explore the mechanism underlying tumor resistance to cisplatin, we observed that increased nuclear export of endogenous p53 protein by pharmacological inducers of ER stress, such as tunicamycin, was associated with the suppression of cisplatin-induced apoptosis. Tunicamycin 202-213 tumor protein p53 Homo sapiens 140-143 18604159-6 2008 Several distinct autophagy inducers (e.g., starvation, rapamycin, lithium, tunicamycin and thapsigargin) stimulate the rapid degradation of p53. Tunicamycin 75-86 tumor protein p53 Homo sapiens 140-143 18838865-3 2008 Here, we show by epistatic analysis that p53 inhibition results in a maximum level of autophagy that cannot be further enhanced by a variety of different autophagy inducers including lithium, tunicamycin-induced stress of the endoplasmic reticulum (ER) or inhibition of Bcl-2 and Bcl-X(L) with the BH3 mimetic ABT737. Tunicamycin 192-203 tumor protein p53 Homo sapiens 41-44 18838865-4 2008 Chemical inducers of autophagy (including rapamycin, lithium, tunicamycin and ABT737) induced rapid depletion of the p53 protein. Tunicamycin 62-73 tumor protein p53 Homo sapiens 117-120