PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32325339-0 2020 Exploiting oxadiazole-sulfonamide hybrids as new structural leads to combat diabetic complications via aldose reductase inhibition. Oxadiazoles 11-21 aldo-keto reductase family 1 member B Homo sapiens 103-119 27544072-1 2016 In continuation of our previous efforts directed towards the development of potent and selective inhibitors of aldose reductase (ALR2), and to control the diabetes mellitus (DM), a chronic metabolic disease, we synthesized novel coumarin-thiazole 6(a-o) and coumarin-oxadiazole 11(a-h) hybrids and screened for their inhibitory activity against aldose reductase (ALR2), for the selectivity against aldehyde reductase (ALR1). Oxadiazoles 267-277 aldo-keto reductase family 1 member B Homo sapiens 129-133 27544072-9 2016 Hence, the results of this study revealed that coumarinyl thiazole and oxadiazole derivatives could act as potential ALR1/ALR2 inhibitors. Oxadiazoles 71-81 aldo-keto reductase family 1 member B Homo sapiens 122-126