PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34604209-4	2021	In the current study, we demonstrated that tunicamycin (a novel ERS inducer) can induce the apoptosis of HSCs and increase the concentration of intracellular Ca2+ and the expression of ERS protein GRP78, apoptosis protein caspase-12, and Bax, while it can decrease the antiapoptosis protein expression of Bcl-2.	Tunicamycin	43-54	BCL2 apoptosis regulator	Homo sapiens	305-310	
32237184-8	2020	Also, induction of autophagy by tunicamycin resulted in apoptosis in diabetic PBMCs as observed by caspase 3 cleavage and reduced expression of Bcl2.	Tunicamycin	32-43	BCL2 apoptosis regulator	Homo sapiens	144-148	
19347031-3	2009	We targeted Bcl-2 to mitochondria or endoplasmic reticulum (ER) and induced apoptosis using several apoptotic stimuli that initiate ER and/or mitochondrial signaling pathways (UV radiation, TNF and cycloheximide, staurosporine, thapsigargin and tunicamycin).	Tunicamycin	245-256	BCL2 apoptosis regulator	Homo sapiens	12-17	
32266019-9	2020	Western blot analysis demonstrated that the expression of Bax and caspase-3 was upregulated and the expression of Bcl-2 was downregulated in TM-treated human melanocytes.	Tunicamycin	141-143	BCL2 apoptosis regulator	Homo sapiens	114-119	
28631572-10	2017	With the increased tunicamycin concentration, there were increased expressions of Bax and cleaved caspase-3, decreased expression of Bcl-2, and lower phosphorylation of PI3K/Akt/mTOR signaling pathway-related proteins.	Tunicamycin	19-30	BCL2 apoptosis regulator	Homo sapiens	133-138	
22225575-7	2012	Interestingly, co-treatment with tunicamycin and melatonin also decreased the expression of COX-2 and significantly increased the rate of apoptosis by elevating the levels of CHOP and reducing the Bcl-2/Bax ratio.	Tunicamycin	33-44	BCL2 apoptosis regulator	Homo sapiens	197-202	
29936187-10	2018	mRNA and protein ratios of apoptotic modulators (Bax/Bcl2) are higher in 158JP oligodendrocytes which are also more vulnerable than 158N cells to tunicamycin-induced ER-stress.	Tunicamycin	146-157	BCL2 apoptosis regulator	Homo sapiens	53-57	
28246472-7	2017	Dramatically increased CCAAT-enhancer-binding protein homologous protein level, suppressed COX-2 and decreased Bcl-2/Bax ratio by melatonin or ATF-6 siRNA contributed the enhanced HepG2 cell apoptosis under tunicamycin (an ER stress inducer) stimulation.	Tunicamycin	207-218	BCL2 apoptosis regulator	Homo sapiens	111-116	
18160625-12	2008	In contrast, ER-Bcl-2 protected against apoptosis during tunicamycin-induced ER stress.	Tunicamycin	57-68	BCL2 apoptosis regulator	Homo sapiens	16-21	
17379544-7	2007	When the HeLa cells stably expressing Bcl-2 were treated with tunicamycin, endogenous RTN3 increased in the cell microsomal fraction.	Tunicamycin	62-73	BCL2 apoptosis regulator	Homo sapiens	38-43