PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25827060-4 2015 Here, we demonstrate that thapsigargin (TG) and tunicamycin (TM), two ERS inducers activated macrophages were able to increase TRAIL mRNA and protein expression in RAW264.7 macrophages, the culture supernatant of THP-1 cells, and mouse peritoneal macrophages, indicating that ERS as a potent inducer of TRAIL transcription and expression in macrophages. Tunicamycin 48-59 TNF superfamily member 10 Homo sapiens 127-132 27603596-0 2017 Tunicamycin enhances human colon cancer cells to TRAIL-induced apoptosis by JNK-CHOP-mediated DR5 upregulation and the inhibition of the EGFR pathway. Tunicamycin 0-11 TNF superfamily member 10 Homo sapiens 49-54 27603596-2 2017 This paper reports that the combination of tunicamycin plus TRAIL produced a strong synergistic effect in TRAIL-sensitive human colon cancer HCT116 cells and TRAIL-resistant HT-29 cells. Tunicamycin 43-54 TNF superfamily member 10 Homo sapiens 106-111 27603596-2 2017 This paper reports that the combination of tunicamycin plus TRAIL produced a strong synergistic effect in TRAIL-sensitive human colon cancer HCT116 cells and TRAIL-resistant HT-29 cells. Tunicamycin 43-54 TNF superfamily member 10 Homo sapiens 106-111 27603596-3 2017 On a cellular mechanistic level, tunicamycin-enhanced TRAIL-induced apoptosis by death receptor (DR) 5 upregulation and DR4 deglycosylation. Tunicamycin 33-44 TNF superfamily member 10 Homo sapiens 54-59 27603596-6 2017 In addition, tunicamycin inhibited epidermal growth factor receptor glycosylation and the downstream signaling pathways, Akt and extracellular signal-regulated kinases activation, which might also be required for TRAIL sensitization by tunicamycin. Tunicamycin 13-24 TNF superfamily member 10 Homo sapiens 213-218 27603596-6 2017 In addition, tunicamycin inhibited epidermal growth factor receptor glycosylation and the downstream signaling pathways, Akt and extracellular signal-regulated kinases activation, which might also be required for TRAIL sensitization by tunicamycin. Tunicamycin 236-247 TNF superfamily member 10 Homo sapiens 213-218 27603596-7 2017 In summary, tunicamycin effectively enhanced TRAIL-induced apoptosis might through JNK-CHOP-mediated DR5 upregulation and the inhibition of the epidermal growth factor receptor pathway. Tunicamycin 12-23 TNF superfamily member 10 Homo sapiens 45-50 25827060-4 2015 Here, we demonstrate that thapsigargin (TG) and tunicamycin (TM), two ERS inducers activated macrophages were able to increase TRAIL mRNA and protein expression in RAW264.7 macrophages, the culture supernatant of THP-1 cells, and mouse peritoneal macrophages, indicating that ERS as a potent inducer of TRAIL transcription and expression in macrophages. Tunicamycin 61-63 TNF superfamily member 10 Homo sapiens 127-132 22426894-0 2012 Tunicamycin sensitizes human prostate cells to TRAIL-induced apoptosis by upregulation of TRAIL receptors and downregulation of cIAP2. Tunicamycin 0-11 TNF superfamily member 10 Homo sapiens 47-52 22426894-0 2012 Tunicamycin sensitizes human prostate cells to TRAIL-induced apoptosis by upregulation of TRAIL receptors and downregulation of cIAP2. Tunicamycin 0-11 TNF superfamily member 10 Homo sapiens 102-107 22426894-1 2012 The addition of tunicamycin to prostate cancer cells enhances cell death mediated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Tunicamycin 16-27 TNF superfamily member 10 Homo sapiens 85-140 22426894-1 2012 The addition of tunicamycin to prostate cancer cells enhances cell death mediated by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Tunicamycin 16-27 TNF superfamily member 10 Homo sapiens 142-147 22426894-2 2012 In this study, we investigated whether tunicamycin, an endoplasmic reticulum stress inducer, can potentiate TRAIL-induced apoptosis in human prostate cancer cells. Tunicamycin 39-50 TNF superfamily member 10 Homo sapiens 108-113 22426894-5 2012 We found that tunicamycin promoted TRAIL-induced apoptosis by the upregulation of death receptor (DR)4 and DR5 and the downregulation of cellular inhibitor of apoptosis 2 (cIAP2). Tunicamycin 14-25 TNF superfamily member 10 Homo sapiens 35-40 19307757-0 2009 Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin. Tunicamycin 0-11 TNF superfamily member 10 Homo sapiens 21-26 19307757-3 2009 In this study, we showed that tunicamycin, a naturally occurring antibiotic, was a potent enhancer of TRAIL-induced apoptosis through downregulation of survivin. Tunicamycin 30-41 TNF superfamily member 10 Homo sapiens 102-107 19307757-4 2009 The tunicamycin-mediated sensitization to TRAIL was efficiently reduced by forced expression of survivin, suggesting that the sensitization was mediated at least in part through inhibition of survivin expression. Tunicamycin 4-15 TNF superfamily member 10 Homo sapiens 42-47 19307757-6 2009 Furthermore, silencing cyclin D1 by RNA interference reduced survivin expression and sensitized thyroid cancer cells to TRAIL; in contrast, forced expression of cyclin D1 attenuated tunicamycin-potentiated TRAIL-induced apoptosis via over-riding downregulation of survivin. Tunicamycin 182-193 TNF superfamily member 10 Homo sapiens 206-211 19307757-7 2009 Collectively, our results demonstrated that tunicamycin promoted TRAIL-induced apoptosis, at least in part, by inhibiting the expression of cyclin D1 and subsequent survivin. Tunicamycin 44-55 TNF superfamily member 10 Homo sapiens 65-70 18978361-0 2009 Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells. Tunicamycin 0-11 TNF superfamily member 10 Homo sapiens 46-101 18978361-2 2009 In the present study, the effect of tunicamycin, a possible apoptosis enhancer, on TRAIL-induced apoptosis in endometriotic stromal cells (ESC) was determined. Tunicamycin 36-47 TNF superfamily member 10 Homo sapiens 83-88 18978361-8 2009 RESULTS: Tunicamycin increases both DR5 mRNA (P < 0.005) and TRAIL-induced apoptosis (P < 0.0001) in ESC. Tunicamycin 9-20 TNF superfamily member 10 Homo sapiens 64-69 18978361-9 2009 The increase in TRAIL-induced apoptosis in ESC by tunicamycin was suppressed (P < 0.05) by z-VAD-fmk. Tunicamycin 50-61 TNF superfamily member 10 Homo sapiens 16-21 18978361-10 2009 Transfection with DR5 siRNA suppressed the tunicamycin-induced increase in DR5 mRNA and abrogated the up-regulation of TRAIL-induced apoptosis by tunicamycin. Tunicamycin 146-157 TNF superfamily member 10 Homo sapiens 119-124 17575157-3 2007 We show in this study that the endoplasmic reticulum (ER) stress inducer, tunicamycin, selectively up-regulated the cell surface expression of TRAIL-R2, but not other members of the TNF receptor family, and enhanced TRAIL-induced apoptosis in cultured melanoma cells and fresh melanoma isolates. Tunicamycin 74-85 TNF superfamily member 10 Homo sapiens 143-148 17575157-4 2007 Tunicamycin-mediated sensitization of melanoma cells to TRAIL-induced apoptosis was associated with increased activation of the caspase cascade and reduction in mitochondrial membrane potential and was inhibited by a recombinant TRAIL-R2/Fc chimeric protein. Tunicamycin 0-11 TNF superfamily member 10 Homo sapiens 56-61 16024639-2 2005 In this study, we showed that tunicamycin, a naturally occurring antibiotic, is a potent enhancer of TRAIL-induced apoptosis through up-regulation of DR5 expression. Tunicamycin 30-41 TNF superfamily member 10 Homo sapiens 101-106 16024639-3 2005 Tunicamycin significantly sensitized PC-3, androgen-independent human prostate cancer cells, to TRAIL-induced apoptosis. Tunicamycin 0-11 TNF superfamily member 10 Homo sapiens 96-101 16024639-4 2005 The tunicamycin-mediated enhancement of TRAIL-induced apoptosis was markedly blocked by a recombinant human DR5/Fc chimeric protein. Tunicamycin 4-15 TNF superfamily member 10 Homo sapiens 40-45 16024639-7 2005 Furthermore, the tunicamycin-mediated sensitization to TRAIL was efficiently reduced by DR5 small interfering RNA, suggesting that the sensitization was mediated through induction of DR5 expression. Tunicamycin 17-28 TNF superfamily member 10 Homo sapiens 55-60 15155747-11 2004 Interestingly, TRAIL-resistant cells were resensitized to TRAIL by tunicamycin pretreatment, which increased cell surface expression of DR4 and KILLER/DR5. Tunicamycin 67-78 TNF superfamily member 10 Homo sapiens 15-20 15155747-11 2004 Interestingly, TRAIL-resistant cells were resensitized to TRAIL by tunicamycin pretreatment, which increased cell surface expression of DR4 and KILLER/DR5. Tunicamycin 67-78 TNF superfamily member 10 Homo sapiens 58-63 17914579-0 2007 Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin. Tunicamycin 125-136 TNF superfamily member 10 Homo sapiens 24-29 15155747-12 2004 Our data suggest that tumor cells may become resistant to TRAIL through regulation of the death receptor cell surface transport and that resistance to TRAIL may be overcome by the glycosylation inhibitor/endoplasmic reticulum stress-inducing agent tunicamycin. Tunicamycin 248-259 TNF superfamily member 10 Homo sapiens 151-156