PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6089434-1	1984	After long-term blockade of M-cholinoreactive structures by means of atropine activities of lactate-, malate- and isocytrate dehydrogenases (LDH, MDH, IDH, respectively) was decreased in smooth muscles of pigeon stomach.	Lactic Acid	92-99	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	151-154	
33778723-11	2020	The sensitivity, specificity, and AUC of the 2HG/(lipid + lactate) ratio for predicting IDH-mutant gliomas were 79% (22 of 28), 92% (47 of 51), and 0.90 (95% CI: 0.81, 0.96; C statistics, 0.90), respectively.	Lactic Acid	58-65	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	88-91	
33778723-13	2020	The 2HG/(lipid + lactate) ratio was significantly better for predicting IDH mutation status than the 2HG concentration alone (P < .01).	Lactic Acid	17-24	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	72-75	
33778723-14	2020	In glioblastoma, the 2HG/(lipid + lactate) ratio was also better for predicting IDH mutations than the 2HG concentration alone, with borderline significance (P = .052).	Lactic Acid	34-41	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	80-83	
31960518-5	2020	Specifically, the enzymes involved in the metabolism of glutamate, lactate, and enzymes involved in the conversion of alpha-ketoglutarate were increased in IDH1 mut gliomas.	Lactic Acid	67-74	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	156-160	
32646946-9	2020	We additionally found evidence for codependent effects of 1p/19q codeletion and IDH mutations with regard to lactate concentrations for World Health Organization tumor grades II and III, with lower lactate levels in patients exhibiting the codeletion.	Lactic Acid	109-116	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	80-83	
32646946-9	2020	We additionally found evidence for codependent effects of 1p/19q codeletion and IDH mutations with regard to lactate concentrations for World Health Organization tumor grades II and III, with lower lactate levels in patients exhibiting the codeletion.	Lactic Acid	198-205	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	80-83	
32646946-11	2020	CONCLUSIONS: We found indirect evidence for metabolic reprogramming in IDH-mutant tumors with significantly lower lactate concentrations compared with IDH wild-type tumors and a near-normal intracellular pH.	Lactic Acid	114-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	71-74	
31960518-8	2020	We conclude that in IDH1 mut glioma metabolism is rewired (increased input of lactate and glutamate) to preserve TCA-cycle activity in IDH1 mut gliomas.	Lactic Acid	78-85	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	20-24	
31960518-8	2020	We conclude that in IDH1 mut glioma metabolism is rewired (increased input of lactate and glutamate) to preserve TCA-cycle activity in IDH1 mut gliomas.	Lactic Acid	78-85	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	135-139	
27144334-4	2016	The goal of this study was therefore to investigate the impact of the IDH1 mutation on the pyruvate-to-lactate flux.	Lactic Acid	103-110	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	70-74	
27437179-5	2016	In particular, mutant IDH1 gliomas are associated with low levels of lactate dehydrogenase A (LDHA) and monocarboxylate transporters 1 and 4 (MCT1, MCT4), three proteins involved in pyruvate metabolism to lactate.	Lactic Acid	69-76	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	22-26	
27437179-8	2016	Mutant IDH1 cells and tumors produced significantly less hyperpolarized [1-(13)C] lactate compared to GBM, consistent with their metabolic reprogramming.	Lactic Acid	82-89	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	7-11	
29662077-5	2018	Importantly, inhibition of mutant IDH1 may lead to the reprogramming of tumor metabolism, suggested by simultaneous changes in glutathione, glutamine, glutamate, and lactate.	Lactic Acid	166-173	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	34-38	
28578659-0	2017	Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells.	Lactic Acid	55-62	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	105-109	
28578659-1	2017	BACKGROUND: Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential.	Lactic Acid	154-161	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	142-148	
25706986-11	2015	Specifically, a significant drop in the concentration of glutamate, lactate and phosphocholine as well as the expected elevation in 2-hydroxyglutarate were observed in mutant IDH1 cells when compared to their wild-type counterparts.	Lactic Acid	68-75	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	175-179	
25251602-6	2015	Notably, lactate level was lower in MT-IDH2 cells which produced more 2-HG than MT-IDH1 cells, indicating that the Warburg effects can be overridden by the production of 2-HG.	Lactic Acid	9-16	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	83-87	
23456655-7	2013	The CSF levels of the citric, isocitric, and lactic acids were significantly higher in grade I-III gliomas with mutant IDH than in those with wild-type IDH.	Lactic Acid	45-57	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	119-122