PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34121978-10 2021 Cell viability and apoptosis in STF-083010 and Tunicamycin (Tm) co-treated cells were evaluated using BrdU, MTT, Annexin V-FITC/PI staining, and caspase-12 and -3 activities assays. Tunicamycin 47-58 caspase 3 Homo sapiens 145-162 34775235-4 2022 Pre-treatment with DA-9805 (1 mug/ml) attenuated upregulation of glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-3 in SH-SY5Y neuroblastoma cells treated with thapsigargin (1 microg/ml) or tunicamycin (2 microg/ml). Tunicamycin 231-242 caspase 3 Homo sapiens 147-156 34121978-10 2021 Cell viability and apoptosis in STF-083010 and Tunicamycin (Tm) co-treated cells were evaluated using BrdU, MTT, Annexin V-FITC/PI staining, and caspase-12 and -3 activities assays. Tunicamycin 60-62 caspase 3 Homo sapiens 145-162 33714955-6 2021 Furthermore, we found that ATF4 inhibition reduced tunicamycin-induced caspase-3 activation, ROS production, ELAM-1 expression, and HTMCs phagocytosis impairment. Tunicamycin 51-62 caspase 3 Homo sapiens 71-80 31978676-10 2020 A significant increase was observed in C22-C24 CERs, C1P, caspase-3, caspase-12, NFkappaB1 mRNA and NF-kappaB p65 protein levels in cells treated with TM compared to controls. Tunicamycin 151-153 caspase 3 Homo sapiens 58-67 32237184-8 2020 Also, induction of autophagy by tunicamycin resulted in apoptosis in diabetic PBMCs as observed by caspase 3 cleavage and reduced expression of Bcl2. Tunicamycin 32-43 caspase 3 Homo sapiens 99-108 32714930-7 2020 At the same time, staurosporine, nifedipine, and tunicamycin elicited an intermediate activation of caspase-3. Tunicamycin 49-60 caspase 3 Homo sapiens 100-109 32266019-9 2020 Western blot analysis demonstrated that the expression of Bax and caspase-3 was upregulated and the expression of Bcl-2 was downregulated in TM-treated human melanocytes. Tunicamycin 141-143 caspase 3 Homo sapiens 66-75 30389633-10 2019 More importantly, both xanthatin and tunicamycin, an endoplasmic reticulum stress (ERS) inducing compound, increased the levels of CHOP and cleaved-caspase-3 in HepG2 cells, but their effects were significantly abolished by siRNA-mediated knockdown of CHOP. Tunicamycin 37-48 caspase 3 Homo sapiens 148-157 31888113-8 2019 Consistent with the inhibition of COX-2 or p38 MAPK, copretreatment with TM and MLPE drastically recovered cytotoxicity and caspase-3 activation in the presence of DOX. Tunicamycin 73-75 caspase 3 Homo sapiens 124-133 28951205-10 2017 The inhibition of tunicamycin-induced caspase-3 cleavage by YAP1-5SA was markedly attenuated in ANKRD1-knockdown cells. Tunicamycin 18-29 caspase 3 Homo sapiens 38-47 29650257-5 2018 An ER stress-inducing chemical, tunicamycin, increased the activities of caspase-3 and -4, whereas pretreatment with NPY decreased caspase-3 and -4 activities during the ER stress response. Tunicamycin 32-43 caspase 3 Homo sapiens 73-89 30107908-5 2018 We demonstrated here that oxicam-NSAIDs suppressed the activation of caspase-3 and cell death caused by MPP+ or ER stress-inducer, tunicamycin, in SH-SY5Y cells. Tunicamycin 131-142 caspase 3 Homo sapiens 69-78 29744053-3 2018 Results: In the present study, we showed that intestinal epithelial cells (IEC-6) incubated with tunicamycin led to caspase-3-dependent apoptotic cell death. Tunicamycin 97-108 caspase 3 Homo sapiens 116-125 28951205-4 2017 In cultured VSMC, tunicamycin caused cell death accompanied by an increase in caspase-3 processing and C/EBP homologous protein (CHOP) expression. Tunicamycin 18-29 caspase 3 Homo sapiens 78-87 28951205-6 2017 Tunicamycin further decreased cell viability followed by an increase in caspase-3 processing in the absence of YAP1 when compared with treatment only with tunicamycin or siYAP1. Tunicamycin 0-11 caspase 3 Homo sapiens 72-81 24962313-10 2014 Knockdown endogenous BiP with siRNA abolished the suppression of propofol on tunicamycin-mediated activation of CHOP and caspase-3. Tunicamycin 77-88 caspase 3 Homo sapiens 121-130 27915415-0 2017 Exendin-4 protects HUVECs from tunicamycin-induced apoptosis via inhibiting the IRE1a/JNK/caspase-3 pathway. Tunicamycin 31-42 caspase 3 Homo sapiens 90-99 27915415-8 2017 Similarly, the ratio of p-IRE1alpha/IRE1alpha, p-JNK/JNK and active caspase-3/procaspase-3 were increased by tunicamycin (10 mug/ml); an effect that was counteracted by Exendin-4. Tunicamycin 109-120 caspase 3 Homo sapiens 68-77 27915415-8 2017 Similarly, the ratio of p-IRE1alpha/IRE1alpha, p-JNK/JNK and active caspase-3/procaspase-3 were increased by tunicamycin (10 mug/ml); an effect that was counteracted by Exendin-4. Tunicamycin 109-120 caspase 3 Homo sapiens 78-90 26419929-4 2015 Treating HepG2 cells with human recombinant CTRP9 significantly ameliorated palmitate- or tunicamycin-induced dysregulation of lipid metabolism, caspase 3 activity and chromatin condensation, which lead to reduction of hepatic triglyceride (TG) accumulation. Tunicamycin 90-101 caspase 3 Homo sapiens 145-154 19411306-8 2009 The activation of caspase-3 induced by hyperoxia or tunicamycin was diminished and immunoglobulin heavy chain-binding protein/glucose-regulated protein 78-kDa (BiP/GRP78) induction was increased in ERp57 knockdown cells. Tunicamycin 52-63 caspase 3 Homo sapiens 18-27 22923171-3 2012 Exposure of cells to tunicamycin (TM)-induced apoptosis was accompanied by cleavage of caspase-3, PARP-1 and CD44v6 ectodomain. Tunicamycin 21-32 caspase 3 Homo sapiens 87-96 22923171-3 2012 Exposure of cells to tunicamycin (TM)-induced apoptosis was accompanied by cleavage of caspase-3, PARP-1 and CD44v6 ectodomain. Tunicamycin 34-36 caspase 3 Homo sapiens 87-96 22426894-4 2012 The combined treatment with tunicamycin and TRAIL significantly induced apoptosis, and stimulated caspase-3, -8 and -9 activity, as well as the cleavage of poly (ADP-ribose) polymerase. Tunicamycin 28-39 caspase 3 Homo sapiens 98-118 22912727-7 2012 Interestingly, nuclear translocation of procaspase-3 (proCASP3) was observed in cells either overexpressing TRB3 or under tunicamycin-induced ER stress. Tunicamycin 122-133 caspase 3 Homo sapiens 40-52 22912727-7 2012 Interestingly, nuclear translocation of procaspase-3 (proCASP3) was observed in cells either overexpressing TRB3 or under tunicamycin-induced ER stress. Tunicamycin 122-133 caspase 3 Homo sapiens 54-62 22699051-9 2012 Compared with tunicamycin and cisplatin alone, the combined treatment significantly increased Bax expression and decreased Bcl-2 expression in the cells; tunicamycin up-regulated the expression of GRP-78 and enhanced the activity of caspase-3. Tunicamycin 14-25 caspase 3 Homo sapiens 233-242 22699051-9 2012 Compared with tunicamycin and cisplatin alone, the combined treatment significantly increased Bax expression and decreased Bcl-2 expression in the cells; tunicamycin up-regulated the expression of GRP-78 and enhanced the activity of caspase-3. Tunicamycin 154-165 caspase 3 Homo sapiens 233-242 22699051-10 2012 CONCLUSION: Tunicamycin can inhibit the proliferation of CNE-1 and CNE-2 cells and enhance cisplatin-induced cell death, the mechanism of which may involve excessive endoplasmic reticulum stress response and increased activity of caspase-3. Tunicamycin 12-23 caspase 3 Homo sapiens 230-239 19643964-8 2009 The induced caspase-4 and caspase-3 activities by tunicamycin and the stimulated IL-8 protein expression by IL-1beta were markedly reduced by caspase-4 inhibitor Z-LEVD-fmk. Tunicamycin 50-61 caspase 3 Homo sapiens 26-35 19411306-11 2009 Overexpression of ERp57 also augmented tunicamycin-induced caspase-3 activation and reduced BiP/GRP78 induction. Tunicamycin 39-50 caspase 3 Homo sapiens 59-68 19411306-13 2009 It appears that knockdown of ERp57 confers cellular protection against hyperoxia- or tunicamycin-induced apoptosis by inhibition of caspase-3 activation and stimulation of BiP/GRP78 induction. Tunicamycin 85-96 caspase 3 Homo sapiens 132-141 17681378-6 2007 Caspase-3 staining revealed that neuronal death is primarily due to apoptosis in tunicamycin-treated slice cultures. Tunicamycin 81-92 caspase 3 Homo sapiens 0-9 19302790-4 2009 Activation of caspase-12 and caspase-3 by tunicamycin was significantly reduced in cells transfected with wild-type Atm (AT5BIVA/wtATM). Tunicamycin 42-53 caspase 3 Homo sapiens 29-38 18788711-3 2008 Both Chinese propolis and chrysin concentration-dependently inhibited such cell death, the tunicamycin-induced activation of caspase-3, and the effects of tunicamycin on mitochondria [release of cytochrome c into the cytosol and disruption of the mitochondrial membrane potential (DeltaPsim)]. Tunicamycin 91-102 caspase 3 Homo sapiens 125-134 16388830-10 2006 Thapsigargin and tunicamycin each significantly activated caspase-3, -9, and -2 in the intrinsic apoptotic pathway in SH-SY5Y cells. Tunicamycin 17-28 caspase 3 Homo sapiens 58-79