PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30312017-8 2019 Brain lactate content and MCT2 protein level were increased in curcumin-treated APP/PS1 mice than in APP/PS1 mice. Lactic Acid 6-13 presenilin 1 Mus musculus 84-87 30383244-4 2018 We found that lactate content and expressions of cerebral MCT1, MCT2, and MCT4 were decreased in APP/PS1 mice. Lactic Acid 14-21 presenilin 1 Mus musculus 101-104 23640454-7 2013 In PS1-KI mice, the drug increased brain lactate dehydrogenase activity leading to a net increase in lactate levels, while no effects were observed on mitochondrial respiration. Lactic Acid 41-48 presenilin 1 Mus musculus 3-6 29946959-5 2018 In addition, our results reveal that the 13C-enrichments of the C3 of alanine were significantly lower and the C3 of lactate have a tendency to be lower in the brain of APP/PS1 mice than WT mice. Lactic Acid 117-124 presenilin 1 Mus musculus 173-176 26865611-4 2016 Analysis of hippocampal interstitial fluid by in vivo microdialysis revealed a significant elevation in lactate levels in APP/PS1 mice relative to control mice at 12 months of age. Lactic Acid 104-111 presenilin 1 Mus musculus 126-129 26865611-11 2016 However, elevated lactate levels in APP/PS1 mice indicate perturbed lactate processing, a factor that may contribute to cognitive decline in AD. Lactic Acid 18-25 presenilin 1 Mus musculus 40-43 26865611-11 2016 However, elevated lactate levels in APP/PS1 mice indicate perturbed lactate processing, a factor that may contribute to cognitive decline in AD. Lactic Acid 68-75 presenilin 1 Mus musculus 40-43