PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19834331-7 2010 TUDCA treatment inhibited tunicamycin-induced ER stress as evidenced by the attenuation of phosphorylation of eukaryotic translation initiation factor-2a and glucose reactive protein-78. Tunicamycin 26-37 eukaryotic translation initiation factor 2A Homo sapiens 110-153 34716302-7 2021 PERK inhibitor ameliorated autophagy, fibrotic protein expression and apoptosis in TM-treated cells, indicating a role of the PERK/eIF2alpha pathway in autophagy activation during ER stress. Tunicamycin 83-85 eukaryotic translation initiation factor 2A Homo sapiens 131-140 18544642-8 2008 In vitro, palmitate, thapsigargin, and tunicamycin but not oleate induced endoplasmic reticulum stress in HepG2 cells, including increased transcripts CHOP, ERN1, GADD34, and PERK, and increased XBP1 splicing along with phosphorylation of eukaryotic initiation factor eIF2alpha, JNK1, and c-jun. Tunicamycin 39-50 eukaryotic translation initiation factor 2A Homo sapiens 268-277 12556489-2 2003 In this report, we show that the expression of human GADD34 in cultured cells reversed eIF-2 alpha phosphorylation induced by thapsigargin and tunicamycin, agents that promote protein unfolding in the endoplasmic reticulum (ER). Tunicamycin 143-154 eukaryotic translation initiation factor 2A Homo sapiens 87-98 19007793-5 2009 Furthermore, PACT-induced PKR activation is essential for tunicamycin-induced apoptosis, since PACT as well as PKR null cells are markedly resistant to tunicamycin and show defective eIF2alpha phosphorylation and C/EBP homologous protein (CHOP, also known as GADD153) induction especially at low concentrations of tunicamycin. Tunicamycin 58-69 eukaryotic translation initiation factor 2A Homo sapiens 183-192 14690445-3 2003 In contrast, tunicamycin, A23187, and low concentrations of cycloheximide promoted eIF2alpha phosphorylation in Sf9 cells but without apoptosis. Tunicamycin 13-24 eukaryotic translation initiation factor 2A Homo sapiens 83-92 34533242-7 2021 Biochemical experiments further discovered that rosamultin could inhibit p38 and JNK activation, and downregulate the levels of CHOP and proteins in its upstream PERK-eIF2alpha-ATF4 signaling pathway stimulated by cisplatin or tunicamycin. Tunicamycin 227-238 eukaryotic translation initiation factor 2A Homo sapiens 167-176 31894252-7 2020 Subsequent to experimentally inducing ER stress in AGR2vH-overexpressing CCA cells using tunicamycin, the UPR pathway was activated by the upregulation of UPR marker genes (activating transcription factor 6, eukaryotic initiation factor 2a and spliced X-box binding protein 1), UPR proteins [binding immunoglobulin protein/glucose-regulated protein (GRP)78 kDa and phosphorylated eukaryotic translation initiation factor 2a] and UPR downstream targets (GRP94). Tunicamycin 89-100 eukaryotic translation initiation factor 2A Homo sapiens 380-423 32979141-7 2021 In conclusion, this study found that naringin combined with tunicamycin+BAY 11-7082 efficiently induced apoptotic cell death in HT29 colon cancer cells via oxidative stress and the PERK/eIF2alpha/ATF4/CHOP pathway, suggesting that naringin combined with tunicamycin plus BAY 11-7082 could be a new combination therapy strategy for effective colon cancer treatment with minimal side effects on healthy cells. Tunicamycin 60-71 eukaryotic translation initiation factor 2A Homo sapiens 186-195 31974624-5 2020 The present study demonstrated that 3 microM tunicamycin (TM) increased the expression of the ER stress-related proteins protein kinase RNA-like endoplasmic reticulum kinase (PERK), alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) and C/EBP homologous protein (CHOP) in human primary epidermal melanocytes. Tunicamycin 45-56 eukaryotic translation initiation factor 2A Homo sapiens 243-252 31974624-5 2020 The present study demonstrated that 3 microM tunicamycin (TM) increased the expression of the ER stress-related proteins protein kinase RNA-like endoplasmic reticulum kinase (PERK), alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) and C/EBP homologous protein (CHOP) in human primary epidermal melanocytes. Tunicamycin 58-60 eukaryotic translation initiation factor 2A Homo sapiens 243-252 28631572-8 2017 With tunicamycin treatment, phosphorylation of PERK and eIF2alpha and CHOP expression increased. Tunicamycin 5-16 eukaryotic translation initiation factor 2A Homo sapiens 56-65 29620275-7 2018 Compared with in cells prior to treatment, human leukemia cells treated with tunicamycin exhibited increased expression of p-PERK, p-eIF2alpha and GRP78 after 72 h (P<0.05). Tunicamycin 77-88 eukaryotic translation initiation factor 2A Homo sapiens 133-142 28841673-2 2017 We demonstrated the induction of ER stress in response to tunicamycin stimulation, as evidenced by increased expression of chaperone proteins Grp78, Grp94, and enhanced eukaryotic initiation factor 2 subunit 1 (eIF2alpha) phosphorylation in hepatocellular carcinoma cells. Tunicamycin 58-69 eukaryotic translation initiation factor 2A Homo sapiens 211-220 28630443-6 2017 Both chaperones mitigate tunicamycin induced PERK-eIF2alpha-ATF4-CHOP arm of UPR and expression of BiP. Tunicamycin 25-36 eukaryotic translation initiation factor 2A Homo sapiens 50-59 26419929-6 2015 Furthermore, CTRP9 decreased palmitate- or tunicamycin-induced ER stress markers, such as eIF2alpha, CHOP and IRE-1, in HepG2 cells. Tunicamycin 43-54 eukaryotic translation initiation factor 2A Homo sapiens 90-99 26718307-7 2016 PFKFB3 also modulated the expressions of PERK, ATF3, IRE1, p-eIF2alpha and MMP13 in tunicamycin-exposed chondrocytes. Tunicamycin 84-95 eukaryotic translation initiation factor 2A Homo sapiens 61-70 25160872-5 2016 Meanwhile, 2,4-DCP acted similarly as ER stress agonist tunicamycin (Tu) to activate all three branches (IRE1alpha, ATF6 and eIF2alpha) of ER stress. Tunicamycin 56-67 eukaryotic translation initiation factor 2A Homo sapiens 125-134 25160872-5 2016 Meanwhile, 2,4-DCP acted similarly as ER stress agonist tunicamycin (Tu) to activate all three branches (IRE1alpha, ATF6 and eIF2alpha) of ER stress. Tunicamycin 69-71 eukaryotic translation initiation factor 2A Homo sapiens 125-134 25737469-4 2015 Although NaF and tunicamycin both induced PERK activation followed by eIF2alpha phosphorylation and ATF4 expression, CHOP expression was only induced by tunicamycin. Tunicamycin 17-28 eukaryotic translation initiation factor 2A Homo sapiens 70-79 25428129-4 2015 Tunicamycin induced the phosphorylation and activation of PERK and eIF2alpha within 2 h in RPTC, which was followed by the induction of GRP78 and CHOP. Tunicamycin 0-11 eukaryotic translation initiation factor 2A Homo sapiens 67-76 23537656-9 2013 The addition of HDL3 to the culture medium of tunicamycin-treated cells induced: (i) the reduction of ER stress, expressed as decreased levels of eIF-2alpha and SAPK/JNK, and (ii) a partial recovery of the secreted apoE and CETP levels in lipid-loaded macrophages. Tunicamycin 46-57 eukaryotic translation initiation factor 2A Homo sapiens 146-156 23281479-5 2013 We found that metabolic dysregulation was associated with induction of eIF2alpha signaling and CHOP up-regulation during challenge with tunicamycin or Velcade. Tunicamycin 136-147 eukaryotic translation initiation factor 2A Homo sapiens 71-80