PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3138512-6 1988 The rate at which the blood was cleared of lactate increased from 22.7 +/- 2.2 at rest to 44.2 +/- 11.2 ml x kg-1 x min-1 after 25 minutes of exercise. Lactic Acid 43-50 CD59 molecule (CD59 blood group) Homo sapiens 116-121 2621761-2 1989 with terminal heart rate and blood lactate of 152 +/- 6 beats min-1 and 6.9 +/- 0.89 mM, respectively. Lactic Acid 35-42 CD59 molecule (CD59 blood group) Homo sapiens 62-75 3138512-7 1988 From secondary labeling of lactate with glucose carbons, the rate of glucose conversion to lactate was estimated to be 0.65 +/- 0.16 mg x kg-1 x min-1 during exercise. Lactic Acid 27-34 CD59 molecule (CD59 blood group) Homo sapiens 145-150 3138512-7 1988 From secondary labeling of lactate with glucose carbons, the rate of glucose conversion to lactate was estimated to be 0.65 +/- 0.16 mg x kg-1 x min-1 during exercise. Lactic Acid 91-98 CD59 molecule (CD59 blood group) Homo sapiens 145-150 3566386-6 1987 Lactate levels increased during flow reduction (p = .028), especially at flow rates less than 0.5 L min-1 m-2. Lactic Acid 0-7 CD59 molecule (CD59 blood group) Homo sapiens 100-105 3325487-4 1987 The lactate threshold was assessed in terms of both the absolute work rate (ml.kg-1.min-1) and relative work rate. Lactic Acid 4-11 CD59 molecule (CD59 blood group) Homo sapiens 84-89 3987210-7 1985 At a steady state lactate concentration of 25.5 mM, maternal to foetal flux rate was 30.1 mumol min-1 and foetal to maternal flux rate was 34.0 mumol min-1, in agreement with measurements reported by other workers. Lactic Acid 18-25 CD59 molecule (CD59 blood group) Homo sapiens 96-101 28829688-9 2017 Blood lactate and HR were liable to daily fluctuations of 0.14-0.22 mmol L-1 and 4-5 beats min-1 respectively. Lactic Acid 6-13 CD59 molecule (CD59 blood group) Homo sapiens 91-96 6705283-8 1984 However, 5 patients showed a decreased myocardial lactate extraction after 10 micrograms/kg min-1 of intravenous dobutamine, 3 from group I and 2 from group II. Lactic Acid 50-57 CD59 molecule (CD59 blood group) Homo sapiens 92-97 7272661-6 1981 The net rate of lactate removal was .30 mmol.L-1.min-1. Lactic Acid 16-23 CD59 molecule (CD59 blood group) Homo sapiens 49-54 28149379-4 2016 Multi-exponential modeling showed values above 450 ml min-1 of the SC in the two last bouts of exercise (those with intensities above the lactate threshold). Lactic Acid 138-145 CD59 molecule (CD59 blood group) Homo sapiens 54-59 28425966-5 2017 Pre-training, resting lactate appearance was 3.6 +- 0.5 vs. 3.6 +- 0.4 mg kg-1 min-1 in GF and C, and was increased to 11.2 +- 1.4 vs. 8.8 +- 0.7 mg kg-1 min-1 by exercise (Exercise: p < 0.01). Lactic Acid 22-29 CD59 molecule (CD59 blood group) Homo sapiens 79-84 28425966-5 2017 Pre-training, resting lactate appearance was 3.6 +- 0.5 vs. 3.6 +- 0.4 mg kg-1 min-1 in GF and C, and was increased to 11.2 +- 1.4 vs. 8.8 +- 0.7 mg kg-1 min-1 by exercise (Exercise: p < 0.01). Lactic Acid 22-29 CD59 molecule (CD59 blood group) Homo sapiens 154-159 24149782-7 2010 The lactate threshold was higher than ventilatory one both in obese and normal weight women (1.11 +- 0.21 vs 0.88 +- 0.18 L min(-1), p < 0.001; 0.94 +- 0.15 vs 0.79 +- 0.23 L min(- 1), p < 0.01, respectively). Lactic Acid 4-11 CD59 molecule (CD59 blood group) Homo sapiens 124-130 24842984-5 2014 Compared with nonusers, risk of lactic acidosis or elevated lactate concentrations in current metformin users was significantly associated with a renal function <60 mL/min/1.73 m(2) (adjusted HR 6.37 [95% CI 1.48-27.5]). Lactic Acid 60-67 CD59 molecule (CD59 blood group) Homo sapiens 171-176 24149782-7 2010 The lactate threshold was higher than ventilatory one both in obese and normal weight women (1.11 +- 0.21 vs 0.88 +- 0.18 L min(-1), p < 0.001; 0.94 +- 0.15 vs 0.79 +- 0.23 L min(- 1), p < 0.01, respectively). Lactic Acid 4-11 CD59 molecule (CD59 blood group) Homo sapiens 178-185 20106363-6 2010 The high lactate group showed significantly lower weight-indexed cardiopulmonary bypass flow rate (101 + or - 6.5 mL/kg(-1)/min(-1) vs 131 + or - 6.0 mL/kg(-1)/min(-1), P = .0013), oxygen delivery during cardiopulmonary bypass (mean 12.7 + or - 0. Lactic Acid 9-16 CD59 molecule (CD59 blood group) Homo sapiens 124-130 20826630-6 2010 RESULTS: In GLUFRU, lactate appearance (120 +- 6 mumol kg-1 min-1), lactate disappearance (121 +- 7 mumol kg-1 min-1), and oxidation (127 +- 12 mumol kg-1 min-1) rates increased significantly (P < 0.001) in comparison with glucose alone (94 +- 16, 95 +- 16, and 97 +- 16 mumol kg-1 min-1, respectively). Lactic Acid 20-27 CD59 molecule (CD59 blood group) Homo sapiens 64-69 20106363-6 2010 The high lactate group showed significantly lower weight-indexed cardiopulmonary bypass flow rate (101 + or - 6.5 mL/kg(-1)/min(-1) vs 131 + or - 6.0 mL/kg(-1)/min(-1), P = .0013), oxygen delivery during cardiopulmonary bypass (mean 12.7 + or - 0. Lactic Acid 9-16 CD59 molecule (CD59 blood group) Homo sapiens 160-166 19053964-4 2009 RESULTS: Arterial lactate and cardiac output increased to 15.3 +/- 4.2 mM and 20.8 +/- 1.5 L min(-1) respectively (mean +/- SD). Lactic Acid 18-25 CD59 molecule (CD59 blood group) Homo sapiens 93-99 16845226-9 2006 Moreover, the increase in pedalling rate from 60 to 120 rev.min(-1) was accompanied by a significantly higher increase of oxygen cost of cycling and by a significantly higher plasma lactate concentration in subjects from group H. We concluded that the muscle mechanical efficiency, expressed by the VO2/PO ratio, during cycling in the range of power outputs 30-120 W, performed at 60 as well as 120 rev.min(-1), is significantly lower in the individuals with the highest content of MyHC II, when compared to the individuals with the lowest content of MyHC II in the vastus lateralis. Lactic Acid 182-189 CD59 molecule (CD59 blood group) Homo sapiens 60-66 17140255-6 2006 The cellular uptake of D-lactate and butyrate exhibited pH- and concentration-dependence (D-lactate, Km of 26.5 +/- 2.2 mM and Vmax of 72.0 +/- 14.5 nmol mg-1 min-1; butyrate, Km of 0.8 +/- 0.3 mM, Vmax of 29.3 +/- 2.5 nmol mg-1 min-1, and a diffusional clearance of 2.1 microL mg-1 min-1). Lactic Acid 23-32 CD59 molecule (CD59 blood group) Homo sapiens 159-164 17140255-6 2006 The cellular uptake of D-lactate and butyrate exhibited pH- and concentration-dependence (D-lactate, Km of 26.5 +/- 2.2 mM and Vmax of 72.0 +/- 14.5 nmol mg-1 min-1; butyrate, Km of 0.8 +/- 0.3 mM, Vmax of 29.3 +/- 2.5 nmol mg-1 min-1, and a diffusional clearance of 2.1 microL mg-1 min-1). Lactic Acid 23-32 CD59 molecule (CD59 blood group) Homo sapiens 229-234 17140255-6 2006 The cellular uptake of D-lactate and butyrate exhibited pH- and concentration-dependence (D-lactate, Km of 26.5 +/- 2.2 mM and Vmax of 72.0 +/- 14.5 nmol mg-1 min-1; butyrate, Km of 0.8 +/- 0.3 mM, Vmax of 29.3 +/- 2.5 nmol mg-1 min-1, and a diffusional clearance of 2.1 microL mg-1 min-1). Lactic Acid 23-32 CD59 molecule (CD59 blood group) Homo sapiens 229-234 12369738-8 2002 But, generation of the same external mechanical power output at 120 rev min(-1) causes more stepper increase (p < 0.01) in the plasma growth hormone concentration [GH]pl and plasma lactate concentrations [La]pl when compared to that observed during cycling at 60 rev x min(-1). Lactic Acid 184-191 CD59 molecule (CD59 blood group) Homo sapiens 72-78 15815939-4 2005 The blood lactate concentration at sub-maximal running speed (425 m min(-1)) was significantly greater in H than in N (paired t-test: P<0.05). Lactic Acid 10-17 CD59 molecule (CD59 blood group) Homo sapiens 68-74 10331398-10 1999 Net splanchnic lactate balance switched from a basal net uptake (3.2+/-0.6 micromol kg(-1) x min(-1) to a net output between 60 and 120 min and tended to zero thereafter. Lactic Acid 15-22 CD59 molecule (CD59 blood group) Homo sapiens 93-99 9565925-7 1998 Heart rate and lactate concentration by an equivalent submaximal workload (5 km.h-1) were significant reduced (from 138 +/- 21 beats.min-1 to 113 +/- 20 beats.min-1, P < 0.05, and from 2.6 +/- 1.4 mmol.L-1 to 1.3 +/- 0.6 mmol.L-1, P < 0.05); all patients experienced a clear reduction of fatigue and could carry out normal daily activities again without substantial limitations. Lactic Acid 15-22 CD59 molecule (CD59 blood group) Homo sapiens 133-138 9565925-7 1998 Heart rate and lactate concentration by an equivalent submaximal workload (5 km.h-1) were significant reduced (from 138 +/- 21 beats.min-1 to 113 +/- 20 beats.min-1, P < 0.05, and from 2.6 +/- 1.4 mmol.L-1 to 1.3 +/- 0.6 mmol.L-1, P < 0.05); all patients experienced a clear reduction of fatigue and could carry out normal daily activities again without substantial limitations. Lactic Acid 15-22 CD59 molecule (CD59 blood group) Homo sapiens 159-164 9049519-8 1997 Cardiac free carnitine balance changed from uptake (255 +/- 107 pmol.min-1, mean +/- SEM) to release, (-150 +/- 66 pmol.min-1) at 30 min after pacing in the group with lactate production. Lactic Acid 168-175 CD59 molecule (CD59 blood group) Homo sapiens 69-74 9498656-5 1998 NIDDM patients had increased lactate turnover rates (16.18+/-0.92 vs 12.14+/-0.60 micromol x kg(-1) x min(-1), p < 0.01) and a moderate rise in glucose production (EGP) (15.39+/-0.87 vs 12.52+/-0.28 micromol x kg(-1) x min(-1) , p = 0.047). Lactic Acid 29-36 CD59 molecule (CD59 blood group) Homo sapiens 102-108 9347274-5 1997 At 20 W, chronic heart failure patients had a leg flow similar to controls, but showed increased lactate release (from resting 11.7 +/- 33 to 142 +/- 125 micrograms.min-1 P < 0.0001 vs controls, from resting 5.7 +/- 15.4 to 50 +/- 149 micrograms.min-1 ns), higher arterial concentration of free fatty acids (781 +/- 69 vs 481 +/- 85 mumol.l-1; P < 0.01), lower femoral vein HCO3 (24.1 +/- 2.6 vs 26.3 +/- 1.7 mmol.l-1; P < 0.05) and base excess (-2.3 +/- 2.3 vs -0.24 +/- 1.7 mmol.l-1; P = 0.01). Lactic Acid 97-104 CD59 molecule (CD59 blood group) Homo sapiens 165-170 9049519-8 1997 Cardiac free carnitine balance changed from uptake (255 +/- 107 pmol.min-1, mean +/- SEM) to release, (-150 +/- 66 pmol.min-1) at 30 min after pacing in the group with lactate production. Lactic Acid 168-175 CD59 molecule (CD59 blood group) Homo sapiens 120-125 8262701-5 1993 However, at similar lactate levels, heart rate during rowing on the water was approximately 10 beats.min-1 higher than during the ergometer multistage step test, due to the different duration of exercise. Lactic Acid 20-27 CD59 molecule (CD59 blood group) Homo sapiens 101-106 8243814-7 1993 Gluconeogenesis from lactate decreased by approximately 40%, from 6.2 +/- 0.6 to 3.8 +/- 0.5 mumol.kg-1 x min-1 (P < 0.005); lactate oxidation increased from 5.6 +/- 0.8 to 7.9 +/- 1.1 mumol.kg-1 x min-1 (P < 0.005), with no change in plasma lactate concentrations or total lactate Rd. Lactic Acid 21-28 CD59 molecule (CD59 blood group) Homo sapiens 106-111 8243814-7 1993 Gluconeogenesis from lactate decreased by approximately 40%, from 6.2 +/- 0.6 to 3.8 +/- 0.5 mumol.kg-1 x min-1 (P < 0.005); lactate oxidation increased from 5.6 +/- 0.8 to 7.9 +/- 1.1 mumol.kg-1 x min-1 (P < 0.005), with no change in plasma lactate concentrations or total lactate Rd. Lactic Acid 21-28 CD59 molecule (CD59 blood group) Homo sapiens 201-206 8895265-6 1996 Regional myocardial lactate uptake (RMLU) and extraction (RMLE) increased significantly (P < 0.05) at 50 ng.kg-1.min-1 (10.2 +/- 3.8 mumol/min and 8.2% +/- 3.0%, respectively) as compared to control (-1.1 +/- 3.0 mumol/min and -1.3% +/- 3.3%, respectively). Lactic Acid 20-27 CD59 molecule (CD59 blood group) Homo sapiens 116-121 7771674-5 1995 The determination of several substrates such as pyruvate, lactate, and cortisone using appropriate PEG-stabilized enzymes is demonstrated with this FI instrument at 25 or 50 microliters min-1 with sample throughputs of the order of 2-3 min per sample. Lactic Acid 58-65 CD59 molecule (CD59 blood group) Homo sapiens 186-191 8128891-10 1993 Yet, the arterial-coronary sinus (a-cs) lactate difference was lower during hypoxaemia than normoxaemia and isotope data indicated that this was caused by a myocardial lactate release of approximately 90 mumol min-1 which was at hand during hypoxaemia but not normoxaemia, whether hypoxaemic exercise preceded or succeeded normoxaemic exercise. Lactic Acid 168-175 CD59 molecule (CD59 blood group) Homo sapiens 210-215 8120827-13 1993 The skeletal muscle dialysate lactate concentration (1 microliter min-1: 1.16 +/- 0.2 mM) was higher than in adipose tissue (0.76 +/- 0.08 mM, P < 0.05), where the absolute amount of lactate that could be removed from the tissue (at 4 microliters min-1) was only half of that in skeletal muscle (0.8 +/- 0.11 vs. 1.76 +/- 0.23 nmol min-1, P < 0.05). Lactic Acid 30-37 CD59 molecule (CD59 blood group) Homo sapiens 66-71 8404995-3 1993 With the highest lactate infusions, plasma lactate increased up to 7 mM (compared to 1.1 +/- 0.13 mM during control sodium bicarbonate infusions, n = 10) and LGN averaged 4.73 +/- 0.23 mumol kg-1 min-1 (compared to 1.57 +/- 0.26 mumol kg-1 min-1 in bicarbonate control experiments, P < 0.001). Lactic Acid 17-24 CD59 molecule (CD59 blood group) Homo sapiens 196-201 8404995-3 1993 With the highest lactate infusions, plasma lactate increased up to 7 mM (compared to 1.1 +/- 0.13 mM during control sodium bicarbonate infusions, n = 10) and LGN averaged 4.73 +/- 0.23 mumol kg-1 min-1 (compared to 1.57 +/- 0.26 mumol kg-1 min-1 in bicarbonate control experiments, P < 0.001). Lactic Acid 17-24 CD59 molecule (CD59 blood group) Homo sapiens 240-245 8404995-4 1993 The data relating plasma lactate concentration to LGN best fit a sigmoidal curve which plateaued at plasma lactate concentrations of approximately 6 mM and yielded an ED50 of 2.04 +/- 0.20 (SD) mM and a Vmax (6.25 +/- 1.2) (SD) (mumol kg-1 min-1). Lactic Acid 25-32 CD59 molecule (CD59 blood group) Homo sapiens 240-245 1325260-3 1992 The most demanding firefighting operations required a mean VO2 of 41.5 ml/kg.min-1 with peak lactate concentrations of 6 to 13.2 mM. Lactic Acid 93-100 CD59 molecule (CD59 blood group) Homo sapiens 77-82 1449301-11 1992 Mean lactate consumption 5 minutes after reperfusion was significantly greater (p = 0.0001) in group 1 (31.8 +/- 6.3 micrograms.min-1 x g-1) than in group 2 (-0.59 +/- 0.1 microgram.min-1 x g-1), indicating superior metabolic recovery in the blood cardioplegia hearts. Lactic Acid 5-12 CD59 molecule (CD59 blood group) Homo sapiens 128-133 1449301-11 1992 Mean lactate consumption 5 minutes after reperfusion was significantly greater (p = 0.0001) in group 1 (31.8 +/- 6.3 micrograms.min-1 x g-1) than in group 2 (-0.59 +/- 0.1 microgram.min-1 x g-1), indicating superior metabolic recovery in the blood cardioplegia hearts. Lactic Acid 5-12 CD59 molecule (CD59 blood group) Homo sapiens 182-187 2044538-5 1991 The first-order rate constant (min-1) for decline of arterialised venous blood lactate concentration after the intense exercise was 0.027 (0.003) in PR, 0.058 (0.025) in SL, 0.034 (0.002) in OL, and in RA was 0.028 (0.002) [mean (SEM), n = 6 subjects]. Lactic Acid 79-86 CD59 molecule (CD59 blood group) Homo sapiens 31-36