PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31001279-8	2019	Indeed, activation of AMPK via treatment with the AMP-mimetic AICAR significantly reduced neutrophil lactate production in response to PMA stimulation, a phenomenon that we also observed for neutrophils pre-treated with mtDAMPs.	Lactic Acid	101-108	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	22-26	
33336150-9	2020	Further, AMPK critically maintained the activity of pyruvate dehydrogenase complex (PDH), the rate limiting enzyme involved in TCA cycle, thus favoring the pyruvate metabolism towards TCA cycle rather than converting it to lactate.	Lactic Acid	223-230	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	9-13	
26315350-4	2016	AMPK was activated in this situation, following by the rapid glycolysis and accumulation of lactic acid, leading to a high incidence of pale, soft, exudative (PSE)-like meat.	Lactic Acid	92-103	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4	
29399091-8	2018	However, SDHB and AMPK were identified to suppress lactic acid production in CRC cells, indicating that each had an inhibitory effect on aerobic glycolysis.	Lactic Acid	51-62	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	18-22	
20818598-7	2010	The LDH activity slightly increased and reached a peak after 6 h. During serum treatment, the activity of AMPK was suppressed and the ATP level showed a dramatic 30% increase after 1 h. In contrast, the lactate level was gradually increased and then reverted to the background level after 24 h. The activity of LDH was slightly decreased after 12 h and eventually returned to the background level.	Lactic Acid	203-210	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	106-110	
23540408-8	2013	CONCLUSION: These results suggest that AMPK is transiently phosphorylated following forebrain ischemia in the hippocampal CA1 region and inhibition of AMPK has neuroprotective effects against ischemic damage through the reduction of ATP depletion and lactate accumulation in the hippocampal CA1 region.	Lactic Acid	251-258	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	39-43	
23540408-8	2013	CONCLUSION: These results suggest that AMPK is transiently phosphorylated following forebrain ischemia in the hippocampal CA1 region and inhibition of AMPK has neuroprotective effects against ischemic damage through the reduction of ATP depletion and lactate accumulation in the hippocampal CA1 region.	Lactic Acid	251-258	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	151-155	
12546686-15	2003	In addition to altering malonyl-CoA levels, AMPK can also increase glycolytic rates, resulting in an increased uncoupling of glycolysis from glucose oxidation and an enhanced production of protons and lactate.	Lactic Acid	201-208	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	44-48	
34973450-9	2022	Mechanistically, lactate increases the activity of adenosine monophosphate-activated protein kinase (AMPK) and suppresses the phosphorylation of serine/threonine kinase 1 (Akt) and mammalian target of rapamycin (mTOR).	Lactic Acid	17-24	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	51-99	
34973450-9	2022	Mechanistically, lactate increases the activity of adenosine monophosphate-activated protein kinase (AMPK) and suppresses the phosphorylation of serine/threonine kinase 1 (Akt) and mammalian target of rapamycin (mTOR).	Lactic Acid	17-24	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	101-105	
16848549-4	2006	Earlier and faster post-mortem AMPK activation was responsible for the significantly lower pH and higher lactic acid accumulation (p<0.05) seen in PSE muscle, which resulted in the occurrence of PSE meat.	Lactic Acid	105-116	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	31-35